CURRICULUM VITAE Christopher B. Newgard, Ph.D. PERSONAL
CURRICULUM VITAEChristopher B. Newgard, Ph.D.PERSONALBorn September 18, 1956 in Copenhagen, DenmarkAmerican citizenship attained June, 1976Married, with four childrenHome address:664 Brookview Dr.Chapel Hill, NC 27514Contact:Phone: 919-668-6059 (office); FAX: 919-668-6044; email: chris.newgard@duke.eduPROFESSIONAL TRAINING AND APPOINTMENTS1974-1978B.S. in Botany/Zoology, Duke University, Durham, N.C.Summer,1978Director, Student Originated Studies Project (NSF). Organized a groupof eight students to carry out an interdisciplinary study entitled, "FactorsInfluencing Stunted Growth in Crassostrea virginica (American oyster) inthe White Oak River, N.C", performed at the Duke University MarineLaboratory, Beaufort, N.C.Oct., 1978Oct., 1979Predoctoral fellow, Institute of Medical Physiology, University of Copenhagen,Denmark. Studied the physiology and biosynthesis of pancreatic islet peptides,with emphasis on somatostatin, in the laboratory of Dr. Jens Holst.Oct., 1979Sept., 1980Predoctoral fellow, University of Texas Southwestern MedicalCenter at Dallas. Performed studies on the evolutionary and physiological roles ofpancreatic islet peptides, in the laboratory of Dr. Roger Unger.Sept., 1980May, 1984Graduate student, Department of Biochemistry, University of TexasSouthwestern Medical Center at Dallas. Performed dissertation entitled, "Studies onthe Mechanism of Hepatic Glycogen Synthesis in the Fasted-Refeeding Rat" in thelaboratory of Dr. J. Denis McGarry and Dr. Daniel Foster. Ph.D. degree receivedMay, 1984.July, 1984July, 1987Postdoctoral fellow, Department of Biochemistry & Biophysics, University ofCalifornia, San Francisco. Studied the structure and function of mammalianisozymes of glycogen phosphorylase in the laboratory of Dr. Robert Fletterick.Aug., 1987-Assistant Professor, Department of Biochemistry and the Center for Diabetes
Aug., 1992Research, University of Texas Southwestern Medical Center at Dallas.Sept., 1992Sept., 1995Associate Professor, Departments of Biochemistry, Internal Medicine and theCenter for Diabetes Research, University of Texas Southwestern Medical Centerat Dallas.Sept., 1994-Gifford O. Touchstone, Jr. and Randolph G. Touchstone Distinguished Chair inDiabetes Research, University of Texas Southwestern Medical Center at Dallas.Sept., 1995-Professor, Departments of Biochemistry, Internal Medicine, and Center forDiabetes Research, University of Texas Southwestern Medical Center at Dallas.Sept., 2000Feb. 2002Co-Director, Touchstone Center for Diabetes Research, University of TexasSouthwestern Medical Center at DallasMarch, 2002-Director, Sarah W. Stedman Nutrition and Metabolism Center; W. David and SarahW. Stedman Distinguished Professor, Departments of Pharmacology & CancerBiology and Medicine, Duke University Medical CenterJuly, 2013-Founding Director, Duke Molecular Physiology Institute, Duke University MedicalCenterHONORS AND AWARDSSigma Xi Graduate Research Award, University of Texas Southwestern MedicalCenter at Dallas, April, 1984Career Development Award, American Diabetes Association, 1989-1992Distinguished Alumnus Award, University of Texas Southwestern GraduateSchool of Biomedical Sciences, November, 1991Max Miller Lecture, Central Society for Clinical Research, November, 1992Co-Chair, NIH Workshop on "Cellular and Molecular Approaches to AchievingEuglycemia in Diabetes", April, 1994Lilly Lecturer, Australian Diabetes Society, September, 1994Member, Congressionally-Mandated Diabetes Research Working Group,November, 1997-1999William Stadie Award, American Diabetes Association, Pennsylvania Affiliate,February, 1998Sigma Xi Lectureship, University of Texas Southwestern Medical Center
