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LIVINGBIOLOGICSBiologics Workflow Solutions

Introduction Biomolecular Discovery Immune FunctionBIG MOLECULESBIGGER BREAKTHROUGHS Characterization Safety and Efficacy Manufacturing Informatics ServicesThe powerful role of precision biologics as part of therapeutic strategies –monoclonal antibodies, recombinant proteins, vaccines, and targetednext-generation cell and gene therapies – becomes increasingly apparentevery day. Unlike traditional chemically synthesized drugs, which act on ahydrophobic pocket of a protein to activate or inhibit a kinase pathway,biotherapeutics pharmacological action is by way of binding to its targetor immunomodulation.Harnessing large molecules to create safe and effective therapies is acomplex and expensive undertaking. So we help scientists like youdevelop and streamline your entire biologics workflow, helping youovercome the challenges to bringing consistent, high-quality, biologicalmedicines to market – faster than ever before.TECHNOLOGY Genomics Solutions Detection Solutions Cellular Imaging Solutions In Vivo Imaging Solutions Analytical Instrumentation Analytical Consumables Contact Us

IntroductionDISCOVERY RIGHT ON TARGET Biomolecular Discovery Immune Function Characterization Safety and EfficacyBiomolecular drug discovery is taking the disease andtarget biology from early research, and validatingthrough target model systems while collecting evidencesupporting the target rationale and mechanism ofaction of the target biology.Finding the right biomolecular lead to the target ofinterest is a critical challenge in taking a target’s biologyand making it druggable. Accelerating biomoleculardiscovery by using a combination of in vitro and in vivotechniques, coupled with powerful software, helpstransform data into insights. These techniques include: Cellular imaging for in vitro target validation In vivo imaging for target discovery and validation Highly interactive visualization for rapid identificationand isolation of biologics In silico computer-aided research ManufacturingTARGETIDENTIFICATIONAND VALIDATIONCLONESELECTION ANDDEVELOPMENTLEAD DISCOVERYAND SCREENING Informatics ServicesTECHNOLOGY Genomics SolutionsTARGET IDENTIFICATION Detection SolutionsEarly stages of biomolecular discovery consist of target identificationand validation. Molecular characterization and cellular and in vivoimaging technologies, physiologically relevant and predictive modelsystems, and data analytics software enable identification andvalidation of disease targets.READ MORE Cellular Imaging Solutions In Vivo Imaging Solutions Analytical Instrumentation Analytical Consumables Contact Us

IntroductionDISCOVERY RIGHT ON TARGET Biomolecular Discovery Immune Function Characterization Safety and EfficacyBiomolecular drug discovery is taking the disease andtarget biology from early research, and validatingthrough target model systems while collecting evidencesupporting the target rationale and mechanism ofaction of the target biology.Finding the right biomolecular lead to the target ofinterest is a critical challenge in taking a target’s biologyand making it druggable. Accelerating biomoleculardiscovery by using a combination of in vitro and in vivotechniques, coupled with powerful software, helpstransform data into insights. These techniques include: ManufacturingTARGETIDENTIFICATIONAND VALIDATIONCLONESELECTION ANDDEVELOPMENTLEAD DISCOVERYAND SCREENING Genomics SolutionsCLONE SELECTION AND DEVELOPMENT Detection SolutionsWe offer multiple chemistries for high-throughput antigen-proteinelucidation that, when coupled with our integrated automationsolutions, move you quickly through your lead discovery workflows. Cellular Imaging Solutions In Vivo Imaging Solutions Analytical Instrumentation Analytical Consumables In vivo imaging for target discovery and validation In silico computer-aided research ServicesTECHNOLOGY Cellular imaging for in vitro target validation Highly interactive visualization for rapid identificationand isolation of biologics InformaticsREAD MORE Contact Us

