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Cogni ve PanelHealth Action PlanMay 9, 2019Demo ClientKit #1234ABCD5678
Table of ContentsUnderstand Your Genetics3How These Traits Affect rcise12Further Testing13TraitsDepression17Inflammation19Oxidative Stress20Alzheimer's Disease21Anxiety23Dementia25Mild Cognitive Impairment26Parkinson's Disease27Client SummaryDemo Client May 9, 2019312
Understand Your GeneticsThis report is broken down into three main sections: TraitImpact, Recommendations and Trait Detail. Depending onthe number of traits being reviewed, your report willcontain multiple trait and recommendation detailsections. Terms and sections of the report are definedbelow.DNADNA is a long, ladder-shaped molecule. The rungs of the ladder are madeof two amino acids pairing together, these are called bases. They alwayspair the same way, A (Adenine) with T (Thymine), and C (Cytosine) with G(Guanine). The body is constantly replicating DNA strands.GENESNPVARIANTGenes are the basic units of heredity (passeddown from generation to generation). Theyare made of DNA and provide theinstructions for how our body works, whatwe look like, etc. Humans have between20,000 - 25,000 genes. We inherit half ofthem from our mother and half from ourfather.A SNP is a Single Nucleotide Polymorphism. SNPsoccur when the amino acids making up the basepair do not come together in the same way as theoriginal DNA strand. For example, the originalstrand may have had an A but the replicatedstrand has a G. SNPs are common and many ofthem have no impact to the individual, however,some can change how our body works.Variants are how SNPs are referred to in thisreport. When the amino acid in the copiedstrand is different from the original, it iscalled a variant - it varies from the original.Variants are not necessarily 'good' or 'bad'they are simply different from the original.The depiction of variants is shown as: / (both copies have different amino acids), /(one copy has a different amino acid), -/(both copies have the same amino acid as theoriginal) or U (one copy is indeterminate).Reading This Report1Trait ImpactThis report focuses on traits. These aretypically groups of SNPs that have asimilar impact on the body’s function.We use a proprietary algorithm todetermine the impact a group of SNPsmay have on a specific function in thebody based on your individual testresults.2TraitsThe traits in our reports aretypically grouped by body function,a symptom type, a disease, anutrient need, or a response toenvironment. Within the traitpages, you will see the SNPs thatare looked at for that trait, yourvariant type and recommendationsto optimize health and minimize riskbased on your individual results.3RecommendationsYour genes, and therefore yourSNPs, will not change during yourlife. However, this report focuseson SNPs whose impact can beinfluenced by external factors likediet, exercise, supplements, andlifestyle changes.Disclaimer - The recommendations in this report have been carefully prepared and reviewed for you by your health and wellness provider, based on his or herreasoned medical judgment about your personal health needs. Be sure that you have shared with your health and wellness provider all relevant information aboutyour health, including any medications or dietary supplements you may be taking, and any medical conditions you may be experiencing, before you adopt any of theserecommendations. This test is performed via DNA sequencing. As with all genetic testing with the highest possible standards, the data generated during thelaboratory process will have a 99% sensitivity and specificity.Demo Client May 9, 20193