Graduate School, November, 1998Gerold and Kayla Grodsky Award for Oustanding Scientific Achievement, JuvenileDiabetes Foundation, June, 1999Pfizer Visiting Professor, University of Virginia, January, 2001Outstanding Scientific Achievement (Lilly) Award, American Diabetes Association,June, 2001Meadow Brook Lectureship in Medicine and Surgery, Meadow Brook EndowmentFund, Detroit, MI, June, 2001MERIT Award, National Institutes of Health, Grant R01 DK46492-09Kroc Lectureship, University of Pennsylvania Diabetes Research Center, March,2003Solomon Berson Award and Lectureship, American Physiological Society, April,2003Albert and Miriam Weinstein Visiting Professor in Diabetes Research, VanderbiltUniversity Medical Center, March, 2003Robert C. Nordlie Visiting Professor, University of North Dakota Medical Center,January, 2004Lepkovsky Memorial Lecture, Department of Nutrition and Toxicology, Universityof California, Berkeley, December, 2005Co-Chair, Keystone Symposium on Beta Cell Biology, Taos, NM, 2006Nelson Goldberg Lecture in Signal Transduction and Metabolism, Department ofBiochemistry, University of Minnesota, February, 2006Bristol Meyers-Squibb “Freedom to Discover” Award in Metabolic Research, 2006Golden Apple Award for Medical Student Teaching, Duke University MedicalCenter, 2006Lydia J. Roberts Visiting Professorship and Memorial Lecture, University ofChicago, 2006Chair, Keystone Symposium on Beta Cell Biology, Snowbird, Utah, 2008Keynote Address, All Faculty Retreat, UT Houston Medical Center, 2008
Endocrine Society/Merck Visiting Professorship, UCSF Diabetes Center, 2011Co-Organizer (with Alan Attie and Phil Scherer), Keystone Symposium on Diabetes,Santa Fe, NM, 2012Co-Organizer (with Siliva Corvera), FASEB Conference on Glucose TransporterBiology, Snowmass, CO, 2013Michael Brownlee Visiting Lecture, Joslin Diabetes Center, February, 2014Donald Steiner Award and Lectureship for Distinguished Research in Diabetes,University of Chicago, May, 2014Lead Organizer, FASEB Conference on Glucose Transporter Biology, Big Sky, MT,July, 2015Endocrine Society Visiting Professor, Tulane University Medical Center, September,2015Duke Medical Alumni Association Distinguished Faculty Award, November, 2016Keynote Speaker, FASEB Conference on Glucose Transporter Biology, Snowmass,CO, July 2017Delbert Fisher Visiting Professor in Endocrinology, UCLA Geffen School ofMedicine and Cedars Sinai Medical Center, July, 2019Endocrine Society Outstanding Innovator Award and Plenary Lecture, EndocrineSociety Annual Meeting, San Francisco, March, 2020Charles Hollenberg Memorial Lecture, Banting and Best Diabetes Center, Universityof Toronto, May, 2020EDITORIAL AND GRANT REVIEW EXPERIENCEMember, NIDDK Catalyst Award Editorial/Oversight Board, 2018Member, NIDDK special review panel for High Impact, Interdisciplinary Grants(RC2), 2016Editorial Board, Cell Metabolism, 2012Member, ADA “Pathway to Stop Diabetes” Study Section, 2015Associate Editor, Journal of Clinical Investigation, March, 2012-November, 2017
Associate Editor, Molecular Endocrinology, 2008-2013Editorial Board, Endocrine Reviews, 2006-2009Editorial Board, Molecular Endocrinology, 2005-2008Member, NIH Metabolism Study Section, 1995-1999Member, Grant Review Board, American Diabetes Association, 1997-2001Editorial Board, Diabetes, 2001-2004Editorial Board, American Journal of Physiology, 2001-2004Editorial Board, Journal of Biological Chemistry, 1992-1997Medical Advisory Board, Juvenile Diabetes Foundation International, 1992-1996Member, NIH Program Project Site Visit Team, UCSF, March, 1994Ad-hoc reviewer, NIH Metabolism Study Section, 1994Veteran's Administration Study Section (Endocrinology, April, 1992)Scientific Review Committee, American Heart Association, Texas Affiliate, 1992OTHER ACADEMIC ACTIVITIESDuke School of Medicine Research Planning Committee, 2017-2018Medical Center Executive Council, Duke University Medical Center, 2002Search Committees (Duke): Chairman of Internal Medicine, 2017-2018 and 20022003; Dean of the Medical School, 2003; Chief, Cardiology, 2006; Chief, Endocrine(Chair), 2013; Chief, Nephrology, 2016.Various Dean’s Committees, including Shared Resources, Financial Redesign,Faculty Salary and Compensation, Strategic Priorities, Duke University MedicalCenter, 2005-presentSenior Advisory Committee, Department of Pharmacology and Cancer Biology,Duke University Medical Center, 2002-