IntroductionDISCOVERY RIGHT ON TARGET Biomolecular Discovery Immune Function Characterization Safety and EfficacyBiomolecular drug discovery is taking the disease andtarget biology from early research, and validatingthrough target model systems while collecting evidencesupporting the target rationale and mechanism ofaction of the target biology.Finding the right biomolecular lead to the target ofinterest is a critical challenge in taking a target’s biologyand making it druggable. Accelerating biomoleculardiscovery by using a combination of in vitro and in vivotechniques, coupled with powerful software, helpstransform data into insights. These techniques include: Cellular imaging for in vitro target validation In vivo imaging for target discovery and validation Highly interactive visualization for rapid identificationand isolation of biologics In silico computer-aided research ManufacturingTARGETIDENTIFICATIONAND VALIDATIONCLONESELECTION ANDDEVELOPMENTLEAD DISCOVERYAND SCREENING Informatics ServicesTECHNOLOGY Genomics SolutionsLEAD DISCOVERY AND SCREENING Detection SolutionsLabs that efficiently and accurately identify key drug discoveryparameters can quickly promote the most appropriate targets anddevelop medicines to affect them. Our screening and lead-discoverysolutions let you manage screening data from raw imports, QC,analytics, and visualizations – and publish and share that data, too.READ MORE Cellular Imaging Solutions In Vivo Imaging Solutions Analytical Instrumentation Analytical Consumables Contact Us

IntroductionLEVERAGING THE BODY’S IMMUNE RESPONSES Biomolecular Discovery Immune Function CharacterizationAn immune response to a biological entity is highlydynamic, involving multiple processes andcomponents. Understanding the effect of theseprocesses is critical for an effective, predictivetreatment. In vitro functional assays cancharacterize this response with the scale necessaryto support discovery research. These include: Cytotoxicity Cytokine release and cell signaling Cellular responses Safety and Efficacy ManufacturingIN VITRO ASSAYSLIVE-CELL IMAGING Informatics ServicesTECHNOLOGYIN VITRO ASSAYS Genomics SolutionsWe offer a range of highly sensitive immunoassays, including Cr51,TRF-based assay technology, and next-gen no-wash assays, forcharacterizing the cytokine response, measuring signaling events,and understanding the antibody-dependent cellular cytotoxicity(ADCC) of biologics. Detection SolutionsREAD MORE Cellular Imaging Solutions In Vivo Imaging Solutions Analytical Instrumentation Analytical Consumables Contact Us

IntroductionLEVERAGING THE BODY’S IMMUNE RESPONSES Biomolecular Discovery Immune Function CharacterizationAn immune response to a biological entity is highlydynamic, involving multiple processes andcomponents. Understanding the effect of theseprocesses is critical for an effective, predictivetreatment. In vitro functional assays cancharacterize this response with the scale necessaryto support discovery research. These include: Cytotoxicity Cytokine release and cell signaling Cellular responses Safety and Efficacy ManufacturingIN VITRO ASSAYSLIVE-CELL IMAGING Informatics ServicesTECHNOLOGYLIVE-CELL IMAGING Genomics SolutionsImaging with live cells provides detailed information on the specificityand cytotoxicity. Our high-content and in-incubator live-cell imagingsolutions enable long-term quantification of cocultures in 2D or 3Dmodel systems. Detection Solutions Cellular Imaging Solutions In Vivo Imaging Solutions Analytical InstrumentationREAD MORE Analytical Consumables Contact Us

IntroductionKNOW YOUR BIOLOGICS INSIDE AND OUT Biomolecular Discovery Immune Function CharacterizationCharacterization of biologics ensures stabilityof drugs in terms of the structure, specificactivity against the target, and maintenanceof their functional characteristics as definedby critical quality attributes (CQAs) that mustbe met to comply with regulatory guidelines.With information gleaned from early drugdiscovery characterization, developabilityapproaches can mitigate risk in late drugdevelopment during CMC testing. GMPcompliance and qualification embedded inanalytical instrumentation guarantee safeand effective drug products for clinical trials,while reducing time to market. Safety and EfficacyIDENTITYTESTINGPOTENCYTESTINGPURITY ANDIMPURITYPROFILESTABILITYTESTING Manufacturing Informatics ServicesTECHNOLOGYIDENTITY TESTING Genomics SolutionsIdentification of a biological product during late drug discovery is animportant step in establishing the specific type of molecule beingdeveloped and launched as a therapeutic – monoclonal antibody,recombinant protein, nucleic acid or viral vector, and so on. Varioustechniques can be used to confirm the identity of a biological product. Detection SolutionsREAD MORE Cellular Imaging Solutions In Vivo Imaging Solutions Analytical Instrumentation Analytical Consumables Contact Us

