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Course ContentPhysiologyFirst M.B.B.S. ( From August 2019)(Based on Medical Council of India, Competency based Undergraduate curriculum for theIndian Medical Graduate, 2018. Vol. 1; page no.91-118 )Lectures(hours)-160Self directed learning ( hours)-Teaching hours25Small group teachings/tutorials/Integrated teaching/Practicals(hours)-310divided equally in all three subjects .Competency No.Topics & subtopics1General PhysiologyTotal(hours) -495 Early clinical exposure(hours)- 90 to bePY. 1.1Structure and Functions of a Mammalian CellPY. 1.2Principles of HomeostasisPY. 1.3Intercellular communicationPY. 1.4Apoptosis – Programmed cell deathPY. 1.5Transport mechanisms across cell membranesPY. 1.6Fluid compartment of the body, its ionic composition & measurementsPY. 1.7Concept of pH & Buffer systems in the bodyPY. 1.8Molecular basis of resting membrane potential and action potential in excitable tissuePY. 1.9Methods used to demonstrate the functions of the cells and its products, its communication and their applications inClinical care and research.2Topic: HematologyPY. 2.1Composition & functions of blood componentsPY. 2.2Original, forms, variations and functions of plasma proteinsPY. 2.3Synthesis and functions of Hemoglobin & explain its breakdown. Describe variants of hemoglobin

PY. 2.4RBC formation (erythropoiesis & its regulation) and its functionsPY. 2.5Types of anaemias & JaundicePY. 2.6WBC formation (granulopoiesis) & its regulationPY. 2.7Formation of platelets, functions & variationsPY. 2.8Physiological basis of hemostasis and anticoagulants. Describe bleeding & clotting disorders (Hemophilia, purpura)PY. 2.9Different blood groups and clinical importance of blood grouping, blood banking and transfusionPY. 2.10Types of immunity , development of immunity and its regulationPY. 2.11Estimation Hb, RBC, TLC, RBC indices, DLC, Blood group, BT/CTPY. 2.12Tests for ESR, Osmotic fragility, Hematocrit , findings and interpretion of test results etc.PY. 2.13Steps for reticulocyte and platelet count3Nerve and Muscle PhysiologyPY. 3.1Structure and functions of a neuron and neuroglia; Nerve Growth Factor & other growth factors/cytokinesPY. 3.2Types, functions & properties of nerve fibersPY. 3.3Degeneration and regeneration in Peripheral nervesPY. 3.4Structure neuro-muscular junction and transmission of impulsesPY. 3.5Action of neuro-muscular blocking agentsPY. 3.6Pathophysiology of Myasthenia gravisPY. 3.7Types of muscle fibres and their structurePY. 3.8Action potential and its properties in different muscle types (skeletal & smooth)PY. 3.9Molecular basis of muscle contraction in skeletal and in smooth muscles

PY. 3.10Mode of muscle contraction (isometric and isotonic)PY. 3.11Energy source and muscle metabolismPY. 3.12Gradation of muscular activityPY. 3.13Muscular dystrophy: myopathiesPY. 3.14ErgographyPY. 3.15Effect of mild, moderate and severe exercise and changes in cardiorespiratory parametersPY. 3.16Harvard Step test and impact on induced physiologic parameters in a simulated environmentPY. 3.17Strength-duration curvePY. 3.18Computer assisted learning (i) amphibian nerve – muscle experiments (ii) amphibian cardiac experiments4Gastro-intestinal PhysiologyPY. 4.1Structure and functions of digestive systemPY. 4.2Composition, mechanism of secretion, functions, and regulation of saliva, gastric, pancreatic, intestinal, juices and bilesecretionPY. 4.3GIT movements, regulation and functions ,defecation reflex. Role of dietary fibre.PY. 4.4Physiology of digestion and absorption of nutrientsPY. 4.5Source of GIT hormones, their regulation and functionsPY. 4.6Gut-Brain AxisPY. 4.7Structure and functions of liver and gall bladderPY. 4.8Gastric function tests, pancreatic exocrine function test & liver function testsPY. 4.9Physiology aspects of; peptic ulcer, gastro- oesophageal reflux disease, vomiting, diarrhea , constipation, Adynamicileus, Hirschsprung’s diseasePY. 4.10Clinical examination of the abdomen in a normal volunteer or simulated environment

