Appendices To Glyphosate
SERA TR-052-22-03a-AppAppendices to GlyphosateHuman Health and Ecological Risk AssessmentFINAL REPORTSubmitted to:Paul Mistretta, CORUSDA/Forest Service, Southern Region1720 Peachtree RD, NWAtlanta, Georgia 30309USDA Forest Service Contract: AG-3187-C-06-0010USDA Forest Order Number: AG-43ZP-D-09-0031SERA Internal Task No. 52-22Submitted by:Patrick R. DurkinSyracuse Environmental Research Associates, Inc.8125 Solomon SealManlius, New York 13104E-Mail: SERA INC@msn.comHome Page: www.sera-inc.comNovember 29, 2010
LIST OF APPENDICESAppendix 1: Selected Toxicity Data from Material Safety Data Sheets . 3Appendix 2: Toxicity to Mammals . 11Appendix 3: Toxicity to Birds . 40Appendix 4: Toxicity to Terrestrial Invertebrates . 45Appendix 5: Toxicity to Terrestrial Plants. 48Appendix 6: Toxicity to Fish . 55Appendix 7: Toxicity to Aquatic-Phase Amphibians . 80Appendix 8: Toxicity to Aquatic Invertebrates . 93Appendix 9: Toxicity to Aquatic Plants. 107Appendix 10: Gleams-Driver Simulations. 116
Appendix 1: Selected Toxicity Data from Material Safety Data SheetsA1 Table 1: Mammalian Toxicity Data from MSDSs . 3A1 Table 2: Aquatic Toxicity Information from MSDS . 5Note: The order and color coding of the formulations is consistent with that of Tables 4 and 5 ofthe current Forest Service risk assessment.A1 Table 1: Mammalian Toxicity Data from MSDSsFormulation NameAccord XRTImitator PlusKGro Grass and WeedKillerDuraMaxDurango DMA (GF-1280)RapidFireAccord XRT IIGlyfos AquaticGlyfos X-TRAGlyphoMate 41 or ProntoAquaNeatForesters’ Non SelectiveAqua StarBuccaneerBuccaneer PlusCornerstoneCornerstone PlusCredit ExtraCredit Systemic ExtraEliminator [need label]Gly-4 PlusGlyphoganGly Star PlusGlyphosate 41 Plus orGLY- 4 PlusHoncho (a.k.a. RoundupOriginal)Honcho PlusMirageRazorRazor ProRoundup Original MaxRoundup Pro ConcentrateRoundup ProMaxRoundup UltraDryRoundup tion.LC50(mg/L) 5000 5000 5000 5000 5.23 5000 5000 5000 5000 5000 5000 2000 5000 5000 5000 5000 5000 5000 5000 5000 5000 5000 5000 5000 5000 5000 5000 5000 5000 4000 2000 2000 5000 5000 5000 5000 5000 5000 5000 5000 5000 5000 2000 5000 5000 5.63 5.63 5.63 5.63 4.24 2.86 2.05 4.24 2.08 2.52.6 5000 5000 5000 5000 5000 5000 5000 5000 50003700 5000Eye IrritationSkin Irritation2.61.6 2.10 2.052.6 4.86 2.6 2.5CornealCornealCornealCornealMay causeMay ateModerateSlightSlightSlightSlightMay causeMay itating 2000 4.86ModerateSlight 5000 5000 5000 5000 5000 5000 5000 5000 5000 50002.61.61.6 2.05 ight 2.013Non-irritatingMild
Appendix 1: Selected Toxicity Data from Material Safety Data Sheets (continued)A1 Table 1: Mammalian Toxicity Data from MSDSsFormulation NameRoundup WeatherMaxRT 3AccordAquaMaster (a.k.a. Exportand Rodeo)Glyphosate VMFRattlerHelosate PlusAccord ConcentrateAccord SP (a.k.a.Glyphosate Plus)DiamondbackDurango (GF-1279)Glyphomax PlusGlyphomax XRTGlyproRanger ProRodeoRoundup ProRoundup ProDryHi-yield tion.LC50(mg/L) 5000 5000 5000 5000 5000 5000 1.2 1.2 1.3ModerateModerateNon-irritating 5000 5000 50005000 5000 5000 5000 50005000 5000 4.24 1.3 3.183.28 reSlight 5000 5000 5000 5000 5000 50005108 500051083,794 5000 5000 5000 5000 5000 5000 5000 5000 5000 5000 htSlightSlightYes 5.23 5.0 5.23 6.372.9 6.372.9 2.64Eye IrritationSkin y gNon-irritatingSlightYes