Member, Admissions Committee, Univ. of Texas Southwestern Graduate School ofBiomedical Sciences, 1992-1997Member, Intellectual Property Advisory Committee, Univ. Texas SouthwesternMedical Center, 1995-2002Member, Steering Committee, Graduate Program in Biochemistry & MolecularBiology, UTSWMC, 1991-2002Scientific Advisory Boards, Academic: Diabetes Research Institute, University ofMiami; UCSF Diabetes Center; Univ. Pennsylvania DERC; Sanford BurnhamInstitute, San Diego; Sanford Burnham Institute, OrlandoScientific Advisory Boards, Industry: CVMED Board, Pfizer; Global DiabetesAdvisory Board, Lilly; Diabetes Advisory Board, Merck; Diabetes Advisory Board,Novo-Nordisk; multiple biotech company SABsMember, Board of Directors, Founding Scientist, and PrincipalConsultant, BetaGene, Inc., Dallas, TX, 1992-2002INDIVIDUALS TRAINED IN THE NEWGARD LABORATORYPrevious Trainees:TraineePostdoc/PredocPeriod PositionMilburn, J.Postdoc1987-89M.D.Univ. TexasSouthwesternPrivate PracticeIrving, TXMiyaura, C.Postdoc19891991Ph.D.Showa Univ.TokyoFaculty, ShowaUniv., TokyoFoix, A-G.Postdoc19901991Ph.D.Univ. ofBarcelonaFaculty, Dept. ofBiochemistry,Univ. BarcelonaSchnedl, W.Postdoc19921993M.D.Univ. of Graz, Faculty,AustriaUniv. GrazFerber, S.Postdoc19911993Ph.D.Joslin Diabetes Faculty, ChaimCenter, Harvard Sheba Med Ctr,Tel AvivCoats, W.Predoc1987-B.S.Univ. ofSchool teacher
1993WyomingHughes, S.Predoc19881993B.S.Austin College Staff Scientist,ZymoGenetics,SeattleQuaade, C.Predoc19881992M.S.Univ. ofCopenhagenBeltrandelRio,H.Postdoc1992-Ph.D., M.D.Michigan State Director, DiabetesRes, Lexicon Inc.Minassian, C.Postdoc19951996Ph.D.Univ. Lyon(France)Becker, TPredoc1992-B.S.Millersville U. Faculty, Duke UnivSestak, A.Predoc1991-B.S.Trinity College Private practiceNoel, L.Predoc19961991-B.S.Univ. ofVirginiaNoel, R.Predoc19921996B.S.St. Mary'sFaculty, Duke(San Antonio)Trinh, K.Postdoc1996-98M.D., Ph.D.Univ. Toronto Faculty, U. TorontoHohmeier, H.Postdoc1995-1998M.D., Ph.D.Univ.GottingenFaculty,Duke Univ.Antinozzi, P.Predoc1993-1999Ph.D.Univ. FloridaFaculty, WakeForest Med Ctr.O'Doherty, R.Postdoc1994-1999Ph.D.VanderbiltFaculty, Univ.PittsburghBerman, H.Predoc1994-1999B.S.UCLAPrivate PracticeMulder, H.Postdoc1998-2000M.D., Ph.D.Univ. LundFaculty, Univ. LundTelemaque S.Postdoc1998-2000Ph.D.UTSWMCFaculty, Univ. ArkansasGasa, R.Postdoc1997-2000Ph.D.Univ.BarcelonaFaculty, Univ BarcelonaChief Exec. Officer,Interface BiotechScientist,Univ. LyonSchool Teacher
Jensen, P-B.Postdoc1999-2001Ph.D.Hagedorn Inst. Staff Scientist,U. Copenhagen Seahorse BioChen, G.Predoc1997-2001M.S.Wuhan Univ.Faculty, Univ. Tenn.Sherry, D.VisitingProfessor1999-2001Ph.D.UTSWMC/UT DallasProfessor, UTSouthwesternBoucher, A.Postdoc2000-Ph.D.Univ. LyonSchool teacherMurase, K.Postdoc2000-Ph.D.Takeda Co.Staff Scientist,Takeda ChemicalsTran, V.Predoc1997-M.S.Univ. Houston Faculty, Univ.HoustonYang, R-J.Postdoc2000-Ph.D.Univ. IndianaStaff Scientist,MerckMuoio, D.Res. Fac.2002-2004Ph.D.UNC-Ch HillFaculty, Duke Univ.Takekawa, S.Postdoc2002-Ph.D.Univ. OsakaScientist, TakedaSchisler, J.Predoc2001-2005B.S.Univ. ToledoFaculty, UNCJoseph J.Postdoc2004-Ph.D.U. TorontoFaculty, Univ.WaterlooIlkayeva, O.Postdoc2002-Ph.D.UTSWDirector,Metabolomics Core Lab,Stedman CenterClark, C.Predoc1999-B.S.UC RiversideSchool teacherPresley, B.Predoc2001-B.S.DukePrivate practiceFueger, P.Postdoc2004-2008Ph.D.VanderbiltFaculty, City of HopeCollier, J.Postdoc2004-2009Ph.D.LSUMCFaculty, Universityof TennesseeVanhoose, A.Postdoc2007-2009Ph.D.VanderbiltPostdoctoral Fellow,Vanderbilt2003-2008B.S.DrakeMedical ConsultantRonnebaum, S. Predoc
Odegaard, M.Predoc2004-2009B.S.Univ. Minn.Postdoc, EPAFerrara, C.Predoc2005-2009B.S.DukeFaculty, UCSFKhoo, C.Postdoc2011-2012MDSingaporeFaculty, NUS, SingaporeNewbern, D.Postdoc2009-MDDuke PedFellowFaculty, Duke PediatricsTessem, J.Postdoc2008-2013Ph.D.U. ColoradoFaculty, BYURosa, T.Grad Stud. 2010-2015MSUniv. Pittsburgh Research ScientistPetersen BGrad Stud 2012-2018BSNortheastern U Biotech, Boulder COWhite, P.Postdoc2012-2017PhDUniv. LavalFaculty, DMPIMcGarrah, R.Postdoc2015-2017MDUNCFaculty, DMPIStephens, S.Postdoc2008-2014-Ph.D.DukeFaculty, Univ. IowaCoppola, A.Postdoc2007-2013Ph.D.YaleCollege teacherHayes, H.Postdoc2008-2014Ph.D.DukeSenior Editor, AmericanJournal ExpertsGlynn, E.Postdoc2010-PhDUT-Galveston Principal Scientist,BeachbodyTraineePostdoc/PredocPeriod PositionAn, J.Postdoc1998-Ph.D.Eli LillyResearch AssociateJensen, M.V.Postdoc2000-Ph.D.Univ. Odense(Denmark)Research AssociateLu, D.Postdoc2000-Ph.D.Univ. OsakaResearch AssociateHaldeman JPostdoc2018-PhDMillersville U. Postdoctoral FellowZhang LPostdoc2014-PhDUNCCurrent Trainees:Postdoctoral Fellow
