HEALTH SCIENCES CENTER 32ND ANNUAL . - Marshall University

HEALTH SCIENCES CENTER32ND ANNUAL RESEARCH DAYAT MARSHALL UNIVERSITYMARCH 6, 2020Oral and Poster PresentationsMarshall University Medical Center Huntington, West VirginiaPlanning CommitteePast Invited Lecturers2019 WinnersGuest SpeakerList of PresentersConference AgendaAbstracts:Oral Session 1Oral Session 2Oral Session 3Oral Session 4Poster Session 1Poster Session 2Evaluation codeScan QR codePage 4Page 6Page 10Page 11Page 12-13Page 14Page 21Page 27Page 35Page 41Page 47Page Atrium8:30am10:30am1:15pm3:15pm9:30 am2:30pm

This event is supported annually by educational grantsfrom the following Endowments:Dr. Albert C. Esposito MemorialThelma V. Owen MemorialRichard J. Stevens MemorialFaculty Disclosure Policy 2020As a provider accredited by the ACCME, Marshall UniversityJoan C. Edwards School of Medicine must ensure balance, independence,objectivity, and scientific rigor in all its individually provided or jointlyprovided educational activities. All event faculty participating in aprovided activity are expected to disclose to the activity audience anysignificant financial interest or other relationship with the manufacturer(s)of any commercial product(s) and/or provider(s) of commercial servicesdiscussed in an educational presentation and 2) with any commercialsupporter(s) of the activity. Also, all event faculty are required to discloseany planned discussion of an unlabeled use of a commercial product oran investigational use not yet approved for any purpose by the FDA.No Faculty Disclosure or conflicts of interest are indicated for thisCME activity.Disclosure of Conflicts of InterestMarshall University Joan C. Edwards School of Medicine (MUJCESOM)requires instructors, planners, managers and other individuals who arein a position to control the content of this activity to disclose any realor apparent conflict of interest they may have as related to the contentof this activity. All identified real or apparent conflicts of interest arethoroughly reviewed and resolved by MUJCESOM’s planning process forfair balance, scientific objectivity of studies mentioned in the materialsor used as the basis of content, and appropriateness of patient carerecommendations. Disclosure information will be presented verbally orin print to participants before presentation of the agenda lectures.Completed faculty disclosure forms are on file in the CME Office.Marshall University Joan C. Edwards School of Medicine is accredited by theAccreditation Council for Continuing Medical Education (ACCME)to provide continuing medical education for physicians.2 MARSHALL UNIVERSITY MEDICAL CENTER

2 0 2 0 R E S E A R C H D AYThe conference will consist of a series of oral and posterpresentations highlighting basic and clinical research performedby School of Medicine students, residents and fellows. Please usepages 12 and 13, to locate presenters, their abstracts, presentationtimes and location of presentation. The complete agendabegins on page 14. The complete syllabus is available online esearch-graduateeducation/research-dayINTENDED AUDIENCEThe Health Science Center 32nd Annual Research Day atMarshall University is designed for physicians, residents, basicscientists, medical students, graduate students, and otherinterested health professionals.GOALS1) To involve faculty, medical and graduate students in theprocess required to formally present their research in eitheroral or poster presentations.2) To inform and involve the community in ongoing researchat Marshall University Joan C. Edwards School of Medicine.3) To encourage the attitude among faculty, residents, andstudents for Continuing Medical Education in the area ofclinical research.GLOBAL LEARNING OBJECTIVESBy the end of these lectures the participant will be able to:1) Compare different approaches to medical investigation.2) Compare and contrast the importance of basic research andcellular mechanisms as it relates to human disease.3) Discuss and review research related to current and futureimprovements in the clinical management of patients.4) Interpret and analyze data for medical investigation topotentially determine the effectiveness towards improvingpatient care.5) Stress the importance of translational research benefits to thebasic scientist in support of the practicing physician.32ND ANNUAL RESEARCH DAY 3