Appendix 1: Selected Toxicity Data from Material Safety Data Sheets (continued)A1 Table 2: Aquatic Toxicity Information from MSDSRainbowTroutLC50(mg/L)DaphniaLC50(mg/L) 1000930AccordConcentrate 2500918Accord SP(a.k.a.GlyphomaxPlus)60Accord XRT 1000FormulationNameAccordAccord XRT IIAqua StarBluegillLC50(mg/L) 1000MostSensitiveAquaticLC50(mg/L)Notes onMSDS1093010Toxicity databased on IPAsaltNotes on Aquatic DataBluegill: Griffen and Thompson 1981, MRID78662, in EPA 1993c give 1000 mg/L for a62.4% formulation.Trout: Thompson and Griffen 1981, MRID78661, in EPA 1993c give 1000 mg/L for a62.4% formulation.All values are identical to MSDS for Rodeo.Trout: The LC50 for Rodeo is 430.1 mg a.e./LMRID 40579301/1985. This would correspondto 1417.6 mg form/L.Daphnia: Cannot identify study. 918 mg/L ishigher than technical grade glyphosate.Trout: 60 mg formulation/L would correspondto about 26 mg a.e./L. Cannot identify study.Conversely, this 60 mg/L is in the range ofunformulated glyphosate as well as the a.e. LC50for 80WDG (a.k.a. Glygran WDG) formulation(an IPA salt, granular?).Trout: Thompson and Griffen 1981, MRID78661, in EPA 1993c give 1000 mg/L for a62.4% formulation.Daphnia: The LC50 of 930 mg./L is consistentwith unformulated glyphosate.This formulation is identical to Durango andGlyphomax XRT (Fonseca 2010a).0.15.88.2AquaMaster(a.k.a. Exportand Rodeo) 1000 1000930AquaNeat120 a.e.86 a.e.780 a.e.Buccaneer5.88.211Aquatic dataon similarformulation.5The bluegill is 5.8 mg formulation/L from Forbiset al. 1982a.Trout: 8.2 mg form/L from Forbis et al. 1982b.The data from Bringolf et al. (2007) indicatesthat this formulation does not contain a POEAsurfactant.Bluegill: Griffen and Thompson 1981, MRID78662, in EPA 1993c give 1000 mg/L for a62.4% formulation.Trout: Thompson and Griffen 1981, MRID78661, in EPA 1993c give 1000 mg/L for a62.4% formulation.Daphnia: The LC50 of 930 mg./L is consistentwith unformulated glyphosate.Bluegill: From McAllister and Forbes 1978a notcorrecting for purity of the acid.Trout: From Thompson and McAllister 1978,MRID 136339.Daphnia: From McAllister and Forbes 1978b notcorrecting for purity of acid.The bluegill is 5.8 mg formulation/L from Forbiset al. 1982a.Trout: 8.2 mg form/L from Forbis et al. 1982b.Daphnia: May be 10.5 mg form/L for a 30% a.e.formulation from Drottar and Krueger 2000c
Appendix 1: Selected Toxicity Data from Material Safety Data Sheets (continued)A1 Table 2: Aquatic Toxicity Information from (mg/L)Notes onMSDSBuccaneer Plus2442160Aquatic dataon product 11CornerstonePlus2442160Mammalian:product orcomponents.Aquatic:similar orcomponentsAquatic dataon product orsimilarformulation.Credit Extra120 a.e.86 a.e.780 a.e.Aquatic: Dataon a.e. Maycontainethoxylatedtallowamines.Credit SystemicExtra120 a.e.86 a.e.780 a.e.Aquatic: Dataon a.e. Maycontainethoxylatedtallowamines.Diamondback 1000 1000930DuraMaxDurango (GF1279)0.110Durango DMA(GF-1280)Eliminator [need0.18.21111label]6Notes on Aquatic DataBluegill: Morrill 1973 gives an LC50 of 24 mg/Lfor acid.Trout: 42 mg form/L would correspond to about12.7 mg a.e./L. Cannot identify.Daphnia: May be from Swarbrick and Shillabeer1999b, 164.3 mg form/L for a 27.25%formulation.The bluegill is 5.8 mg formulation/L from Forbiset al. 1982a.Trout: 8.2 mg form/L from Forbis et al. 1982b.Daphnia: May be 10.5 mg form/L for a 30% a.e.formulation from Drottar and Krueger 2000cBluegill: Morrill 1973 gives an LC50 of 24 mg/Lfor acid.Trout: 42 mg form/L would correspond to about12.7 mg a.e./L. Cannot identify.Daphnia: May be from Swarbrick and Shillabeer1999b, 164.3 mg form/L for a 27.25%formulation.Bluegill: From McAllister and Forbes 1978a notcorrecting for purity of the acid.Trout: From