Molecular, Cellular, Developmental Biology
Molecular, Cellular, Developmental Biology2020-2021
This booklet is intended to supplement the Yale College Programs of Study for the Academic Year 2020- 2021.The latter contains brief descriptions of all Undergraduate MCDB y/#coursestextThe MCDB major is offered by the department of Molecular, Cellular, Developmental Biology. Forfurther information contact:Crystal AdamchekUndergraduate Registrar, YSB 235MCDB DepartmentYale Science Building, 260 Whitney Ave(203) 432-3839, Fax: (203) 432-6161Email: crystal.adamchek@yale.eduProfessor Douglas Kankel, YSB 111Director of Undergraduate StudiesMolecular Cellular and Developmental BiologyTable of ContentsIntroduction .3What can being a MCDB Major do for me? .3Courses for Students Majoring in Other Subjects.4MCDB Roadmap .5Requirements by Major .6Acceleration Credits .6Placement Exam .6Interdisciplinary Tracks .7The Senior Requirement .7The BA degree . 8The BS degree. 8The BS INT degree. 8The BS/MS degree . 8Research Opportunities .8Research Courses . 9Summer Research .10Where to Get Advice .11The First Year. 11Upperclassmen. 11Peer Mentors . 12Advisors .13MCDB Faculty .13Recommendations for Premedical Students .19Studies Abroad .19The Combined BS/MS Degree Program .19Facilities .20Courses in MCDB .222018-2019 Undergraduate Research Projects .25Undergraduate Prizes and Awards.29Addendums: Worksheets for MCDB MajorsResearch Guidelines2
The Major in Molecular, Cellular, Developmental Biology(MCDB) At Yale UniversityIntroductionThe science of biology is extremely broad, ranging across the domains of molecules, cells, tissuesand organs, organisms, and ecosystems. Moreover, biology explores questions of evolutionaryhistory and the processes of evolutionary change as well as the mechanisms by which cells,organisms, and ecosystems function. Students majoring in Molecular, Cellular, and DevelopmentalBiology receive a thorough yet varied liberal education and preparation for professional careers in adiverse array of fields. Practical applications of topics studied in the major include the developmentof biologicals and pharmaceuticals, the practice of medicine, and a pursuit of the scientific bases forunderstanding the development and function of biological systems.Molecular, Cellular, and Developmental Biology (MCDB) offers programs for students wishing toconcentrate on molecular biology, cell biology, genetics, and their applications to problems in celland developmental biology, neurobiology, and various aspects of computational and quantitativebiology. Interdisciplinary opportunities are available within the major in the biotechnology,neurobiology and quantitative biology tracks.The MCDB major offers many opportunities for independent laboratory research. With approval fromthe DUS, research can be conducted under the supervision of faculty membersThe teaching and research facilities in biology are primarily distributed in the new Yale ScienceBuilding, Yale West Campus and the SCL teaching laboratory facilities. There are about 30 facultymembers, 60 postdoctoral fellows, 70 graduate students and approximately 300 undergraduatestudents that work and study in these buildings. The quality and breadth of expertise in thisbiological community has made Yale a premier center for both students and scientists.What can being a MCDB Major do for me?The major in MCDB contributes to a liberal education as well as providing excellent preparation fora wide range of professional careers in medicine, public health, the pharmaceutical andbiotechnology industries, science writing, teaching, as well as biological research. MCDBundergraduates at Yale have a high rate of acceptance at medical and graduate schools. Today,with the use of genetic testing in court cases, the patenting of biological products, procedures forassessing environmental impact, and the general importance of biological issues in the publicarena, this major can also be helpful in law, business, consulting and government careers.Official Yale College program and course information is found in Yale College Programs of Study,available on line at http://catalog.yale.edu/ycps/.3