Cognitive PanelHow These Traits Affect YouThis page provides a high-level snapshot of the clinical significance of each trait within this panel. The results are intwo categories: traits that are ranked high, medium or low impact as well as traits for which there is an explicit result(i.e. categorical such as "yes" or "no"). At the end of this page are a summary of any non-reportable (NR) traits. Theresults for these traits are unable to be determined from the sample submitted. Recommendations are made for traitswith high or medium impact only.HighMediumLowImpact Traits1234Impact Traits5678910ImpactLearn More1DepressionHIGHPage 172InflammationHIGHPage 193Oxidative StressHIGHPage 204Alzheimer's DiseaseMEDIUMPage 215AnxietyMEDIUMPage 236DementiaMEDIUMPage 257Mild Cognitive ImpairmentMEDIUMPage 268Parkinson's DiseaseMEDIUMPage 279Concussion with TBILOW10Omega 3Demo Client May 9, 2019LOW4
Cognitive PanelRecommendationsSupplementsBelow is a list of recommended supplements curated specifically for you based on the Supplement sections foundwithin your report. Supplement recommendations are listed in order of importance based on your individual geneticresults. The traits generating each recommendation are listed just below them. These recommendations have beenreviewed by your healthcare provider. Please contact your provider if you have any questions.Supplement Recommendation & Linked Traits1 Vitamin CAlzheimer's Disease, Anxiety,Depression, Oxidative Stress,Parkinson's Disease2 Vitamin D3Alzheimer's Disease, Depression,Inflammation, Parkinson's Disease3 FolateDepression, Inflammation, MildCognitive Impairment4 MagnesiumAnxiety, Depression, Mild CognitiveImpairment5 Omega-3Alzheimer's Disease, Anxiety,Depression6 ProbioticsAnxiety, Depression7 ResveratrolAlzheimer's Disease, Mild CognitiveImpairmentDemo Client May 9, 2019DetailsCommentsSupplement with 500 - 1,000 mg of vitaminC per day.Supplement with 3,000 IUs of vitamin D3 perday.Supplement with 400 - 800 mcg of methylfolate per day.Supplement with 300 - 500 mg ofmagnesium per day.Supplement with 2 - 5 g of omega-3 fattyacid supplement that contains essential fattyacids DHA and EPA.Supplement with a 10 - 50 billion CFUprobiotic per day.Supplement with 150 - 2,000 mg ofresveratrol per day.5
Cognitive Panel8 Vitamin EOxidative Stress, Parkinson'sDisease9 ZincRecommendationsSupplement with 100 - 400 IUs of vitamin Eper day.Supplement with 10 - 40 mg of zinc per day.Depression, Oxidative Stress10 AntioxidantsDementia11 AshwagandhaAnxiety12 Betaine Hydrochloride(HCl)Consider taking 1,000 - 5,000 mg of anantioxiant supplement daily.Supplement with 250 - 300 mg ofashwagandha per day.Supplement with 1 - 2 g of betainehydrochloride (HCl) with meals for at least 6months.Inflammation13 CholineDementia14 Combined NutraceuticalDementia15 CurcuminInflammation16 Docosahexaenoic Acid(DHA)Supplement with 250 - 500 mg of cholineper day.Consider supplementing a nutraceuticalcontaining: 320 mg Bacopa monner extract,100 mg L-theanine, 30 mg saffron extract,9.5 mg vitmain B6, 450 mcg biotin, 400 mcgfolic acid, 33 mcg vitmain B12, and 25 mcgvitamin D3 each day for at least 8 weeks.Supplement with 250 - 2,000 mg of curcuminextract per day.Supplement with 2 g of DocosahexaenoicAcid (DHA) per day.Mild Cognitive Impairment17 L-CarnitineDementiaDemo Client May 9, 2019Supplement with 500 mg - 4 g of L-carnitineper day.6
