MICR*3230 Immunology

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MICR*3230 ImmunologyFall 2020Section(s): C01Department of Molecular and Cellular BiologyCredit Weight: 0.50Version 1.00 - October 06, 20201 Course Details1.1 Calendar DescriptionThis course provides an introduction to the immune response of the vertebrate host, the cellsand tissues of the lymphoid system, humoral and cell-mediated immunity, the concept ofimmunity to diseases and current techniques in immunology.Pre-Requisites:BIOL*1090, BIOC*25801.2 Course DescriptionThis course provides an introduction to the immune response of the vertebrate host, the cellsand tissues of the lymphoid system, humoral and cell-mediated immunity, the concept ofimmunity to diseases and current techniques in immunology.1.3 TimetableMon, Wed, Fri, 11:30AM-12:20PM (online through Courselink and Zoom)Start Date: Friday September 11, 20201.4 Final ExamTues. Dec. 15 7-9 pmExam time and location is subject to change. Please see WebAdvisor for the latestinformation.2 Instructional Support

MICR*3230 C01 F20 v1.002.1 Instructional Support TeamInstructor:Email:Jennifer l:Bonnie Mallardmcb3230@uoguelph.ca3 Learning Resources3.1 Required ResourcesImmunology (Textbook)Immunology, 8th Edition, 2013, by Judith A. Owen, Jenny Punt, Sharon A. Stanford. W.H.Freeman & Co. (Online and hard-copy versions available, and on reserve in the library).3.2 RespondusRespondus will be used via Courselink for mid-term and final exams3.2 Tutorial & Question and Answer sessionsTwice a week on Tues. at 2pm and Thurs. at 10 am, online tutorial and question and answersessions will be facilitated by the Teaching Assistants using the Courselink VirtualClassroom.4 Learning OutcomesThe goal of this course is to learn structure and function of the vertebrate immune system inan integrated manner with an emphasis on host defense mechanisms against harmful agentsand maintenance of homeostasis. An understanding of the application of the knowledge ofimmunology in health and disease is desired. At the end of the course, students should beable to explain, analyze and apply:1. Immunology terms2. Structure and function of the cells/organs of the immune system3. Structure and function of immunological molecules4. Results of basic immunological techniques5. Development of humoral and cell mediated immune responses to infectious disease6. Advanced experimental applications in immunology5 Teaching and Learning ActivitiesLearning Strategy: A structured interactive lecture and discussion strategy, using illustrationsPage 2 of 13

MICR*3230 C01 F20 v1.00and multi media, will be used to emphasize the basic concepts. Lectures will be primarilyasynchronous (i.e., recorded and posted to Courselink during the assigned class time) withoptions for synchronous (i.e. live lectures) that will be recorded and posted after theclass. Students are encouraged to read the topics before lecture discussions to enhanceunderstanding and construct informal discussion groups to support their learning. Briefguided notes, to accompany the lectures, will be available via Courselink website. Onlineoffice hours will be held for up to 30 min following each scheduled class using the Courselinkvirtual classroom tool. Students are encouraged to ask questions relating to the learningmaterials during and outside the class. Students are encouraged to take advantage ofcoaching offered via a weekly structured ‘Tutorial’ on the topics covered during the lecturesand, also, a weekly ‘Question-Answer’ session. In general, the average grade for the courseis usually 70-72% in class size exceeding 350 students.5.1 Course Content & Lecture ScheduleInstructors: Geddes-McAlister (weeks 1-8), Mallard (week 9-15)WeekTopics Covered in LectureChapterReadings1-3A. Introduction: Dr. Jennifer GeddesMcAlisterIntroduction to the courseNo. OfLectures1(Kuby 8th Immunology Resources)3-5An overview of the Immune System12Cells, Organs and Microenvironments2244B. Innate Immunity:Innate Immunity(including one guest lecture from PhDPage 3 of 13

