2021 PROXY STATEMENT

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2021 PROXYSTATEMENT

NOTICEMAY 5, 2021OF 2021 ANNUAL MEETINGOF SHAREHOLDERS3:00 p.m. Eastern TimePlaceThere is no physical location for Danaher’s2021 Annual Meeting. Shareholdersmay instead attend virtually atwww.virtualshareholdermeeting.com/DHR2021.ITEMS OF BUSINESS1. To elect the twelve directors named in the attached ProxyStatement to hold office until the 2022 annual meetingof shareholders and until their successors are electedand qualified.2. To ratify the selection of Ernst & Young LLP as Danaher’sindependent registered public accounting firm for the yearending December 31, 2021.3. To approve on an advisory basis the Company’s namedexecutive officer compensation.4. To act upon a shareholder proposal requesting that Danaheramend its governing documents to reduce the percentageof shares required for shareholders to call a special meetingof shareholders from 25% to 10%.5. To consider and act upon such other business as mayproperly come before the meeting or at any postponement oradjournment thereof.WHO CAN VOTEShareholders of Danaher Common Stock at the close of businesson March 8, 2021. YOUR VOTE IS IMPORTANT. PLEASE SUBMITYOUR PROXY OR VOTING INSTRUCTIONS AT YOUR EARLIESTCONVENIENCE, WHETHER OR NOT YOU PLAN TO ATTENDTHE ANNUAL MEETING.A list of shareholders of record will be available during the meetingfor inspection by shareholders of record for any legally validpurpose related to the annual meeting at the meeting center site atwww.virtualshareholdermeeting.com/DHR2021.DATE OF MAILINGWe intend to mail the Notice Regarding the Availabilityof Proxy Materials (“Notice of Internet Availability”), orthe Proxy Statement and proxy card as applicable, to ourshareholders on or about March 25, 2021.By order of the Board of Directors,JAMES F. O'REILLYVice President, Deputy General Counsel and SecretaryII2021 PROXY STATEMENTREVIEW YOUR PROXY STATEMENT ANDVOTE IN ONE OF THE FOLLOWING WAYS:VIA THE INTERNETVisit the website listed on your Notice ofInternet Availability, proxy card or votinginstruction formBY TELEPHONECall the telephone number on your proxy cardor voting instruction formBY MAILSign, date and return your proxy card or votinginstruction form in the enclosed envelopePlease refer to the enclosed proxy materials or theinformation forwarded by your bank, broker, trustee orother intermediary to see which voting methods areavailable to you.ATTENDING THE MEETINGTo attend the virtual meeting, you will need toenter the 16-digit control number included onyour proxy card, Notice of Internet Availability ofProxy Materials or voting instruction form.

IMPORTANT NOTICE Regarding the Availability ofProxy Materials for the Shareholder Meeting to beheld on May 5, 2021. This Proxy Statement and theaccompanying Annual Report are available freeof charge at: https://materials.proxyvote.com/235851or Y STATEMENT SUMMARY 04PROPOSAL 1 – ELECTION OF DIRECTORS OF DANAHER 13CORPORATE GOVERNANCE 19DIRECTOR COMPENSATION 28DIRECTOR INDEPENDENCE AND RELATEDPERSON TRANSACTIONS 30BENEFICIAL OWNERSHIP OF DANAHER COMMON STOCKBY DIRECTORS, OFFICERS AND PRINCIPAL SHAREHOLDERS 32PROPOSAL 2 – RATIFICATION OF INDEPENDENT REGISTEREDPUBLIC ACCOUNTING FIRM 34AUDIT COMMITTEE REPORT 36COMPENSATION DISCUSSION AND ANALYSIS 37COMPENSATION COMMITTEE REPORT 52COMPENSATION TABLES AND INFORMATION 53SUMMARY OF EMPLOYMENT AGREEMENTS AND PLANS 69PROPOSAL 3 – ADVISORY VOTE ON NAMED EXECUTIVEOFFICER COMPENSATION 76PROPOSAL 4 – SHAREHOLDER PROPOSAL REQUESTINGTHAT DANAHER AMEND ITS GOVERNING DOCUMENTSTO REDUCE PERCENTAGE OF SHARES REQUIREDFOR SHAREHOLDERS TO CALL SPECIAL MEETINGOF SHAREHOLDERS FROM 25% TO 10% 78GENERAL INFORMATION ABOUT THE ANNUAL MEETING 80OTHER INFORMATION 84

