COMPOUNDED STERILE PREPARATIONS RECONSTITUTION, DILUTION .
FH Pharmacy DepartmentCOMPOUNDED STERILE PREPARATIONSRECONSTITUTION, DILUTION AND STABILITY CHART (ADULT)DRUG(Manufacturer or BrandName)CONCENTRATED SOLUTIONDILUTED SOLUTION(reconstituted or premixed commercial vial / amp)(minibag, minibag-plus)SizeDiluentSoln ConcBeyond UseDateMINIBAGStd IV SolnBag Vol orMax ConcBeyondUse DateMINIBAG-PLUS orCOMMERCIAL PREMIXBeyond UseDoseDateACYCLOVIR3500 mg/10 mLpremix50 mg/mL24 hr RTD5W10 mg/mL1 g/100 mL D5Wpremix250 mg/mL 24 hr FD5W(Sabex)AMPHOTERICIN B1,4Fluid Restn:25 mL(central line)discard if precipitated; same BUDfor dilution in NS30 days Fpale yellow does not indicate loss ofpotency; dark solutions should bediscarded; same BUD for dilutionin NS30 days Fvials stored in fridge; dilution inD5W only; protect from lightduring storage (vials andsolutions)100 mL500 mg/2 mLAdditional Information500 mg/100 mL D5W do not refrigerate minibags;30 days RT(PPC)AMIKACIN2,3Available to Sitesfor stockfrom PDDC5 mg/mL24 hr FD5Wperipheral:0.1mg/mLmax central: 1mg/mL100 mg/20 mL premix5 mg/mL24 hr FD5W1-2 mg/mL10 days Fvials stored in fridge; use 5 micronfilter to add dose to infusion bag;dilution in D5W onlyLiposomal50 mg4 mg/mL24 hr FD5W0.2 - 2 mg/mL11 days F(Ambisome )AMPICILLIN1,3vials stored in fridge; use 5 micronfilter to add dose to infusion bag;dilution in D5W only250 mg50 mg10 mL SWFI(Fungizone )AMPHOTERICIN B1.3Lipid Complex(Abelcet )AMPHOTERICIN B1.3(NOVO; PPC)500 mg(NOVO; PPC)(Teva, PPC)ARGATROBAN(Pfizer)12 mL SWFI50 mL0.9 mL SWFIFluid Restn:25 mL50 mL1.8 mL SWFIFluid Restn:25 mL1 g (NOVO)3.5 mL SWFI 250 mg/mL 1 hr RT1 g (PPC)3.4 mL SWFI2 g (NOVO)6.8 mL SWFI50 mLFluid Restn:25 mL72 hr F50 mLFluid Restn:25 mL100 mL1250 mg/2.5 mL premixNS100 mg/mL 24 hr RTD5WNS250 mg/250 mL48 hr F250 mg/50 mL NSMB 500 mg/50 mL NSMB 250 mg/50 mL NSMB 500 mg/50 mL NSMB 1 g/50 mL NS MB 30 days RT1 g/50 mL NS MB 1 g/50 mL NS MB 1 g/50 mL NS MB 2 g/100 mL NSMB 2 g/100 mL NS MB 20 mg/mL NS 48 hr; BUD fordilution in D5W: 2 hr RT or 4 hr Fbag stable for 24 hr RT in ambientindoor light and 48 hr F andprotected from lightPage 1FH CIVA Reconstitution, Dilution and Stability Chart (ADULT) -August 2014
DRUGCONCENTRATED SOLUTIONDILUTED SOLUTION(reconstituted or premixed commercial vial / amp)(minibag, minibag-plus)Size(Manufacturer or BrandName)DiluentSoln ConcBeyond UseDateMINIBAGStd IV SolnAZITHROMYCIN1,6500 mg4.8 mL SWFI 100 mg/mL 24 hr F500 mg1.5 mL SWFI1g3 mL SWFI(Azactam )2g6 mL SWFICALCIUM CHLORIDE5 g/50 mLpremixD5WBag Vol orMax Conc1-2 mg/mL250-500 mLBeyondUse Date7 days F(Zithromax )AZTREONAM1,3use entirevialMINIBAG-PLUS orCOMMERCIAL PREMIXBeyond UseDoseDate500 mg/250 mLD5W MB Available to Sitesfor stockfrom PDDC250 mg/250 mL D5W30 days RT500 mg/250 mL D5WMB 500 mg/50 mL24 hr FD5W2 