Mahatama Jyotiba Phule Rohilkhand University , Bareilly

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M. J. P. ROHILKHAND UNIVERSITYBAREILLYDEARTMENT OF PHARMACYSyllabusMaster of Pharmacy (M.Pharm)(Pharmacology)Effective from academic session 2013-141

Subject and evaluation scheme, M.Pharm (Pharmacology)Name of SubjectM. Pharm. I Year, Ist SemesterstModern Analytical TechniquesModern Analytical Techniques PracticalPharmaceutical BiotechnologyPharmacology and Drug therapyPharmacology and Drug therapy PracticalMarks AllottedPaper (H/W) Internal . Pharm Ist Year, IInd SemesterPharmacotherapeuticsPharmacotherapeutic PracticalExperimental Pharmacology and Drug EvaluationExperimental Pharmacology and Drug EvaluationPracticalRecent Advances in Pharmacologynd30rdM. Pharm II Year, III SemesterResearch MethodologyWorkshop on Research MethodologySynopsis Presentation & Viva VoceM. Pharm IInd Year, IVth SemesterDissertation Work Presentation Viva voce2

External Marks: 70Internal Marks: 30Total Marks: 100Semester-I(Pharmacology)Paper 1-MODERN ANALYTICAL TECHNIQUES4 hours/week1- Theory, instrumentation and applications with regard to drug analysis, decomposition productindentification and estimation, metabolite analysis and special methods based on: Ultraviolet-visiblespectrophotometry, Infrared spectrophotometry and Fluorimetry.2- Theory, instrumentation and basic principles and recent advances of:1. 1H Nuclear Magnetic Resonance Spectroscopy (1H NRM): Concepts of chemical shift,spin-spin coupling, coupling constant, shielding and deshielding effects.2. Mass Spectroscopy: Introduction, different techniques of ionization (CI, EI & FABMS)isotopic abundance, molecular on fragmentation, base peaks etc, Nitrogen rule.3. Chromatographic methods, principles and applications of: Gas-chromatographyincluding GC-MS; High performance liquid chromatography; Electrophoresis (gel andcapillary) with an emphasis on specific examples of biological assay methods by HPTLC.Books Recommended:1. Willard H.H., Merrit L.L., Dean J.A., Settle P.A., Instrumental Methods of Analysis, Van Nostrand.2. Skoog D.A., Heller F.J., Nieman T.A., Principles of Instrumental Analysis, WB Saunders.3. Hunson J.W., ed. Pharmaceutical Analysis, Modern Methods, part A & B, Marcel Dekker.4. Schirmer R.E., ed. Modern Methods of Pharmaceutical Analysis, Vols 1, 2. Boca Raton F.L., CRCPress.5. Mann C.K. et al., Instrumental Analysis Harper & Row.6. Jaffe H.H., Orchin M., Theory & Applications of Ultraviolet Spectroscopy, Willy.7. Silverstein, Spectrometric identification of Organic Compounds, Willy.8. Bovey F., Jelinski L., Miran P., Nuclear Magnetic Resonance Spectroscopy, Sau: Diego Academic.9. Stothers J.B., Carbon-13 NMR.Spectroscopy, Academic.10. Gordy W., Theory & Applications of Electron Spin Resonance, Willy.11. Haswell S.J., ed. Atomic Absorption Spectroscopy, Elsevier.12. Ardrey R.E., Pharmaceutical Mass Spectra, Pharmaceutical Press, London.13. Budzikiewicz et al., Interpretation of Mass Spectra of Organic Compounds, Holden-Day SanFrancisco.14. Beckett and Stenlake, Practical Pharmaceutical Chemistry, CBS.15. Stahl E., Thin Layer Chromatography- A laboratory Handbook, Springer-Verlag16. Giddings J.C., Principles and Theory- Dynamics of Chromatography, Marcel Dekker.17. Sethi P.D., Quantitative Analysis of Pharmaceutical formulations, CBS Publishers, New Delhi.18. Kemp William, Organic spectroscopy, Pal grave, New York.19. Kalsi P.S., Spectroscopy of organic compounds, New age publishers, New Delhi.20. Gross - Mass Spectrometry21. WHO - Quality Assurance of Pharmaceuticals, Vol. I, II.22. Sethi P.D., HPLC, Quantitative Analysis of Pharmaceutical Formulations, CBS Publishers, Delhi.23. Sethi P.D., HPTLC, Quantitative Analysis of Pharmaceutical Formulations, CBS Publishers, Delhi.24. Haffmann, Chromatography.25. Sethi and Charcgankar, Identification of Drugs in Pharmaceutical Formulations by TLC.26. Robert D. Braun, Introduction to Instrumental Analysis.27. Wilfried M.A. Niessen- Liquid Chromatography-Mass Spectrometry.3