PROXY STATEMENT SUMMARYTo assist you in reviewing the proposals to be acted upon at our 2021 Annual Meeting, below is summaryinformation regarding the meeting, each proposal to be voted upon at the meeting and Danaher Corporation’sbusiness performance, corporate governance, sustainability program and executive compensation. The followingdescription is only a summary and does not contain all of the information you should consider before voting. Formore information about these topics, please review Danaher’s Annual Report on Form 10-K for the year endedDecember 31, 2020 and the complete Proxy Statement. In this Proxy Statement, the terms “Danaher” or the“Company” refer to Danaher Corporation, Danaher Corporation and its consolidated subsidiaries or the consolidatedsubsidiaries of Danaher Corporation, as the context requires. All financial data in this Proxy Statement refers tocontinuing operations unless otherwise indicated.2021 Annual Meeting of ShareholdersTIME AND DATELOCATIONRECORD DATE3:00 p.m. Eastern timeWednesday, May 5, 2021www.virtualshareholdermeeting.com/DHR2021March 8, 2021Voting MattersProposalDescriptionPROPOSAL 1 – Election of directors(page 13)We are asking our shareholders to elect each of the twelve directorsidentified below to serve until the 2022 Annual Meeting of shareholders.We are asking our shareholders to ratify our Audit Committee’s selectionPROPOSAL 2 – Ratification of the appointment of Ernst & Young LLP (“E&Y”) to act as the independent registered publicof the independent registered publicaccounting firm for Danaher for 2021. Although our shareholders are notaccounting firm (page 34)required to approve the selection of E&Y, our Board believes that it isadvisable to give our shareholders an opportunity to ratify this selection.Board RecommendationF OR each nomineeFORPROPOSAL 3 – Advisory vote to approvenamed executive officer compensation(page 76)We are asking our shareholders to cast a non-binding, advisory voteon the compensation of the executive officers named in the SummaryCompensation Table (the “named executive officers” or “NEOs”). Inevaluating this year’s “say on pay” proposal, we recommend that youreview our Compensation Discussion and Analysis, which explainshow and why the Compensation Committee of our Board arrived at itsexecutive compensation actions and decisions for 2020.FORPROPOSAL 4 – Shareholder proposal(page 78)You are being asked to consider a shareholder proposal requesting thatDanaher amend its governing documents to reduce the percentageof shares required for shareholders to call a special meeting ofshareholders from 25% to 10%.AGAINSTPlease see the sections titled “General Information About the Meeting” and “Other Information” beginning on page 80 forimportant information about the proxy materials, voting, the Annual Meeting, Company documents, communications and thedeadlines to submit shareholder proposals and director nominations for next year’s annual meeting of shareholders.042021 PROXY STATEMENT