Cognitive Panel18 L-Lysine and L-ArginineAnxiety19 L-TheanineAnxiety20 Lavender OilAnxiety21 MultivitaminInflammation22 Niacinamide (Vitamin B3)Parkinson's Disease23 PhosphatidylserineAnxiety24 Riboflavin (Vitamin B2)Parkinson's Disease25 SAMe (S-Adenosyl-LMethionine)RecommendationsSupplement with a combination of 2.64 g perday of L-lysine and 2.64 g of L-arginine perday.Supplement with 200 mg of L-theanine perday.Supplement with 80 mg of an oral lavendarsupplement per day.Supplement with a multivitamin that includesactivated B vitamins.Supplement with 1 - 3 g of niacinamide(vitamin B3) per day.Supplement with 400 mg ofphosphatidylserine per day.Supplement with 100 - 400 mg of riboflavin(vitamin B2) per day.Supplement with 800 mg of SAMe per day.Depression26 Vitamin B12Mild Cognitive ImpairmentSupplement with 500 mcg of vitamin B12 perday.Note - If you are taking any medications, consult with your practitioner before starting any new supplements as they may have adverseeffects with your medications.Demo Client May 9, 20197
Cognitive PanelRecommendationsDietBelow is a list of dietary recommendations curated specifically for you based on the Diet sections found within yourreport. Diet recommendations are listed in order of importance based on your individual genetic results. The traitsgenerating each recommendation are listed just below them. These recommendations have been reviewed by yourhealthcare provider. Please contact your provider if you have any questions.Diet Recommendation & Linked Traits1 Anti-Inflammatory DietDepression, Inflammation2 Consume Fatty FishAlzheimer's Disease, Mild CognitiveImpairment3 Folate Rich FoodsDetailsCommentsConsume a diet rich in anti-inflammatoryfoods.Consume 5 to 6 oz of cold-water fatty fish 2to 3 times per week.Consume a diet rich in folate.Depression, Mild CognitiveImpairment4 Fruits and VegetablesInflammation, Oxidative Stress5 Magnesium Rich foodsInclude fruits and vegetables at every meal toincrease levels of antioxidants in the body,especially strawberries, blueberries, broccoli,sprouts, and green leafy vegetables.Consume a diet rich in magnesium.Anxiety, Depression6 Mediterranean DietInflammation, Mild CognitiveImpairment7 Beta-CaroteneAlzheimer's Disease8 Calorie RestrictionOxidative StressDemo Client May 9, 2019Adopt a Mediterranean-style diet thatincludes a variety of antioxidant-rich foods,heart healthy fats, and complexcarbohydrates.Aim to get the recommended 6 to 15 mg ofbeta-carotene from the diet per day.Reduce overall calorie intake to create acalorie deficit.8
Cognitive Panel9 Caution with Iron RichFoodsRecommendationsAvoid excessive dietary iron intake.Parkinson's Disease10 Consume BeneficialProbioticsConsume 6 to 8 oz of probiotic-rich foodsdaily.Alzheimer's Disease11 Diet QualityDementia12 Dietary FiberInflammation13 FlavonoidsParkinson's Disease14 Gluten Free DietDepression15 Low Glycemic Index FoodsAlzheimer's Disease16 Nut ConsumptionInflammation17 Potassium Rich FoodsConsume a diet that is low in saturated fats,high in antioxidants, and high in B vitamins.Increase dietary fiber intake to recommended25 g for females and 30 g for males.Aim to eat 6 servings, approximately 1,000mg, per day of flavinoid foods.Avoid gluten-containing foods such as bakedgoods, cereals, or other foods processed in afacility that also processes gluten.Choose low-glycemic index foods to avoidblood sugar spikes.Consume a variety of nuts including almonds,walnuts, macadamia nuts, and brazil nuts.Consume a diet rich in potassium.Dementia18 Reduce Your Dietary FatIntakeReduce the amount of fat in the diet to nomore than 20% of total daily caloric intake(no more than 22 g of saturated fat).Parkinson's DiseaseDemo Client May 9, 20199
Cognitive Panel19 Selenium Rich FoodsRecommendationsConsume a diet rich in selenium.Mild Cognitive Impairment20 Vitamin C Rich FoodsConsume a diet rich in vitamin C.Alzheimer's Disease21 Vitamin E Rich FoodsAlzheimer's Disease22 Zinc Rich FoodsAim to get at least 15 mg of tocopherols(vitamin E) from a combintation of diet andsupplementation per day.Consume a diet rich in zinc.DepressionDemo Client May 9, 201910