28. Harry G. Brittain, Spectroscopy of Pharmaceutical Solids.29. George S., Steroid Analysis in Pharmaceutical Industry.30. Higuchi, Pharmaceutical Analysis.31. Bidingmeyer, Practical HPLC Methodology and Applications.32. Hoffmann, Mass Spectrometry: Principle and Application.33. Scott, Techniques and Practice of Chromatography.34. Wilkins, Identification of Microorganism by Mass Spectrometry.35. Wu, Handbook for Size Exclusion Chromatography and related Techniques.Paper 2: PRACTICALS OF MODERN ANALYTICAL TECHNIQUESExternal Marks: 70Internal Marks: 30Total Marks: 1006 hours/weekPractical Based on theoryPaper 3: PHARMACEUTICAL BIOTECHNOLOGYExternal Marks: 70Internal Marks: 30Total Marks: 1004 hours/week1. Status and Scope of Biotechnology in Pharmacy Enzyme immobilization-Principles andPharmaceutical applications.2. Biotechnology based pharmaceutical using recombinant DNA Technology, interferons andreverse transcriptase.3. Optimization of fermentation processes-Ethyl Alcohol, Antibiotics, Vitamins, Amino acidsand Pharmaceutical solvents-raw materials, process and process validation.4. Bo-technology & GMP Formulation approaches to protein stabilization. Regulatory aspects ofBiotechnology based pharmaceuticals.5. Introduction to Bioinformatics.Book Recommended:1. Wiseman A.,ed, Principles of Bio-technology”, Chapman & Hall.2. Antebi E, Fishlock D. Biotechnology-Strategies for life. Cambridge.3. Higgins 1.1., Best, DJ & Jones. Biotechnology, Principles & Applications. BlackwellScientific Publications, Oxford.4. Stanbary P.F. and Whitaker. A Principles of Fermentation Technology. Pergamon Press,Oxford.5. Golub E. The limits of Medicine: How Science shapes our Hope for the cure. Time Books,New York.6. Bickerstaff GF. Enzymes in Industry and Medicine, New Studies in Biology. EdwinArnold, London.4

7. Glick. BR, Pasternak J.I. Molecular Biotechnology-Principles and Applications ofRecombinant DNA. ASM Press Washington.PAPER 4: PHARMACOLOGY AND DRUG THERAPYExternal Marks: 704 hours/weekInternal Marks: 30Total Marks: 1001: Principles of General Pharmacology1. Introduction2. Sources of drugs3. Dosage forms of drugs4. Routes of drug administration5. Mechanisms of drug actions6. Factors affecting drug actions7. Biotransformation of drugs8. Pharmacokinetics of drugs9. Pharmacodynamics of drugs10. Drug interactions11. Adverse drug reactions2: Drugs acting on Autonomic nervous system1. Introduction2. Parasympathetic nervous system3. Sympathetic nervous system4. Ganglionic stimulating agents5. Ganglionic blocking agents6. Adrenergic neuron blocking agents3: Drugs acting on Peripheral nervous system1. Skeletal muscle relaxants2. Local anaesthetics4: Drugs acting on Central nervous system1. Introduction2. General anaesthetics3. Alcohol4. Anxiolytics and hypnotics5. antidepressants6. Antimanics7. Antipsychotics8. CNS stimulants9. Psychomimetics10. Antiepileptics11. Opioid analgesics12. Drug dependence and drug abuse5