PROXY STATEMENT SUMMARYBusiness Highlights2020 PerformanceCOVID-19 RESPONSEThe COVID-19 pandemic posed an unprecedented challenge to our business in 2020, and in response we havefocused on the health and well-being of our associates, mitigating disruptions to our businesses and deploying thefull breadth of our portfolio in the fight against the virus:Developed and Implemented a Pandemic Response PlanTo mitigate disruptions to our business, we developed and implemented a Pandemic Response Plan which buildsupon our businesses’ existing business continuity plans. The Pandemic Response Plan leverages CDC and WHOguidance to establish a flexible framework within which our operating companies have the discretion to act accordingto local needs, regulatory guidance and requirements, while mandating certain Company-wide policies whereappropriate.Provided Crucial Support in the Fight Against COVID-19Danaher’s businesses have stepped up to provide crucial support in the fight against COVID-19:zz As of March 1, 2021, our businesses have collectively enabled or produced approximately 100 million COVID-19related diagnostic tests.zz Healthcare providers are using Beckman Coulter’s antibody serology test to diagnose COVID-19 immune status,supporting both individual health decisions as well as population-based immunity monitoring.zz Radiometer’s point-of-care blood gas analyzers have been critical tools for emergency rooms dealing with surges ofinfected patients.zz Pall’s and Cytiva’s bioprocessing products are being used in a significant number of the COVID-19 related vaccineand therapeutic projects underway globally as of March 1, 2021.Supporting Our AssociatesWe launched a global Employee Assistance Program in March 2020 to ensure a consistent support structure formental health and well-being across the Company and expanded the program over the course of 2020 to provideenhanced support with respect to childcare, eldercare and tutoring, among other areas. In the U.S., we have providedbenefits beyond the requirements of the Families First Act, for example by extending our leave policy to cover eldercare and providing for voluntary leaves even in certain circumstances not required by the law. We have implementedsafety precautions on a facility-specific basis, such as work-from-home requirements where feasible and in manycases staggered work shifts, restricted work zones and daily temperature screenings. The results of our 2020Associate Engagement Survey validate the impact of these efforts: 88% of surveyed associates felt satisfied withDanaher’s efforts to care for associates during the pandemic, while 93% of surveyed associates agreed that theirleaders took actions to maintain a safe work environment.BUSINESS PERFORMANCENotwithstanding the pandemic, in 2020 Danaher:zz continuedto invest in future growth, investing 1.3 billion in research and development and acquiring the Cytivabusiness (previously the Biopharma business of General Electric Company’s (“GE”) Life Sciences division) from GEfor a cash purchase price of approximately 20.7 billion;zz returnedapproximately 500 million to common stockholders through cash dividends (marking the 28th year in arow Danaher has paid a dividend on its common stock); andzz grewour business on a year-over-year basis as illustrated below:24.5%REVENUE GROWTH50.0%NET EARNINGSGROWTH 6.2BOPERATING CASHFLOW2021 PROXY STATEMENT05

PROXY STATEMENT SUMMARYLong-Term PerformanceWe believe a long-term performance period most accurately compares relative performance within our peer group. Overshorter periods, performance comparisons may be skewed by the easier performance baselines of peer companies that haveexperienced periods of underperformance.Danaher has not experienced a sustained period of underperformance over the last twenty-five years (i.e., 1996-2020). We believethe consistency of our performance over that period is unmatched within our peer group. Danaher ranks number one in its peergroup over the past twenty-five years based on compounded average annual shareholder return, and is the only companyin its peer group whose total shareholder return (“TSR”) outperformed the S&P 500 Index:zz overzz byevery rolling 3-year period from and including 1996-2020; andmore than 600 basis points over every rolling 3-year period from and including 2001-2020.Danaher’s compounded average annual shareholder return has outperformed the S&P 500 Index over each of the last one,two, three, five-, ten-, fifteen-, twenty- and twenty-five year periods:9000%DHR8000%#17000%6000%IN PEER GROUP5000%based on compounded averageannual shareholder returnfrom 1996‑20204000%3000%2000%S&P 5001000%0%12/31/9519.1%25 yearsS&P 500: 9.6%0612/31/0015.6%20 yearsS&P 500: 7.5%12/31/0517.4%15 yearsS&P 500: 9.9%12/31/1020.6%10 yearsS&P 500: 13.9%2021 PROXY STATEMENT26.5%5 yearsS&P 500: 15.2%12/31/1534.4%3 yearsS&P 500: 14.1%12/31/2047.4%2 yearsS&P 500: 24.8%45.2%1 yearS&P 500: 18.4%