Cognitive PanelRecommendationsLifestyleBelow is a list of lifestyle recommendations curated specifically for you based on the Lifestyle sections found withinyour report. Lifestyle recommendations are listed in order of importance based on your individual genetic results.The traits generating each recommendation are listed just below them. These recommendations have beenreviewed by your healthcare provider. Please contact your provider if you have any questions.Lifestyle Recommendation & Linked Traits1 Brain ExerciseAlzheimer's Disease, Mild CognitiveImpairment, Parkinson's Disease2 MeditationAnxiety, Depression3 Intermittent FastingInflammation4 Lemon Balm Essential OilsAlzheimer's Disease5 Reduce StressOxidative Stress6 Sleep ConsistencyInflammationDemo Client May 9, 2019DetailsCommentsEngage in daily brain stimulating activities,such as puzzles, crosswords, or reading, for atleast 30 minutes.Engage in 10 to 20 minutes of mindfulnessmeditation 2 or more times per week.Try intermittent fasting (fasting for 14 hoursdaily) or alternate day fasting (fasting for 24hours every other day).Apply a lemon balm essential oil twice dailyfor at least 4 weeks.Engage in enjoyable hobbies such asgardening, sports, or other leisure activitiesto help reduce stress.Stick to a consistent sleep routinue thatconsists of going to sleep and waking up atapproximately the same time each day.11
Cognitive PanelRecommendationsExerciseBelow is a list of exercise recommendations curated specifically for you based on the Exercise sections found withinyour report. Exercise recommendations are listed in order of importance based on your individual genetic results.The traits generating each recommendation are listed just below them. These recommendations have beenreviewed by your healthcare provider. Please contact your provider if you have any questions.Exercise Recommendation & Linked Traits1 Aerobic ActivityAlzheimer's Disease, Anxiety,Dementia, Depression, MildCognitive Impairment, OxidativeStress, Parkinson's Disease2 YogaDepression, Oxidative Stress3 DancingDepression4 QigongAnxietyDemo Client May 9, 2019DetailsCommentsAim for 20 to 30 minutes of aerobic physicalactivity most days of the week.Incorporate at least 1 to 2 yoga sessions intoyour weekly excercise routine.Incorporate 45 to 60 minutes of danceseveral times per week into your normalexercise routine.Practice Qigong 30 minutes per day, 3 to 4times per week.12
Cognitive PanelRecommendationsFurther TestingBelow is a list of further testing recommendations curated specifically for you based on the Further Testing sectionsfound within your report. Further Testing recommendations are listed in order of importance based on yourindividual genetic results. The traits generating each recommendation are listed just below them. Theserecommendations have been reviewed by your healthcare provider. Please contact your provider if you have anyquestions.Further Testing Recommendation& Linked Traits1 Homocysteine LevelsDetailsCommentsCheck blood homocysteine levelsAlzheimer's Disease, Anxiety,Dementia, Depression,Inflammation, Mild CognitiveImpairment, Parkinson's Disease2 AntioxidantsTest for circulating antioxidant levelsDementia, Mild CognitiveImpairment, Parkinson's Disease3 Vitamin D3 (25-OH)Test blood levels of vitamin D3 (25-OH)Depression, Mild CognitiveImpairment, Parkinson's Disease4 C-Reactive Protein (CRP) orhsCRPTest levels of C-Reactive Protein (CRP) orhsCRPInflammation5 CarotinoidsDepression6 Erythrocyte SedimentationRate (ESR)Test alpha-carotene, beta-carotene, betacryptoxanthin, lycopene, lutein, zeaxanthinand serum Vitamin ATest erythrocyte sedimentation rate (ESR) inbloodInflammation7 FibrinogenTest fibrinogen levels in the bodyInflammationDemo Client May 9, 201913