CREDIT STATEMENTMarshall University Joan C. Edwards School of Medicinedesignates this live educational activity for a maximum of5.0 AMA PRA Category 1 Credits . Physicians should only claimcredit commensurate with the extent of their participation in theactivity. (Session Registration and Evaluation are required).EVALUATION FORM CompletionPlease follow specific instructions for completing the bar codedevaluation form. Keep your “X’s” in the bubbles and your writtencomments in the designated boxes. Your input is needed forplanning future events.ASSISTED SERVICESIf special arrangements are required for an individual with adisability to attend these events, please contact ContinuingMedical Education at (304) 691-1770 no later than 1 week beforethe event date or See a CME Representative at the RegistrationArea on the day of the event.NO RELEVANT CONFLICTS INDICATED BY DISCLOSUREUma Sundaram, MD, Conference Chair, Vice-Dean, Researchand Graduate EducationDavid N. Bailey, MBA, Assistant Dean, CMERichard D. Egleton, PhD, Associate Professor, Biomedical SciencesElsa I. Mangiarua, PhD, Professor, Biomedical SciencesParis N. Johnson, Program Support Coordinator, CME RegistrationAmy Jones, Program Support Coordinator, CME RegistrationSheanna Spence, MSJ, Director of External AffairsJoseph A. Haun, IT Client Services Manager4 MARSHALL UNIVERSITY MEDICAL CENTER

R E S E A R C H D AY

PAST INVITED LECTURERS2019 Bishr Omary, MD, PhDExecutive Vice Dean for Research and Chief Scientific Officer, Chair Departmentof Molecular and Integrative Biology at the Univeristy of Michigan and the nextpresident of the AGA.1. The Intermediate Filament Cytoskeleton in Health and Disease2018 Zijian Xie, PhDDirector Marshall Institute for Interdisciplinary Research (MIIR)1. The Discovery of Na/K-ATPase as a Potential Drug Target for Multiple Human Diseases2017 Julian E. Bailes, Jr., MDNeurosurgery SpecialistNorthShore Medical Group, Evanston, IL1. Concussions2016 Naji Abumrad, MDChair Emeritus, Department of SurgeryJohn L. Sawyers Professor of SurgeryVanderbilt University School of MedicineNashville, TN1. The Life of an Academic Surgeon Persevere, Don’t be afraid, Explore2015 Richard J. Johnson, MDTomas Berl Professor and ChiefDivision of Renal Diseases and HypertensionUniversity of Colorado Anshutz CampusAurora, CO1. The Role of Sugar (fructose) in the Great Epidemics of Diabetes and Obesity2014 - Jose S. Pulido, MD, MS, MBA, MPHProfessor of Ophthalmology and Molecular MedicineAssociate in Neuro-oncologyMayo Clinic Cancer CenterRochester, MN1. The Topology of Blinding Eye Disease2. Breaking bad and Breaking good2013 - John J. Cannell, MDExecutive DirectorVitamin D CouncilSan Luis Obispo, CA1. The Use of Vitamin D in Clinical Practice2012 - William Thies, Ph.D.Vice President, Medical Scientific AffairsAlzheimer’s AssociationChicago, IL1. Alzheimers Today and the Future2011 – Susan S. Smyth, MD, Ph.D.Professor of MedicineDirector, MD/Ph.D. ProgramUniversity of Kentucky1. Cardiovascular Complications of Obesity6 MARSHALL UNIVERSITY MEDICAL CENTER