5Cardiovascular Physiology (CVS)PY. 5.1Functional anatomy of heart including chambers sounds; and Pacemaker tissue and conducing system.PY. 5.2Properties of cardiac muscle including its morphology, electrical, mechanical and metabolic functionsPY. 5.3Events occurring during the cardiac cyclePY. 5.4Generation, conduction of cardiac impulsePY. 5.5Physiology of electrocardiogram (E.C.G.), its applications and the cardiac axisPY. 5.6Abnormal ECG, arrhythmias, heart block and myocardial infarction.PY. 5.7Haemodynamics of circulatory systemPY. 5.8Local and systemic cardiovascular regulatory mechanismsPY. 5.9Factors affecting heart rate, regulation of cardiac output & blood pressurePY. 5.10Regional circulation including microcirculation, lymphatic, coronary, cerebral, capillary, Skin, foetal, pulmonary andsplanchnic circulationPY. 5.11Patho-physiology of shock, syncope and heart failurePY. 5.12Blood pressure & pulse recording at rest and in different grades of exercise and postures in a volunteer or simulatedenvironmentPY. 5.13Record and interpret normal ECG in a volunteer or simulated environmentPY. 5.14Cardiovascular autonomic function tests in a volunteer or simulated environmentPY. 5.15Clinical examination of the cardiovascular system in a normal volunteer or simulated environmentPY. 5.16Recording Arterial pulse tracing using finger plethysmography in a volunteer or simulated environment6PY. 6.1Respiratory PhysiologyFunctional anatomy of respiratory tract

PY. 6.2Mechanics of normal respiration, pressure changes during ventilation, lung volume and capacities, alveolar surfacetension, compliance, airway resistance, ventilation, V/P ratio, diffusion capacity of lungsPY. 6.3Transport of respiratory gases: Oxygen and Carbon dioxideRegulation of respiration -- Neural & chemicalPY. 6.4Physiology of high altitude deep sea divingPY. 6.5Principles of artificial respiration oxygen therapy, acclimatization and decompression sicknessPY. 6.6Pathophysiology of dyspnea, hypoxia, cyanosis asphyxia; drowning, periodic breathingPY. 6.7Lung function tests & their clinical significancePY. 6.8Technique to perform & interpret SpirometryPY. 6.9Examination of the respiratory system in a normal volunteer or simulated environmentPY. 6.107Technique to perform measurement of peak expiratory flow rate in a normal volunteer or simulated environmentRenal PhysiologyPY. 7.1Structure and function of kidneyPY. 7.2Structure and functions of juxta glomerular apparatus and role of renin-angiotensin systemPY. 7.3Mechanism of urine formation and processes involvedPY. 7.4Significance & implication of Renal clearancePY. 7.5Renal regulation of fluid and electrolytes & acid-base balancePY. 7.6Innervations of urinary bladder, physiology of micturition and its abnormalitiesPY. 7.7Artificial kidney, dialysis and renal transplantationPY. 7.8Renal Function TestsPY. 7.9Cystometry and discuss the normal cystometrogram

8Endocrine PhysiologyPY. 8.1Physiology of bone and calcium metabolismPY. 8.2Synthesis, secretion, transport, physiological actions, regulation and effects of altered (hypo and hyper) secretion ofpituitary gland, thyroid gland, parathyroid gland, adrenal gland, pancreas and hypothalamusPY. 8.3Physiology of Thymus & Pineal GlandPY. 8.4Function tests: Thyroid gland; Adrenal cortex, Adrenal medulla and pancreasPY. 8.5Metabolic and endocrine consequences of obesity & metabolic syndrome, Stress response. Outline the psychiatrycomponent pertaining to metabolic syndromePY. 8.6Mechanism of action of steroid, protein and amine hormones9Reproductive PhysiologyPY. 9.1Sex determination; sex differentiation and their abnormalities and outline psychiatry and practical implementation ofsex determinationPY. 9.2Puberty: onset, progression, states; early and delayed puberty and outline adolescent clinical and psychologicalassociationPY. 9.3Male reproductive system: functions of testis and control of spermatogenesis & factors modifying it and outline itsassociation with psychiatric illnessPY. 9.4Female reproductive system: (a) functions of ovary and its control; (b) menstrual cycle – hormonal, uterine andovarian changesPY. 9.5Physiological effects of sex hormonesPY. 9.6Contraceptive methods for male and female. Discuss their advantages & disadvantagesPY. 9.7Effects of removal of gonads on physiological functionsPY. 9.8Physiology of pregnancy, parturition & lactation and outline the psychology and psychiatry-disorders associated withit