IntroductionKNOW YOUR BIOLOGICS INSIDE AND OUT Biomolecular Discovery Immune Function CharacterizationCharacterization of biologics ensures stabilityof drugs in terms of the structure, specificactivity against the target, and maintenanceof their functional characteristics as definedby critical quality attributes (CQAs) that mustbe met to comply with regulatory guidelines.With information gleaned from early drugdiscovery characterization, developabilityapproaches can mitigate risk in late drugdevelopment during CMC testing. GMPcompliance and qualification embedded inanalytical instrumentation guarantee safeand effective drug products for clinical trials,while reducing time to market. Safety and EfficacyIDENTITYTESTINGPOTENCYTESTINGPURITY ANDIMPURITYPROFILESTABILITYTESTING Manufacturing Informatics ServicesTECHNOLOGYPOTENCY TESTING Genomics SolutionsBioassays, including cell-based assays, help determine the potency of thedrug substance, as well as evaluating the reproducibility and stability ofthe drug product. Most regulatory agencies require potency studiesbefore the release of any biologic compound under GMP guidelines. Detection Solutions Cellular Imaging Solutions In Vivo Imaging Solutions Analytical InstrumentationREAD MORE Analytical Consumables Contact Us

IntroductionKNOW YOUR BIOLOGICS INSIDE AND OUT Biomolecular Discovery Immune Function CharacterizationCharacterization of biologics ensures stabilityof drugs in terms of the structure, specificactivity against the target, and maintenanceof their functional characteristics as definedby critical quality attributes (CQAs) that mustbe met to comply with regulatory guidelines.With information gleaned from early drugdiscovery characterization, developabilityapproaches can mitigate risk in late drugdevelopment during CMC testing. GMPcompliance and qualification embedded inanalytical instrumentation guarantee safeand effective drug products for clinical trials,while reducing time to market. Safety and EfficacyIDENTITYTESTINGPOTENCYTESTINGPURITY ANDIMPURITYPROFILESTABILITYTESTING Manufacturing Informatics ServicesTECHNOLOGYPURITY AND IMPURITY PROFILE Genomics SolutionsWhether they occur during drug formulation or as APIs age, impuritiescan affect the safety and efficacy of biologics, even in small amounts.We offer innovative solutions for detection of all types and amounts ofimpurities, helping streamline your impurity profile workflows whilemaintaining GMP compliance in both late drug discovery and later drugdevelopment stages. Detection SolutionsREAD MORE Cellular Imaging Solutions In Vivo Imaging Solutions Analytical Instrumentation Analytical Consumables Contact Us

IntroductionKNOW YOUR BIOLOGICS INSIDE AND OUT Biomolecular Discovery Immune Function CharacterizationCharacterization of biologics ensures stabilityof drugs in terms of the structure, specificactivity against the target, and maintenanceof their functional characteristics as definedby critical quality attributes (CQAs) that mustbe met to comply with regulatory guidelines.With information gleaned from early drugdiscovery characterization, developabilityapproaches can mitigate risk in late drugdevelopment during CMC testing. GMPcompliance and qualification embedded inanalytical instrumentation guarantee safeand effective drug products for clinical trials,while reducing time to market. Safety and EfficacyIDENTITYTESTINGPOTENCYTESTINGPURITY ANDIMPURITYPROFILESTABILITYTESTING Manufacturing Informatics ServicesTECHNOLOGYSTABILITY TESTING Genomics SolutionsBefore a drug gains market approval, it’s subject to a rigorous and highlyregulated stability testing regimen to ensure safety, integrity, shelf life,and responsiveness to environmental conditions. Our technologicalinnovation and new methodologies, together with diligence andmeticulous documentation, can give you better control of the stabilitytesting process. Detection SolutionsREAD MORE Cellular Imaging Solutions In Vivo Imaging Solutions Analytical Instrumentation Analytical Consumables Contact Us