g/100 mL100 mg/mLNS7 g/1000 mL30 days F7 g/1000 mL NSCALCIUM GLUCONATE1000 mg/10 mLpremix(10%)100 mg/mL 24 hr FD5W(Abbott, PPC)CASPOFUNGIN1(Cancidas )CEFAZOLIN50 mg10.5 mL SWFI 5 mg/mL70 mg10.5 mL SWFI 7 mg/mL500 mg2.3 mL SWFI 200 mg/mL50 - 100 mL1 hr RTNSFluid Restn:100 mL for doses 50 mg10 mL of 10% 1g Ca Glu 93 mgCa 2.3 mmol 4.6 mEq;re-dissolve crystals by warming;same BUD in NS7 days F35 mg/100 mL NS100 - 250 mL48 hr F50 mg/250 mL NS70 mg/250 mL NSvials stored in fridge; for 35 mgdose: use 70 mg vial for two doses;do not use reconstitution device;reconst. overfill -dose in 10 mL;dilution in NS only71g4.5 mL SWFI 200 mg/mL 24 hr F500 mg/50 mL D5WD5W 1 g - 50 mL 1 g - 100 mL30 days F1 g/50 mL D5WFluid Restn:25 mLTeva, Sandoz, Apo)CEFAZOLIN /METRONIDAZOLE2(METCEF / CEFMET)CEFOTAXIME1,310 g45 mL SWFI200 mg/mLsee Cefazolinreconstitution2 g/100 mL D5Wadd Cefazolin dose to 100 mL12 days FMetronidazole premix bag500 mg2.3 mL SWFI1g4.6 mL SWFI 200 mg/mL 24 hr F(Claforan )2g9 mL SWFICEFOXITIN31g4.7 mL SWFI2g9 mL SWFI10 g45 mL SWFI(Teva, Apo)do not use Cornwall Syringemax concentration foradministration: 20 mg/mL; SpecialAccess drug7 days F1 g/50 mlAdditional InformationD5W 1 g - 50 mL 1 g - 100 mL24 hr FFluid Restn:25 mL200 mg/mL 24 hr FD5W 1 g - 50 mL 1 g - 100 mLCefaz/Metronidazole1 g/500 mgCefaz/Metronidazole2 g/500 mg500 mg/50 mL D5W1 g/50 mL D5Wreconstitution volumes for 500 and1 g vials differ from themanufacturer vol; same BUD fordilution in NSprotect from light during storagesame BUD for dilution in NS2 g/100 mL D5W1 g/50 mL D5W13 days F2 g/100 mL D5Wreconstitution volumes differ fromthe manufacturer vol ; same BUDfor dilution in NSPage 2FH CIVA Reconstitution, Dilution and Stability Chart (ADULT) -August 2014
DRUGDILUTED SOLUTION(minibag, minibag-plus)Size(Manufacturer or BrandName)CEFTAZIDIME3CONCENTRATED SOLUTION(reconstituted or premixed commercial vial / amp)Diluent1 g (Ceftaz)4.8 mL SWFI1 g (PPC)4.4 mL SWFI2 g (Ceftaz)8 mL SWFI2g (PPC,Fortaz)8.8 mL SWFI(Ceftaz , Fortaz , PPC)6 g (Fortaz)26 mL SWFICEFTRIAXONE3250 mg2.4 mL SWFI(Rocephin , Sandoz)CEFUROXIME2,3(Zinacef , PPC)CHLORAMPHENICOL(Chloromycetin )CIPROFLOXACINSoln ConcBeyond UseDate200 mg/mL 24 hr F19.2 mL SWFI10 g95 mL SWFI750 mg5.7 mL SWFI1.5 g11.3 mL SWFI 125 mg/mL 24 hr F10 mL SWFIBeyondUse DateD5W 1 g - 50 mL 1 g - 100 mL7 days F100 mg/mL 24 hr FD5W 1 g - 50 mL 1 g - 100 mLCLOXACILLIN8(Teva)500 mg/50 mL D5W1 g/50 mL D5WFluid Restn: 25 mLD5W 1.5 g - 50 mL 1.5 g - 100 mL500 mg/50 mL D5W14 days F750 mg/50 mL D5WFluid Restn:25 mL2100 mg/mL 24 hr RTD5W50 mLFluid Restn:25 mL1.5 g/50 mL D5Wpremix600 mg/4 mLpremixreconstitution volumes differ fromthe manufacturer vol;Fortaz, PPC - vent vialsCeftaz - reduced vial pressure;same BUD for dilution in NSsame BUD for dilution in NSprotect from