Prevention And Treatment Of Pressure Ulcers: Clinical .

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Prevention andTreatment ofPressure Ulcers:Clinical PracticeGuideline

Copyright National Pressure Ulcer Advisory Panel, European Pressure Ulcer Advisory Panel and Pan PacificPressure Injury AllianceISBN-10: 0-9807396-5-9 (in print)ISBN-13: 978-0-9807396-5-7 (in print)ISBN-17: 978-0-6480097-1-9 (digital version)Published by Cambridge Media on behalf of National Pressure Ulcer Advisory Panel, European Pressure UlcerAdvisory Panel and Pan Pacific Pressure Injury AllianceAll rights reserved. Apart from any fair dealing for the purposes of private study, research or review, aspermitted under the Copyright Act, no part may be reproduced or copied in any form or by any means withoutwritten permission. Requests to reproduce information can be emailed to admin@internationalguideline.comafter reviewing the general statement on content use at sted citation:National Pressure Ulcer Advisory Panel, European Pressure Ulcer Advisory Panel and Pan Pacific Pressure InjuryAlliance. Prevention and Treatment of Pressure Ulcers: Clinical Practice Guideline. Emily Haesler (Ed.).Cambridge Media: Osborne Park, Western Australia; 2014Disclaimer:This guideline was developed by the National Pressure Ulcer Advisory Panel, the European Pressure UlcerAdvisory Panel and the Pan Pacific Pressure Injury Alliance. It presents a comprehensive review and appraisalof the best available evidence at the time of literature search related to the assessment, diagnosis, preventionand treatment of pressure ulcers. The recommendations in this guideline are a general guide to appropriateclinical practice, to be implemented by qualified health professionals subject to their clinical judgment of eachindividual case and in consideration of the patient consumer’s personal preferences and available resources.The guideline should be implemented in a culturally aware and respectful manner in accordance with theprinciples of protection, participation and partnership.Printed copies of the English version of this guideline can be ordered, and PDFs downloaded, from the followingwebsites:NPUAPEPUAPWounds Australia (previously Australian Wound Management Association) website:Hong Kong Enterostomal Therapists Association SocietyNew Zealand Wound Care Society (NZWCS)Wound Healing Society SingaporeInternational Pressure Ulcer Guideline sginternationalguideline.com

CLINICAL PRACTICE GUIDELINEINTRODUCTIONINTRODUCTIONForewordThis Clinical Practice Guideline presents recommendations and summarizes the supporting evidence forpressure ulcer prevention and treatment. The first edition was developed as a four year collaborationbetween the National Pressure Ulcer Advisory Panel (NPUAP) and the European Pressure Ulcer AdvisoryPanel (EPUAP). In this second edition of the guideline, the Pan Pacific Pressure Injury Alliance (PPPIA) hasjoined the NPUAP and EPUAP. This edition of the guideline has been developed over a two year period toprovide an updated review of the research literature, extend the scope of the guideline and producerecommendations that reflect the most recent evidence. It provides a detailed analysis and discussion ofavailable research, critical evaluation of the assumptions and knowledge in the field, recommendations forclinical practice, a description of the methodology used to develop the guideline and acknowledgements ofthe 112 experts formally involved in the development process.A Quick Reference Guideline version that contains excerpts from the Clinical Practice Guideline is alsoavailable. The quick reference guideline is intended for busy health professionals who require a quickreference in caring for individuals in the clinical setting. Users should not rely on excerpts from the QuickReference Guideline alone.The goal of this international collaboration was to develop evidence-based recommendations for theprevention and treatment of pressure ulcers that could be used by health professionals throughout theworld. An explicit scientific methodology was used to identify and critically appraise all available research. Inthe absence of definitive evidence, expert opinion (often supported by indirect evidence and otherguidelines) was used to make recommendations. Drafts of the recommendations and supporting evidencewere made available to 986 invited stakeholders (individuals and organizations) around the world. The finalguideline is based on available research and the accumulated wisdom of the NPUAP, EPUAP, PPPIA andinternational stakeholders. In this edition of the guideline, a consensus voting process (GRADE) was used toassign a strength to each recommendation. The strength of recommendation identifies the importance ofthe recommendation statement based on potential to improve patient outcomes. It provides an indicationto the health professional of the confidence one can have that the recommendation will do more good thanharm, and can be used to assist in prioritizing pressure ulcer related interventions.Printed copies of the English version of the Clinical Practice Guideline are available through links provided onthe following websites:NPUAP website:www.npuap.orgEPUAP website:www.epuap.orgWounds Australia (previously Australian Wound Management Association) website: www.woundsaustralia.com.auHong Kong Enterostomal Therapist Society website:www.etnurse.com.hkNew Zealand Wound Care Society (NZWCS) website:www.nzwcs.org.nzWound Healing Society Singapore l Pressure Ulcer Guideline website:www.internationalguideline.comSuggested CitationThe NPUAP, EPUAP and PPPIA welcome the use and adaptation of this guideline at an international, nationaland local level. We request citation as the source, using the following format:National Pressure Ulcer Advisory Panel, European Pressure Ulcer Advisory Panel and Pan PacificPressure Injury Alliance. Prevention and Treatment of Pressure Ulcers: Clinical PracticeGuideline. Emily Haesler (Ed.). Cambridge Media: Osborne Park, Western Australia; 2014.1