Courses for Students Majoring in Other SubjectsFor students who do not intend to major in MCDB, there are a variety of courses that have noprerequisites. (*Note: All courses list the Primary instructor first)MCDB 040bMCDB 050aScience and Politics of CancerImmunology and MicrobesRobert BazellPaula KavathasTTh 1.00-2.15TTh 1.00-2.15MCDB 065aMCDB 103aMCDB 105aorMCDB 105bScience & Politics of HIV/AIDSCancerAn Issues Approach to BiologyRobert BazellAlexia BelperronFall: John CarlsonJennifer MarlonRonit KaufmanTTh 2.30-3.45MW 1:00-2:15PMMW 11.35-12.25MCDB 106bMCDB 109bMCDB 175LaBiology of Malaria, Lyme & OtherVector-Borne DiseasesImmunity and ContagionExploring the Microbial WorldSpring:Don Engelman,Shirin BahmanyarYannick JacobCandice PaulsenRonit KaufmanAlexia BelperronMW 1.00-2.15Paula KavathasIain DawsonTTh 2.30-3.45Th 2.30-5.30The programs in the MCDB major are designed to enhance a liberal education as well as offerexcellent preparation for professional and graduate study in the biological sciences, and inmedicine and other health-related fields. The following diagram provides an overview of themajor; details are provided on the following pages. In addition to the standard major, MCDB offersthree interdisciplinary programs of study in the biotechnology, neurobiology and quantitative biologytracks. As described below, the senior requirement differs for the BA, the BS, the BS Intensivemajor, and the combined BS/MS degrees.4
MCDB RoadmapClass of 2021 and beyondMolecular, Cellular, andDevelopmental BiologyDegrees OfferedBABSBS IntensiveBS/MSBIOL 101, 102, 103, and 1041 course in MATH 115 or higher or S&DS course at YalePrerequisitesfor enteringthe major2 term lecture sequence in CHEM 2 Labs3 terms in CHEMor PHYS2 terms PHYS1 term Organic CHEM 1 Lab5.5 CourseCreditsbeyond prereqsRequirementsfor each degree9 Course Creditsbeyond prereqs11 CourseCreditsbeyond prereqs11 CourseCreditsbeyond prereqs 6 Grad Credits(consult DUS)2 courses fromMCDB 200, 202,205, 210, 290,300 (orMB&B 300)3 courses fromMCDB 200, 202, 205, 210, 290, 300(or MB&B 300)1 Bioscience Lab2 MCDB Labs2 General Electivesfrom core courses or upper level MCDB courses (MCDB 250 and above)1 Special Electivefrom MCDB 350 or higherSeniorRequirementsSenior Essayor1 termMCDB 475MCDB 485/486or2 termsMCDB 475MCDB 495/496MCDB 585(jr. spring)MCDB 595/596(sr. year)Biotechnology: MCDB 370; 1 elective from MCDB 350 or higher;1 elective from MB&B 420, 443, BENG 351, 352, 410, 435,CENG 210, 411, CPSC 437, 445, 470, or 475.Special TrackRequirementsNeurobiology: MCDB 320; 1 elective from MCDB 350 or higher;1 elective from BENG 410, CPSC 475, 310, 315 415, 430, MCDB 361,PSYC 270, S&DS 101.Quantitative Biology: MCDB 330; 1 elective from MCDB 350 or higher;1 elective from MCDB 320, 361, 461, MB&B 302, 435, 452, 523,PHYS 402, MATH 246, or CPSC 475; 2 labs numbered MCDB 201L or above.5
Requirements by MajorBelow are the requirements formally approved by the Yale College Faculty for the Classes of 2023 and beyond. Students inthe Class of 2022 and previous classes may fulfill the requirements of the major that were in place when they entered themajor in MCDB as described in previous editions of the bulletin. Alternatively, they may fulfill the requirements for the majoras described below for the Class of 2023 and subsequent classes. Major: Molecular, Cellular, Developmental Biology Major: Molecular, Cellular, Developmental Biology - Intensive MCDBMCDBMCDBMCDB- Standard Track- Neurobiology Track- Biotechnology Track- Quantitative Biology TrackMCDB, IntensiveMCDB, IntensiveMCDB, IntensiveMCDB, Intensive- Standard Track- Neurobiology Track- Biotechnology Track- Quantitative Biology TrackStudents interested in the biotechnology, neurobiology, or quantitative biology tracks should consult an advisor for the track.Biotechnology Track