light during storage(vials and solutions); light darkenssoln without affecting potency;same BUD for dilution in NS24 hr RT200 mg/100 mLD5W premix400 mg/200 mLD5W premix300 mg/2 mLAdditional Information2 g/100 mL D5W14 days F or200 mg/100 mL D5WRT out of wrapsame BUD for dilution in NS30 days F or400 mg/200 ml D5WRT out of wrap300 mg/50 mL D5W150 mg/mL 24 hr F(Sabex)2 g/100 mL D5W14 days F(Hospira)CLINDAMYCIN3Available to Sitesfor stockfrom PDDC250 mg/50 mL D5W2g1g vialBag Vol orMax ConcFluid Restn:25 mL9.6 mL SWFI58 mL SWFIStd IV SolnMINIBAG-PLUS orCOMMERCIAL PREMIXBeyond UseDoseDate1 g/50 mL D5W1g7.5 gMINIBAG900 mg/6 mLpremix9 g/60 mLpremix500 mg1.7 mL SWFI1g3.4 mL SWFI 250 mg/ mL 24 hr F2g6.8 mL SWFID5W 600 mg - 50 mL 600 mg -100 mL 30 days Fmax:18 mg/mL450 mg/50 mL D5Wsame BUD for dilution in NS600 mg/50 mL D5W900 mg/100 mL D5WD5W 1 g - 50 mL 1 g in 100-250mLFluid Restn:25 mL500 mg/50 mL D5W14 days F1 g/50 mL D5Wsame BUD for dilution in NS2 g/100 mL D5WPage 3FH CIVA Reconstitution, Dilution and Stability Chart (ADULT) -August 2014
DRUGCONCENTRATED SOLUTIONDILUTED SOLUTION(reconstituted or premixed commercial vial / amp)(minibag, minibag-plus)Size(Manufacturer or BrandName)DiluentSoln ConcBeyond UseDateMINIBAGStd IV SolnCOTRIMOXAZOLE2,8,95 mLpremix16 mgTMP/80 mg 24 hr RTSMX/mLD5W(Septra )Bag Vol orMax ConcBeyondUse Date5 mL 125 mLD5W (1:25 diln)24 hr RT5 mL 75 mLD5W (1:15 diln)3 hr RT5 mL 50 mLD5W (1:10 diln)1.5 hr RTMINIBAG-PLUS orCOMMERCIAL PREMIXBeyond UseDoseDateAvailable to Sitesfor stockfrom PDDCbecause of the short stability,Pharmacy sends vials; same BUDfor dilution in NSDAPTOMYCIN18500 mg10 mL NS50 mg/mL24 hr FNS100 mg10 mL SWFI10 mg/mL24 hr FD5W50 mL10 days F250 mL0.1 - 1 mg/mL72 hr Fvials are stored in fridge; do notshake vial during reconstitution,gently swirl contents; dilute in NSonly(Cubicin )DOXYCYCLINE3contains LATEX(APP)DROTRECOGIN5 mg2.5 mL SWFI20 mg(Xigris )3 hr RTNS10 mL SWFIprotect from light during storage100 mg/250 mL D5W and infusion; Special Access;same BUD for in NS12 hr F 14 hr RT(24 hr total)50 mL2 mg/mL100 mLAdditional Informationvials stored in fridge; minimiseagitation during preparation; do nottubeERTAPENEM3500 mg/50 mL NS1g10 mL SWFI100 mg/mL 24 hr FNS50 mL5 days F1 g/50 mL NSMB 30 days RTdilute in NS only1 g/50 mL NS MB (Invanz )ERYTHROMYCIN500 mgLACTOBIONATE10 mL SWFI2,350 mg/mL1g20 mL SWFI1000 mcg/20mLpremix24 hr FNS 500 mg -250 mL 500 mg -500 mL 24 hr Fmax: 5 mg/mL500 mg/250 mL NSdilute in NS only; BUD of minibags1 g/500 mL NScan be extended to 10 days F by addingNa Bicarb 8.4% 0.2 mL to 50 mL, 0.4 mLto 100 mL, 1 mL to 250 mL or 2 ml to 500mL bag(Erythrocin IV )FENTANYL PCA50 mcg/mLNS2000 mcg/100 mL 30 days F20 mcg/mL - 100 mLNS IPUMP BAGprotect from light during storagePage 4FH CIVA Reconstitution, Dilution and Stability Chart (ADULT) -August 2014