PROXY STATEMENT SUMMARYCorporate Governance HighlightsOur Board of Directors recognizes that Danaher’s success over the long-term requires a robust framework of corporategovernance that serves the best interests of all our shareholders. Below are highlights of our corporate governance framework.Boardrefreshment remains a key area of focus for us, as evidenced by the 2019 additions of Drs. Jessica L. Mega and Pardis C. Sabeti and 2020 addition of Rainer M. Blair to our Board. To further build on the enhanced gender,age and national origin diversity from these appointments, Danaher has formally initiated a director searchspecifically focused on adding to the Board a Person of Color from an underrepresented community.OurBylaws provide for proxy access by shareholders. OurChairman and CEO positions are separate. OurBoard has established a Lead Independent Director position. All of our directors are elected annually.In uncontested elections, our directors must be elected by a majority of the votes cast, and we have a directorresignation policy that applies to any incumbent director who fails to receive such a majority. Our shareholders have the right to act by written consent.Shareholdersowning 25% or more of our outstanding shares may call a special meeting of shareholders. Wehave never had a shareholder rights plan. Wehave no supermajority voting requirements in our Certificate of Incorporation or Bylaws. All members of our Audit, Compensation and Nominating and Governance Committees are independent as definedby the New York Stock Exchange listing standards and applicable SEC rules.Danaher(including its subsidiaries during the period we have owned them) has made no political contributions since at least 2012, has no intention of contributing any Danaher funds for political purposes and discloses its political expenditurespolicy on its public website. The 2020 CPA-Zicklin Index of Corporate Political Disclosure and Accountability rankedDanaher as a First Tier company.2021 PROXY STATEMENT07

PROXY STATEMENT SUMMARYShareholder Engagement ProgramWe actively seek and highly value feedback from our shareholders. During 2020, in addition to our traditional Investor Relationsoutreach efforts, we engaged with shareholders representing approximately 25% of our outstanding shares on topicsincluding our business strategy and financial performance, governance and executive compensation programs and sustainabilityinitiatives. We shared feedback received during these meetings with our Nominating and Governance Committee andCompensation Committee, informing their decision-making.Board of DirectorsBelow is an overview of each of the director nominees you are being asked to elect at the 2021 Annual Meeting.Other PublicCompanyBoardsPrincipal Professional ExperienceCommitteeMembershipsRainer M. Blair2020President and Chief Executive Officer, Danaher CorporationE, F, S0Linda Hefner Filler*2005Former President of Retail Products, Chief Marketing Officer and ChiefMerchandising Officer, Walgreen Co.N ,S0Teri List*2011Former Executive Vice President and Chief Financial Officer, Gap Inc.A, C2Walter G. Lohr, Jr.*1983Retired partner, Hogan LovellsA, C, F, N0Jessica L. Mega, MD, MPH*2019Chief Medical and Scientific Officer, Verily Life Sciences LLCS0Mitchell P. Rales1983Chairman of the Executive Committee, Danaher CorporationEFSteven M. Rales1983Chairman of the Board, Danaher CorporationE, F, S1Pardis C. Sabeti, MD, D.Phil*2019Investigator, Howard Hughes Medical InstituteS0John T. Schwieters*2003Principal, Perseus TDCA ,N0Alan G. Spoon*1999Former Managing General Partner, Polaris PartnersC3Raymond C. Stevens, PhD*2017Provost Professor of Biological Sciences and Chemistry, and Directorof The Bridge Institute, at the University of Southern California; ChiefExecutive Officer, ShouTiS0Elias A. Zerhouni, MD*2009Former President, Global Research & Development, Sanofi S.A.N, S0NameDirectorSince,2Chair * Independent DirectorA Audit Committee C Compensation Committee E Executive Committee F Finance Committee N Nominating & Governance Committee S Science & Technology Committee082021 PROXY STATEMENT

