And Telomere Support System
HealthyAgingand Telomere Support SystemStep-by-Step GuideBeforeOnce, I could barely walk around the block.Now I can cycle 130 kilometers at a time.I look and feel so confident now.MARINA BAKKER, AGE 542011 ISABODY CHALLENGE FINALISTPlan Your Shake & Cleanse Days PAGE 2Create Your Path to Success PAGE 2Plan Your Shake & Cleanse Days PAGE 3Customize Your 30 Days to Fit Your Lifestyle PAGE 5Find Resources for Support PAGE 6
Healthy Aging and TelomereSupport System OverviewCongratulations on your choice to take the next step toward comprehensivewellness and longevity. The Healthy Aging and Telomere Support System helpsyou stay on track with a 30-day stock of quality products to keep your bodycleansed and nourished the Isagenix way. In addition, you get healthy aging andcomplete nutrition support from our revolutionary Ageless Essentials withProduct B IsaGenesis . Aging never felt, and looked, so good.YOUR HEALTHY AGING SYSTEM CONTAINSTHE FOLLOWING LIFE-CHANGING PRODUCTS:(1) Ionix Supreme: Liquid or PowderBeat stress and increase mental and physical performance naturally withthis powerful Adaptogen-rich tonic.*(1) Cleanse for Life : Liquid or PowderCleanse your way to better health with a synergistic blend of gentle herbs andnutrients to support the body’s natural ability to remove toxins and impurities.*(2) IsaLean Shake: or IsaLean Pro ShakeLose or maintain your weight, stay full, and build or maintain lean muscle with thismeal replacement shake in the world.* Available in Strawberry Cream,Creamy French Vanilla, and Creamy Dutch Chocolate(1) Ageless Essentials with Product B IsaGenesis (Men or Women)A foundational product for your best health and longevity. This 30-daysupplement includes superior healthy aging and whole-body nutritionalsupport. Featuring the newest fourth generation of Product B IsaGenesis forgreater cellular and telomere support, plus a full spectrum of vitamins, minerals,omega-3s and antioxidants for complete nourishment.(1) 2-Day Cleanse Support Kit12 Isagenix Snacks , 4 IsaFlush capsules, 4 Natural Accelerator capsules. Theproducts inside the 2-Day Cleanse Support Kit are to be used on Cleanse Days.Follow the instructions on the Cleanse Day Planner (page 3).Your Pak,Your Way IsaLean ShakeOR IsaLean Pro Canisters or packets Any flavor comboIsagenix is committed to providing you flexibility and simplicity tailoredto help you maximize results. Customize any system or pak with any flavor,packaging or upgrade option. Ionix SupremeSome days you feel like vanilla, some days are made for chocolate, othersyou just want to grab your Cleanse for Life and go. You want the best foryour health and your business, and we want to provide you the best options.Now you can Cleanse for Life Custom build your system or pak the way you like; it’s your call. Canister, sticksor liquid Canister, liquidor singles Ageless Essentials with Product BIsaGenesis For Men or WomenEnjoy Autoship Rewards Pricing with a simple discount structure.Now you can pick any flavor or package and upgrade options are all up to you!* These statements have not been evaluated by the Food and Drug Administration.These products are not intended to diagnose, treat, cure or prevent any disease.Your Path to SuccessFor best results, follow the steps below1.Use the Shake and CleanseDay planner (page 3) toremind you when to take eachproduct. Print additional copiesas needed (IsaProduct.com)and use this tool to suport yoursuccess.2. Follow the Healthy Agingand Telomere SupportSystem monthly scheduleor create a customizedschedule using our Cleanseand Shake Day guidelinesand custom calendar tool(page 5). Planning your daysin advance will help youcreate a routine that fits yourlifestyle and supports yourgoals.3. Take your measurementsand track your successwith