DRUG(Manufacturer or BrandName)CONCENTRATED SOLUTIONDILUTED SOLUTION(reconstituted or premixed commercial vial / amp)(minibag, minibag-plus)SizeDiluent1000 mcg/20FENTANYL / BUPIVACAINE mL (fentanyl)EPIDURAL100 mg/20 mLpremix(bupivacaine)Soln ConcBeyond UseDate50 mcg/mL(fentanyl)5 mg/mL(bupivac)MINIBAGStd IV SolnNSBag Vol orMax ConcBeyondUse Date2 mcg/mL fentanyl0.0625% bupivac250 mL2 mcg/mL fentanyl0.08% bupivac250 mL30 days F2 mcg/mL fentanyl0.1% bupivac 250mL2 mcg/mL fentanyl0.125% bupivac100 mLFLUCONAZOLE(Baxter)FOMEPIZOLE(Antizol )FUROSEMIDE2,3protect from light during storagedo not refrigerate; BUD for dosestransferred to empty viaflex bags 30 days RTpremix1000 mg/mL 24 hr RTD5W100 mL24 hr RTsolution in vial is clear to yellow;same BUD for dilution in NS40 mg/4 mLpremix10 mg/mLD5W50-100 mLusual: 1 mg/mLmax: 5 mg/mL24 hr RTdo not refrigerate; do not use ifyellow discolouration; same BUDfor dilution in NSD5W 50 kg: 250-500mL (1-2 mg/mL) 50 kg: 0.1-0.2mg/mL3 days FSpecial Access drug10 mL diluent 50 mg/mL24 hr F(Fucidin Leo )GENTAMICINAdditional Information1500 mg/1.5mL500 mg1,8Available to Sitesfor stockfrom PDDC2 mcg/mL fentanyl0.0625% bupivac250 mL NS2 mcg/mL fentanyl0.08% bupivac250 mL NS2 mcg/mL fentanyl0.1% bupivac250 mL NS2 mcg/mL fentanyl0.125% bupivac100 mL NS200 mg/100 mL NSpremix30 days RT400 mg/200 mL NS out of wrappremix(Abbott)FUSIDATE SODIUM1,8GANCICLOVIRMINIBAG-PLUS orCOMMERCIAL PREMIXBeyond UseDoseDateprepared in Biological Safety Cabinet80 mg/2 mLpremix800 mg/20 mL premix40 mg/mL28 days RTsee Cytotoxic Medication Reconstitution ChartNS 80 mg - 50 mL 80 mg - 100 mL 30 days FFluid Restn:25 mL(Sabex)60 mg/50 ml NSpremix80 mg/50 mL NS30 days RTpremix100 mg/100 mL NS out of wrappremix120 mg/100 mL NSpremixsame BUD for dilution in D5WPage 5FH CIVA Reconstitution, Dilution and Stability Chart (ADULT) -August 2014
DRUG(Manufacturer or BrandName)CONCENTRATED SOLUTIONDILUTED SOLUTION(reconstituted or premixed commercial vial / amp)(minibag, minibag-plus)SizeDiluentHEPARIN1,310,000 units/mL premix(PPC; BBraun)HYDROCORTISONESODIUM SUCCINATE2Soln Conc10,000units/mL1.8 mL SWFI 50 mg/mL250 mg1.8 mL SWFI 125 mg/mL 24 hr F3.8 mL SWFI 125 mg/mLHYDROMORPHONE PCA50 mg/5 mLpremixHYDROMORPHONEEPIDURAL50 mg/5 mL(hydromorph)premix100 mg/20 mL(bupivacaine)IMIPENEM / CILASTATIN5,8Std IV SolnD5WBag Vol orMax ConcBeyondUse Date500 mL24 hr RT10 mg/mL10 mg/mL(hydromor)5 mg/mL(bupivac)(Merk, Omega)INFLIXIMAB10 mL NSsee additional 50 mg/mLinfoD5W250-1000 mLNS40 mg/100 mLNS20 mcg/mLhydromorphone30 days F0.1% bupivacaine250 mLNS24 hr F(Remicade )allow to standfor 5 min10 mg/mL24 hr RTmay be prepared in CIVA LAFH or BSCLEUCOVORINsame BUD for dilution in NS0.4 mg/mL - 100 mLNS IPUMP BAG30 days F 500 mg-100 mL 500 mg-250 mL 48 hr