TEACHINGMedical Biochemistry: Carbohydrate Metabolism, Glycogen Metabolism, ProteinGlycosylation (9 lectures per year), 1988-presentMetabolic Regulation (Advanced course in the Biochemistry & Molecular Biologygraduate program). Course director and lecturer, 1991-2002Genetic Engineering and Gene Therapy (Advanced course in the Biochemistry & MolecularBiology graduate program). Course co-director and lecturer, 1996-2002Graduate School Core Course (beginning 1991): Organizer and lecturer for "liver chunk"section of the course, 1991-1999Medical Student Endocrinology: The Endocrine Pancreas, Metabolic Effects of Glucagon andInsulin (2 lectures per year), 1989-1997Graduate Biochemistry, First Year Course (prior to 1991): Amino Acid MetabolismMolecular Endocrinology (Biochemistry Department course): Insulin Action, insulinsecretion, 1988-1990Advanced Cell & Molecular Biology: Genetic Basis of Diabetes, 1988-1990Allied Health Physiology: The Endocrine Pancreas, 1989-1994Pharm 234, Module on Metabolic Regulation, Duke, 2002Medical Biochemistry, Carbohydrate and lipid metabolism, Duke, 2002-
BIBLIOGRAPHYPRIMARY PUBLICATIONS IN PEER-REVIEWED JOURNALS(Web of Science h-factor, 94, August, 2019)1) Newgard, C.B. and Holst, J. J. 1981. Heterogeneity of Somatostatin Like Immunoreactivity(SLI) in Extracts of Porcine, Canine, and Human Pancreas. Acta Endocrinologica 98: 564-572.2) Berelowitz, M., LeRoith, D., vonSchenck, H., Newgard, C., Szabo, M., Frohman, L., Shiloach,J., and Roth, J. 1982. Somatostatin Like Immunoreactivity and Biological Reactivity is Present inTetrahymena pyriformis, a Ciliated Protozoan. Endocrinology 110: 1939-1944.3) Newgard, C.B., Hirsch, L., Foster, D.W., and McGarry, J. D. 1983. Studies on the Mechanismby Which Exogenous Glucose is Converted into Liver Glycogen in the Rat -- A Direct or an IndirectPathway? Journal of Biological Chemistry 258: 8046-8052.4) Newgard, C.B., Foster, D.W., and McGarry, J. D. 1984. Evidence for Suppression of HepaticGlucose-6-Phosphatase with Carbohydrate Feeding. Diabetes 33: 192-195.5) Newgard, C.B., Moore, S.V., Foster, D.W., and McGarry, J. D. 1984. Efficient HepaticGlycogen Synthesis in Refeeding Rats Requires Continued Carbon Flow Through the GluconeogenicPathway. Journal of Biological Chemistry 259: 6958-6963.6) Kuwajima, M., Newgard, C.B., Foster, D.W., and McGarry, J. D. 1984. Time Course andSignificance of Changes in Fructose-2,6-Bisphosphate Levels During Refeeding of Fasted Rats.Journal of Clinical Investigation 21: 1108-1111.7) Kuwajima, M., Newgard, C.B., Foster, D.W., and McGarry, J. D. 1986. The GlucosePhosphorylating Capacity of Liver as Measured by Three Independent Assays. Implications for theMechanism of Glycogen Synthesis. Journal of Biological Chemistry 261: 8849-8853.8) Newgard, C.B., Nakano, K., Hwang, P.K., and Fletterick, R.J. 1986. Sequence Analysis of thecDNA Encoding Human Liver Glycogen Phosphorylase Reveals Tissue-Specific Codon Usage.Proceedings of the National Academy of Sciences U.S.A. 83: 8132-8136.9) Newgard, C.B., Fletterick, R.J., Anderson, L.A., and R.V. Lebo. 1986. The Polymorphic Locusfor Glycogen Storage Disease VI (Liver Glycogen Phosphorylase) Maps to Chromosome 14.American Journal of Human Genetics 40: 351-364.10) Rath, B., Newgard, C.B., Sprang, S., Goldsmith, E., & R.J. Fletterick. 1987. Modeling theBiochemical Differences Between Rabbit Muscle and Human Liver Phosphorylase. Proteins:Structure, Function & Genetics, 2: 225-235.11) Newgard, C.B., Littman, D., Van Genderen, C., Smith, M., & R.J. Fletterick. 1988. HumanBrain Glycogen Phosphorylase: Cloning, Sequence Analysis, Tissue Expression, Gene Mapping, and