MICR*3230 C01 F20 v1.00WeekTopics Covered in LectureChapterReadingsNo. OfLectures5 (165-198)23(69-103)1Antibody structure3(69-103);1Immunoglobulin (BCR) genes6(205-236)1B cell Development and differentiationand Effector Response: Development ofAntibody mediated immunity112student at Brock University working on hostpathogen interactions with COVID-19)Online quiz - Wed. Sept. 23, 2020 (openbook)Complement System6C. Recognition and Response:Antigens, B cell Antigen Receptor (BCR)and Signaling, Antigen- AntibodyInteractionsOnline quiz - Wed. Oct. 7, 2020 (openbook)6-77-8D. The Organization and Expression ofLymphocyte Receptor Genes:Page 4 of 13

MICR*3230 C01 F20 v1.00WeekTopics Covered in LectureChapterReadingsNo. OfLecturesMHC & antigen presentation84T cell receptors and signaling3(95-101);7(247-255); 9and 113Cytokines and Chemokines43Effector Response: Development of Cellmediated immunity13(427-446)4Mid Term Examination - Fri. Oct. 23,2020 (online with Courselink andRespondus)9-14E. Cell Mediated Immunity: Dr. BonnieMallardOnline quiz - Mon. Nov. 9, 2020 (openbook)15 (506-508)Online quiz - Mon. Nov. 23, 2020 (openbook)14-15F. Infection and Immunity:Immunity to infection with focus on HIV-Page 5 of 1317(553-574)3

MICR*3230 C01 F20 v1.00WeekTopics Covered in LectureChapterReadingsNo. OfLecturesAIDS18 (593-623)Final Examination - Dec. 15 7-9pm (onlinewith Courselink and Respondus)6 Assessments6.1 Methods of AssessmentForm ofAssessmentWeight ofAssessmentDate ddressed(Location)Quiz 15%Wed. Sept. 23, 2020Courselink (openbook)Chapters 1,2,41, 2 and 6Quiz 25%Wed. Oct. 7, 2020Courselink (openbook)Chapter 5 &3(assignedreadings)1,2 and 6Midterm35%Fri. Oct. 23, 2020(Courselink andRespondus)All material todate1 to 6Quiz 35%Mon. Nov. 9,Chapters 8, 31 and 2Page 6 of 13

MICR*3230 C01 F20 v1.00Form ofAssessmentWeight ofAssessmentDate ddressed(Location)2020 Courselink(open book)(95-101), 7(247-255), 9,11Quiz 45%Mon. Nov. 23,2020 Courselink(open book)Chapters 4, 13(427-446), 15(506-508)1,2,3 and 4Final45%Dec. 15th 7-9 pm(Courselink andRespondus)Entire coursecontentdeliveredduring thelectures1 to 66.2 NoteQuizzes: Four online quizzes (5% grade each) will be held during pre- and post-midtermsessions. The online quiz will be open for two days, i.e., 48 hours where students will be expectedto answer ten randomly generated multiple-choice questions. Once the session is begun, it must be completed within 30 min. Prior to beginning the quiz, computer functionality, proper battery charge/powerconnection etc. must be ensured for successful completion of quiz. No alternate quiz session will be available resulting in the loss of marks towards thegrade, should it be missed.Midterm: A 50 min midterm examination (worth 35% of grade) will comprise 45 multiplechoice and/or other objective type of questions where best answer must be chosen. Some questions may emphasize interpretation or explanation of experimentalPage 7 of 13

MICR*3230 C01 F20 v1.00observations or diagrams. Any student missing the midterm examination will need to write a 100% (80% Final plus20% Quizzes) final examination. Additional information is availableat: aduate/current/c08/c08ac.shtmlFinal: A two-hour comprehensive and cumulative examination (worth 45% of grade) will coverthe entire course learning materials. The examination will involve 90 objective type questions(e.g., True and False, multiple choice & some multiple part questions). Some questions may require interpretation and explanation of experimentalobservations or diagrams. Students requiring service or accommodation, whether due to an identified, ongoingdisability or a short-term disability should contact the Student Accessibility Services assoon as possible at 519-824-4120 ext. 56208(website: https://www.uoguelph.ca/csd/)7 Course Statements7.1 Course Specific Notes Students are required to regularly check course announcements via Courselink. Online office hours will be held for up to 30 min after each scheduled course time usingCourselink Virtual Classroom. No e-mail sent to MCB3230@uoguelph.ca will be considered as confidentialunless clearly stated. If pertinent, these could be discussed during the lectures. Students are encouraged to take advantage of ‘tutorials’ and ‘Question - AnswerSessions’ by the Teaching Assistant. Use of cell phones during the lecture is prohibited. Electronic recording of classes is expressly forbidden without prior written consent ofthe instructor. When recordings are permitted they are solely for the use of theauthorized student and may not be reproduced, or transmitted to others, without theexpress written consent of the instructor. Students are encouraged to participate in fair faculty and course evaluation which willbe announced in advance via the course website. Any unusual incidence during the conduct of examination must be immediately broughtto the attention of Professors in the examination hall. Students are not allowed to wear baseball hats (or hats that hide wandering eyes)Page 8 of 13