Fmax: 5 mg/mLNS250 mL0.4 - 4 mg/mL250 mg/100 mL NS30 days RTMB 250 mg/100 mL NSMB 500 mg/100 mL NS30 days RTMB 500 mg/100 mL NSMB 5 mL NS0.1 mg/mLusing reconstitution device and NSminibag add 10 mL; shake and addsuspension to the bag; repeat;second rinsing of vial required totransfer entire dose; colorless toyellow without affecting potency;BUD in D5W - 6 hrsvial may be reconstituted with NSremoved from final bag; do not useif opaque or discolored; dilution inNS onlysee Cytotoxic Medication Reconstitution Chart250 mg/50 mLD5W premix500 mg/100 mLD5W premix750 mg/150 mLD5Wpremix0.5 mgprotect from light during storage20 mcg/mLhydromorphoneprotect from light during storage0.1% bupivacaine 250mL NS24 hr F(Levaquin )(PPC)Additional Information3 months RT25,000 units/500or F out ofmL D5W Excel bagwrap24 hr RT500-1000 mLmax 1 mg/mL9LEVOTHYROXINE14Available to Sitesfor stockfrom PDDC1 g/250 mL NS10 mL SWFI100 mgMINIBAG-PLUS orCOMMERCIAL PREMIXBeyond UseDoseDate100-1000 mL250 mg500 mgLEVOFLOXACIN28 days For RT100 mg500 mg(Teva)Beyond UseDateMINIBAG30 days RT orF out of wrapstable in syringes for 7 days F andadministered IV push24 hr FPage 6FH CIVA Reconstitution, Dilution and Stability Chart (ADULT) -August 2014
DRUGCONCENTRATED SOLUTIONDILUTED SOLUTION(reconstituted or premixed commercial vial / amp)(minibag, minibag-plus)Size(Manufacturer or BrandName)DiluentSoln ConcBeyond UseDateMINIBAGStd IV SolnBag Vol orMax ConcBeyondUse DateLINEZOLID3(Zyvoxam IV )MAGNESIUM SULFATE2(Sabex)MEROPENEM3600 mg/300 mLD5W premix5 g /10 mL(50%)premix500 mg10 mL SWFI500 mg/mL 24 hr F1g(Solumedrol , Teva)METOCLOPRAMIDE(Maxeran )METRONIDAZOLE50 - 500 mL24 hr FNS20 mL SWFI500 mg1g15.6 mL SWFI10 mg/2 mLpremix5 mg/mL24 hr F5 days F30 days RTout of wrapsame BUD for dilution in NS500 mg/50 mL NSMB 30 days RT1 g/100 mL NSMB NS 250 mg in 50-250mL48 hr Fmax: 50 mg/mLD5W 50 mg - 50 mL24 hr F 50 mg - 100 mL(Flagyll )MICAFUNGIN175 mL NS20 mg/mL24 hr FD5W500 mg/10 mL premix50 mg/mLMORPHINE EPIDURAL15 mg/mL(morphine)premix100 mg/20 mL(bupivacaine)15 mg/mL(morphine)5 mg/mL(bupivac)BUD in D5W - 24 hr F250 mg/50 mL NSdo not refrigerate; protect fromlight during storage; BUD fordoses transferred to emptyviaflex bags - 30 days RTprotect from light during storageand infusion; mix vials genlty;same BUD for dilution in NS50 - 150 mg in 1007 days FmL(Micamine )MORPHINE PCA500 mg/50 mL NSMB 1 g/100 mL NSMB same BUD for dilution in NS500 mg/100 mL NS 30 days RTpremixout of wrap100 mgAdditional Informationsee Cytotoxic Medication Reconstitution Chart7.8 mL SWFI62.5 mg/mL 24 hr FAvailable to Sitesfor stockfrom PDDC30 days FFluid Restn:20mg/mLmay be prepared in CIVA LAFH or BSCMESNAMETHYLPREDNISOLONED5W10 mg/mL50 mg/mL(Merrem )MINIBAG-PLUS orCOMMERCIAL PREMIXBeyond UseDoseDateNS200 mg/100 mL30 days F2 mg/mL - 100 mL NS