Comparison with the Human Liver and Muscle Isozymes. Journal of Biological Chemistry 263:3850-3857.12) Leffert, J., Newgard, C.B., Okamoto, H., Milburn, J.L., and Luskey, K. 1989. Cloning of RatAmylin and Tissue-specific Expression in Pancreatic Islets. Proceedings of the National Academy ofSciences U.S.A. 86: 3127-3130.13) Iynedjian, P.B., Pilot, P-R.,, Nouspikel, T., Milburn, J.L., Quaade, C., Hughes, S., Ucla, C. andNewgard, C.B. 1989. Differential Expression and Regulation of the Glucokinase Gene in Liver andIslets of Langerhans. Proceedings of the National Academy of Sciences U.S.A. 86: 7838-7842.14) Johnson, J., H., Newgard, C.B., Milburn, J.L., Lodish, H. F., and Thorens, B. 1990. The HighKm Glucose Transporter of Islets of Langerhans is Functionally Similar to the Low AffinityTransporter of Liver and has an Identical Primary Sequence. Journal of Biological Chemistry 265,6548-6551.15) Chen, L., Alam, T., Johnson, J. H., Hughes, S., Newgard, C. B., and Unger, R. H. 1990.Regulation of b-cell Glucose Transporter Gene Expression. Proceedings of the National Academy ofSciences U. S. A. 87, 4088-4092.16) Johnson, J. H., Ogawa, A., Chen, L., Orci, L., Newgard, C. B., Alam, T., and Unger, R. H. 1990.Underexpression of High Km Glucose Transporters in b-cells: Role in Noninsulin-DependentDiabetes. Science 250, 546-549.17) Orci, L., Ravazzola, M., Baetens, D., Inman, L., Amherdt, M., Peterson, R. G., Newgard, C. B.,Johnson, J. H., and Unger, R. H. 1990. Evidence that Downregulation of b-cell Glucose Transportersin Noninsulin-Dependent Diabetes May Be the Cause of Diabetic Hyperglycemia Proceedings of theNational Academy of Sciences U.S.A. 87, 9953-9957.18) Miyaura, C., Chen, L., Appel, M., Alam, T., Hughes, S. D., Milburn, J. L., Unger, R. H., andNewgard, C. B. 1991. Expression of reg/PSP, a Pancreatic Exocrine Gene: Relationship to Changesin Islet b-cell Mass. Molecular Endocrinology 5 (2), 226-234.19) Hughes, S. D., Quaade, C., Milburn, J. L., Cassidy, L., and Newgard, C. B. 1991. Expression ofNormal and Novel Glucokinase mRNAs in Anterior Pituitary and Islet Cells. Journal of BiologicalChemistry 266, 4521-4530.20) Quaade, C., Hughes, S. D., Coats, W., Sestak, A., Iynedjian, P. B., and Newgard, C. B. 1991.Characterization of the Protein Products Predicted by Variant Glucokinase Transcripts. FEBS Letters280, 47-52.21) Coats, W., Browner, M., Fletterick, R. J., and Newgard, C. B. 1991. An Engineered LiverGlycogen Phosphorylase with AMP Allosteric Activation. Journal of Biological Chemistry 266,16113-16119.
22) Newgard, C. B., Norkiewicz, B., Hughes, S., Frenkel, R. A., Coats, W. S., Martiniuk, F. andJohnston, J. M. 1991. Developmental Expression of Glycogenolytic Enzymes in Rabbit Tissues:Possible Relationship to Fetal Lung Maturation. Biochimica et Biophysica Acta 1090: 333-342.23) Hughes, S. D., Johnson, J. H., Quaade, C., and Newgard, C. B. 1992. Engineering of GlucoseStimulated Insulin Secretion and Biosynthesis in Non-islet Cells. Proceedings of the NationalAcademy of Sciences U. S. A. 89: 688-692.24) Gomez-Foix, A. M., Coats, W. S., Baque, S., Alam, T., Gerard, R., and Newgard, C. B. 1992.Adenovirus-Mediated Transfer of the Muscle Phosphorylase Gene into Hepatocytes Confers AlteredRegulation of Glycogen Metabolism. Journal of Biological Chemistry 267: 25129-25134.25) Inman, L. R., McAllister, C. T., Chen, L., Hughes, S., Newgard, C. B., Unger, R. H., andJohnson, J. H. 1993. Autoantibodies to GLUT-2 in New Onset Insulin-Dependent Diabetes Mellitus.Proceedings of the National Academy of Sciences, U.S. A. 90: 1281-1284.26) Hughes, S. D., Quaade, C., Johnson, J. H., Ferber, S., and Newgard, C. B. 1993. Transfection ofAtT-20ins Cells with GLUT-2 but not GLUT-1 confers Glucose-Stimulated Insulin Secretion:Relationship to Glucose Metabolism. Journal of Biological Chemistry 268: 15205-15212.27) Ferber, S., BeltrandelRio, H., Johnson, J. H., Noel, R. J., Cassidy, L.E., Clark, S., Becker, T. C.,Hughes, S. D., and Newgard, C. B. 1994. GLUT-2 Gene Transfer into Insulinoma Cells Confers bothHigh and Low Affinity Glucose-Stimulated Insulin Release: Relationship to Glucokinase Activity.Journal