Cognitive Panel8 Folate TestingRecommendationsTest folate levelsInflammation9 GlutathioneTest Glutathione serum levelsAlzheimer's Disease10 IL-6 TestingTest for levels of IL-6Inflammation11 MagnesiumTest magnesium levelsDepression12 ManganeseTest blood manganese levelsAlzheimer's Disease13 Markers of Oxidative StressTest markers of oxidative stressOxidative Stress14 Methylmalonic LevelsTest for methylmalonic levelsDepression15 Non-Ceruloplasmin-BoundCopperTest non-ceruloplasmin-bound copper levelsMild Cognitive Impairment16 Serum B12 LevelsMeasure serum B12 levelsDepression17 Serum IronTest serum iron levelsParkinson's Disease18 TNF-alphaTest for TNF-alphaInflammationDemo Client May 9, 201914
Cognitive Panel19 Vitamin C TestRecommendationsTest blood vitamin C levelsParkinson's Disease20 ZincTest serum zinc levelsDepressionDemo Client May 9, 201915
Trait DetailsAppendix 1Cogni ve PanelMay 9, 2019Demo ClientKit #1234ABCD5678
Cognitive PanelHigh ImpactDepressionPeople with similar genetic markers may be predisposed or at a higher risk for depression.GeneSNPVariantImpactHTR1Ars6295 / HighHTR1Ars878567 / HighFKBP5rs3800373 / HighFKBP5rs1360780 / HighFKBP5rs9296158 / HighCRHR1rs110402 / HighGNB3rs5443 / HighCHRH2rs3779250 / HighMTHFRrs1801133 /-MediumKSR2rs7973260 /-MediumLHPPrs35936514-/-LowSLC6A15rs1545843 s2522833 /-LowRecommendationsThese recommendations are based on the genetic findings in the chart above.SUPPLEMENTDIETLIFESTYLEDemo Client May 9, 2019 Omega-3 Zinc Vitamin C Vitamin D3 Folate Magnesium Probiotics SAMe (S-Adenosyl-LMethionine) Magnesium Rich foods Zinc Rich Foods Anti-Inflammatory Diet Folate Rich Foods Gluten Free Diet Meditation17
Cognitive PanelEXERCISEFURTHER TESTINGDemo Client May 9, 2019High Impact Dancing Aerobic Activity Yoga Carotinoids Serum B12 Levels Homocysteine Levels Zinc Vitamin D3 (25-OH) Methylmalonic Levels Magnesium18
Cognitive PanelHigh ImpactInflammationPeople with similar genetic markers may be more likely to experience increased levels of inflammation, which is thebody’s natural response to an injury, wound, or infection.GeneSNPVariantImpactTNF-αrs1800629 / HighIL6rs1800795 / HighTNF-αrs1799724 /-MediumPTPN22rs2476601 /-MediumIL-10rs1800872 /-LowTNF-αrs1799964-/-LowIL23Rrs2201841 /-LowIL-10rs3024505-/-LowRecommendationsThese recommendations are based on the genetic findings in the chart above. Multivitamin Betaine Hydrochloride (HCl) Vitamin D3 Folate Curcumin Anti-Inflammatory Diet Dietary Fiber Mediterranean Diet Nut Consumption Fruits and VegetablesLIFESTYLE Sleep Consistency Intermittent FastingFURTHER TESTING Homocysteine Levels IL-6 Testing C-Reactive Protein (CRP) orhsCRP Erythrocyte SedimentationRate (ESR) Fibrinogen Folate Testing TNF-alphaSUPPLEMENTDIETDemo Client May 9, 201919
Cognitive PanelHigh ImpactOxidative StressPeople with similar genetic markers may experience higher levels of oxidative stress due in part to 879 / HighCDKNrs10811661 / 4637584-/-LowSOD2rs4880 /-LowRecommendationsThese recommendations are based on the genetic findings in the chart above. Zinc Vitamin EDIET Calorie RestrictionLIFESTYLE Reduce StressEXERCISE Aerobic ActivityFURTHER TESTING Markers of Oxidative StressSUPPLEMENTDemo Client May 9, 2019 Vitamin C Fruits and Vegetables Yoga20
Cognitive PanelMedium ImpactAlzheimer's DiseasePeople with similar genetic markers may be at a higher risk for developing Alzheimer’s disease.GeneSNPVariantImpactCD2Aprs9349407 / HighSORL1rs11218343 / HighSPSB1rs11121365 /-MediumBIN1rs744373 /-MediumABCA7rs3764650 /-MediumCR1rs3818361 /-MediumRAB20rs56378310 /-MediumMS4A4Ers670139 5999145-/-LowCR1rs6656401-/-LowAPOErs7412 / 75650NRNot ReportableRecommendationsThese recommendations are based on the genetic findings in the chart above.SUPPLEMENTDIETLIFESTYLEDemo Client May 9, 2019 Omega-3 Vitamin C Vitamin D3 Resveratrol Vitamin C Rich Foods Low Glycemic Index Foods Consume BeneficialProbiotics Consume Fatty Fish Vitamin E Rich Foods Beta-Carotene Lemon Balm Essential Oils Brain Exercise21