5: Drugs acting on Gastrointestinal tract1. Introduction2. Peptic ulcer3. Antiemetics4. Anti-constipation agents5. Antidiarrhoeals6: Miscellaneous topics1. Drug use in the pediatrics2. Drug use in the geriatrics3. Vitamins and antioxidants4. Essential medicines5. Rational use of drugs6. Gene therapy7. Drug patentsBooks Recommended1. K.K. Maheshwari. Drugs Pharmacology, 1st edition, Vallabh Publication, New Delhi.India.2. Goodman and Gillman’s. The pharmacological basis of therapeutics, 10th edition,Pergamon press, New York, U.S.A., 20013. Dipiro, J.T., Pharmacotherapy: A Pathologic Approach, Appleton Lange, U.S.A., 1997.4. Munson, P.L., Principles of pharmacology, Chapman and Hall, ITP an internationalpublishing company, New York.PAPER 5: PRACTICAL OF PHARMACOLOGY AND DRUG THERAPYExternal Marks: 706 hours/weekInternal Marks: 30Total Marks: 100Practicals based on theoryExternal Marks: 70Internal Marks: 30Total Marks: 100SEMESTER-II(PHARMACOLOGY)PAPER 6: PHARMACOTHERAPEUTICS4 hours/week1: Drugs acting on Renal system1. Diuretics2. Antidiuretics2: Drugs acting on Cardiovascular system1. Pharmacotherapeutic of angina pectoris2. Pharmacotherapeutic of hypertension6

3. Pharmacotherapeutic of cardiac arrhythmias4. Pharmacotherapeutic heart failure5. Pharmacotherapeutic of hyperlipidaemia and hypercholestrolaemia3: Drugs acting on Respiratory system1. Pharmacotherapeutic of asthma2. Pharmacotherapeutic of cough4: Drugs acting on Endocrinal system1. Introduction2. Hormones3. Thyroid and antithyroid drugs4. Vitamin-D5. Calcitonin and calcium balance6. Insulin7. Hypoglycaemic agents8. Contraceptives9. Anabolics and catabolics5: Drugs acting on Hematopoietic system1. Hematopoietic agents2. Coagulants and anticoagulants3. Fibrinolytics, thrombolytics and antiplatletics6: Pharmacotherapeutics of microbial diseases1. Chemotherapy2. Sulfonamides3. Tetracyclines and chloramphenicol4. Quinolones and fleuroquinolones5. Anminoglycosides6. Penicillins7. Cephalosporins8. β-Lactum antibiotics9. Macrolides10. Tuberculosis11. Leprosy12. Fungal infections13. Viral Infections14. Sepsis15. Malaria16. Helminthes17. Anticancer agentsBooks Recommended1. K.K. Maheshwari. Drugs Pharmacology, 1st edition, Vallabh Publication, NewDelhi. India.2. Goodman and Gillman’s. The pharmacological basis of therapeutics, 10 th edition,Pergamon press, New York, U.S.A., 20013. Dipiro, J.T., Pharmacotherapy: A Pathologic Approach, Appleton Lange, U.S.A.,1997.7