our easy-to-usemeasurement tracker (page4). Use the measuring tapeincluded in your Welcome Kit.4. Success loves company—so be sure to enlist anaccountability partner orIsagenix coach like yourenrolling sponsor, spouse,friend or co-worker. Havethis person join you in yourtransformation or have themoffer you daily support byproviding encouragement,tracking your progress andkeeping you focused. You canalso get helpful tips from the“Personal Coaching” section ofIsaProduct.com.5. Buy healthy foods andplan healthy meals. Limittemptation by removingunhealthy foods and snacksfrom your home includingsodas, foods with artificialsweeteners and coloring, andjunk food.Visit IsaProduct.com for healthy recipes.2
Now You’re Ready to BeginSHAKE DAY PLANNERCLEANSE DAY PLANNEREarly Morningqq Drink 1 serving of Ionix Supremeqq Drink 1–2 glasses of purified waterMorning—Breakfastqq Enjoy an IsaLean Shakeqq Take 1 A.M. packet of the Ageless Essentials withProduct B IsaGenesis Late Morning—Snackqq Optional: Choose one serving of a Shake Day snackqq Drink 1–2 glasses of purified waterEarly Afternoon—Lunchqq Eat a healthy, low-glycemic and balanced 400–600calorie mealMid-Afternoon—Snackqq Optional: Choose one serving of a Shake Day snackEvening—Dinnerqq Eat a healthy, low-glycemic and balanced 400–600calorie mealqq Take 1 A.M. packet of the Ageless Essentials withProduct B IsaGenesis Early Morning—Cleanse 1qq Enjoy 1 Deep Cleansing serving* (4 oz) of Cleanse for Lifeqq Take 1 Natural Accelerator capsuleqq Take 1 A.M. packet of the Ageless Essentials withProduct B IsaGenesis Mid Morning—Snackqq Drink 1 serving of Ionix Supremeqq Recommended: Enjoy up to 2 IsaDelight Plus chocolatesqq Take 2 Isagenix Snacks —30 minutes after consumingIsaDelight Plus chocolatesqq Drink 1–2 glasses of purified waterLate Morning—Cleanse 2qq Enjoy 1 Deep Cleansing serving* (4 oz) of Cleanse for LifeEarly Afternoon—Snackqq Take 2 Isagenix Snacks qq Take 1 Natural Accelerator capsuleqq Drink 1–2 glasses of purified waterMid Afternoon—Cleanse 3qq Enjoy 1 Deep Cleansing serving* (4 oz) of Cleanse for LifeEarly Evening—Snackqq Take 2 Isagenix Snacks qq Drink 1–2 glasses of purified waterEvening—Cleanse 4qq Enjoy 1 Deep Cleanse serving* (4 oz) of Cleanse for Lifeqq Take 1 P.M. packet of the Ageless Essentials withProduct B IsaGenesis .Late Evening—Bedtimeqq Take 1–2 IsaFlush capsules with 8 oz of purified waterSHAKE DAY SNACK OPTIONS (product sold separately) 2 Isagenix Snacks 1 FiberSnacks 1 SlimCakes 1–2 IsaDelight Plus (milk or dark chocolate)1–2 servings of Replenish Whey Thins SHAKE DAY SUPPORT OPTIONAdd 2 oz Cleanse for Life to 64 oz of purified water and drinkthroughout the day. (Additional Cleanse for Life will need to bepurchased).* Follow “Deep Cleansing Directions” on the Cleanse for Life label toensure proper serving size.CLEANSE SUPPORT OPTIONS (product sold separately) For a boost of energy or to manage blood sugar, eat ¼ apple or pear1–2 IsaDelight Plus chocolates (milk or dark chocolate)1–2 servings of Replenish (if you are exercising)2 Isagenix Snacks For more Shake and Cleanse Day tips and tools, see the guidelines section on Page 4 and visit IsaProduct.comRecommended / Optional products sold separately3
Product Usage Calendar & GuidelinesHealthy Aging and Telomere Support System Calendar(Start on any day of the week)SSSSSSShake Day GuidelinesSDay 1Day 2Day 3Day 4Day 5Day 6Day 7SSCSSSSDay 8SDay 15SDay 22SDay 29Day 9Day 10SSDay 16SDay 23Day 11SDay 17Day 18CSDay 24Day 25Day 1 2Day 13SDay 14S*SDay 20Day 19SDay 21SDay 26SDay 27Day 28SDay 30Upper Knee (right)Upper Knee (left)Calf (right)Calf (left)Upper Thigh (right)Upper Thigh (left)ButtocksAbdomenWaistDiaphragmChestUpper Arm (right)Upper Arm (left)NeckWeightMeasurementsDay30 Engage in an exercise program with both aerobic andresistance