Thompson and McAllister 1978,MRID 136339.Daphnia: From McAllister and Forbes 1978b notcorrecting for purity of acid.Bluegill: From McAllister and Forbes 1978a notcorrecting for purity of the acid.Trout: From Thompson and McAllister 1978,MRID 136339.Daphnia: From McAllister and Forbes 1978b notcorrecting for purity of acid.Bluegill: Griffen and Thompson 1981, MRID78662, in EPA 1993c give 1000 mg/L for a62.4% formulation.Trout: Thompson and Griffen 1981, MRID78661, in EPA 1993c give 1000 mg/L for a62.4% formulation.Daphnia: The LC50 of 930 mg./L is consistentwith unformulated glyphosate.Aquatic:Based largelyor completelyon a.e.This formulation is identical to Accord XRT andGlyphomax XRT (Fonseca 2010a).Aquatic:SimilarproductsBluegill: Cannot identify. EPA 1993c cites atrout LC50 of 8.2 mg/L for Roundup 41.8%Daphnia: May be 10.5 mg form/L for a 30% a.e.formulation from Drottar and Krueger 2000cTrout: This appears to be MRID 70895, 11 mgformulation/L for a 41% IPA formulation
Appendix 1: Selected Toxicity Data from Material Safety Data Sheets (continued)A1 Table 2: Aquatic Toxicity Information from C50(mg/L)DaphniaLC50(mg/L)780 a.e.MostSensitiveAquaticLC50(mg/L)Notes onMSDSForesters’ NonSelective120 a.e.86 a.e.Gly-4 Plus11.9 a.e.18.6 a.e.Glyfos Aquatic 1000 a.i. 1000 a.i.930 a.i.Based on IPAsaltGlyfos X-TRA11.918.621.6Aquatic:Appears toindicate thattoxicity is inunits offormulation.Glyphogan5.88.212.9Based on a.e.?Bluegill: From McAllister and Forbes 1978a notcorrecting for purity of the acid.Trout: From Thompson and McAllister 1978,MRID 136339.Daphnia: From McAllister and Forbes 1978b notcorrecting for purity of acid.Bluegill: Cannot associate 11.9 mg/L with astudy.Trout: Cannot associate 18.6 a.e./L with a study.Bluegill: Griffen and Thompson 1981, MRID78662, in EPA 1993c give 1000 mg/L for a62.4% formulation.Trout: Thompson and Griffen 1981, MRID78661, in EPA 1993c give 1000 mg/L for a62.4% formulation.Daphnia: The LC50 of 930 a.i./L corresponds toabout 688 mg a.e./L. This is close tounformulated glyphosate.Bluegill: 11.9 mg form/L would correspond toabout 3.6 mg a.e./L. An LC50 of 3.7 mg a.e./L isgiven in Appendix J, MRID 162296/1979Trout: 18.6 mg form/L would correspond toabout 5.6 mg/L. This is in the range offormulation studies - e.g., 5.5 mg a.e./L for a36% a.i. formulation.Daphnia: Cannot identify study. In the range ofRoundup formulations if value is a.e.The bluegill is 5.8 mg formulation/L from Forbiset al. 1982a.Trout: 8.2 mg form/L from Forbis et al. 1982b.Daphnia: Cannot identify formulation LC50 of12.9 mg/L. This would correspond to about 3.9mg a.e./L. This is in the range of Roundupformulations.No aquaticdata in MSDSGlyphoMate 41or ProntoGlyphomaxPlus [need label]109105 100GlyphomaxXRTGly Star PlusNotes on Aquatic Data10 to 1005.88.27Aquatic:Based largelyor completelyon a.e.MSDS statesa.e. units.Trout: Cannot identify. 109 mg form/L wouldcorrespond to 33 mg a.e./L. This is less thanLC50s of unformulated glyphosate.Daphnia: Cannot identify 105 mg form/L with astudy. This would correspond to about 32 mga.e./L. This is below the LC50 for unformulatedglyphosate but is in the range of less toxicsurfactant formulations -- i.e., MRID 78657, 21.7 mg a.e./L.This formulation is identical to Accord XRT andDurango (Fonseca 2010a).The MSDS is not correct in indicating that theunits of the toxicity values apply to glyphosateacid. The bluegill is 5.8 mg formulation/L fromForbis et al. 1982a.Trout: 8.2 mg form/L from Forbis et al. 1982b.
