M. Pharm. (Pharmacognosy & Phytochemistry)

Syllabus of M. Pharm2013-2014M. Pharm. (Pharmacognosy & Phytochemistry)TERMINOLOGY:S MEANS SEMESTER.MPN MEANS MASTER OF PHARMACOGNOSY & PHYTOCHEMISTRY.L MEANS LECTURE.T MEANS TUTORIAL.P MEANS -MPN-2S2-MPN-2PSecondS2-MPN-3S2-MPN-4Faculty of PharmacyLSubjectResearch Project (P)Advances InPharmacognosy &Phytochemistry -IAdvances InPharmacognosy &Phytochemistry – I(P)Advances InPharmacognosy &Phytochemistry - IIElective – 1Total1TPMarksMidSem.Exam.Assign./ Quiz00 00 1603 01 00403000 00 08T.A.EndSem.Exam.Total001010 10010 100150150301010 10015003 01 00301010 10015003 01 0009 03 2430160104010 10050 500150750Integral University

Syllabus of M. Pharm2013-2014Name of the Course : Research Project (P)Course code: S2-MPN-1 PSemester : IIDuration : 120 HrsMaximum Marks : 150Teaching SchemePractical : 16 Hrs/weekExamination SchemeMid Semester Exam: 40MarksAssignment & Quiz: 00MarksT. A. : 10 MarksEnd Semester Exam: 100MarksName of the Course : Advances In Pharmacognosy & Phytochemistry - ICourse code: S2-MPN-2Semester : IIDuration : 40 HrsMaximum Marks : 150Teaching SchemeExamination SchemeTheory : 03 Hrs/weekMid Semester Exam: 30 MarksTutorial: 01 Hrs/weekAssignment & Quiz:10 MarksT. A.: 10 MarksEnd Semester Exam: 100 MarksUnit -1ContentChemotaxonomy: Significance in sclassification of medicinal plants,distribution of chemotaxonomic groups of constituents in plantkingdom like alkaloids, glycosides and terpenoids.Hrs07Unit -2Biogenetic pathways for the production of phytopharmaceuticals, such ascardiac glycosides,coumarins, flavones, menthol, nicotinic acid,quinidine, papaverine and ergocryptine.07Unit -3Industrially important volatile oils: Natural occurrence, theirchemistry, ontogenic variation and trade.Application of UV, IR, NMR, 1HNMR, 13CNMR and Massspectroscopy for structural elucidation of phytosterols, flavonoids andterpenoids.Recent advances in the field of Pharmacognosy and Phytochemistry withspecial reference to anticancer, antidiabetic, anti-inflammatory,hepatoprotective, adaptogenic and immunomodulators, memoryenhancers, antiviral agents and antihyperlipidemics.05Marine Pharmacognosy: Definition, present status, classification ofimportant bioactive agents, general methods of isolation andpurification, study of important bioactive agents, chemistry and uses.03Unit -4Unit -5Unit -6Faculty of Pharmacy20607Integral University

Syllabus of M. PharmUnit -7Unit-82013-2014Nutraceuticals: Global market prospects and study of five importantplants and their products in the international market.Poisonous and toxic plants with special reference to mushrooms.Total030240Text Books:It is strongly recommended that some standard book/s be used for practicals. The choice ofbook/s is left to the concerned teachers.Reference books :1. W.C. Evans, 2002. “Trease& Evan’s Pharmacognosy”. WB.Saunders& co., London.2. T. Swain, 1963. “Chemical plant Taxonomy”. Academic Press, London.3. C.A Stace, 1985. “Plant Taxonomy and Biosystematics”. Edward Arnold, London.4. C.K. Atal, “Cultivation and Utilization of Medicinal plants”. R.R.L. Jammu5. H.E. Street, 1997. “Plant Cell and Tissue Culture”. Blackwell Scientific, London.6. N. Takashashi, 1986. “Chemistry of Plant Hormones” CRC Press Inc., Florida.7. A.R. Gennaro, 2000.”Remington: The Science & Practice of Pharmacy”. Lippincott Williams& Wilkins, Philadelphia.8. Kaufmann, “Natural products for plants”. CRC press New York.9. K. Nakanishi, 1977. “Chemistry of Natural Products”. Kodansha Book Publishing Company,Osaka (Japan).Faculty of Pharmacy3Integral University