IntroductionSAFETY FIRST, LAST, ALWAYS Biomolecular Discovery Immune Function Characterization Safety and EfficacyDuring all stages of drug development,comprehensive studies are required to uncover anypotential risks to patients from biological products,and to guarantee that they’re effective. Preclinicaldevelopment, including small animal model testing,is required to identify side effects such asimmunotoxicity of the large-molecule candidate onthe immune system. Stringent regulations such asGLP, GMP, and GCP are in place to minimize risks,guarantee safety, and accelerate the process of abiological product approval.IMMUNOGENICITY AND PHARMACOKINETIC/PHARMACODYNAMIC (PK/PD) MODELING Manufacturing Informatics ServicesCLINICAL TRIALSDRUG REPURPOSINGTECHNOLOGY Genomics SolutionsIMMUNOGENICITY AND PHARMACOKINETIC/PHARMACODYNAMIC (PK/PD) MODELING Detection SolutionsThe immunogenic potential of biotherapeutic drug molecules canhave an effect at any point, from the drug’s administration to itsmetabolism and elimination. So it’s important to understand theimpact of immunogenicity on the PK/PD properties of a largemolecule drug.READ MORE Cellular Imaging Solutions In Vivo Imaging Solutions Analytical Instrumentation Analytical Consumables Contact Us

IntroductionSAFETY FIRST, LAST, ALWAYS Biomolecular Discovery Immune Function Characterization Safety and EfficacyDuring all stages of drug development,comprehensive studies are required to uncover anypotential risks to patients from biological products,and to guarantee that they’re effective. Preclinicaldevelopment, including small-animal-model testing,is required to identify side effects such asimmunotoxicity of the large molecule candidate onthe immune system. And stringent regulations suchas GLP, GMP, and GCP are in place to minimizerisks, guarantee safety, and accelerate the processof a biological product approval.IMMUNOGENICITY AND PHARMACOKINETIC/PHARMACODYNAMIC (PK/PD) MODELING Manufacturing Informatics ServicesCLINICAL TRIALSDRUG REPURPOSINGTECHNOLOGY Genomics SolutionsCLINICAL TRIALS Detection SolutionsOur informatics solutions for clinical development aredesigned to streamline clinical trial data visualization andanalysis with real-time access to data in all phases of thediscovery-to-commercialization process. Cellular Imaging Solutions In Vivo Imaging Solutions Analytical Instrumentation Analytical ConsumablesREAD MORE Contact Us

IntroductionSAFETY FIRST, LAST, ALWAYS Biomolecular Discovery Immune Function Characterization Safety and EfficacyDuring all stages of drug development,comprehensive studies are required to uncover anypotential risks to patients from biological products,and to guarantee that they’re effective. Preclinicaldevelopment, including small-animal-model testing,is required to identify side effects such asimmunotoxicity of the large molecule candidate onthe immune system. And stringent regulations suchas GLP, GMP, and GCP are in place to minimizerisks, guarantee safety, and accelerate the processof a biological product approval.IMMUNOGENICITY AND PHARMACOKINETIC/PHARMACODYNAMIC (PK/PD) MODELING Manufacturing Informatics ServicesCLINICAL TRIALSDRUG REPURPOSINGTECHNOLOGY Genomics SolutionsDRUG REPURPOSING Detection SolutionsHuge amounts of archived research and data can be quicklyretrieved and reanalyzed using informatics solutions. Whenused in conjunction with validated technology solutions,informatics technology can help you streamline workflows toenable repurposing of drugs from late-stage preclinical phasesand clinical trials.READ MORE Cellular Imaging Solutions In Vivo Imaging Solutions Analytical Instrumentation Analytical Consumables Contact Us

IntroductionBIOMANUFACTURING BETTER HEALTH Biomolecular Discovery Immune Function CharacterizationThe highly complex and costly process ofbiomanufacturing is one of the key differencesbetween small- and large-molecule drugdevelopment. Even the slightest manufacturingprocess change can affect a biologic’s safety andefficacy. So the entire process must be carefullyplanned and closely monitored to remain compliantwith regulatory strictures, with robustcharacterization technologies for the evaluation ofvaccines and therapeutics and repurposed drugsduring CMC protocols and QA/QC batch releasesof commercially available medicines. Safety and Efficacy ManufacturingCMC TESTINGQA/QC Informatics ServicesTECHNOLOGYCMC TESTING Genomics SolutionsThe CMC testing of drug substances and drug products plays a criticalrole in guaranteeing the quality of the drug product entering clinicaltrials. Once completed, the validated methods and technologies aretransferred to quality control (QC) in commercial manufacturing. Detection Solutions Cellular Imaging Solutions In Vivo Imaging Solutions Analytical InstrumentationREAD MORE Analytical Consumables Contact Us