of Biological Chemistry 269: 11523-11529.28) Becker, T., BeltrandelRio, H., Noel, R. J., Johnson, J. H., and Newgard, C. B. 1994.Overexpression of Hexokinase I in Isolated Islets of Langerhans via Recombinant Adenovirus:Enhancement of Glucose Metabolism and Insulin Secretion at Basal but not Stimulatory GlucoseLevels. Journal of Biological Chemistry 269: 21234-21238.29) Baque, S., Newgard, C. B., Gerard, R. D., Guinovart, J. J., and Gomez-Foix, A. M. 1994.Adenovirus-mediated Delivery into Myocytes of Muscle Glycogen Phosphorylase, the EnzymeDeficient in Glycogen Storage Disease Type V. Biochemical Journal 304: 1009-1014.30) Schnedl, W., Ferber, S., Johnson, J. H., and Newgard, C. B. 1994. Streptozotocin Transport andCytotoxicity: Specific Enhancement in GLUT-2 Expressing Cells. Diabetes 43: 1326-1333.31) Milburn, J. L., Jr., Hirose, H., Lee, Y.H., Nagasawa, Y., Ogawa, A., Ohneda, M., BeltrandelRio,H., Newgard, C. B., Johnson, J. H., and Unger, R. H. 1995. Pancreatic b-cells in Obesity: Evidencefor Induction of Functional, Morphologic, and Metabolic Abnormalities by Increased Long ChainFatty Acids. Journal of Biological Chemistry 270: 1295-1299.32) Argaud, D., Lange, A.J., Becker, T.C., Okar, D.A., El-Maghrabi, R., Newgard, C.B., and Pilkis,S.J. 1995. Adenovirus-mediated Overexpression of Liver 6-PF-2-K/Fru-2,6-P2ase in GluconeogenicRat Hepatoma Cells: Paradoxical Effect on Fru-2,6-P2 Levels. Journal of Biological Chemistry 270:24229-24236
33) Becker, T., Noel, R. J., Johnson, J. H., Lynch, R. M., Hirose, H., Tokuyama, Y., Bell, G. I., andNewgard, C. B. 1996. Differential Effects of Overexpressed Glucokinase and Hexokinase I in IsolatedIslets: Evidence for Functional Segregation of the High and Low Km Enzymes. Journal of BiologicalChemistry 271: 390-39434) O’Doherty, R., Lehman, D., Seoane, J., Gomez-Foix, A. M., Guinovart, J.J., and Newgard, C.B.1996. Differential Metabolic Effects of Adenovirus-Mediated Glucokinase and Hexokinase IOverexpression in Rat Primary Hepatocytes. Journal of Biological Chemistry 271: 20524-2053035) Seoane, J., Gomez-Foix, A.M., O’Doherty, R. M., Gomez-Ara, C., Newgard, C. B., andGuinovart, J. J. 1996. Glucose-6-phosphate Produced by Glucokinase, but not Hexokinase is theSignal for the Activation of Hepatic Glycogen Synthase. Journal of Biological Chemistry 271: 237562376036) Wang, M-Y., Zhou, Y-T., Newgard, C.B., and Unger, R.H. 1996. A Novel Leptin ReceptorIsoform in Rat. FEBS Lett. 392: 87-90.37) Agius, L., Peak, M., Newgard, C.B., Gomez-Foix, A. M., and Guinovart, J. J. 1996. Evidencefor a Role of Glucose-induced Translocation of Glucokinase in the Control of Hepatic GlycogenSynthesis. Journal of Biological Chemistry 271: 30479-3048638) Chen, G., Koyama, K., Yuan, X., Lee, Y., Zhou, Y-T., O’Doherty, R.M., Newgard, C.B., andUnger, R. H. 1996. Disappearance of Body Fat in Normal Rats Induced by Adenovirus-mediatedLeptin Gene Therapy. Proceedings of the National Academy Sciences, U.S.A 93: 14795-1479939) Clark, S., Quaade, C., Constandy, H., Hansen, P., Halban, P., Ferber, S., Newgard, C.B.,Normington, K. 1997. Novel Insulinoma Cell Lines Produced by Iterative Engineering of GLUT-2,Glucokinase, and Human Insulin Expression. Diabetes 46: 958-96740) Hohmeier, H., BeltrandelRio, H., Clark, S., Henkel-Reiger, R., Normington, K, and Newgard,C.B. 1997. Regulation of Insulin Secretion from Novel Engineered Insulinoma Cell Lines. Diabetes46: 968-97741) Noel, L. E. and Newgard, C. B. 1997. Structural Domains that Contribute to Substrate Specificityin Facilitated Glucose Transporters are Distinct from Those Involved in Kinetic Function: Studieswith GLUT1/GLUT2 Chimeras. Biochemistry 36: 5465-547542) Argaud, D., Kirby, T. L., Newgard, C.B., Lange, A.J. 1997. Glucose Stimulation of Glucose-6phosphatase Gene Expression in Primary Hepatocytes and Fao Hepatoma Cells. Requirement forGlucokinase Expression. Journal of Biological Chemistry 272: 12854-1286143) Koyama, K., Chen, G., Wang, M-Y, Lee, Y., Shimabukuro, M., Zhou, Y-T., Newgard, C.B.,Unger, R.H. 1997. Leptin and Diabetes: b-cell Function in Hyperleptinemic rats. Diabetes 46: 12761280.