Cognitive PanelMedium ImpactEXERCISE Aerobic ActivityFURTHER TESTING Manganese GlutathioneDemo Client May 9, 2019 Homocysteine Levels22
Cognitive PanelMedium ImpactAnxietyPeople with similar genetic markers may be at a higher risk for anxiety-related disorders, such as generalized anxietydisorder and panic disorder.GeneSNPVariantImpactLOCI5225rs1709393 / HighSLC6A4rs25531 / HighCAMKMTrs1067327 / HighRGS2rs4606 / HighMAOArs6323 / HighACCN1rs280039 /-MediumLOC101927284rs9302001 /-MediumTMEM132Drs7309727 /-MediumTMEM16Brs12579350 /-MediumSDK2rs3816995 /-MediumMFHAS1rs12682352 /-MediumMAGI1rs35855737 TR1Ars6295-/-LowCOMTrs4680 s6265-/-LowNPY5Rrs12501691-/-LowNPYrs16147 mmendationsThese recommendations are based on the genetic findings in the chart above.SUPPLEMENTDemo Client May 9, 2019 Omega-3 Vitamin C Magnesium Probiotics L-Lysine and L-Arginine Lavender Oil Phosphatidylserine Ashwagandha23
Cognitive PanelMedium Impact L-TheanineDIET Magnesium Rich foodsLIFESTYLE MeditationEXERCISE QigongFURTHER TESTING Homocysteine LevelsDemo Client May 9, 2019 Aerobic Activity24
Cognitive PanelMedium ImpactDementiaPeople with similar genetic markers may be at a higher risk for developing certain forms of dementia in older age.GeneSNPVariantImpactAPOErs7412 / HighPHLDB2rs951660 /-MediumTNF-αrs1799724 /-MediumHLArs9268856 /-MediumSYKrs290227 /-MediumTNFRSF19rs9317882 /-MediumFAM134Brs10041159 rs769449-/-LowRecommendationsThese recommendations are based on the genetic findings in the chart above. L-Carnitine Choline Antioxidants Combined NutraceuticalDIET Potassium Rich Foods Diet QualityEXERCISE Aerobic ActivityFURTHER TESTING Homocysteine Levels AntioxidantsSUPPLEMENTDemo Client May 9, 201925
Cognitive PanelMedium ImpactMild Cognitive ImpairmentPeople with similar genetic markers may be at a higher risk for mild cognitive impairment.GeneSNPVariantImpactHRK/FBXW8rs7294919 / HighASTN2rs7852872 /-MediumLHFPrs9315702 se recommendations are based on the genetic findings in the chart above. Folate Vitamin B12 Magnesium Resveratrol Docosahexaenoic Acid (DHA) Folate Rich Foods Selenium Rich Foods Mediterranean Diet Consume Fatty FishLIFESTYLE Brain ExerciseEXERCISE Aerobic ActivityFURTHER TESTING Non-Ceruloplasmin-BoundCopper Homocysteine Levels Vitamin D3 (25-OH) AntioxidantsSUPPLEMENTDIETDemo Client May 9, 201926
Cognitive PanelMedium ImpactParkinson's DiseasePeople with similar genetic markers may be at a higher risk for developing Parkinson’s disease.Demo Client May 9, 201927
Cognitive PanelMedium ImpactGeneSNPSNCArs199498 / HighRAB7L1rs823128 / HighSNCArs356219 / HighGPNMBrs199347 / HighVPS13Crs2414739 / HighSNCArs2736990 / HighGCH1rs11158026 / HighSIPA1L2rs10797576 / HighBCKDK/STX1Brs14235 / HighHLA-DQB1rs9275326 / HighMCCC1rs11711441 / HighSREBF1rs11868035 / HighINPP5Frs117896735 / HighMCCC1rs12637471 / HighRAB7L1rs823114 /-MediumRAB7L1rs823118 /-MediumBST1rs4698412 /-MediumSNCArs11012 /-MediumLRRK2rs1994090 /-MediumMIR4697rs329648 /-MediumBST1rs11724635 /-MediumSNCArs17577094 /-MediumSNCArs8070723 /-MediumSNCArs2942168 /-MediumFAM47Ers6812193 /-MediumSNCArs393152 /-MediumSNCArs12185268 -/-LowDemo Client May 9, 2019VariantImpact28
Cognitive PanelMedium 3rs6430538-/-LowTMEM175rs6599388NRNot ReportableSNCArs356220NRNot ReportableRecommendationsThese recommendations are based on the genetic findings in the chart above. Vitamin C Vitamin D3 Riboflavin (Vitamin B2) Vitamin E Niacinamide (Vitamin B3) Caution with Iron Rich Foods Reduce Your Dietary FatIntake FlavonoidsLIFESTYLE Brain ExerciseEXERCISE Aerobic ActivityFURTHER TESTING Homocysteine Levels Vitamin D3 (25-OH) Vitamin C Test Antioxidants Serum IronSUPPLEMENTDIETDemo Client May 9, 201929