Advisors:Ronald Breaker, 311 YSB (432-9389)Craig Crews, 250 YSB (432-9364)Farren Isaacs, ISTC 850WC 333 (737-3156)Kenneth Nelson, 137 YSB (432-5013)Joseph Wolenski, C112 YSB (432-6912)Neurobiology Track AdvisorsPaul Forscher, 120 YSB (432-6344)Haig Keshishian, 228 YSB (432-3478)Robert Wyman, 139 YSB (432-3475)Weimin Zhong, 225 YSB (432-9233)Quantitative Biology Track Advisors:Murat Acar, ISTC 850WC 122(737-3255)Damon Clark, C148 YSB (432-0750)Thierry Emonet, C169 YSB (432-3516)Douglas Kankel, 111 YSB (432-3532)Acceleration CreditsAcceleration credit awarded in chemistry, mathematics, and physics, or completion of advancedcourses in those departments, is accepted instead of the relevant prerequisites for the MCDB major.Students who already have mathematics preparation equivalent to MATH 115a or b or higher areencouraged to take additional mathematics, such as MATH 120a or b, 222a or b, or 225a or b, ENAS151a or b, 194a or b, or statistics (e.g. S&DS 105a or 100b or higher preferred).Premedical students will likely need to take the laboratory with introductory physics, although it isnot required for the major in MCDB. Premedical students should consider the advisability oftaking the introductory MCDB laboratory MCDB S121La or 221La. Note that the premedicalrequirements and the prerequisites for both MCDB and MB&B majors are substantially the same,so students do not have to choose among these paths during their freshman year.Official Yale College program and course information is found in Yale College Programs of Study,available on line at e/.Placement ExamStudents with a 5 on the AP Biology exam, a score of 7 on the IB Biology higher-level exam, a scoreof A on the GCE Biology A-level exam, or the equivalent on other national standardized exams areeligible to take a placement examination administered at Yale. Based on the results of theexamination, a student may place out of one or more courses in the BIOL 101–104 sequence. Oneor more of these foundational Biology courses (or their equivalent placement) may be explicitlyrequired as prerequisites for upper-level MCDB courses. More information on the Placement Examcan be found at this website: reregistration/biology/.6
Interdisciplinary TracksAs alternatives to the standard MCDB track, students can choose either the biotechnology, neurobiology or thequantitative biology tracks. The requirements for each of these interdisciplinary tracks differ somewhat from those ofthe standard major.PrerequisitesBA: 6.0 CreditsBS: 9.5 CreditsCore CoursesBA: 3.0 CreditsBS: 4.0 CreditsGeneral ElectivesBiotechnologyNeurobiologyQuantitative BiologySame as BA or BSSame as BA or BSSame as BA or BSSame as BA or BSSame as BA or BSSame as BA or BSPLUS*: MCDB 370PLUS*: MCDB 320PLUS*: MCDB 330Same as BA or BSSame as BA or BSSame as BA or BSADDITIONAL CHOICES:BENG 351BENG 352BENG 410BENG 435CENG 210CENG 411CPSC 437CPSC 445CPSC 470CPSC 475MB&B 420MB&B 443ADDITIONAL CHOICES:BENG 410CPSC 475MCDB 240MCDB 310MCDB 315MCDB 361MCDB 415MCDB 425MCDB 430MCDB 440PSYC 200PSYC 270PSYC 320PSYC 376ADDITIONAL CHOICES:CENG 320CPSC 475CPSC 440BENG 467/ENAS 567MATH 246MATH 251MB&B 452MB&B 320MB&B 435MB&B 523MCDB 361MCDB 461PHYS 402*While these are required forthe track, they will be countedas an elective for the major*While these are required for thetrack, they will be counted as anelective for the major(Note: PSYC 110 is a prerequisite formany PSYCH courses, but does NOTsubstitute as an elective for anytrack)1.0 CreditsSpecial Electives*While these are required for thetrack, they will be counted as anelective for the majorSame as BA or BSSame as BA or BSSame as BA or BSSame as BA or BSAt least 1 Lab must befrom MCDB 341L-345L.Same as BA or BSSame as BA or BS(2 laboratory courses requiredfor the BS)(BENG 355L or CENG 412L cansubstitute for 2 ½ credit labswith permission)Senior RequirementsBA: 0-1.0 CreditsBS: 2.0 CreditsBS INT: 4.0 CreditsSame as BA or BSSame as BA or BSSame as BA or BS1.0 CreditsLaboratoriesBA: 0.5 CreditsBS: 1.0 Credits (or more)The Senior RequirementIn addition to the course work described on previous pages, all majors in Yale College mustsatisfy a senior requirement. In MCDB, this can be accomplished in any of several ways,depending on whether the student is a candidate for a BA, BS, BS INT, or BS/MS degree. Thesenior requirement must be done during the senior year. (See 2020-21 Senior Requirement7