PY. 9.9Interpret a normal semen analysis report including(a) sperm court, (b) sperm morphology and (c) sperm motility, as per WHO guidelines and discuss the resultPY. 9.10Physiological basis of various pregnancy testsPY. 9.11Hormonal changes and their effects during perimenopause and menopausePY. 9.12Common causes of infertility in a couple and role of IVF in managing a case of infertility10PY. 10.1NeurophysiologyOrganization of nervous systemPY. 10.2Functions and properties of synapse, reflex, receptorsPY. 10.3Somatic sensations & sensory tractsPY. 10.4Motor tracts, mechanism of maintenance of tone, control of body movements, posture and equilibrium & vestibularapparatusPY. 10.5Structure and functions of reticular activating system, autonomic nervous system (ANS)PY. 10.6Spinal cord, its functions, lesion & sensory disturbancesPY. 10.7Functions of cerebral cortex, basal ganglia thalamus, hypothalamus. Cerebellum and limbic system and theirabnormalitiesPY. 10.8Behavioural and EEG characteristics during sleep and mechanism responsible for its productionPY. 10.9Physiological basis of memory, learning and speechPY. 10.10Chemical transmission in the nervous system. (Outline the psychiatry element)PY. 10.11Clinical examination of the nervous system: Higher functions, sensory system, motor system, reflexes, cranial nervesin a normal volunteer or simulated environmentPY. 10.12Normal EEG formsPY. 10.13Perception of smell and taste sensation

PY. 10.14Patho-physiology of altered smell and taste sensationPY. 10.15PY. 10.16Functional anatomy of ear and auditory pathways & physiology of hearingPathophysiology of deafness. Hearing testsFunctional anatomy of eye, physiology of image formation, physiology of vision including colour vision, refractiveerrors, colour blindness, physiology of pupil and light reflexPhysiological basis of lesion in visual pathwayAuditory & visual evoke potentials(i) Testing of visual acuity, colour and field of vision and (ii) hearing (iii) Testing for smell and (iv) taste sensation involunteer/ simulated environmentPY. 10.17PY. 10.18PY. 10.19PY. 10.2011Integrated PhysiologyPY. 11.1PY. 11.2PY. 11.3PY. 11.4Mechanism of temperature regulationAdaptation to altered temperature (heat and cold)Mechanism of fever, cold injuries and heat strokeCardio-respiratory and metabolic adjustment during exercise; physical training effectsPY. 11.5PY. 11.6PY. 11.7Physiological consequences of sedentary lifestylePhysiology of InfancyPhysiology of aging; free radicals and antioxidantsCardio-respiratory changes in exercise (isometric and isotonic) with that in the resting state and under differentenvironmental conditions (heat and cold)Interpretation of growth chartsInterpretation of anthropometric assessment of infantsConcept, criteria for diagnosis of Brain death and its implicationsPhysiological effects of meditationPY. 11.8PY. 11.9PY. 11.10PY. 11.11PY. 11.12

PY. 11.13PY. 11.14History taking and general examination in the volunteer / simulated environmentBasic Life Support in a simulated environment

Paper wise distribution of topicsYear: First MBBSPaperISubject:SectionPhysiologyTopicsAMCQs on all topics of the paper IB&CGeneral PhysiologyBloodRespiratory SystemCardio Vascular System,Cardio-respiratory and metabolic adjustment during exerciseRenal systemGastro intestinal systemLife style, aging, MeditationAETCOM module no. 1.2 & 1.3Scenario based / application questions can be on any topic of thepaper IFor long answer question and scenario based / applicationquestions , topics will not be repeatedIIAMCQs on all topics of the paper IIB&CEndocrine PhysiologyReproductive System, Physiology of InfancySpecial sensesCentral nervous system including brain deathTemperature Regulation & appliedNerve muscle physiologyScenario based / application questions can be on any topic of thepaper IIFor long answer question and scenario based / applicationquestions , topics will not be repeated