INTRODUCTIONCLINICAL PRACTICE GUIDELINELimitations and Appropriate Use of This Guideline Guidelines are systematically developed statements to assist health professional and patient consumerdecisions about appropriate health care for specific clinical conditions. The recommendations may not beappropriate for use in all circumstances. The decision to adopt any particular recommendation must be made by the health professional withconsideration to available resources and circumstances of the individual patient. Nothing contained in thisguideline is to be considered medical advice for specific cases. Because of the rigorous methodology used to develop this guideline, the Guideline Development Groupmembers believe that the research supporting these recommendations is reliable and accurate. Everyeffort has been made to critically appraise the research contained within this document. However, we donot guarantee the reliability and accuracy of individual studies referenced in this document. This guideline is intended for education and information purposes only. This guideline contains information that was accurate at the time of publication. Research and technologychange rapidly and the recommendations contained in this guideline may be inconsistent with futureadvances. The health professional is responsible for maintaining a working knowledge of research andtechnology advances that may affect his or her clinical decision making. Generic names of products have been used. Nothing in this guideline is intended as endorsement of aspecific product. Nothing in this guideline is intended as advice regarding coding standards or reimbursement regulations. The guideline does not seek to provide full safety and usage information for products and devices;however commonly available safety and usage tips have been included. Adverse events reported in theincluded research have been reported in the evidence summaries and caution statements. All productsshould be used according to manufacturer’s directions.AbstractThis guideline is the result of a collaborative effort among the National Pressure Ulcer Advisory Panel(NPUAP), European Pressure Ulcer Advisory Panel (EPUAP) and Pan Pacific Pressure Injury Alliance (PPPIA).A comprehensive literature review was conducted on pressure ulcer prevention and treatment. A rigorousscientific methodology was used to appraise available research and make evidence-based recommendationsfor the prevention and treatment of pressure ulcers. Draft guidelines were made available to 986 invitedstakeholder individuals and organizations/societies and stakeholder feedback was considered by theguideline developers. In the final development process, the guideline development team used a consensusvoting process (GRADE) to assign strengths of recommendation. Strength of recommendations indicate theextent to which one can be confident that adherence to a recommendation will do more good than harm,and are indented to assist the health professional to prioritize interventions. The guideline includes 575explicit recommendations and/or research summaries for the following pressure ulcer topics: etiology;prevalence and incidence; risk assessment; skin and tissue assessment; preventive skin care; prophylacticdressings; microclimate control; fabrics and textiles; nutrition; repositioning and early mobilization; supportsurfaces; medical device related pressure ulcers; pressure ulcer classification; wound assessment; monitoringof healing; pain assessment and treatment; cleansing; debridement; wound dressings (including growthfactors and biological wound dressings); assessment and treatment of infection and biofilms; biophysicalagents (e.g. electrical stimulation, negative pressure wound therapy, electromagnetic field treatment); andsurgery. Additional sections address the specific needs of special populations including bariatric individuals,critically ill individuals, older adults, pediatric individuals, individuals in palliative care and individuals in theoperating room setting. The guideline includes sections to assist in implementing the guideline withinorganizations, including quality improvement strategies, quality indicators, health professional educationand recommendations to assist patient consumers. The guideline also includes the NPUAP/EPUAPInternational Pressure Ulcer Classification system, complete with full Category/Stage descriptions andillustrative photography.2