44) Shimabukuro, M., Koyama, K., Chen, G., Wang, M-Y., Lee, Y., Newgard, C.B., Unger, R.H.1997. Direct Antidiabetic Effect of Leptin Through Triglyceride Depletion of Tissues. ProceedingsNational Academy of Sciences 94: 4637-464145) Noel, R.J., Antinozzi, P., McGarry, J.D., and Newgard, C.B. 1997. Engineering of GlycerolStimulated Insulin Secretion in Islet b-cells: Differential Metabolic Fates of Glucose and GlycerolProvide Insight into Mechanisms of Stimulus-Secretion Coupling. Journal of Biological Chemistry272: 18621-18627.46) Zhou, Y-T., Shimabukuro, M., Koyama, K., Lee, Y., Wang, M-Y., Trieu, F., Newgard, C.B., andUnger, R.H. 1997. Induction by Leptin of Uncoupling Protein-2 and Enzymes of Fatty AcidOxidation. Proceedings of the National Academy of Sciences, U.S.A. 94: 6386-6390.47) Trinh, K., Minassian, C., Lange, A., O’Doherty, R. M., and Newgard, C.B. 1997. Adenovirusmediated Expression of the Catalytic Subunit of Glucose-6-phosphatase in INS-1 Cells: Effects onGlucose Cycling, Glucose Usage, and Insulin Secretion. Journal of Biological Chemistry 272: 2483724842.48) Seoane, J., Trinh, K., O’Doherty, R., Gomez-Foix, A.M., Lange, A.J., Newgard, C.B., andGuinovart, J.J. 1997. Metabolic Impact of Adenovirus-Mediated Overexpression of the Glucose-6Phosphatase Catalytic Subunit in Primary Hepatocytes. Journal of Biological Chemistry 272: 2697226977.49) Wang, M-Y., Koyama, K., Shimabukuro, M., Newgard, C.B., and Unger, R. H. 1998. Ob-RbGene Transfer to Leptin-Resistant Islets Reverses Diabetogenic Phenotype. Proceedings of theNational Academy of Sciences, U.S.A. 95: 714-718.50) Hohmeier, H., Thigpen, A., Tran, V., Davis, R., and Newgard, C.B. 1998. Stable Expression ofManganese Superoxide Dismutase (MnSOD) in Insulinoma Cells Prevents IL-1b-InducedCytotoxicity and Reduces Nitric Oxide Production. Journal of Clinical Investigation 101: 1811-1820.51) Berman, H. K. and Newgard, C.B. 1998. Fundamental Metabolic Differences BetweenHepatocytes and Islet b-cells Revealed by Glucokinase Overexpression. Biochemistry 37: 4543-4552.52) Antinozzi, P., Segall, L., Prentki, M., McGarry, J.D., and Newgard, C.B. 1998. Molecular orPharmacologic Perturbation of the Link Between Glucose and Lipid Metabolism is Without Effect onGlucose-Stimulated Insulin Secretion: A Re-evaluation of the Long-chain Acyl CoA Hypothesis.Journal of Biological Chemistry 273: 16146-16154.53) Scott, D.K., O’Doherty, R. M., Stafford, J.M., Newgard, C.B., and Granner, D.K. 1998. TheRepression of Hormone-activated PEPCK Gene Expression by Glucose is Insulin-Independent butRequires Glucose Metabolism. Journal of Biological Chemistry 273: 24145-24151.54) Zhou, Y-T., Shimabukuro, M., Wang, M-Y., Lee, Y., Higa, M., Milburn, J.L., Newgard, C.B.,and Unger, R.H. 1998. Role of Peroxisome Proliferator-Activated Receptor a in Disease of Pancreaticb-cells. Proceedings National Academy of Sciences, U.S.A. 95: 8898-8903.