Client SummaryAppendix 2Cogni ve PanelMay 9, 2019Demo ClientKit #1234ABCD5678
Client Summary Report: Cognitive PanelBelow is a summary of the genetic data that we test for in this Health Action Plan. Recommendations are given for traits with Medium andHigh Impact.Traits are listed in order of trait impact. Please look at the Trait Impact Summary Report for more information.TraitGeneSNP/RSIDClinical 1Ars6295Increased risk of majordepressive disorder / HighDepressionHTR1Ars878567Increased risk of majordepressive disorder / High / HighDepressionFKBP5rs3800373Increased risk of majordepressive disorderfollowing traumaticeventDepressionFKBP5rs1360780Increased risk ofdepressive disorders / High / HighDepressionFKBP5rs9296158Increased risk of majordepressive disorderfollowing traumaticeventDepressionCRHR1rs110402Increased risk of majordepressive disorder / HighDepressionGNB3rs5443Increased risk of majordepressive disorder / HighDepressionCHRH2rs3779250Increased risk of majordepressive disorder / HighDepressionMTHFRrs1801133Increased risk of majordepressive disorder /-MediumDepressionKSR2rs7973260Increased risk fordepression /-MediumDepressionLHPPrs35936514Increased risk of majordepressive disorder-/-LowDepressionSLC6A15rs1545843Increased risk of majordepressive disorder /-LowDepressionSLC6A4rs25531Increased risk of majordepressive disorder-/-LowDemo Client May 9, 2019Comments31
TraitGeneSNP/RSIDClinical T1rs12415800Increased risk of majordepressive disorder-/-LowDepressionPCLOrs2522833Increased risk ofdepressive disorders /-LowInflammationTNF-αrs1800629Increased risk ofelevated inflammatoryresponse / HighInflammationIL6rs1800795Increased risk ofelevated circulatingIL-6 cytokines / HighInflammationTNF-αrs1799724Increased risk ofelevated inflammatoryresponse /-MediumInflammationPTPN22rs2476601Increased risk ofelevated inflammatoryresponse /-MediumInflammationIL-10rs1800872Increased risk ofelevated inflammatoryresponse /-LowInflammationTNF-αrs1799964Increased risk ofelevated 41Increased risk ofelevated inflammatoryresponse /-LowInflammationIL-10rs3024505Increased risk ofelevated inflammatoryresponse-/-LowOxidative StressUGTrs1105879Increased risk forelevated levels ofoxidative stress / HighOxidative StressCDKNrs10811661Increased risk forelevated levels ofoxidative stress / HighOxidative StressGSTP1rs1695Increased risk forelevated levels ofoxidative stress-/-LowOxidative StressCYP1A1rs1048943Increased risk forelevated levels ofoxidative stress-/-LowDemo Client May 9, 2019Comments32
TraitGeneSNP/RSIDClinical SignificanceVariantTypeSNPImpactScoreOxidative StressLRRK2rs34637584Increased risk forelevated levels ofoxidative stress-/-LowOxidative StressSOD2rs4880Increased risk forelevated levels ofoxidative stress /-LowAlzheimer'sDiseaseCD2Aprs9349407Increased risk for AD / HighAlzheimer'sDiseaseSORL1rs11218343Increased risk for AD / HighAlzheimer'sDiseaseSPSB1rs11121365Increased risk for ADdevelopment afterMCI diagnosis /-MediumAlzheimer'sDiseaseBIN1rs744373Increased risk for AD /-MediumAlzheimer'sDiseaseABCA7rs3764650Increased risk for earlyonset AD /-MediumAlzheimer'sDiseaseCR1rs3818361Increased risk for lateonset AD /-MediumAlzheimer'sDiseaseRAB20rs56378310Increased risk for ADdevelopment afterMCI diagnosis /-MediumAlzheimer'sDiseaseMS4A4Ers670139Increased risk for AD /-MediumAlzheimer'sDiseaseBDH1rs2484Increased risk for ADdevelopment afterMCI ased risk for AD-/-LowAlzheimer'sDiseasePLD3rs145999145Increased risk for AD-/-LowAlzheimer'sDiseaseCR1rs6656401Increased risk for lateonset AD-/-LowAlzheimer'sDiseaseAPOErs7412Normal - decreasedrisk for AD / LowAlzheimer'sDiseaseST6GAL1rs3936289Increased risk for ADdevelopment afterMCI diagnosis-/-LowDemo Client May 9, 2019Comments33