Appendix 1: Selected Toxicity Data from Material Safety Data Sheets (continued)A1 Table 2: Aquatic Toxicity Information from C50(mg/L)DaphniaLC50(mg/L)930GlyphosateVMF 1000 1000Glyphosate 41Plus or GLY- 4PlusGlypro11.9 a.e.18.6 a.e.Helosate Plus5.6 a.e. 25009182.3 a.e.3 a.e.5.88.211Honcho Plus2442160Notes on Aquatic DataMSDS doesnot specifya.e. orformulation.Give data onRodeo.Aquaticappears to beon a.e.Bluegill: Griffen and Thompson 1981, MRID78662, in EPA 1993c give 1000 mg/L for a62.4% formulation.Trout: Thompson and Griffen 1981, MRID78661, in EPA 1993c give 1000 mg/L for a62.4% formulation.Bluegill: Cannot associate 11.9 mg/L with astudy.Trout: Cannot associate 18.6 a.e./L with a study.All values are identical to MSDS for Rodeo.Trout: The LC50 for Rodeo is 430.1 mg a.e./LMRID 40579301/1985. This would correspondto 1417.6 mg form/L.Daphnia: Cannot identify study. 918 mg/L ishigher than technical grade glyphosate.Bluegill: Cannot associate 5.6 mg/L with a studybut this is in the range of Roundupformulations,Trout: Cannot associate 2.3 mg a.e./L with aspecific study but this is in the range ofRoundup formulations.Daphnia: Cannot associated 3 mg a.e./L with aspecific study but this is in the range orRoundup formulations.No detailedinformationon MSDS.Aquatic:similarproducts andoncomponents.Aquatic:product,similarproducts andoncomponents.The bluegill is 5.8 mg formulation/L from Forbiset al. 1982a.Trout: 8.2 mg form/L from Forbis et al. 1982b.Daphnia: May be 10.5 mg form/L for a 30% a.e.formulation from Drottar and Krueger 2000cBluegill: Morrill 1973 gives an LC50 of 24 mg/Lfor acid.Trout: 42 mg form/L would correspond to about12.7 mg a.e./L. Cannot identify.Daphnia: May be from Swarbrick and Shillabeer1999b, 164.3 mg form/L for a 27.25%formulation.No detailedinformationon MSDS.Cannot locateMSDSImitator PlusKGro Grass andWeed KillerMirageNotes onMSDS 100Hi-yield KillzallHoncho /L)8.237Moredetailedecotox onMSDS248Bluegill: Cannot identify. EPA 1993c cites atrout LC50 of 8.2 mg/L for Roundup 41.8%.Trout: 37 mg form/L would correspond to about11.2 mg a.e./L. Cannot identify study.Daphnia: Cannot identify formulation study with24 mg/L. Corresponds to about 7.3 mg a.e./L.This is somewhat above the range for Roundupformulations.
Appendix 1: Selected Toxicity Data from Material Safety Data Sheets (continued)A1 Table 2: Aquatic Toxicity Information from MSDSFormulationNameRanger tes onMSDSAquatic:Product andcomponents.RapidFireRattlerNotes on Aquatic DataBluegill 7.3 mg/L is formulation LC50 fromDrottar and Krueger 2000 for a 41%formulation.Daphnia: May be 10.5 mg form/L for a 30% a.e.formulation from Drottar and Krueger 2000cTrout: Cannot identify specific study but dataare consistent with formulation toxicity.0.1Acute oral onmouse notrat. Noecotox onMSDSRazor86 a.e.120 a.e.780 a.e.Razor Pro120 a.e.86 a.e.780 a.e. 2500918RodeoRoundupOriginal Max5.2Roundup Pro7.3Roundup ProConcentrate7.3Aquatic: TheMSDS doesnot specifyformulationor a.e. 1008Aquatic:similarproducts andcomponents5.411Aquatic:similarproducts andcomponents5.411Aquatic:similarproducts andcomponents9Bluegill: From McAllister and Forbes 1978a notcorrecting for purity of the acid.Trout: From Thompson and McAllister 1978,MRID 136339.Daphnia: From McAllister and Forbes 1978b notcorrecting for purity of acid.Bluegill: From McAllister and Forbes 1978a notcorrecting for purity of the acid.Trout: From Thompson and McAllister 1978,MRID 136339.Daphnia: From McAllister and Forbes 1978b notcorrecting for purity of acid.Trout: The LC50 for Rodeo is 430.1 mg a.e./LMRID 40579301/1985. This would correspondto 1417.6 mg form/L.Daphnia: Cannot identify study. 918 mg/L ishigher than technical grade glyphosate.Bluegill: Cannot identify study with toxicityvalue of 5.2 mg/L.Daphnia: Cannot identify study with toxicityvalue of 8 mg/L. For a K formulation, thiswould be equivalent to about 3.2 mg a.e./L.This is consistent with MRID 45365004, an IPAformulation.Bluegill 7.3 mg/L is formulation LC50 fromDrottar and Krueger 2000a for a 41%formulation.Daphnia: May be 10.5 mg form/L for a 30% a.e.formulation from Drottar and Krueger 2000cTrout: Cannot identify specific study but dataare consistent with formulation toxicity.Bluegill 7.3 mg/L is formulation LC50 fromDrottar and Krueger 2000a for a 41%formulation.Daphnia: May be 10.5 mg form/L for a 30% a.e.formulation from Drottar and Krueger 2000cTrout: Cannot identify specific study but dataare consistent with formulation toxicity.