Syllabus of M. Pharm2013-2014Name of the Course : Advances In Pharmacognosy & Phytochemistry – I (P)Course code: S2-MPN-2PSemester : IIDuration : 120 HrsMaximum Marks : 150Teaching SchemePractical : 08 Hrs/weekExamination SchemeMid Semester Exam:30 MarksAssignment & Quiz:10 MarksT. A.: 10 MarksEnd Semester Exam: 100 MarksSuggested List of Laboratory Experiments :1. Isolation of Rutin from Rutagraveolens2. Hesperidin from Orange peel3. Aloin from Aloes4. Rhein from rhizome of Rheum species5. piperine from piper nigrum6. Quinine from Cinchona bark7. berberine from Berberisaristata8. Caffeine from Tea leaves9. Menthol from Mentha species10. Diosgenin from Dioscorea and Trigonella species. Determination of Antharacenederivatives inSenna by spectrophotometric method (Fair Buarian 1975)11. Reserpine in Rauwolfia by photometric method12.13.14.15.16.17.18.19.20.21.Carvone content of Umbelliferous fruitsCitral content in Lemon grass oilBitter principles of ChirataSolanaceous drugsTropane alkaloids using Vitali Morin reactionquantitative estimation of Saponin as per W.H.O. protocol in suitable plant materialResin content in sample of podophyllum by B.P.C. methodOptical rotation of oil of LemonAcid value of Colophony resin by B.P. method. Antimicrobial activity of some volatile oils.Examination of Rhubarb for the presence of Rhapontic Rhubarb by the useof paper chromatography and ultraviolet light.Faculty of Pharmacy4Integral University

Syllabus of M. Pharm2013-2014Name of the Course : Advances In Pharmacognosy & Phytochemistry – II(Standardization and Evaluation of Natural Product Drugs and Formulations)Course code: S2-MPN-3Semester : IIDuration : 40 HrsMaximum Marks : 150Teaching SchemeExamination SchemeTheory : 03 Hrs/weekMid Semester Exam:30 MarksTutorial: 01 Hrs/weekAssignment & Quiz: 10 MarksT. A.: 10 MarksEnd Semester Exam: 100MarksUnit-1ContentIntroduction: Factors affecting squality of crude drugs, methods fordocumentation and preservation of crude drugs and their products,detection of common adulterants, microbial contamination, toxicmetals, pesticides, insecticides and insect infestation in whole andpowdered drugs.Hrs06Standardization requirements of herbal medicines, traditional andfolklore remedies and preparations: their quality, safety and efficacyassessment.Importance of monographs of medicinal plants, their comparativestudy as per IP, API, Unani, Pharmacopoeia, HomoeopathicPharmacopoeia, Siddha Pharmacopoeia, BHP, JapanesePharmacopoeia, Chinese Pharmacopoeia, European Pharmacopoeia,USP (dietary supplements), WHO and EMEA guidelines and ESCOPmonographs for medicinal products.05Quantitative assays to determine extraction efficiency: generalmethods of analysis: estimation of alkaloids, steroids, terpenoids andflavonoids: active component analysis and purity determinationusing UV, GLC, HPTLC and electrophoretic methods.Quality control of single and multicomponent plant drugs and plantderived classical Ayurvedic and Unani formulations by study ofHPTLC and HPLC fingerprints.06Unit-6Natural products-derived combinatorial libraries and theirsignificance in drug discovery programs. Shelf life study, protocolsto study stabilization of herbal based products. Assessment ofphysical, physic-chemical and chemical parameters at differentstages.03Unit-7Bioavailability and pharmacokinetic significance for herbaldrugs with examples of clinically used herbal drugs.04Unit-8Preparation of DMF for herbal medicines.02Unit-9Patents: IPR and Regulatory Affairs related to plants and ty of Pharmacy5070540Integral University