Internal AssessmentPhysiologyApplicable w.e.f August 2019 onwards examination for batches admitted from June 2019 onwardsSr.NoI-Exam (December)Theory1100Practical(Including 05Marks forJournal & LogBook )50II-Exam (March )TotalMarksTheory150100Preliminary ExaminationsSr.No1Theory200III-Exam (July)Practical Including10 Marks forJournal & Log Book100Sr.NoTotal Marks3001PracticalIncluding 05Marks forJournal & LogBook50Total Marks150Remedial internal assessment examination forNon - eligible studentsOctoberPractical Including 10TheoryMarks for Journal &Total MarksLog Book200100300

1. There will be 3 internal assessment examinations in the academic year. The structure of Preliminary examinationsshould be similar to the structure of University examination.2. There will be only one additional examination for absent students (due to genuine reason) after approval by theCommittee Constituted for the same. It should be taken after preliminary examination and before submission ofinternal assessment marks to the University.3. First internal assessment examination will be held in December, second internal assessment examination will be heldin March and third internal assessment examination will be held in July.4. Internal assessment marks for theory and practical will be converted to out of 40. Internal assessment marks, afterConversion, should be submitted to university by 7th of August.5. The student must secure at least 50% marks for total marks (combined in theory and practical / clinical: not less than40% marks in theory and practical separately) assigned for internal assessment in a particular subject in order to beeligible for appearing at the final university examination of that subject. Internal assessment marks will reflect asseparate head of passing at the summative examination.6. Remedial internal assessment examination for Non - eligible students: Student who were not eligible due to lessthan 50% combined or less than 40% in any theory or practical, will re appear as repeater student for Prelim examwhich will be conducted before Supplementary Exam. His/her internal assessment will be calculated on the basis ofthis Examination marks only. Students who will not be eligible in this Examination will appear with regular batch asrepeater student.7. The internal assessment marks of the remedial examination alone shall be considered and converted into out of 40.8. Conversion Formula for calculation of marks in internal assessment examinations

Internal assessment Eligibility to appear for final University examinationTotal marks: Conversion(after conversion out of 40)formula (out of 40) (40% Separately in Theory and Practical, 50% Combined)FirstIASecondIAThird IA(Prelim)Theory100100200400Total marks obtained1016 (minimum)Practical5050100200Total marks obtained516 (minimum)Total of Theory PracticalMust be 40.9. Conversion formula for calculation of marks in Remedial internal assessment examinationEligibility to appear for Supplementary Exam.Remedial Exam Int. Assess. marks conversion formula (after conversion out of 40 )(Prelim)(out of 40)(40% Separately in Theory and Practical, 50%Combined)Theory200Practical100Total marks obtained5Total marks obtained2.516 (minimum)16 (minimum)Total of Theory PracticalMust be 40.While preparing Final Marks of Internal Assessment, the rounding-off marks shall done as illustrated in following tableInternal Assessment Marks15.01 to 15.4915.50 to 15.99Final rounded marks1516

First Year MBBS Practical Mark’s Structure Internal Assessment Examinations I & II (Applicablefor batch admitted in M.B.B.S Course from Academic Year 2019-20 & onwards)PhysiologyMax.MarksHematologyClinical Examination/Human Physiology expt. / Short exercisesJournal/LogbookOral VivaTotalABCDE152051050