Alternatives)The BA degreeThe requirement can be met in either of two ways: by submitting a senior essay of 15-20 pagesevaluating current research in a field of biology; or by successful completion of one credit ofSenior Independent Research (MCDB 475a or b).A senior choosing to fulfill the requirement with a senior essay must consult with a faculty advisoron the scope and literature for the topic and that advisor must submit their written approval tothe office of the director of undergraduate studies at least one month before the paper is due inthe student’s last term at Yale. The senior essay may be related to the subject matter of a course,but the essay is a separate departmental requirement in addition to any work required for thatcourse. It does not count toward the grade in any course. The senior essay must be completedand submitted via email to mcdb.undergraduateregistrar@yale.edu at the office of the director ofundergraduate studies by the last day of classes. Students electing this option should obtain anapproval form from the office of the director of undergraduate studies.The BS degreeThe BS differs from the BA in its greater emphasis on individual research. The senior requirementfor the standard BS is two contiguous terms of Senior Research: MCDB 485a/486b. Althoughnot preferred, students may take 2 contiguous terms of MCDB 475, at least one of which mustbe taken during the senior year. Ordinarily both terms of Research will be taken during thesenior year, but it is possible for a student to begin work toward the senior requirement in thespring of the junior year by taking MCDB 475b, continue the research over the summer, andcomplete such research during the fall of the senior year by taking MCDB 475a –this latter pathmust be pre-approved by the DUS. Yale College does not grant academic credit for summerresearch unless the student is enrolled in an independent research course in Yale SummerSession.The BS INT degreeFor the MCDB BS Intensive major, students fulfill the senior requirement by taking MCDB495a/496b, Senior Research Intensive, for four credits during their senior year.The BS/MS degreeSee the section entitled The Combined BS/MS Degree Program.Research OpportunitiesThere are many opportunities for students to carry out research in the laboratory of a facultymember. A broad spectrum of state-of-the-art research activities is performed at Yale in theMCDB department and in related departments, including those in the Yale Medical School. Thisresearch is carried out in the fields of molecular biology, biochemistry, genetics, cell biology,neurobiology, physiology, computational biology, plant sciences, and evolution, among manyothers. All interested students are encouraged to participate in independent research. Studentsmay work in laboratories for academic credit and/or experience. Financial support may beavailable in some cases, but students being paid will not receive course credit.The choice of a research laboratory should be made in consultation with faculty advisors and thedirector of undergraduate studies. Opportunities can be found on the following web sites:https://mcdb.yale.edu/research, https://database.yuraresearch.org/, and8
https://medicine.yale
concentrate on molecular biology, cell biology, genetics, and their applications to problems in cell and developmental biology, neurobiology, and various aspects of computational and quantitative biology. Interdisciplinary opportunities are available within the major in the biotechnology, neurobiology and quantitative biology tracks.
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