IntroductionBIOMANUFACTURING BETTER HEALTH Biomolecular Discovery Immune Function CharacterizationThe highly complex and costly process ofbiomanufacturing is one of the key differencesbetween small- and large-molecule drugdevelopment. Even the slightest manufacturingprocess change can affect a biologic’s safety andefficacy. So the entire process must be carefullyplanned and closely monitored to remain compliantwith regulatory strictures, with robustcharacterization technologies for the evaluation ofvaccines and therapeutics and repurposed drugsduring CMC protocols and QA/QC batch releasesof commercially available medicines. Safety and Efficacy ManufacturingCMC TESTINGQA/QC Informatics ServicesTECHNOLOGYQA/QC Genomics SolutionsWhether you’re verifying and controlling the quality of your finalproducts or assuring the quality of the processes involved indesigning and manufacturing them, pharma QA/QC is a key part ofcomplying with regulatory mandates while delivering a producteveryone can trust. Detection SolutionsREAD MORE Cellular Imaging Solutions In Vivo Imaging Solutions Analytical Instrumentation Analytical Consumables Contact Us

IntroductionSMARTER QUESTIONSBETTER ANSWERS Biomolecular DiscoveryWith all the advances in biologics discovery, we’re generatingvast amounts of genome and proteome sequencing data.Making sense of all that data is perhaps the challenge of ourtime. So our informatics solutions are designed to speedidentification of therapeutic candidates; help you import, align,and analyze biological sequences; and manage experimental,instrument, and outsourced pharmacology data. Immune Function Characterization Safety and Efficacy Manufacturing Informatics ServicesELECTRONIC LAB NOTEBOOKSWe offer ELNs to meet the needs of scientists and researchers in a wide range of industries, helping you organize and share experimental dataTECHNOLOGYefficiently and communicate seamlessly with the common instruments and devices you use. Read More Genomics SolutionsLEAD DISCOVERY Detection SolutionsOur lead-discovery solutions provide a faster way to help chemists and biologists gain insights into chemical structure and biologics sequence Cellular Imaging Solutionsactivity through a guided search and analysis workflow that queries and represents data in intuitive, intelligent ways. Read MoreDATA VISUALIZATIONOur data visualization platform can empower your team or your entire organization to easily mine scientific and business data and gain insights, inreal time. You can create simple dashboard metrics, predictive applications, or dynamic real-time analytics applications with capabilities such asvisual analytics, data wrangling, predictive analytics, location analytics, and streaming analytics. Read MoreCLINICAL ANALYTICSOur solutions streamline clinical trials with real-time access to data during all phases of clinical development, allowing you to interact withinformation as soon as it’s collected. You’re better able to explore key aspects of the protocol for specified follow-up, ensure adherence byidentifying drop-outs and violations, facilitate data cleaning and data quality, and much more. Read More In Vivo Imaging Solutions Analytical Instrumentation Analytical Consumables Contact Us

IntroductionEXPERT SERVICESWHEREVER YOU NEED THEM Biomolecular DiscoveryMost labs don’t maintain the in-house expertise needed to plan andimplement the types of projects that can transform chaotic laboperations into the sleek, efficient, effective lab of the future. Afterall, you should be concentrating on your core competency – yourscience – and leaving the infrastructure, operations, and even labmanagement to the professionals. That’s why so many smart labsare looking to outsourcing to help them plan, design, deploy, andmanage their lab environments. Immune Function Characterization Safety and Efficacy Manufacturing Informatics ServicesCOMPUTER SYSTEM VALIDATION (CSV)CSV services range from full validation or commissioning for new systems to change-control validation for existing standalone and enterprise systems.Our team follows GAMP 5 templates and aligns with your site’s policies and procedures as they relate to the software development lifecycle. At thesame time, we provide a range of software IQ/OQ offerings, including enhanced-security instrument software products. Read MoreDATA INTEGRITYTECHNOLOGY Genomics Solutions Detection SolutionsMany regulatory agencies have determined that electronic data is more secure than paper documentation and less likely to be manipulated over the Cellular Imaging Solutionsphases of a product’s development lifecycle. But that doesn’t mean electronic lab data is perfect: It must comply with other stringent regulations, In Vivo Imaging Solutionsincluding 21 CFR Part 11 and the EDQM Annex 11. Read MoreINSTRUMENT QUALIFICATIONOur OneSource Instrument Qualification methods maximize your lab productivity while providing ongoing compliance capabilities. We guide your labthrough automated, secure electronic or traditional paper qualification procedures with standard recommended OQ protocols customized to yourspecifications. Read MoreGMP RADIOSYNTHESISOur experienced chemists work with you to design and prepare your radiochemical to your exacting specifications. You have access to our extensivetechnical support resources to help with protocol creation, custom synthesis of radioactive products, stability testing, special packaging, and analyticalservices. Read More Analytical Instrumentation Analytical Consumables Contact Us