Appendix 1: Selected Toxicity Data from Material Safety Data Sheets (continued)A1 Table 2: Aquatic Toxicity Information from arproducts andcomponents8Aquatic:similarproducts andcomponents5.2The oral LD50is for femalerats. Aquatic:No studiesconducted.Aquatic:similarproducts andcomponentsRoundupUltraDry5.4Notes uatic:similarproducts andcomponentsRT 33.138Similarformulation10Notes on Aquatic DataTrout: Cannot be identified but it is clearly aformulation. This may be a rounding of MRID45767101 for a 66% a.i. ammonium formulation(MON78568) with an LC50 of 1.9 mg a.e./L.Daphnia: Cannot identify. The only reasonablyclose study is MRID 45777401 which reports anEC50 of 28.8 mg a.e./L.Bluegill: Cannot identify study with toxicityvalue of 5.2 mg/L.Daphnia: Cannot identify study with toxicityvalue of 8 mg/L. For a K formulation, thiswould be equivalent to about 3.2 mg a.e./L.This is consistent with MRID 45365004, an IPAformulation.Bluegill 7.3 mg/L is formulation LC50 fromDrottar and Krueger 2000 for a 41%formulation.Daphnia: May be 10.5 mg form/L for a 30% a.e.formulation from Drottar and Krueger 2000cTrout: Cannot identify specific study but dataare consistent with formulation toxicity.Bluegill: Cannot identify 3.13 mg/L. Assumingformulation units, this would correspond to 1.5mg a.i./L or 1.23 a.e./L.Daphnia: Cannot identify study with toxicityvalue of 8 mg/L. For a K formulation, thiswould be equivalent to about 3.2 mg a.e./L.This is consistent with MRID 45365004, an IPAformulation.Bluegill: Cannot identify 3.13 mg/L. Assumingformulation units, this would correspond to 1.5mg a.i./L or 1.23 a.e./L.Daphnia: Cannot identify study with toxicityvalue of 8 mg/L. For a K formulation, thiswould be equivalent to about 3.2 mg a.e./L.This is consistent with MRID 45365004, an IPAformulation.
Appendix 2: Toxicity to Mammals (continued)Appendix 2: Toxicity to MammalsA2 Table 1: Glyphosate Technical/Acid, Acute Oral/Gavage Toxicity . 11A2 Table 2: Glyphosate Formulations, Acute Oral/Gavage Toxicity . 12A2 Table 3: Glyphosate Reproductive and Developmental . 16A2 Table 4: Glyphosate Subchronic and Chronic Toxicity . 21A2 Table 5: Surfactant Toxicity Studies . 24A2 Table 6: Case Reports of Human Poisoning . 26A2 Table 7: In vitro studies relating to endocrine function . 29A2 Table 8: In vitro studies on cellular/genetic toxicity. 33A2 Table 9: Field Studies . 37A2 Table 1: Glyphosate Technical/Acid, Acute Oral/Gavage ToxicitySpeciesExposureResponseReference[1]MRID 43728003 [2]Rat (Rattusnorvegicus)Rat (Rattusnorvegicus)Rat (Rattusnorvegicus)Rat (Rattusnorvegicus)Rat (Rattusnorvegicus)Rat (Rattusnorvegicus)Rat (Rattusnorvegicus)Rat (Rattusnorvegicus)RatsAcid, 96%RatsGlyphosate IPALD50: 4800 mg a.e./kg bwNo mortalities.LD50: 4750 mg a.e./kg bwNo mortalities.LD50: 4860 mg a.e./kg bwNo mortalities.LD50: 4400 mg a.e./kg bwNo mortalities.LD50: 4750 mg a.e./kg bwNo mortalities.LD50: 3800 mg a.e./kg bwNo mortalities.LD50: 1920 mg a.e./kg bwNo mortalities.LD50: 4770 mg a.e./kg bwNo mortalities.Reported 72 hour LD50: 5957 mg a.i./kgbw or 4400 mg a.e./kg bwData below are from Baba et al. 1989,Table 1.Dosemg a.i./kgMortality Numberbw398607478417574037688057822677LD50: 5000 mg/kg bwRatsTechnical gradeLD50: 4873 mg/kg bwMiceTechnical gradeLD50: 1568 mg/kg bwAcid, 95%Acid, 97.2%Acid, 88%Acid, 95%Acid, 76%Acid, 96%Acid, 95.4%Glyphosate IPA11MRID 45058306 [2]MRID 46760505 [2]MRID 44320604 [2]MRID 46998805 [2]MRID 41400601 [2]MRID 44142104 [2]MRID 46816107 [2]Baba et al. 1989Smith and Oehme1992 [3]Babaunmi et al.1978Babaunmi et al.1978