PROXY STATEMENT SUMMARYSustainabilityDanaher’s sustainability program is distinctive in that we drive company-wide sustainability initiatives where it makes sense toharness Danaher’s scale, while leveraging our decentralized operating structure to empower our operating companies to pursuesustainability in ways that best fit the needs of their particular stakeholders. Based on a materiality assessment we conductedthat identified the intersection of Danaher’s key strategic and sustainability goals, our sustainability program is structuredaround three pillars: innovation, people and the environment. These three pillars are underpinned by a foundation of integrity,compliance and sound governance.InnovationAt the heart of our sustainability efforts is innovation with purpose. In the spirit of one of our five Core Values,“Innovation Defines Our Future”, our teams work to expand access to healthcare in underserved areas, improvesafety and protect precious natural resources. Danaher invested 1.3 billion in research and development in2020 and as of the end of 2020 held approximately 11,800 patents worldwide, underscoring our commitment toinnovation.PeopleDanaher is committed to attracting, developing, engaging and retaining the best people from around theworld to sustain and grow our science and technology leadership. “Consistently attracting and retainingexceptional talent” is one of our three strategic priorities and “The Best Team Wins” is one of our CoreValues, reflecting the critical role our human capital plays in supporting our strategy. Our human capitalstrategy addresses culture, recruitment, development, engagement and retention, with a particular focuson attracting and engaging diverse talent with the unique perspectives and fresh ideas necessary to driveinnovation, fuel growth and help ensure our technologies and products effectively serve a global customerbase. For more detail on our human capital strategy, please see pages 9-11 of our Annual Report onForm 10-K for the year ended December 31, 2020.I n 2020, Danaher publicly reported for the first time on our global gender diversity overall andat the managerial level, as well as our U.S. People of Color (“POC”) diversity overall and at themanagerial level. We also announced our goal to achieve 40% global gender diversity and 35%U.S. POC diversity by 2025.T hird parties have recognized our human capital initiatives, as Danaher was featured on theFORTUNE World’s Most Admired Companies 2020, Forbes World’s Best Employers 2020, ForbesBest Employers 2020 for New Grads and Forbes 2020 Best Employers for Diversity lists and in2020 for the seventh year in a row the Human Rights Campaign named Danaher one of the BestPlaces to Work for LGBTQ Equality.2021 PROXY STATEMENT09

PROXY STATEMENT SUMMARYEnvironmentWe are committed to reducing the environmental impact of our operations and products, and helpingour customers do the same. We continue to make progress toward this objective by implementingmanagement programs to support our efforts, tracking key metrics to gauge improvement and settinggoals to drive accountability. In particular:zz Beginningin 2019, we began leveraging the power of the Danaher Business System (“DBS”) to mitigatethe environmental impact of our operations by deploying our first DBS environmental sustainability tools,focused on reducing energy use and waste.zz In2019, we reported for the first time metrics relating to energy usage, greenhouse gas emissions,water usage, waste generation and recycling.zz In2020, we announced our intention to achieve the following goals by 2024 (compared to the baselineyear of 2019):YEAR 2024 GOALYEAR 2024 GOALYEAR 2024 GOALREDUCTION INENERGY CONSUMEDREDUCTION IN SCOPE 1/2GREENHOUSE GAS (GHG) EMISSIONS(normalized to annual revenue)(normalized to annual revenue)REDUCTION IN PERCENTAGE OFNON‑HAZARDOUS/NON-REGULATEDWASTE SENT TO LANDFILLSOR INCINERATION15%15%15%zz In2020, we reported for the first time on the key climate-related risks and opportunities ourbusinesses face.At the Board level, Danaher’s Nominating and Governance Committee oversees sustainability and socialresponsibility, and this responsibility is set forth in the committee’s charter. At the management level, Danaher’s SeniorVice President and General Counsel, who reports directly to our CEO, has general oversight responsibility with respect tomatters of sustainability and social responsibility, and is responsible for reviewing and approving Danaher’s sustainabilityreports.More information about Danaher’s sustainability efforts is included in our latest Sustainability Report, available in theInvestors section of our public website, https://www.danaher.com.Executive Compensation HighlightsOverview of Executive Compensation ProgramAs discussed in detail under “Compensation Discussion and Analysis,” with the goal of building long-term value for ourshareholders, we have developed an executive compensation program designed to:zz attractand retain executives with the leadership skills, attributes and experience necessary to succeed in an enterprise withDanaher’s size, diversity and global footprint;zz motivateexecutives to demonstrate exceptional personal performance and perform consistently at or above the levels thatwe expect, over the long-term and through a range of economic cycles; andzz linkcompensation to the achievement of corporate goals that we believe best correlate with the creation of long-termshareholder value.To achieve these objectives our compensation program combines annual and long-term components, cash and equity, and fixedand variable elements, with a bias toward performance-based long-term equity awards tied closely to shareholder returns andsubject to significant vesting and/or holding periods. Our executive compensation program rewards our executive officers whenthey help increase long-term shareholder value, achieve annual business goals and build long-term careers with Danaher.102021 PROXY STATEMENT

