Central Corneal Thickness In The Ocular Hypertension .

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The multivariate model included race, gender, age attesting, baseline refraction, baseline IOP, baselinemedical history and the interaction of race with gender,systemic hypertension and diabetesSignificant relationships–––– Race (p 0.001)Age (p 0.0001)Gender (p 0.014)Diabetes (p 0.0016)Baseline refraction, Baseline IOP, systemic hypertensionand the racial interactions were not statisticallysignificant in the multivariate model

What is “Normal” Corneal Thickness? A recent meta-analysis* of the corneal thicknessliterature found that mean corneal thickness of„normal‟ eyes is 534 µM– 530 µM for optical pachometry– 544 µM for ultrasonic pachymetry Our study demonstrates that subjects in the OHTShave increased corneal thickness (572.4 39 µM)* Doughty & Zaman (2000)Survey of Ophthalmology 44:367-408

Race and Corneal ThicknessMost previous studies of corneal thickness havebeen performed in racially homogeneouspopulations Foster (1998) found thinner corneas (495 µM) in aMongolian population Our study demonstrates that African-AmericanOHTS subjects have thinner corneas than their„others‟ counterparts

Correcting IOP for Corneal Thickness Ehlers (1975) cannulated 29 eyes undergoing cataractsurgery– 5 mmHg/70 µM Doughty & Zaman (2000) meta-analysis– 2.5 mmHg/50 µM Whitacre (1993) and the Rotterdam Eye Study (1997)– 2.0 mmHg/100 µM

Baseline IOP20 Unadjusted15% of 10Subjects50510152025mmHg303540

“Corrected” IOP20 Unadjusted Whitacre15% of 10Subjects50510152025mmHg303540

“Corrected” IOP20 Unadjusted Whitacre15 Doughty% of 10Subjects50510152025mmHg303540

“Corrected” IOP20 Unadjusted Whitacre15 Doughty Ehlers% of 10Subjects50510152025mmHg303540

Clinical Significance45 % of „others‟ had a „corrected‟ IOP 21 mmHg 27.5% of African-American subjects had a „corrected‟IOP 21 mmHg If we choose an arbitrary cutoff of 600 µM, abovewhich corneal thickness affects applanation IOPmeasurement to a clinically significant degree, then: – 28 % of „Others‟ had corneal thickness 600 µM– 12% of African Americans had corneal thickness 600 µM

ConclusionsOHTS subjects have thicker corneas than„normal‟ subjects African-American OHTS subjects have thinnercorneas than their „others‟ counterparts Corneal thickness must be considered in thedevelopment of any risk model for ocularhypertensive patients

OHTS Clinical Centers Bascom Palmer Eye InstituteBaylor Eye ClinicCharles R. Drew UniversityDevers Eye InstituteEmory University Eye CenterEye Associates of Washington, DCEye Consultants of AtlantaEye Doctors of WashingtonEye Physicians and Surgeons of AtlantaGlaucoma Care CenterGreat Lakes OphthalmologyHenry Ford HospitalsJohns Hopkins UniversityJules Stein Eye Institute, UCLAKellogg Eye CenterKresge Eye Institute Krieger Eye InstituteMaryland Center for Eye CareMayo Clinic/FoundationNew York Eye & Ear InfirmaryOhio State UniversitySalus UniversityScheie Eye InstituteUniversity of California, DavisUniversity of California, San DiegoUniversity of California, San FranciscoUniversity of LouisvilleUniversity Suburban Health CenterWashington Eye Physicians & SurgeonsWashington University, St. Louis

OHTS Resource CentersStudy Chairman’s Office&Coordinating CenterWashington UniversitySt. Louis, MOOptic Disc Reading CenterVisual Field Reading CenterBascom Palmer Eye InstituteUniversity of MiamiMiami, FLUniversity of California, DavisSacramento, CA

Eye Consultants of Atlanta Eye Doctors of Washington Eye Physicians and Surgeons of Atlanta Glaucoma Care Center Great Lakes Ophthalmology Henry Ford Hospitals Johns Hopkins University Jules Stein Eye Institute, UCLA Kellogg Eye Center Kresge Eye Institute Krieger Eye Institute Maryland Center for Eye Care

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