Appendix 2: Toxicity to Mammals (continued)A2 Table 1: Glyphosate Technical/Acid, Acute Oral/Gavage ToxicitySpeciesExposureResponseDeer miceGlyphosate IPALD50: 6000 mg/kg bwRabbitTechnical gradeLD50: 3800 mg/kg bwGoat, femaleGlyphosatetechnical, 98.7%LD50: 3500 mg/kg bwGoat, femaleGlyphosate IPA,65% in waterLD50: 5700 mg/kg bwRatTechnical gradeReference[1]McComb et al.2008Smith and Oehme1992[3]WHO 1994summarizingUSDA studyWHO 1994summarizingUSDA studyWHO 1994LD50: 5000 mg/kg bwSame value reported for 3 differentstudies.[1]Studies with only MRID designations are taken from Table 4.31 of U.S. EPA/OPP 2008a and/or Table J-25 ofAppendix J of U.S. EPA/OPP 2008a.[2]MRID is not referenced in Appendix L of U.S. EPA/OPP 2008a or in Attachment 1 of the current Forest Servicerisk assessment[3]All of the studies summarized by Smith and Oehme 1992 are unpublished studies that had been submitted toWHO by Monsanto (rats and mice).A2 Table 2: Glyphosate Formulations, Acute Oral/Gavage ToxicitySpeciesRat (Rattusnorvegicus)Rat (Rattusnorvegicus)Rat (Rattusnorvegicus)Rat (Rattusnorvegicus)Rat (Rattusnorvegicus)Rat (Rattusnorvegicus)Rat (Rattusnorvegicus)Rat , 11.4% a.i.LD50: 357 mg a.e./kg bwMRID 46714802 [2]MON 20033, 63% a.i.This is identified as EPA Reg.No. 524-435 (EZ-JectCapsuls) in Table 5.5 of U.S.EPA/OPP 2008a.MON 77063, 65.4% a.i.This is identified as EPA Reg.No. 524-504 (RoundupUltradry) in Table 5.5 of U.S.EPA/OPP 2008a.This is identified as EPA Reg.No. 62719-323 (Glyphomax)in Table 5.5 of U.S. EPA/OPP2008a. IPA salt, 22.9% a.i.MON 20047, 18.4% a.i.[This is identified as EPAReg. No. 524-400, which isRoundup Rainfast (25.1% IPAor 18.6% a.e.), in Table 5.5 ofU.S. EPA/OPP 2008a.]LD50: 3150 mg a.e./kg bw(5000 mg formulation/ kg bw)MRID 41142304 [2]LD50: 2599 mg a.e./kg bw(5827 mg formulation/ kg bw)MRID 44615502LD50: 724 mg a.e./kg bw(3803 mg formulation/kg bw)MRID 44918601LD50: 460 – 690 mg a.e./kg bw(3750 mg formulation/kg bw) [4]MRID 41305404[3]ClearOut 41 (41% IPA salt),30.3% a.i. [3]Clearout 62 (62% glyphosateIPA), 62% a.i.GF-1667 (62.1% glyphosatedimethyl ammonium salt),49% a.i. [3] Dow formulation.L D50: 606 mg a.e./kg bw (limittest)L D50: 1240 mg a.e./kg bw (limittest)LD50: 2450 mg a.e./kg bwNote: The 690 mg a.e./kg bwappears to be calculatedfrom the formulationtoxicity value. The sourceof the lower bound of 460 mga.e./kg bw is not clear.12MRID 44883104MRID 45657801MRID 46730705
Appendix 2: Toxicity to Mammals (continued)A2 Table 2: Glyphosate Formulations, Acute Oral/Gavage ToxicitySpeciesRat (Rattusnorvegicus)AgentGF-1280 (50.8% glyphosatedimethylammonium), 40.1%a.i.Note: GF-1280 typicallycontains 50.2% of theDMA salt of glyphosate.Rat (Rattusnorvegicus)Rat (Rattusnorvegicus)Rat (Rattusnorvegicus)Rat (Rattusnorvegicus)HM-0548 5905-LTE mixtureof ammonium salt (19.68%)and IPA (13.36%), 25% a.e.?MON 60696 (70.1%monoammonium salt),54% a.i. [3]MON 78634 (71.8%ammonium salt), 65.2% a.i. [3]Nufarm RUP0532 (41%Glyphosate as IPA andammonium salts), 30.3% a.i.ResponseReference[1]LD50: 2005 mg a.e./kg bwNote: This is the basisfor the LD 50 of 5000mg/kg bw on the MSDSsfor Accord XRT II,Duramax, Durango DMA.Back calculating forformulation, the LD 50would be 5334 mgformulation/kg bw.LD50: 1250 mg a.e./kg bwMRID 46775603LD50: 2700 mg a.e./kg bwMRID 43049302LD50: 1304 mg a.e./kg bwMRID 46087001 [2]LD50: 1515 mg a.e./kg bwMRID 45386802LD50: 4000 mg a.e./kg bwMRID 45044402MRID 47236803 [2][3]Rat (Rattusnorvegicus)56077-LL -Phoss-8, 80% a.i.Rat (Rattusnorvegicus)Rat (Rattusnorvegicus)Roundup L&G Ready to Use(glyphosate IPA), 0.85% a.i.Spray–Charlie (44% GLY41(524-475 with 41% IPA),15.2% a.i.?Dual Salt Fully Loaded(glyphosate IPA and