55) Koyama, K., Shimabukuro, M., Chen, G., Wang, M-Y., Lee, Y., Kalra, P. S., Dube, M.G., Kalra,S.P., Newgard, C.B., and Unger, R.H. 1998. Resistance to Adenovirally-induced Hyperleptinemia inRats: Comparison of Ventromedial Hypothalamic Lesions with Mutated Leptin Receptors. Journal ofClinical Investigation 102: 728-73356) Shimabukuro, M., Wang, M-Y., Zhou, Y-T., Newgard, C.B., and Unger, R.H. 1998. Protectionagainst b-cell Lipoapoptosis Through Leptin-Dependent Maintenance of Bcl-2 Expression.Proceedings National Academy of Sciences, U.S.A. 95: 9558-9561.57) Baque, S., Montell, E., Guinovart, J. J., Newgard, C.B., Gomez-Foix, A.M. 1998. Expression ofGlucokinase in Cultured Human Muscle Cells Confers Insulin-Independent and GlucoseConcentration Dependent Glucose Disposal and Storage. Diabetes 47: 1392-1398.58) Berman, H.K., O’Doherty, R.M., Anderson, P., and Newgard, C.B. 1998. Overexpression ofProtein Targeted to Glycogen (PTG) in Rat Hepatocytes Causes Profound Activation of GlycogenSynthesis Independent of Normal Hormone- and Substrate-Mediated Regulatory Mechanisms.Journal of Biological Chemistry 273: 26421-26425.59) Trinh, K., O’Doherty, R., Anderson, P., Lange, A.J., and Newgard, C.B. 1998. Perturbation ofFuel Homeostasis Caused by Overexpression of the Glucose-6-Phosphatase Catalytic Subunit in Liverof Normal Rats. Journal of Biological Chemistry 273: 31615-31620.60) Wang, M-Y, Koyama, K., Shimabukuro, M., Mangelsdorf, D., Newgard, C.B., and Unger, R.H.1998. Overexpression of Leptin Receptors (Ob-Rb) in Pancreatic Islets of Zucker Diabetic Fatty RatsResores GLUT-2, Glucokinase, and Glucose-stimulated Insulin Secretion. Proceedings NationalAcademy Sciences U.S.A. 95: 11921-11926.61) Shimabukuro, M., Higa, M., Zhou, Y-T., Wang, M-Y, Newgard, C.B., and Unger, R.H. 1998.Lipoapoptosis in beta-cells of Obese, Prediabetic fa/fa Rats: Role of Serine Palmitoyl TransferaseOverexpression. Journal of Biological Chemistry 273: 32487-32490.62) Wang, M-Y, Shimabukuro, M., Lee, Y., Trinh, K., Chen, J-L., Newgard, C.B., and Unger, R.H.1999. Adenovirus-mediated Overexpression of Uncoupling Protein-2 in Pancreatic Islets of ZuckerDiabetic Fatty Rats Increases Oxi
Lilly Lecturer, Australian Diabetes Society, September, 1994 Member, Congressionally-Mandated Diabetes Research Working Group, November, 1997-1999 William Stadie Award, American Diabetes Association, Pennsylvania Affiliate, February, 1998 Sigma Xi Lecture
Curriculum Vitae Guide The terms curriculum and vitae are derived from Latin and mean "courses of my life". Résumé, on the other hand, is French for “summary.” In industry, both in and outside of the US, people refer to curriculum vitae (CV)s and résumés interchangeably. Curriculum Vitae vs. Résumés
CV curriculum vitae CV v. resume – Length – Scholarly/scientific. Curriculum Vitae CV curriculum vitae CV v. resume – Length – Scholarly/scientific – Detailed. Curriculum Vitae (CV) Name, title, curren
A Curriculum Vitae Also called a CV or vita, the curriculum vitae is, as its name suggests, an overview of your life's accomplishments, most specifically those that are relevant to the academic realm. In the United States, the curriculum vitae is used
3.0 TYPES OF CURRICULUM There are many types of curriculum design, but here we will discuss only the few. Types or patterns are being followed in educational institutions. 1. Subject Centred curriculum 2. Teacher centred curriculum 3. Learner centred curriculum 4. Activity/Experience curriculum 5. Integrated curriculum 6. Core curriculum 7.
1 Curriculum Vitae and List of Publications I. Curriculum Vitae 1. Personal Details David Roe Electronic Address: droe@univ.haifa.ac.il 2. Higher Education Year of Approval of Degree Name of Institution Degree and Department Period of Study BA in Psychology 1991 Cum Laude 1989-1991 Brown University Masters of Philosophy 1995 Masters of Science
Vita vs. Vitae (pronounced VEE-tye, not VEE-tay) The correct term for the CV is the “curriculum vitae” Latin meaning “[the] course of [my] life” “vitae”is plural for the word “vita” but in the case of curriculum vitae, itis a modifier for the singu
3 www.understandquran.com ‡m wQwb‡q †bq, †K‡o †bq (ف ط خ) rُ sَ _ْ یَ hLbB َ 9 آُ Zviv P‡j, nv‡U (ي ش م) اْ \َ َ hLb .:اذَإِ AÜKvi nq (م ل ظ) َ9َmْ أَ Zviv uvovj اْ ُ Kَ hw ْ َ Pvb (ء ي ش) ءَ Cﺵَ mewKQy ءٍ ْdﺵَ bِّ آُ kw³kvjx, ¶gZvevb ٌ یْ"ِKَ i“Kz- 3
standard , and tick applicability , Say How notes column , Risk and opportunities column , . (ISO 14001 requirement) Clause 6.1.4 Planning action Elimination of hazards and risks –either by the OH & S system or other BMS. Cross reference to Clause 8 (controls) and Clause 9 (M & M) Tip 8 Add plans to excel work book for year . Clause 6.2.1 OH & S objectives at all levels & Clause 6.2.2 .