CLINICAL PRACTICE GUIDELINEINTRODUCTIONStrengths of Evidence and Strengths of RecommendationsFull explanation of the methodology is available in Appendix 1: Guideline Methodology. Individual studieswere assigned a ‘level of evidence’ based on study design and quality. The body of evidence supporting eachrecommendation was given a ‘strength of evidence’. A consensus voting process (GRADE) involving all theexperts formally engaged in the guideline development was used to assign a ‘strength of recommendation’that indicates the confidence the health professional can have that the recommended practice will improvepatient outcomes (i.e., do more good than harm). The overall aim of the ‘strength of recommendation’ is tohelp health professionals to prioritize interventions.Strengths of EvidenceThe recommendation is supported by direct scientific evidence from properly designed andAimplemented controlled trials on pressure ulcers in humans (or humans at risk for pressureulcers), providing statistical results that consistently support the recommendation (Level 1studies required).BThe recommendation is supported by direct scientific evidence from properly designed andimplemented clinical series on pressure ulcers in humans (or humans at risk for pressure ulcers)providing statistical results that consistently support the recommendation. (Level 2, 3, 4, 5studies)CThe recommendation is supported by indirect evidence (e.g., studies in healthy humans,humans with other types of chronic wounds, animal models) and/or expert opinionStrengths of Recommendation Strong positive recommendation: definitely do it Weak positive recommendation: probably do it No specific recommendation Weak negative recommendation: probably don’t do it Strong negative recommendation: definitely don’t itGuideline Websitehttp://www.internationalguideline.comThe guideline website will remain accessible during the interim period until the next guideline revision. TheQuick Reference Guideline, sponsor acknowledgement, and supportive documents to the guideline areavailable from the website.3

INTRODUCTIONCLINICAL PRACTICE GUIDELINETABLE OF CONTENTSForeword Suggested Citation .Limitations and Appropriate Use of this Guideline .Abstract .Strengths of Evidence and Strengths of Recommendations Guideline Website .Guideline Developers Acknowledgements .Sponsor Acknowledgements .Executive Summary 11223366910BackgroundThe Etiology of Pressure Ulcers .Prevalence and Incidence of Pressure Ulcers .International NPUAP/EPUAP Pressure Ulcer Classification System . .192644Prevention of Pressure UlcersRisk Factors and Risk Assessment Skin and Tissue Assessment .Preventive Skin Care .Emerging Therapies for Prevention of Pressure Ulcers 46687581Interventions for Prevention and Treatment of Pressure UlcersNutrition for Pressure Ulcer Prevention and Treatment .Repositioning and Early Mobilization .Repositioning to Prevent and Treat Heel Pressure Ulcers .Support Surfaces .Medical Device Related Pressure Ulcers .88102115118134Treatment of Pressure UlcersClassification of Pressure Ulcers Assessment and Monitoring of Healing . .Pain Assessment and Treatment .Wound Bed Preparation .Wound Care: Cleansing Wound Care: Debridement .Assessment and Treatment of Infection and Biofilms . .Wound Dressings for Treatment of Pressure Ulcers Biological Dressings for Treatment of Pressure Ulcers .Growth Factors for Pressure Ulcer Treatment Biophysical Agents in Pressure Ulcer Treatment Surgery for Pressure Ulcers .142148158169170173181195205206209223Special PopulationsBariatric Individuals Critically Ill Individuals .Older Adults .Individuals in the Operating Room . .Individuals In Palliative Care .Pediatric Individuals Individuals with Spinal Cord Injury .2362422482542602682764

CLINICAL PRACTICE GUIDELINEINTRODUCTIONImplementing the GuidelineFacilitators, Barriers and Implementation Strategy .Health Professional Education . .Patient Consumers and Their Caregivers . Quality Indicators for this Guideline .Further Research Needs .Glossary of Terms 286294299303313316AppendicesAppendix 1: Guideline Methodology .3325