NH4Salt)Glyphosate Acid 7.10 g/kg SLFormulation, 0.71%EH-1384 (6.75% glyphosateIPA)EH-1386 (50.0% glyphosateIPAGF-772 (40.2% IPA salt)LD50: 40 mg a.e./kg bwMRID 41395601LD50: 70 mg a.e./kg bwMRID 45929403 [2]LD50: 1800 mg a.e./kg bwMRID 45615104LD50: 35.5 mg a.e./kg bwMRID 43746804 [2]LD50: 100 mg a.e./kg bwMRID 45328903 [2]LD50: 740 mg a.e./kg bwMRID 45387703 [2]LD50: 1490 mg a.e./kg bwMRID 45871303GF-887 (54.2% glyphosateIPA)Glyphos (41% IPA) Note:LD50: 2005 mg a.e./kg bwMRID 45819303 [2]LD50: 1515 mg a.e./kg bwMRID 43530002LD50: 1600 mg a.e./kg bwMRID 44125603 [2]Rat (Rattusnorvegicus)Rat (Rattusnorvegicus)Rat (Rattusnorvegicus)Rat (Rattusnorvegicus)Rat (Rattusnorvegicus),Fischer 344Rat (Rattusnorvegicus)Rat (Rattusnorvegicus)Rat (Rattusnorvegicus)Note: Not in Attachment 1– i.e., probably not anIPA formulation.The 41% IPA compositionis consistent withGlyphos X-TRA, aformulation with asurfactant.Glygran WDG glyphosate 80WDG, 80%13
Appendix 2: Toxicity to Mammals (continued)A2 Table 2: Glyphosate Formulations, Acute Oral/Gavage ToxicitySpeciesRat (Rattusnorvegicus)Rat ate, 62% NOSLD50: 3100 mg a.e./kg bwMRID 45101503Glyphosate Unloaded (52.9%IPA), 39.2% a.i.? [Note:LD50: 1960 mg a.e./kg bwMRID 46783403LD50: 1363 mg a.e./kg bwMRID 44953503 [2]LD50: 1835 mg a.e./kg bwMRID 45830201 [2]LD50: 36.5 mg a.e./kg bwMRID 44497001 [2]LD50: 2465 mg a.e./kg bwMRID 44317201 [2]LD50: 1545 mg a.e./kg bwMRID 44863801LD50: 3110 mg a.e./kg bwMRID 44949802LD50: 2130 mg a.e./kg bwMRID 46006803 [2]LD50: 1250 mg a.e./kg bwMRID 47236803 [2]Rat (Rattusnorvegicus)Glyphosate 360g/l SL,27.25% a.i.Glyphosate 500 SL-M (36.7%Glyphosate Potassium)Glyphosate Acid 7.10 g/kg SLFormulationGlyphosate acid formulation500 g/kg WPGlyphosate IPA , 30.9%(NAF-545)Glyphosate premix (62.2%)Note: This is included inAttachment 1 (MRID listingfor IPA)Glyphosate SL (600), 42.6 a.i.(NOS)HM-0548 5905-LTE Mixtureof ammonium salt (19.68%)and IPA (13.36%)HM-2028 (Glyphosate:11.4%)LD50: 357 mg a.e./kg bwMRID 46714802 [2]Rat (Rattusnorvegicus)Rat (Rattusnorvegicus)LI6130 (13 41% GlyphosateFull Load: 40.6% IPA)LI6167-11, 40.5% IPA (“Halfload”) Note: Specified asLD50: 215 mg a.e./kg bwMRID 46862303LD50: 1500 mg a.e./kg bwMRID 46862103LD50: 1515 mg a.e./kg bwMRID 43020902LD50: 2330 mg a.e./kg bwMRID 44715402LD50: 1885 mg a.e./kg bwMRID 44872702LD50: 1965 mg a.e./kg bwMRID 44809002LD50: 75 mg a.e./kg bwMRID 46473802Study title in Attachment1 indicates 53.8%unloaded formulation.]Rat (Rattusnorvegicus)Rat (Rattusnorvegicus)Rat (Rattusnorvegicus)Rat (Rattusnorvegicus)Rat (Rattusnorvegicus)Rat (Rattusnorvegicus)Rat (Rattusnorvegicus)Rat (Rattusnorvegicus)Note: This is the lowestreported LD 50 .EZJECT in Attachment 1.Rat (Rattusnorvegicus)Rat (Rattusnorvegicus)MON 65005 (41% IPA),30.3% a.e.MON 77945, 44.6% a.e.Rat (Rattusnorvegicus)MON 78063, 37.7% a.e.IPA? Note: This is inNote: Not in Attachment 1– i.e., probably not anIPA formulation.Attachment 1 – i.e.,probably an IPAformulation.Rat (Rattusnorvegicus)MON 78293, 39.3% a.e.,IPA? Note: This is inAttachment 1 – i.e.,probably an IPAformulation.Rat (Rattusnorvegicus)Mon 79186 (2.02%glyphosate IPA), 1.5% a.e.14