4. Munson, P.L., Principles of pharmacology, Chapman and Hall, ITP aninternational publishing company, New York.PAPER 7: PRACTICAL OF PHARMACOTHERAPEUTICSExternal Marks: 706 hours/weekInternal Marks: 30Total Marks: 100Practicals based on theoryPAPER 8: EXPERIMENTAL PHARMACOLOGY AND DRUG EVALUATIONExternal Marks: 704 hours/weekInternal Marks: 30Total Marks: 1001. Principles of experimental pharmacology1.1 Outline of experimental pharmacology.1.2 Principles of experimental pharmacology.1.3 Euthanasia of experimental animals1.4 Common laboratory animals in pharmacological research.1.5 Anaesthetics used in laboratory animals.1.6 Standard techniques used in laboratory animals.1.7 Limitation of animal tests.1.8 Statistical design and analysis.1.9 Regulations for care and use of laboratory animals.2. Drug discoveryBio-assays.Preclinical (biological and safety evaluation).Clinical evaluation (clinical trials) of new drugs.Transgenic animal in the development of new drugs.3. Receptor-ligand binding assays1. General principle and techniques2. Specific assay design for adrenoceptors, dopamine receptors, histamine receptors,GABA and benzodiazepine receptors.4. Basics of biotechnology, and biotechnological tools in drug development5. Basics of nanotechnology, and nano-techniques in drug development.6. Pharmacological techniques to evaluate the following class of drugs1. Analgesics2. Anthelmintics3. Antianginals4. Anti-anxiety or anxiolytics5. Antiarrhythmics6. Anti-cancers8

7. Antidepressants8. Anti-epileptics9. Anti-fertility10. Anti-hypertensives11. Anti-parkinsonian agents12. Anti-thrombotics13. Anti-psychotics14. Anti-ulcer agents15. Antiviral16. Atherosclerosis and Hyperlepidimics17. Anti-diabetics18. Diuretics19. Hypno-sedatives20. Anti-pyretics21. Anti-inflammatory agents22. Local anaesthetics23. Neuromuscular blockers24. Nootopic and cerebroactive agents25. Skeletal muscle relaxantsBooks Recommended1. K.K. Maheshwari. Drug Screening Techniques, 1st edition, Vallabh Publication,New Delhi. India.2. Drug Discovery and Evaluation by Vogel HG. Springer, N Y3. Practical Pharmacology by Burn, J.H. Blackwell Scientific Co. Oxford4. Screening Methods in pharmacology. Vols I and II by A. Turner, Academic Press.5. Evaluation of Drug Activities: Pharmacometrics by Lawrence and Bacharach,Academic Press.6. Drug Bioscreening by Thompson, E.B. VCH, New York7. Various regulatory guideliens like ICH, GCP, Helsinki, USFDA etc.8. Pharmacopoeia: IP, BP, USP etc.9. Transgenic Animal Technology, Second Edition: A Laboratory Handbook by CarlA. Pinkert, Academic press10. Handbook of Experimental Pharmacology by Hofmann, F.B., Springer11. Fundamentals of Experimental Pharmacology by Gohsh, M.N., Scientific BookAgency, Calcutta.PAPER 9: PRACTICAL OF EXPERIMENTAL PHARMACOLOGY AND DRUGEVALUATIONExternal Marks: 706 hours/weekInternal Marks: 30Total Marks: 100Practicals based on theory9

PAPER 10: RECENT ADVANCES IN PHARMACOLOGYExternal Marks: 704 hours/weekInternal Marks: 30Total Marks: 1001. Molecular Pharmacology1.1 Receptor occupancy and cellular signaling systems: G-proteins, cyclic nucleotides,calcium and calcium binding proteins, protein kinases, phosphatidylinositol,phospholipases.2. Pharmacology of ReceptorsClassification, cellular signaling systems, pharmacology of agonists and antagonists ofthe following receptors typesAngiotensin receptorsExcitatory amino acid receptorsPurinorecetorsSerotonin receptorsDopamine receptorsAdrenoceptorsGABA and Benzodiazepine receptorsCanabinoid receptorsNeurosteroid receptorsErb B-receptors3. Ionic channels and their modulatorsClassification and biology of ionic channels. Pharmacology of substances whichmodulate the following channelsCalcium channelsPotassium channelsSodium channelsChloride channels4. NeuropeptidesNeuropeptide-Y, Calcitonin gene related peptide, Cholecystokinin, endogenous opioids,substance-P, ATP binding cassette proteins family.5. Biology of vascular endotheliumEDRF, EDCF, EDHF. Pharmacology of endothelins and nitric oxide. Clinicalimplications of endothelial dysfunctions.6. Cytokinins and chemokininesPharmacological, pathological and clinical implications of various cytokinins andchemokines.7. Cell adhesion molecules and matrix proteinsBiological role of cell adhesion molecules and matrix proteins in various diseases.Potential target sites to develop new drugs for various disorders. GP IIb/IIIa receptorsantagonists. Anti-integrin therapy.8. Growth factors-10