MICR*3230 C01 F20 v1.00during the examination. You may bring to examination - calculator, pen, or pencil butNOT backpack, earphones, or cell phone. Please contact the Course Coordinator for any matter concerning the course.Online BehaviourInappropriate online behaviour will not be tolerated. Examples of inappropriate onlinebehaviour include:·Posting inflammatory messages about your instructor or fellow students·Using obscene or offensive language online·Copying or presenting someone else's work as your own·Adapting information from the Internet without using proper citations or references·Buying or selling term papers or assignments·Posting or selling course materials to course notes websites·Having someone else complete your quiz or completing a quiz for/with another student·Stating false claims about lost quiz answers or other assignment submissions·Threatening or harassing a student or instructor online·Discriminating against fellow students, instructors and/or TAs·Using the course website to promote profit-driven products or services·Attempting to compromise the security or functionality of the learning managementsystem·Sharing your user name and password·Recording lectures without the permission of the instructor7.2 GradingIndicate all course policies regarding in-semester tests and assignment submissions,including time and place for submission of assignments and explicit penalties for latesubmissions.7.3 Religious MattersAs for religious matters, please refer to the university policies .4 Academic IntegrityAcademic integrity is integral to education and students are encouraged to review variouspolicies at: .cfm.8 Department of Molecular and Cellular BiologyStatements8.1 Academic AdvisorsPage 9 of 13

MICR*3230 C01 F20 v1.00If you are concerned about any aspect of your academic program: Make an appointment with a program counsellor in your degree program. B.Sc.Academic Advising or Program Counsellors8.2 Academic SupportIf you are struggling to succeed academically: Learning Commons: There are numerous academic resources offered by the LearningCommons including, Supported Learning Groups for a variety of courses, workshopsrelated to time management, taking multiple choice exams, and general study skills.You can also set up individualized appointments with a learning specialist.http://www.learningcommons.uoguelph.ca/ Science Commons: Located in the library, the Science Commons provides support forphysics, mathematic/statistics, and chemistry. Details on their hours of operations canbe found at: /chemistry-physicshelp and /math-stats-help8.3 WellnessIf you are struggling with personal or health issues: Counselling services offers individualized appointments to help students work throughpersonal struggles that may be impacting their academic performance.https://www.uoguelph.ca/counselling/ Student Health Services is located on campus and is available to provide medicalattention. ic For support related to stress and anxiety, besides Health Services and CounsellingServices, Kathy Somers runs training workshops and one-on-one sessions related tostress management and high performance situations.http://www.selfregulationskills.ca/8.4 Personal informationPersonal information is collected under the authority of the University of Guelph Act (1964),and in accordance with Ontario's Freedom of Information and Protection of Privacy Act(FIPPA) http://www.e-laws.gov.on.ca/index.html. This information is used by Universityofficials in order to carry out their authorized academic and administrative responsibilitiesand also to establish a relationship for alumni and development purposes.For more information regarding the Collection, Use and Disclosure of Personal Informationpolicies please see the Undergraduate ars/undergraduate/current/intro/index.shtml)Page 10 of 13