training. Consult your doctor prior to startingany exercise program. For athletes or those engaging in high-intensity exercise:Consult your trainer or doctor to obtain optimal caloricintake. This may include an extra meal or shake duringthe day. We recommend you do no more than 2 Cleanse Daysconsecutively or within a week and no more than 3consecutive weeks.Measurement trackerDay 11 For meal ideas, go to ChooseMyPlate.gov orIsaProduct.com.Cleanse Day GuidelinesTrack Your ProgressDay 1 It is okay to add Isagenix products such as IsagenixGreens , IsaPro , and IsaFruits to your IsaLean Shake. Drink plenty of water throughout the day. As a guidelinefor healthy adults living in a temperate climate,approximated recommendations** for total waterconsumption is 64 ounces or eight, eight-ounce glassesof waterS Shake DaysC Cleanse Days* To ensure product for next month, make sure to order no later thanday 20 or enroll in the Autoship Rewards program. Enjoying an IsaLean Shake for breakfast is recommended. Only participate in light to moderate levels of exercise onCleanse Days. Drink plenty of water throughout the day. As a guideline forhealthy adults living in a temperate climate, approximatedrecommendations for total water consumption are 64 oz forwomen and 125 oz for men.Additional tools can be foundonline in your Associate Back Officein the “Resources” section andby visiting IsaProduct.com.TotalLostGoalsUse the tape measure included in your Welcome Kit.4
Customize Your Healthy Agingand Telomere Support SystemCREATE A PROGRAM BASED ON YOUR UNIQUE LIFESTYLE.The Healthy Aging and Telomere Support System is a flexible, 30-day program that can easilybe customized to fit your lifestyle and long-term health goals. Day 1 can start any day of theweek. Just remember to include 2 or more Cleanse Days during the month; the rest are ShakeDays. Remember to have at least two Shake Days before your Cleanse Day(s) and follow theShake and Cleanse Day guidelines (on page 4). If you schedule more than two Cleanse Days,you will need to purchase additional Cleanse for Life .Use the calendar below to create your custom, 30-day experience.28 x S Shake Days2 x C Cleanse DaysTo be sure you don’t run out of product by next month; order no later than day 20 or enroll inthe Autoship Rewards program.Please note: When customizing your Healthy Aging and Telomere Support Systemexperience, the Shake and Cleanse Day Guidelines must still be followed (page 4).5
Your Success is Our Success!THAT IS WHY WE HAVE DEVELOPED A COLLECTION OFRESOURCES TO HELP YOU ALONG THE WAY TO A HEALTHIER,MORE ENERGETIC LIFESTYLE.Education: ISAPRODUCT.COMThis easy-to-navigate site contains everything you need to know about theproducts in your 30-Day System. You’ll also have access to coaching calls,product information sheets, videos, fast facts, FAQs, success stories to keepyou motivated, worksheets to track your health goals and much more!Inspiration: ISAMOVIE.COMOur most popular videos demonstrate how Isagenix transforms lives.News: ISAFYI.COMAll of the latest and greatest information about products, incredible deals,breaking news, tips to build your business and much more are in one placeonline!Science ISAGENIXHEALTH.NETLearn more about the science behind our products, FAQs and more!Training: ISAGENIXPODCAST.COMDownload our weekly training calls straight to your iPod, send your prospectsa simple link to the audio or even listen in to the recorded calls from one place.Community: SOCIAL MEDIAAt Isagenix, we’ve long recognized social networking—or what we like tocall “social entrepreneurship”—as a revolutionary way of doing business.IsaGeeks.com, and our Facebook.com/Isagenix, Twitter.com/Isagenix andYouTube.com/Isagenix have something for everyone, including cleansecommunity support and support for creating a business model andleveraging social networks.We have been taking Product Broutinely for a while now because ofour hectic lifestyles. Product B hasgiven us more energy to enjoy life.We are encouraged by how great wefeel and excited about our future.