Biology of various growth factors and their therapeutic potentials. Pharmacology ofcardiac and vascular remodeling.Books Recommended1. Goodman and Gillman’s. The pharmacological basis of therapeutics, 10 th edition,Pergamon press, New York, U.S.A., 20012. Dipiro, J.T., Pharmacotherapy: A Pathologic Approach, Appleton Lange, U.S.A.,1997.3. Munson, P.L., Principles of pharmacology, Chapman and Hall, ITP an internationalpublishing company, New York.4. Latest Reviews of pharmacology, medicine, toxicology, physiology etc.SEMESTER-III(PHARMACOLOGY)Paper 11: RESEARCH METHODOLOGYExternal Marks: 30Internal Marks: 20Total Marks: 504 hours/week1.2.3.4.Research: meaning, purpose, types, objectives of research.Literature survey: use of library, books, journal, medlines, internetSelecting a problem and preparing research proposalDocumentation: Research paper/thesis writing (different parts, key words, implementation ofstatistics discussion, support or non support of hypothesis, practical and theoretical implications.5. Statistical Analysis of data including standard deviation, standard error, student t-test, chi-squaretest, confidence level, null hypothesis, analysis of variance(one and two way), factorial design,ANOVA(one way and two way), multiple comprasion procedures6. Application of software for statistical calculatons like SPSS, foxtronBook Recommended:1. Bolton, Pharmaceuticals Statistics- Practical & Clinical Applications, Marcel Dekker, NewYork.2. Fisher, R.A., Statistical Methods for Research Works, Oliver & Boyd, Edinburgh.3. Chow, Statistical Design and Analysis of Stability Studies, Marcel Dekker, New York.4. Buncher, Statistics in the Pharmaceutical Industry, Marcel Dekker, New York.5. Finney, D.J., Statistical Methods in Biological Assays, Hafner, New York.6. Montgomery, D.C., Introduction to Statistical Quality Control, Willy.7. Khan, Irfan A., Biostatistics for Pharmacy.8. Khan, Irfan, A., Fundamentals of Biostatistics.9. Gauthaman, Biostatistics for Pharmacy students.10. Lipschutz, Introduction to Probability and Statistics.11. Liwan Po, Statistics for Pharmacist.12. William E. Fassett, Computer Application in Pharmacy.13. Ekins, S., Computer Application in Pharmaceutical Research & Development, Wiley.14. Nageswara Rao and Tiwari, Biostatistics and Computer Applications.11

Paper 12: WORKSHOP ON RESEARCH METHODOLOGYExternal Marks: 30Internal Marks: 20Total Marks: 50Workshop on research methodologyPaper 13: SYNOPSIS PRESENTATION & VIVA-VOCEExternal Marks: 100Total Marks: 100SEMESTER-IV(PHARMACOLOGY)Paper 14: DISSERTATION PRESENTATION VIVA-VOCEExternal Marks: 300Total Marks: 30012

BR, Pasternak J.I. Molecular Biotechnology-Principles and Applications of . Munson, P.L., Principles of pharmacology, Chapman and Hall, ITP an international publishing company, New York. . Second Edition: A Laboratory Handbook by Carl A. Pinkert, Academic press 10. Handboo

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