PAST INVITED LECTURERS2010 – Gregory Germino, MDDeputy Director of the National Institute of Diabetes and Digestive & KidneyDisease (NIDDK) at the National Institutes of Health (NIH)Bethesda, Maryland1. Dia-besity: converging problems, emerging science2008 – Gregory Alan Hale, MDAssociate Professor of PediatricsUniversity of Tennessee1. Transplantation and Cellular Therapies: Current Research and Future Opportunities2. An introduction to Hematopoietic Cell Transplantation2007 –Daniel D. Bikle, M.D., Ph.D.Professor of Medicine and DermatologyIn residence University of California1. The skin game: Calcium and vitamin D regulated cellular differentiation2. Vitamin D: how much do we need and why2006 - Mark E. Shirtliff, Ph.D.Assistant Professor, Department of Biomedical SciencesDental School, University of Maryland-BaltimoreBaltimore, Maryland1. Staphylococcus aureus biofilms: in vitro and in vivo studies2006 - J. William Costerton, Ph.D.Director & Professor, Center for Biofilms, School of DentistryUniversity of Southern CaliforniaLos Angeles, California1. Biofilms in Device-related and other Chronic Bacterial Diseases2005 – William F. Balistreri, MDDirector, GastroenterologyCincinnati Children’s Hospital Medical Center1. Inborn Errors of Bile Acid Biosynthesis2. Viral Hepatitis 20052004 – Joseph S. McLaughlin, MDProfessor Emeritus of SurgeryUniversity of Maryland1. Traumatic Ruptured Aorta2. Strange Tumor I Have Known2003 – W. Jackson Pledger, Ph.D.Professor, Interdisciplinary OncologyUniversity of South Florida College of MedicineTampa, Florida1. Regulation of proliferation by cyclin dependent kinase2. Functional genomics and cancer therapy2002 – Alan H. Jobe, M.D., Ph.D.Professor of PediatricsCincinnati Children’s Hospital Medical CenterCincinnati, Ohio1. Mechanisms of lung injury in the preterm2. Translational research on lung maturation based on clinical observations32ND ANNUAL RESEARCH DAY 7

PAST INVITED LECTURERS2001 - Arnold Starr, M.D.Director, Alzheimers’ Research CenterInstitute Brain Research of California, Irvine1. Hearing but not understanding: auditory nerve dysfunction in the presence ofpreserved cochlear receptors2. Patients’ stories and their seminal importance for research2000–Fredrick L. Brancati,M.D.,M.H.S.Associate Professor, Medicine and EpidemiologyJohn Hopkins Medical Institute1. Novel risk factors for type 2 diabetes mellitus and their implications for treatment2. Prevention and clinical epidemeology in the new milleniuum1999 – Robert B. Belshe, MDDirector and Professor, Div. of Infectious Diseases and ImmunologySt. Louis University1. Live attenuated influenza vaccine: using genetics to defeat the flu2. Vaccines for the 21st century1998 – Jerome S. Brody, MDVice-Chairman of Medicine for Research, Professor of MedicineDirector, Pulmonary CenterBoston University School of Medicine1. Lung development: lesson from flies connections to cancer2. Molecular approaches to the diagnosis of lung cancer1997 – Rochelle Hirschhorn, MDProfessor of Medicine, Department of MedicineNYU School of Medicine1. Advances in defects in host defense2. Reflection on the changing face of medicine1996 – Stuart F. Schlossman, MDBaruj Benacerraf Professor of MedicineHarvard Medical SchoolChief, Division of Tumor ImmunologyDana-Barber Cancer Institute, Boston1. Human T-cell activation2. What’s in a name – cd nomenclature1995 – Frank M. Torti, MPH, MD, FACPDirector, Comprehensive Cancer CenterProfessor Charles L. Spurr Professor of MedicineSection Head for Hematology/Oncology, Wake Forest UniversityChairman, Department of Cancer BiologyBowman Gray School of Medicine1. New pathways for the regulation of iron2. Popeye spinach and iron: the politics1994 – Abner Louis Notkins, MDBDirector, Intramural Research ProgramChief, Laboratory of Oral Medicine National Institute of Dental Research,National Institutes of Health, Bethesda, MD1. Polyreactive antibody molecules and matter2. The Bethesda experiment8 MARSHALL UNIVERSITY MEDICAL CENTER