TraitGeneSNP/RSIDClinical seaseADARB2rs10903488Increased risk for ADdevelopment afterMCI creased risk for d risk for ADdevelopment afterMCI creased risk for ADNRNotReportablers1709393Abnormal regulationof basic threatresponse systems,increased risk ofanxiety disorders / Highrs25531Altered serotoninsignaling andincreased risk ofanxiety disorders / Highrs1067327Abnormal regulationof basic threatresponse systems,increased risk ofanxiety disorders / High / tyRGS2rs4606Decreased stresscoping ability,increased risk ofgeneralized anxietydisorderAnxietyMAOArs6323Increased risk ofgeneralized anxietydisorder in females / HighAnxietyACCN1rs280039Increased risk forpanic disorder /-MediumAnxietyLOC101927284rs9302001Increased risk forpanic disorder /-MediumAnxietyTMEM132Drs7309727Increased risk forpanic disorder /-MediumAnxietyTMEM16Brs12579350Increased risk forpanic disorder /-MediumDemo Client May 9, 2019Comments34
TraitGeneSNP/RSIDClinical 3816995Increased risk forpanic disorder /-MediumAnxietyMFHAS1rs12682352Increased risk ofanxiety disorders /-Mediumrs35855737Increased risk ofanxiety disorders andmajor depressivedisorders eased stresscoping ability,increased risk ofgeneralized anxietydisorderAnxietyPLEKHG1rs9372078Increased risk forpanic disorder-/-LowAnxietyHTR1Ars6295Increased risk ofgeneralized anxietydisorder-/-LowAnxietyCOMTrs4680Increased risk ofgeneralized anxietydisorder /-LowAnxietyCALCOCO1rs941184Increased risk forpanic disorder-/-LowAnxietyPKP1rs860554Increased risk forpanic disorder-/-LowAnxietyBDNFrs6265Increased risk ofgeneralized anxi
Anxiety Supplement with 200 mg of L-theanine per day. Lavender Oil Anxiety Supplement with 80 mg of an oral lavendar supplement per day. Multivitamin Inflammation Supplement with a multivitamin that includes activated B vitamins. Niacinamide (Vitamin B3) Parkinson's Disease Supplement with 1 - 3 g
Hush Panel 28 Hush Panel 32 Hush Panel 33 Hush Panel 37 Hush Panel 48 Hush Panel 52 Hush Ply 28 Hush Ply 32 When installing Hush Cem Panel 28 or Hush Cem Panel 32 the tongue and groove joints are to be glued using Hush Cem Panel Adhesive. All joints to be glued, on all sides of the panel to give the best bond. Adhesive not to be spared .
Cost Transparency Storage Storage Average Cost The cost per storage Cost Transparency Storage Storage Average Cost per GB The cost per GB of storage Cost Transparency Storage Storage Devices Count The quantity of storage devices Cost Transparency Storage Storage Tier Designates the level of the storage, such as for a level of service. Apptio .
1 SOCIAL COGNI TIVE THEORY Albert Bandura Stanford University Bandura, A. (1989). Social cognitive theory. In R. Vasta (Ed.), Annals of child development.Vol. 6. Six theories o
the transverse panel-to-panel connections are referred to simply as panel-to-panel connections. Panel-to-panel connections can be nonprestressed or post- . (25 100 mm) flat plastic duct (Fig. 5). One of the connections with a stress of 340 psi (2.34 MPa) had an epoxy bonding agent applied to the
Attach and remove the control panel You can attach the control panel directly to the drive, or use a separate mounting kit. To attach the control panel to a drive: 1. Place the bottom end of the control panel into the slot in the drive. 2. Press the control panel lock clip down. 3. Push the control panel into place. To remove the control panel:
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8 DNA, genes, and protein synthesis Exam-style questions. AQA Biology . ii. Suggest why high humidity is used in theinvestigation. (1 mark) b . The larva eats voraciously but the pupa does not feed. The cells inside the pupa start to break down the larval tissues and form the adult tissues. The larval tissue and adult tissue contain different proteins. The genes in the cells of the larva are .