IntroductionGENOMICS: Automation Improves Workflow EfficiencyOur optimized, automated instruments and kits help you meet the challenges of genomics analysis by providing complete, single-source solutions, from sample to results. Biomolecular Discovery Immune Function Characterization Safety and Efficacy ManufacturingHIGH-THROUGHPUTNUCLEIC ACID ISOLATIONNUCLEIC ACID ANDPROTEIN ANALYSIS InformaticsAUTOMATED LIQUID HANDLINGNGS LIBRARY PREP KITS ServicesTECHNOLOGY Genomics SolutionsDETECTION: Innovative, Integrated Solutions That Accelerate Your WorkflowWhether you’re assessing the early stages of the drug candidate or monitoring an immune response, our assay platforms including immunoassay reagents provide simple,sensitive, streamlined workflows to accelerate your biologics research and therapeutic development. Detection Solutions Cellular Imaging Solutions In Vivo Imaging Solutions Analytical Instrumentation Analytical Consumables Contact UsRADIOCHEMICALS ANDRADIOMETRIC DETECTORSMULTIMODEPLATE READERSMICROPLATESASSAYS AND REAGENTS

IntroductionCELLULAR IMAGING: Phenotype Cellular Responses to Biologics Biomolecular DiscoveryOur powerful tools can help you gain a more complete understanding of cell biology – and deliver greater insights. Immune Function Characterization Safety and Efficacy ManufacturingHIGH-CONTENT IMAGINGLIVE-CELL IMAGINGIMAGE ANALYSISAND DATA SHARINGMICROPLATES FORCELL IMAGING Informatics ServicesTECHNOLOGY Genomics SolutionsIN VIVO IMAGING: The Power of Preclinical Imaging for Biologics DevelopmentWhether you’re monitoring tumor growth and progression, angiogenesis, or metastases, performing toxicology studies, or enhancing your understanding of biologicalpathways, our small-animal imaging tools can streamline your drug development workflows. Detection Solutions Cellular Imaging Solutions In Vivo Imaging Solutions Analytical Instrumentation Analytical Consumables Contact UsOPTICAL IMAGINGMICRO-CT IMAGINGIN VIVO IMAGING REAGENTS

IntroductionANALYTICAL: Driving Quality in Your Biologics WorkflowIdentify and characterize your biological products while ensuring 21 CFR Part 11 compliance by taking advantage of our complete array of high-performance,highly accurate analytical solutions. Biomolecular Discovery Immune Function Characterization Safety and Efficacy Manufacturing InformaticsATOMIC SPECTROSCOPYMOLECULAR SPECTROSCOPYCHROMATOGRAPHYTHERMAL ANALYSIS ServicesTECHNOLOGY Genomics SolutionsTRUST THE CONSUMABLES ENGINEERED FOR YOUR ANALYTICAL INSTRUMENTSWe select only the highest quality products for our consumables portfolio and invest heavily in quality testing and validation, so you can enjoy reliable performance,control operating costs, and maximize instrument uptime. Detection Solutions Cellular Imaging Solutions In Vivo Imaging Solutions Analytical Instrumentation Analytical Consumables Contact Us

For more information visit www.perkinelmer.com/biologicsPerkinElmer, Inc.940 Winter StreetWaltham, MA 02451 USAP: (800) 762-4000 or( 1) 203-925-4602www.perkinelmer.comFor a complete listing of our global offices, visit www.perkinelmer.com/ContactUsCopyright 2020, PerkinElmer, Inc. All rights reserved. PerkinElmer is a registered trademark of PerkinElmer, Inc. All other trademarks are the property of their respective owners.74954PKI

target biology from early research, and validating through target model systems while collecting evidence supporting the target rationale and mechanism of action of the target biology. Finding the right biomolecular lead to the target of interest is a critical challenge in taki

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