Int J Ayu Pharm Chem - Evacollegeofayurved

Int J Ayu Pharm ChemRESEARCH ARTICLEwww.ijapc.come-ISSN 2350-0204Pharmaceutical Standardization of Brahmyadi GhritaNashir N. Parmar1*, Megha Sangwan2, Nandini More3 and Swati Gadgil41,2,3,4Dept. of Rasashastraavum Bhaishajya Kalpana Vigyan, College of Ayurved, Bharati Vidyapeeth DeemedUniversity, Pune, Maharashtra, IndiaABSTRACTBrahmyadi Ghrita (BG) is a polyherbal formulation; explain in ayurvedic classics to treatvarious CNS conditions which comprise Bacopa monnieri, Brassica campestris, Acoruscalamus, Hemidesmus indicus, Saussurea lappa, Piper longum and Rock salt; processed in cowghee. In present study raw drugs were authenticated with Ayurvedic Pharmacopeia of Indiaparameters. Standard operating procedure (SOP) for Brahmyadi Ghrita was developed in threedifferent batches by maintaining drug proportion and temperature. The three batches wereanalysed and values are compared to get the mean scores & standard values were established.KEYWORDSBrahmyadi, Ghrita, StandardizationGreentree Group PublishersReceived 01/04/20 Accepted 25/04/2020 Published 10/05/2020Parmar et al.Int J Ayu Pharm Chem 2020 Vol. 12 Issue 3[e ISSN 2350-0204]Greentree Group Publishers IJAPCwww.ijapc.com96

INTRODUCTIONMETHODOLOGYAyurved has many herbal and herbo-Selection and authentication of rawmineral formulations in the different dosagedrug:forms. Majority of these formulations areAllGhrita preparations. Ghrita is obtained[mentioned above] were procured from thefrom the class of mammalian of animalmarket and were validated using consensuskingdom, especially of cow ghee. Ghrita ismethod. Goghrita(Cow ghee) was procuredthe best Sneha Dravya among all thefrom the Katraj dairy, Pune, Maharasthra.Snehas, because of its power to assimilatingFurther the samples were standardizedthe properties of the substance whichusing Organoleptic and physicochemicalaccompanies it. Ghrita does not give up itsstandardsown properties even though it is mixed upPharmacopeia of India. Authentications ofwith other substances which are havingraw drugs were done in laboratoryother properties. In the preparation offollowingSnehapaka, particular matter and media, inauthenticated samples were selected.specific ratio is taken and heated along withManufacturing of BG8:oil/ghee at a very specific temperature withThe drugs other than Brahmi werecertain duration till the completion test.subjected to grinding separately so as toHere, the principle is to transfer activeconvert them into powder form (80 messconstituent of herbs in lipid and watersize). Freshly collected Brahmi Panchangaaccording to its solubility.Aim of this studywas washed and pounded to get its fineis to establish standard operating procedurepaste. Fine paste of all the remaining dryfor manufacture of Brahmyadi Ghrita1anddrugs was made by triturating them withstandard parameters for the same.water (20 ml) using mortar and edicguidelines.ThenFinally Brahmipaste & paste of remainingPHARMACEUTICAL STUDYhomogenous ,Siddharthak3,Sariva6,Pippali7,Saindhav lavan, Goghrita and water.Instruments:drugs was pounded & mixed to get aVessels,Gasstove,Measuring cylinder, cloth and glass bottle.Cow ghee was heated on low flame. Thetriturated bolus was added to the cow gheeand mixed well. Then the mentionedamount of water was added and mixturewas subjected to heat on low flame until theParmar et al.Int J Ayu Pharm Chem 2020 Vol. 12 Issue 3[e ISSN 2350-0204]Greentree Group Publishers IJAPCwww.ijapc.com97

testing criteria occurred. As the fulfilmentmean score was taken. Organolepticof testing criteria achieved the preparedcharacters and analytical values ofBrahmyadi Ghrita was filtered through aformulated BG are established throughclean cotton cloth and stored in the air tightthis study (Table 1 and 2). These valuesglass bottle.were different from respective values utical process on ghee with andtemperature. These three batches weredrugs not only extract the lipid solubleactive ingredient but also there is a chanceof change in molecular structure of ghee.analyzed in in-house laboratory and meanscore of these were taken.CONCLUSIONSTable 1 Organoleptic parameter of orLight greenishTasteBitter OdorGhee odorSOPs for manufacture of Brahmyadi Ghritaand standard parameters for the same areestablished.Table 2 Analytical parameter of BGAnalytical ParameterReadingpH7Specific Gravity0.9456Wt/ml0.8 wt/mlFree Fatty acid0.78%Moisture0.15%Burto-refractometer reading42.7Refractive index1.4543Saponification value293.12Acid value2.468DISCUSSIONAll raw drugs used for preparation of BGwere within standard limits of API. Forpreparation of Brahmyadi Ghrita standardoperating procedure (SOP) was followed.Similarly three batches were prepared bymaintainingdrugproportionandtemperature. These were analyzed andParmar et al.Int J Ayu Pharm Chem 2020 Vol. 12 Issue 3[e ISSN 2350-0204]Greentree Group Publishers IJAPCwww.ijapc.com98

8. Murthy K. R., Shrikantha, SharangdharaREFERENCES1. AstangHridayam,ByDr.AnnaMoreshvar Kunte, Chaukhamba SurbharatiSamhita, Varanasi Chaukhambaorientalia,Reprint Edition-2009, ch.9, P. 115.Prakashan, Varanasi 2010. Page. No. 780.2. (Brahmi)The Ayurvedic pharmacopoeiaof India, Government of India Ministry ofHealth and Family Welfare, Department ofAyush, Vol.2, Part 1, No. 11, p.25.3. (Sidhharthak)TheAyurvedicpharmacopoeia of India, Government ofIndia Ministry of Health and FamilyWelfare, Department of Ayush, Vol.3, Part1, No. 86, p.194.4. (Vacha)The Ayurvedic pharmacopoeiaof India, Government of India Ministry ofHealth and Family Welfare, Department ofAyush, Vol.2, Part 1, No. 74, p.177.5. (Kushtha)TheAyurvedicpharmacopoeia of India, Government ofIndia Ministry of Health and FamilyWelfare, Department of Ayush, Vol.1,Part1, No. 50, p.105.6. (Sariva)The Ayurvedic pharmacopoeiaof India, Government of India Ministry ofHealth and Family Welfare, Department ofAyush, Vol.1, Part 1, No. 68, p.144.7. (Pippali) The Ayurvedic pharmacopoeiaof India, Government of India Ministry ofHealth and Family Welfare, Department ofAyush, Vol.4,No. 42, p.105.Parmar et al.Int J Ayu Pharm Chem 2020 Vol. 12 Issue 3[e ISSN 2350-0204]Greentree Group Publishers IJAPCwww.ijapc.com99

Int J Ayu Pharm Chem 2020 Vol. 12 Issue 3 www.ijapc.com 96 [e ISSN 2350-0204] Int J Ayu Pharm Chem RESEARCH ARTICLE www.ijapc.com e-ISSN 2350-0204 ABSTRACT Brahmyadi Ghrita (BG) is a polyherbal formulation; explain in ayurvedic classics to treat