Appendix 2: Toxicity to Mammals (continued)A2 Table 2: Glyphosate Formulations, Acute Oral/Gavage ToxicitySpeciesRat (Rattusnorvegicus)Rat (Rattusnorvegicus)Rat (Rattusnorvegicus)AgentMON 79188, 4.42 a.e. IPA?ResponseReference[1]LD50: 221 mg a.e./kg bwMRID 46078502LD50: 2250 mg a.e./kg bwMRID 46009104LD50: 2086 mg a.e./kg bwMRID 47298403LD50: 1515 mg a.e./kg bwMRID 44872602LD50: 1990 mg a.e./kg bwMRID 44873302LD50: 3100 mg a.e./kg bwMRID 45293503Note: This is inAttachment 1 – i.e.,probably an IPAformulation.Nufarm NUP 3G 02 (450 g/Lglyphosate as IPA salt), 45%a.e.NUP-07010 (Glyphosate, a.e.,41.72%) IPA? Note: Thisis in Attachment 1 –i.e., probably an IPAformulation.Rat (Rattusnorvegicus)Rat (Rattusnorvegicus)Rat (Rattusnorvegicus)NUP3a99 (41% glyphosateIPA), 30.3% a.e.NUP3b99 (53.8% glyphosateIPA)NUP5a99 (62% glyphosateMUP) IPA? Note: This isin Attachment 1 – i.e.,probably an IPAformulation.RatsRoundup (41% a.i., 15%surfactant)See doses/responses incolumn 3Reported 72 hour LD50:Baba et al. 19895337 mg formulation/kg bw1619 mg a.e./kg bwData below are from Baba et al.1989, Table 1.DoseMortality dup (360 g/L, 18%LD50: 2300 mg formulation/kg bwDellegrave et al.surfactant)2002MouseRoundupLD50: 5000 mg/kg bwWHO 1994Unit for exposure not specified.RatRoundupLD50: 5000 mg/kg bwWHO 1994Unit for exposure not specified.Goat, femaleRoundupLD50: 4860 mg/kg bwWHO 1994Unit for exposure not specified.[1]Studies with only MRID designations are taken from Table 4.32 of U.S. EPA/OPP 2008a. Some addi
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Glyphosate 1.440 Glyphosate saflufenacil Dash 1.440 24,5 0,5% v/v Glyphosate 2,4-D 1.440 720 Saflufenacil Dash 24,5 0,5% v/v 2,4-D 720 glyphosate: Roundup WG (720 g Kg-1) A eficiência de controle de B. decumbens foi avaliada em diversos perí
The environmental impacts of glyphosate Friends of the Earth Europe, June 2013 Introduction Glyphosate is the world's best-selling chemical herbicide. Glyphosate-containing herbicides, such as Monsanto's Roundup, are the most widely used herbicides in Europe, applied in farming, forestry, parks, public spaces and gardens.
APSA-80 Adjuvant Increases Corn Yield 17.6 bu./acre increase 9-year average Search “APSA-80” at Amway.com to view the full APSA-80 product brochure, as well as historical research data from field test studies and more. Glyphosate with APSA-80 Adjuvant Glyphosate alone Bermuda grass control Glyphosate systemic
APSA-80 Adjuvant Increases Corn Yield 17.6 bu./acre increase 9-year average Search “APSA-80” at Amway.com to view the full APSA-80 product brochure, as well as research data from field test studies and more. Glyphosate with APSA-80 adjuvant Glyphosate alone Bermuda grass control Glyphosate systemic herbicide
67 at doses of glyphosate considered to be "safe" (the US Acceptable Daily Intake - ADI - of 1.75 68 mg/kg bw/day), starting from in utero, may modify the composition of gut microbiome in Sprague 69 . Dawley (SD) rats. 70 Methods 71 Glyphosate alone and Roundup, a commercial brand of GBHs, were administered in drinking
(mostly to glyphosate herbicides, such as Roundup), herbicide use between 1996 and 2011 increased by an estimated 239 million kg. 10. Nearly 67% of agricultural glyphosate herbicide use since 1974 occurred between 2005 and 2014, as GM glyphosate-tolerant crops became widespread. 11. Brazil: GM herbicide-tolerant soy was authorised in 2003.
estrogens. Glyphosate and Roundup can alter sperm counts and sperm motility and alter sexual development in females. Fertility is affected in males. Glyphosate formulations can impact hormonally related breast cell development. (Manservisi, et al., 2019) In fact, regulators have known Roundup damages semen quality since 1995 (Watts, et al., 2016).
Roundup (produced by Monsan-to), is a potential cancer causing agent for humans, based on labo-ratory animal studies.1 The finding adds to the literature of adverse affects linked to glyphosate and has triggered a new round of calls to ban its use. Beyond Pesticides is calling for an end to glyphosate use and urging EPA to suspend its