First Year MBBS Physiology Practical Mark’s Structure (Prelim exam)(Applicable w.e.f August 2019 onwards examination for batches admitted from June 2019 onwards)Seat No.Exercise 1C.V.SMax.Mark’sClinical ExaminationR.SC.N.S. &GeneralSpecialExam &SensesAbdomenExercise 2Exercise Exercise3*4**HematologyShortHumanJournalexercise Physiology & LogExperiment *Short exercises 3 marks each(3X5)1. Case based scenarios/ endocrine disorders photographs .2. Interpretation of function tests. 3. One skeletal graph4. One cardiac graph 5. Calculation** Exercise 4: Human Physiology Experiment 1. Basic Life Support in a simulated environment 2. ECG 3. Spirometry 4. PEFR 5. EEG Interpretation 6.Ergography 7. Harward step test 8. Perimetry* Suggested Methods of AssessmentPreclinical exam & OSPE(Please Note - The above examination pattern will be applicable to the students admitted from Academic Year 2019-20 and onwards, which is informed to allMedical Colleges vide University letter No MUHS /X-1 /UG /1692 /2020 Date: 28/02/2020)

First Year MBBS Physiology Practical Mark’s Structure(MUHS)(Applicable w.e.f August 2019 onwards examination for batches admitted from June 2019 onwards)Exercise 1C.V.SMax.Mark’sClinical ExaminationR.SC.N.S. &GeneralSpecialExam &SensesAbdomenExercise 2Exercise GHI10.010.010.010.010.015.015.08020.0PR/Oral TotalJ100*Short exercises 3 marks each(3X5)1. Case based scenarios/ endocrine disorders photographs .2. Interpretation of function tests. 3. One skeletal graph4. One cardiac graph 5. Calculation** Exercise 4: Human Physiology Experiment 1. Basic Life Support in a simulated environment 2. ECG 3. Spirometry 4. PEFR 5. EEG Interpretation6. Ergography 7. Harward step test 8. Perimetry* Suggested Methods of AssessmentClinical exam & OSPE(Please Note - The above examination pattern will be applicable to the students admitted from Academic Year 2019-20 and onwards, which is informed to allMedical Colleges vide University letter No MUHS /X-1 /UG /1692 /2020 Date: 28/02/2020)

MAHARASHTRA UNIVERSITY OF HEALTH SCIENCES, NASHIKFORMAT / SKELETON OF QUESTION PAPER1. Course and Year:First MBBS2. Subject Code: Appendix - a7. Remu. (PS):8. Remu. (PM):12. Web Old QP: [(applicable w.e.f. Sept. 2020& onwards examinations)3. Subject(PSP):(TT):4. Paper ::9. Web PatternAnatomy / Physiology / Biochemistry: [Instructions:1)2)3)4)5)5. Total MarksI]10. Web Skeleton:6. Total Time100: []11. Web Syllabus:3 Hrs.: []Rs. 300/Rs. 350/]SECTION “A” MCQFill(dark) the appropriate empty circle below the question number once only.Use blue/black ball point pen only.Each Question carries One mark.A student will not be allotted any marks if he/she overwrites, strikes out or puts white ink on the circle once filled(darkened)Do not write anything on the blank portion of the question paper if written anything, such type of act will beconsidered as an attempt to resort to unfair means.SECTION “A” MCQ (20 Marks)Q1.Multiple Choice Questions (Total 20 MCQ of One mark each) (4 MCQ Should be clinical application 1 20)SECTION “B”1) Use blue/black ball point pen only.2) Do not write anything on the blank portion of the question paper. If written anything, such type of act will be consideredas an attempt to resort to unfair means.3) All questions are compulsory.4) The number to the right indicates full marks.5) Draw diagrams wherever necessary.6) Distribution of syllabus in Question Paper is only meant to cover entire syllabus within the stipulated frame. The Questionpaper pattern is a mere guideline. Questions can be asked from any paper’s syllabus into any question paper. Studentscannot claim that the Question is out of syllabus. As It is only for the placement sake, the distribution has been done.7) Use a common answerbook for all sections.Instructions:SECTION “B” (80 Marks)2.Brief answer questions (Any Ten out of Eleven)a)3.b)c)d)e)f)g)h)(10x 2 20)i)j)k)Short Answer Questions (Any Eight out of Nine)(8x5 40)One SAQ has to be on AETCOM Module (For Anatomy 1.1, 1.5, For Physiology 1.2.,1.3&For Biochemistry, 1.4)& Minimum 2 SAQs should be Case Based Questions/ Clinically applied Questions.a)b)c)d)e)f)g)h)i)4.Long Answer Questions (Any Two out of Three)a)b)c)Note: All questions should be structured .Wherever necessary; split up of marks should be specified.(2x 10 20)