12 days F protect from light during storage 13 days F 1 g - 50 mL 1 g - 100 mL CEFAZOLIN7 Teva, Sandoz, Apo) NS CASPOFUNGIN1 (Cancidas ) 50 mg 10.5 mL SWFI 5 mg/mL AZTREONAM1,3 (Azactam ) 7 days F 24 hr F 30 days RT 500 mg/250 mL D5W MB D5W
principles of reconstitution you must follow the manufacturers direction for reconstitution. they will provide: 1. the expiration date 2. type of diluent/solvent to use (sterile water, sterile normal saline, 5% dextrose & bacteriostatic water –some powdered meds for oral use may even be reconstituted with tap water): never assume the type or amount of diluent to be used
3 The guidelines cover areas pertaining to the aspects of compounded sterile preparations, including personnel, facilities, transport and processes involved to produce a sterile medicinal product.
The Reconstitution [Plan/Annex] is a companion document to the [organization name] COOP Plan and focuses on the implementation of Phase IV: Reconstitution. This [Plan/Annex] provides guidance and direction for surviving and/or replacement [organization name] personnel to resume normal organization operations from the original or a replacem
2.6. PROCESS OF RECONSTITUTION AT LETTER OF INTENT (LOI) STAGE: 2.6.1.Application: The application for reconstitution, in the prescribed format along with relevant affidavits/ Undertakings will be submitted to the concerned Area/Territory/Regional Offic
6 2. Disinfection / sterilization and storage of instruments and equipment a) Use pre-packaged, disposable sterile acupuncture needles whenever possible. b) Check the expiry dates of sterile items before use and make sure the packages are intact. c) Package should be opened just before use to prevent contamination. d) Unopened sterile items, e.g. alcohol pads, sterile needles, sterile cotton
1.6 Perform pharmacy non-sterile compounding tasks meticulously, precisely and competently. 1.7 available for the non. Know the operation and correct use of equipment, materials and automated instruments -sterile preparations to be compounded.
DECON-SPORE 200 Plus is available as a 2.3% sporicidal dilution ratio (3 oz/gallon) in a 16 oz trigger spray and 1 gallon container. Both 16 oz and 1 gallon containers are sterile and come in our one-step, ready-to-use, SimpleMix System. Each sterile container of DECON-SPORE 200 Plus is individually double bagged sterile in easy tear packaging.
analyses of published criminal justice statistics, including data about crime, the courts and prison systems in a number of countries. Secondly, there are reviews of a small selection of recent academic literature on criminal justice subjects, which we looked at in order to provide Committee Members with some insights into the directions being taken in current research. 3 In neither case was .