Syllabus of M. Pharm2013-2014Text Books:It is strongly recommended that some standard book/s be used for practicals. The choice ofbook/s is left to the concerned teachers.Reference books :1. Indian Herbal Pharmacopoeia, Vol. 1&2, RRL, IDMA, 1998, 2000.2. Indian Pharmacopoeia, 2010.3. V. Rajpal, 2002. “Standardization of Botanicals”, Eastern Publishers, New Delhi.4. J.B. Harborne, 1998. “Phytochemical methods”, Chapman and Hall.5. K. Paech, 1956. “Modern methods of plant analysis”., Springer-Verlag.Faculty of Pharmacy6Integral University

Syllabus of M. Pharm2013-2014Name of the Course : Elective - 1Course code: S2-MPN-4Semester : IIDuration : 40 HrsMaximum Marks : 150Teaching SchemeTheory : 03 Hrs/weekExamination SchemeMid Semester Exam: 20MarksTutorial: 01 Hrs/weekAssignment & Quiz:10 MarksT. A.: 10 MarksEnd Semester Exam: 100 MarksNOTE: Students have to choose either PART – A or PART – B.Contents -APARTHrsUnit-1General methods of processing of herbs.Unit-2Methods of preparation of extracts.Unit-3Isolation and estimation of Phytoconstituents.Unit-4Herbal formulation development.Unit-5Quality assurance of Herbal formulationsUnit-6Biological evaluation of Herbal drugsTotal40PART – BUnit-1Scope of plant cultivation, factors affecting quality of plant and animaldrugs. Substitution and adulteration of crude drugs.Unit-2Unit-3WHO guidelines on good agricultural and collection practices (GACP) formedicinal plants.Problems and recent trends in pest management, scope of biologicalcontrol and use of environment friendly pesticides especially plant derivedproducts, Pyrethroids, pheromones and juvenile hormones.Unit-4GMP for the production of quality botanicals.Unit-5Herbal cosmetics for skin, hair and dental care. Determination of shelf lifeof raw drugs, powered drugs, extracts, fractions and finished products.Unit-6Global regulatory status of herbal medicines, patents.Total40Text Books: N AFaculty of Pharmacy7Integral University

Syllabus of M. Pharm2013-2014References:Herbal Drug Industry by R. D. Choudhary. 1st Edition, Eastern Publisher, New Delhi, 1996.GMP for Botanicals – Regulatory and Quality issues on Phytomedicine Business horizons, NewDelhi, 1st Edition, 2003, Robert Verpoorte, Pulok K Mukharjee.Herbal Cosmetics – H. Pande, Asia Pacific Business press, New Delhi.H. Pande, “The complete technology book on herbal perfumes and cosmetics”, NationalInstitute of Industrial Research, Delhi.Quality control of herbal drugs by Pulok K Mukarjee, 1st edition, Business horizonspharmaceuticals publisher, New Delhi, 2002.PDR for herbal medicines, 2nd Edition, Medicinal economic company, New Jersey, 2000.Indian Herbal Pharmacopoeia, Volume 1st & 2nd, RRL,LDMA.Text book of Pharmacognosy by C. K. Kokate, Purohit, Gokhlae, 4th Edition, Nirali Prakashan,1996.Text book of Pharmacognosy and Phytochemistry by Rangare.Plant drug Analysis, 2nd edition by Wagner, Bladt.Biological standardization by J. N. Barn, D. J. finley and L. G. Good win.Faculty of Pharmacy8Integral University

study as per IP, API, Unani, Pharmacopoeia, Homoeopathic Pharmacopoeia, Siddha Pharmacopoeia, BHP, Japanese Pharmacopoeia, Chinese Pharmacopoeia, European Pharmacopoeia, USP (dietary supplements), WHO and EMEA guidelines and ESCOP monographs for medicinal products. 07 Unit-4 Quanti