INTRODUCTIONCLINICAL PRACTICE GUIDELINEGUIDELINE DEVELOPERSGuideline Development Group (GDG)NPUAPPamela Mitchell, MN, RN, PGDipWHTR (Wales)Clinical Nurse Consultant, Wound Management,Christchurch Hospital, Christchurch, New Zealand.Professor Emeritus, University of North Dakota Collegeof Nursing, Grand Forks, ND, USASiu Ming Susan Law, BScN, MScN, RN, RM,ETNurse Consultant (Wound Management), PrincessMargaret Hospital, Lai Chi Kok, Kowloon, Hong Kong.Janet Cuddigan, PhD, RN, CWCN, FAANAi Choo Tay, BN, Oncology Nursing, CWSDiane Langemo, PhD, RN, FAAN (NPUAP Chair)Associate Professor, University of Nebraska MedicalCenter College of Nursing, Omaha, NE, USASenior Nurse Clinician, Singapore General Hospital,Singapore, Republic of Singapore.Laurie McNichol, MSN, RN, GNP, CWOCN,CWON-APJapanese Society of Pressure Ulcers ObserverClinical Nurse Specialist/WOC Nurse, Cone Health,Greensboro, North Carolina, USAAssociate Professor, Department of Surgical Science,University of Tokyo, Tokyo, JapanJoyce Stechmiller, PhD, ACNP-BC, FAANMethodologist and Editor-in-ChiefAssociate Professor and Chair, Adult and ElderlyNursing, University of Florida, College of Nursing,Gainsville, FL, USAEPUAPLisette Schoonhoven, PhD (EPUAP Chair)Senior Researcher Nursing Science, Radboud UniversityMedical Center, Scientific Institute for Quality ofHealthcare, Nijmegen, The NetherlandsAssociate Professor, University of Southampton,Faculty of Health Sciences, UKTakafumi Kadono, MD, PhDEmily Haesler, BN, PGDipAdvNursingHonorary Associate, Department of Nursing andMidwifery, La Trobe University, Victoria, AustraliaVisiting Fellow, Academic Unit of General Practice,Australian National University, Canberra, AustraliaSmall Working Group (SWG) MembersBackgroundProfessor in Tissue Viability, Birmingham CityUniversity, Birmingham, UKDirector, Welsh Wound Network, Welsh WoundInnovation Centre, Pontyclun, Wales, UKEtiology: Cees Oomens (Leader), David Brienza,Laura Edsberg, Amit Gefen & Pang Chak Hau Prevalence and Incidence of Pressure Ulcers:Catherine Ratliff (Leader), Yufitriana Amir,Margaret Birdsong, Chang Yee Yee, Emily Haesler,Zena Moore & Lin PerryJan Kottner, PhDPrevention of Pressure UlcersMichael Clark, PhDScientific Director Clinical Research, Clinical ResearchCenter for Hair and Skin Science, Department ofDermatology and Allergy, Charité-UniversitätsmedizinBerlin, GermanyCees Oomens, PhD, IrAssociate Professor, Biomedical EngineeringDepartment, Eindhoven University of Technology,Eindhoven, The NetherlandsPPPIAKeryln Carville, PhD, RN (PPPIA Chair)Risk Factors and Risk Assessment: Jane Nixon(Leader), Katrin Balzer, Virginia Capasso, JanetCuddigan, Ann Marie Dunk, Claudia Gorecki, NancyStotts & Aamir Siddiqui Skin and TissueAssessment: Emily Haesler (Leader), Carina Bååth,Margaret Edmondson, Emil Schmidt & Ai Choo Tay Preventive Skin Care: Emily Haesler EmergingTherapies for Prevention: Kerrie Coleman(Leader), Teresa Conner-Kerr, Susan Law, AnnaPolak, Pamela Scarborough & Jakub TaradajProfessor, Primary Health Care and CommunityNursing, Silver Chain Group and Curtin University,Western Australia, Australia6

CLINICAL PRACTICE GUIDELINEInterventions for Prevention and Treatmentof Pressure UlcersINTRODUCTIONSpecial PopulationsNutrition in Pressure Ulcer Prevention andTreatment: Jos Schols (Leader), Mary EllenPosthauer, Merrilyn Banks, Judith Meijers, NancyMunoz & Susan Nelan Repositioning and EarlyMobilization: Zena Moore (Leader), BarbaraBraden, Jill Trelease & Tracey Yap Repositioningto Prevent and Treat Heel Pressure

prevention and treatment of pressure ulcers that could be used by health professionals throughout the world. An explicit scientific methodology was used to identify and critically appraise all available research. In the absence of definitive evidence, expert opinion (often supported by indirect evidence and other .

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