-John and Lori L.DO YOU WANT TO GET YOUR NEXTHEALTHY AGING AND TELOMERESUPPORT SYSTEM FOR FREE? Do you have friends or family that would benefit fromusing the Healthy Aging and Telomere Support System? Do you want to keep losing weight or feel healthier for life? Do you want to earn a part-time income (vacations, carpayments, mortgages) or even a full-time income?Go to IsagenixBusiness.comor talk with your30 dayHealthy Agingsponsor to learn more about the IsagenixOpportunity!6 2016 Isagenix International, LLCAll Rights Reserved 14-0094 12.17.15
(1) 2-Day Cleanse Support Kit 12 Isagenix Snacks , 4 IsaFlush capsules, 4 Natural Accelerator capsules. The products inside the 2-Day Cleanse Support Kit are to be used on Cleanse Days. Follow the instructions on the Cleanse Day Planner (page 3). Your Pak, Your Way IsaLean Shake OR IsaLean Pro Canisters or packets Any .
suppressing effect of telomere shortening depends on intact DNA damage checkpoint, while telomere shortening can promote genomic instability and cancer progression in checkpoint-deficient cells (Greenberg et al, 1999; Artandi & DePinho, 2000; Artandi et al, 2000). POT1 contributes to both telomere maintenance and telomere protection.
number" for ease of tracking (e.g. "SD BUCCAL TELOMERE 1 of 5"). Label the side of tube with the Qubit reading for that sample and the date the tube was created (month/day/year). Store tubes in a single stock standard SD-DNA box (ORANGE) that is reserved for telomere reagents only. Store in -20 PCR freezer, on telomere shelf (2. nd
telomere length in diverse settings is essential for the advancement of the telomere biology field. A quantitative method to measure mean telomere length using the length distribution of the terminal restriction fragments (TRFs) obtained by Southern blots was reported 20 years ago5. Other methods of telomere length measurement have been developed
rently lacking, its effect appears to be dependent on telomere length (28), local chromatin structure (29) and the distance relative to the telomere (30). Furthermore, the analysis of TPE in cells with different genetic back-grounds suggested that the subtelomeric chromatin and thus also the molecular mechanisms that underpin TPE
HT and Telomere Length has also been reported in the young; Jeanclos and colleagues (Jeanclos et al., 2000) had show that Telomere Length is shorter among younger patients with hypertension compared to healthy subjects at the same age. No studies have demonstrated a direct effect or established th e mechanism by which Telomere Length affects
mean rate of telomere shortening was 60 bp per year in individuals with AD (B -0.060; P 0.006). There was a negative association between age and TL in our study. Our study results showed more significant telomere shortening per year in women than that in men. In addition, individuals with AD had greater telomere
expression is upregulated by telomere shortening in cells from FSHD subjects; in some cases 100-fold between cells with long and short telomeres. The effect is progressive with decreasing telomere length and occurs long before terminal telomere shortening would induce replicative senescence. The targets of DUX4 expression are also upregulated as a
038; 0.004, P 0.01). Other independent determinants of telomere length identified in this model were age, gender, baseline telomere length and fraction of neutrophils in the sample from which the DNA was extracted. Telomere shortening with early PN was independent of post-randomisation factors affected by early PN, including