MAHARASHTRA UNIVERSITY OF HEALTH SCIENCES, NASHIKFORMAT / SKELETON OF QUESTION PAPER1. Course and Year:First MBBS2. Subject Code: Appendix - a7. Remu. (PS):8. Remu. (PM):12. Web Old QP: [(applicable w.e.f. Sept. 2020& onwards examinations)3. Subject(PSP):(TT):4. Paper ::9. Web PatternAnatomy / Physiology / Biochemistry: [Instructions:1)2)3)4)5)5. Total MarksII]:10. Web Skeleton6. Total Time100: []11. Web Syllabus:3 Hrs.: []Rs. 300/Rs. 350/]SECTION “A” MCQFill(dark) the appropriate empty circle below the question number once only.Use blue/black ball point pen only.Each Question carries One mark.A student will not be allotted any marks if he/she overwrites, strikes out or puts white ink on the circle once filled(darkened)Do not write anything on the blank portion of the question paper if written anything, such type of act will beconsidered as an attempt to resort to unfair means.SECTION “A” MCQ (20 Marks)1.Multiple Choice Questions (Total 20 MCQ of One mark each) (4 MCQ Should be clinical application 1 20)SECTION “B”1) Use blue/black ball point pen only.2) Do not write anything on the blank portion of the question paper. If written anything, such type of act will be consideredas an attempt to resort to unfair means.3) All questions are compulsory.4) The number to the right indicates full marks.5) Draw diagrams wherever necessary.6) Distribution of syllabus in Question Paper is only meant to cover entire syllabus within the stipulated frame. The Questionpaper pattern is a mere guideline. Questions can be asked from any paper’s syllabus into any question paper. Studentscannot claim that the Question is out of syllabus. As It is only for the placement sake, the distribution has been done.7) Use a common answer book for all sections.Instructions:SECTION “B” (80 Marks)2.Brief answer questions (Any Ten out of Eleven)a)3.b)c)d)e)f)g)h)i)(10x 2 20)j)k)Short Answer Questions (Any Eight out of Nine)(8x5 40)Minimum 2 SAQs should be Case Based Questions/ Clinically applied Questions.4.a)b)c)d)e)f) g)h)i)Long Answer Questions (Any Two out of Three)b)a)b)c)Note: All questions should be structured .Wherever necessary, split up of marks should be specified.(2x 10 20)

MAHARASHTRA UNIVERSITY OF HEALTH SCIENCES, NASHIKMARKLIST FOR PRACTICAL / ORAL / VIVA VOCE(Summer / Winter – 20 Exam (MBBS UG Courses)(Applicable for batch admitted in M.B.B.S Course from Academic Year 2019-20 & onwards)Course : FIRST MBBSCENTRE :Date : / /20Subject : PhysiologyMarks : (Practical Practical/Clinical Viva ) Min. 50 Max. 100Batch :PracticalSeat No.Max.MarksOral/VivaTotalC.V.CR.SC.N.S. &SpecialsensesAbdomenExercise (2)HematologyExercise (3)ShortExerciseHuman PR/OralTotalABCDEFGHIJ101010101015158020100Note : Both Examiners should jointly conduct practical examination for each student.Verified above entries from Answerbooks and we hereby certify that the marks entered against each Seat Number are found correct.NAME OF EXAMINER1234COLLEGESIGNATURE WITH DATEConvenerInternalExternalExternal

Books recommended:1) Textbooks of Physiology :Guyton - Textbook of PhysiologyGanong - Review of Medical PhysiologyS. Wright - Applied Physiology2) Reference Books :Best and Taylor - Physiological basis of medical practiceBerne & levy. - Principles of PhysiologyDr. V.G. Ranade - Laboratory Manual and Journal of Physiology PracticalsGhai’s VP Varshney, Mona Bedi- Textbook of Physiology -9 th Edition2019.G.K. Pal-Comprehensive Text Book of Medical Physiology.

B & C General Physiology Blood Respiratory System Cardio Vascular System, Cardio-respiratory and metabolic adjustment during exercise Renal system Gastro intestinal system Life style, aging, Meditation AETCOM module no. 1.2 & 1.3 Scenario based /

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