PROXY STATEMENT SUMMARYCompensation GovernanceOur Compensation Committee also recognizes that the success of our executive compensation program over the long-termrequires a robust framework of compensation governance. As a result, the Committee regularly reviews external executivecompensation practices and trends and incorporates best practices into our executive compensation program:// WHAT WE DOWHAT WE DON'T DOFive-year vesting requirement for stock options; three-yearperformance period plus further two-year holding periodfor PSUsNo tax gross-up provisions (except as applicable tomanagement employees generally such as relocation policy)Incentive compensation programs feature multiple, differentperformance measures aligned with the Company’sstrategic performance metricsNo dividend/dividend equivalents paid on unvestedequity awardsShort-term and long-term performance metrics that balance ourabsolute performance and our relative performance versuspeer companiesNo “single trigger” change of control benefitsRigorous, no-fault clawback policy that is triggered even inthe absence of wrongdoingNo active defined benefit pension program since 2003Minimum one-year vesting requirement for 95% of sharesgranted under the Company’s stock planNo hedging of Danaher securities permittedStock ownership requirements for all executive officersNo long-term incentive compensation is denominated orpaid in cash (other than PSU dividend accruals)Limited perquisites and a cap on CEO/CFO personalaircraft usageNo above-market returns on deferred compensation plansIndependent compensation consultant that performs no otherservices for the CompanyNo overlapping performance metrics between short-termand long-term incentive compensation programs2021 PROXY STATEMENT11

PROXY STATEMENT SUMMARYNamed Executive Officers 2020 CompensationThe following table sets forth the 2020 compensation of our named executive officers. Please see pages 53-55 for informationregarding 2019 and 2018 compensation, as well as footnotes.Name andPrincipal tyIncentive PlanCompensationChange inPension Valueand NonqualifiedDeferredCompensationEarningsAll OtherCompensationTotalRainer M. BlairPresident and CEO 949,0670 3,616,939 2,968,651 2,519,3390 342,765 10,396,761Matthew R. McGrew,Executive VicePresident and CFO 726,0000 1,637,982 1,435,173 1,564,5300 166,358 5,530,043Joakim Weidemanis,Executive Vice President 881,5600 5,065,095 4,551,242 1,917,0000 138,301 12,553,198Angela S. Lalor,Senior Vice PresidentHuman Resources 727,157 800,000 1,276,951 1,118,710 1,458,3860 121,041 5,502,245Brian W. Ellis,Senior Vice PresidentGeneral Counsel 636,5220 1,218,0480 78,980 3,560,832Thomas P. Joyce, Jr. Former President and CEO1,352,0000 6,260,748 5,487,776 3,107,797 6,470 549,165 16,763,956286,1160 2,553,117 2,237,419 462,8820 203,265 5,742,799William K. Daniel II,Former ExecutiveVice President12 2021 PROXY STATEMENT867,259 760,023