MICR*3230 C01 F20 v1.009 University Statements9.1 Email CommunicationAs per university regulations, all students are required to check their e-mail account regularly:e-mail is the official route of communication between the University and its students.9.2 When You Cannot Meet a Course RequirementWhen you find yourself unable to meet an in-course requirement because of illness orcompassionate reasons please advise the course instructor (or designated person, such as ateaching assistant) in writing, with your name, id#, and e-mail contact. The grounds forAcademic Consideration are detailed in the Undergraduate and Graduate Calendars.Undergraduate Calendar - Academic Consideration and /undergraduate/current/c08/c08-ac.shtmlGraduate Calendar - Grounds for Academic e Diploma Calendar - Academic Consideration, Appeals and rs/diploma/current/index.shtml9.3 Drop DateStudents will have until the last day of classes to drop courses without academic penalty. Thedeadline to drop two-semester courses will be the last day of classes in the second semester.This applies to all students (undergraduate, graduate and diploma) except for Doctor ofVeterinary Medicine and Associate Diploma in Veterinary Technology (conventional andalternative delivery) students. The regulations and procedures for course registration areavailable in their respective Academic Calendars.Undergraduate Calendar - Dropping /undergraduate/current/c08/c08-drop.shtmlGraduate Calendar - Registration ociate Diploma Calendar - Dropping /diploma/current/c08/c08-drop.shtml9.4 Copies of Out-of-class AssignmentsKeep paper and/or other reliable back-up copies of all out-of-class assignments: you may beasked to resubmit work at any time.Page 11 of 13

MICR*3230 C01 F20 v1.009.5 AccessibilityThe University promotes the full participation of students who experience disabilities in theiracademic programs. To that end, the provision of academic accommodation is a sharedresponsibility between the University and the student.When accommodations are needed, the student is required to first register with StudentAccessibility Services (SAS). Documentation to substantiate the existence of a disability isrequired; however, interim accommodations may be possible while that process is underway.Accommodations are available for both permanent and temporary disabilities. It should benoted that common illnesses such as a cold or the flu do not constitute a disability.Use of the SAS Exam Centre requires students to book their exams at least 7 days in advanceand not later than the 40th Class Day.For Guelph students, information can be found on the SAS websitehttps://www.uoguelph.ca/sasFor Ridgetown students, information can be found on the Ridgetown SAS bilityservices.cfm9.6 Academic IntegrityThe University of Guelph is committed to upholding the highest standards of academicintegrity, and it is the responsibility of all members of the University community-faculty, staff,and students-to be aware of what constitutes academic misconduct and to do as much aspossible to prevent academic offences from occurring. University of Guelph students havethe responsibility of abiding by the University's policy on academic misconduct regardless oftheir location of study; faculty, staff, and students have the responsibility of supporting anenvironment that encourages academic integrity. Students need to remain aware thatinstructors have access to and the right to use electronic and other means of detection.Please note: Whether or not a student intended to commit academic misconduct is notrelevant for a finding of guilt. Hurried or careless submission of assignments does not excusestudents from responsibility for verifying the academic integrity of their work beforesubmitting it. Students who are in any doubt as to whether an action on their part could beconstrued as an academic offence should consult with a faculty member or faculty advisor.Undergraduate Calendar - Academic Graduate Calendar - Academic ars/graduate/current/genreg/index.shtml9.7 Recording of MaterialsPage 12 of 13

MICR*3230 C01 F20 v1.00Presentations that are made in relation to course work - including lectures - cannot berecorded or copied without the permission of the presenter, whether the instructor, a student,or guest lecturer. Material recorded with permission is restricted to use for that course unlessfurther permission is granted.9.8 ResourcesThe Academic Calendars are the source of information about the University of Guelph’sprocedures, policies, and regulations that apply to undergraduate, graduate, and diplomaprograms.Academic rs9.9 DisclaimerPlease note that the ongoing COVID-19 pandemic may necessitate a revision of the format ofcourse offerings and academic schedules. Any such changes will be announced viaCourseLink and/or class email. All University-wide decisions will be posted on the COVID-19website nformation/) and circulated byemail.9.10 IllnessThe University will not normally require verification of illness (doctor's notes) for fall 2020 orwinter 2021 semester courses. However, requests for Academic Consideration may stillrequire medical documentation as appropriate.Page 13 of 13

MICR*3230 Immunology Fall 2020 Section(s): C01 Department of Molecular and Cellular Biology . Immunology (Textbook) Immunology, 8th Edition, 2013, by Judith A. Owen, Jenny Punt, Sharon A. Stanford. . (Kuby 8th Immunology

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