PROPOSAL 1Election of Directors of DanaherWe are seeking your support for the election of the twelve candidates that the Board has nominated to serve on the Boardof Directors (each of whom currently serves as a director of the Company), to serve until the 2022 Annual Meeting ofshareholders and until his or her successor is duly elected and qualified.We believe the nominees set forth below have qualifications consistent with our position as a large, global and diversifiedscience and technology company. We also believe these nominees have the experience and perspective to guide Danaher aswe seek to expand our business in high-growth geographies and high-growth market segments, identify, consummate andintegrate appropriate acquisitions, develop innovative and differentiated new products and services, adjust to rapidly changingtechnologies, business cycles and competition and address the demands of an increasingly regulated environment.Proxies cannot be voted for a greater number of persons than the twelve nominees named in this Proxy Statement. In theevent a nominee declines or is unable to serve, the proxies may be voted in the discretion of the proxy holders for a substitutenominee designated by the Board, or the Board may reduce the number of directors to be elected. We know of no reason whythis will occur.Director NomineesRAINER M. BLAIRAge 56SKILLS AND QUALIFICATIONS:Directorsince: 2020zzzzzzzzCHIEF EXECUTIVEOFFICERCommittees:zz Executivezz Financezz Science &TechnologyOther PublicDirectorships:zz NoneGlobal/internationalLife sciences/healthcarezz Technology/innovation strategyM&APublic company CEO and/or PresidentMr. Blair has served as Danaher’s President and Chief Executive Officer since September 2020. Since joining Danaher in2010, Mr. Blair has served in a series of progressively more responsible general management positions (and as a Danaherofficer since 2014), including as Vice President - Group Executive from March 2014 until January 2017 and as ExecutiveVice President from January 2017 until September 2020. His broad operating and functional experience across diverseend-markets and geographies, in-depth knowledge of Danaher’s businesses and of the Danaher Business System andleadership experience from his service in the U.S. Army are particularly valuable to the Board given the global, diversenature of Danaher’s portfolio. In addition, Mr. Blair adds deep multi-cultural experience having lived on and worked onthree continents.LINDA HEFNER FILLERAge 61SKILLS AND QUALIFICATIONS:Directorsince: 2005zzINDEPENDENTMs. Hefner Filler served as President of Retail Products, Chief Marketing Officer and Chief Merchandising Officer ofWalgreen Co., a national drugstore chain, from January 2015 to April 2017. From March 2013 until June 2014, Ms. HefnerFiller served as President, North America of Claire’s Stores, Inc., a specialty retailer; from May 2007 to June 2012, asExecutive Vice President of Wal-Mart Stores Inc., an operator of retail stores and warehouse clubs, and from April 2009to June 2012 also as Chief Merchandising Officer for Sam’s Club, a division of Wal-Mart; and from May 2004 throughDecember 2006, as Executive Vice President—Global Strategy for Kraft Foods Inc., a food and beverage company.Committees:zz Nominating& Governance(Chair)zz Science &TechnologyOther PublicDirectorships:zz NonezzGlobal/internationalTechnology/innovation strategyzzzzM&ABranding/marketingMs. Hefner Filler has served in senior management roles with leading retail and consumer goods companies, with generalmanagement responsibilities and responsibilities in the areas of marketing, branding and merchandising. Understandingand responding to the needs of our customers is fundamental to Danaher’s business strategy, and Ms. Hefner Filler’s keenmarketing and branding insights have been a valuable resource to Danaher’s Board. Her prior leadership experiences withlarge public companies have given her valuable perspective for matters of global portfolio strategy and capital allocationas well as global business practices.2021 PROXY STATEMENT13

PROPOSAL 1 Election of Directors of DanaherDirector NomineesTERI LISTAge 58SKILLS AND QUALIFICATIONS:Directorsince: 2011zzINDEPENDENTMs. List served as Executive Vice President and Chief Financial Officer of Gap Inc., a global clothing retailer, from January2017 until March 2020. Prior to joining Gap, she served as Executive Vice President and Chief Financial Officer of Dick’sSporting Goods, Inc., a sporting goods retailer, from August 2015 to August 2016, and with Kraft Foods Group, Inc., a foodand beverage company, as Advisor from March 2015 to May 2015, as Executive Vice President and Chief Financial Officerfrom December 2013 to February 2015 and as Senior Vice President of Finance from September 2013 to December 2013.From 1994 to September 2013, Ms. List served in a series of progressively more responsible positions in the accountingand finance organization of The Procter & Gamble Company, a consumer goods company, most recently as Senior VicePresident and Treasurer. Prior to joining Proct

II 2021 PROXY STATEMENT ITEMS OF BUSINESS 1. To elect the twelve directors named in the attached Proxy Statement to hold office until the 2022 annual meeting of shareholders and until their successors are elected and qualified. 2. To r

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