CURRICULUM AND STUDENT GUIDE Cellular . - School Of Medicine

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CURRICULUM AND STUDENT GUIDECellular and Molecular Pharmacology and Physiology (CMPP)Graduate ProgramUniversity of Nevada, Reno1. Program DescriptionThe Cellular and Molecular Pharmacology and Physiology (CMPP) program is part of theinterdisciplinary Molecular Biosciences graduate program at the University of Nevada, Reno. Themission of the CMPP program is to prepare students for a competitive research and teaching career inbiomedical sciences. A flexible multidisciplinary basic science curriculum is combined with advancedcourses in cellular and molecular biology, pharmacology and physiology provides the background andunderstanding needed for students to succeed in conducting biomedical research. Individual mentoringby the faculty fosters development of skills in critical thinking, experimental design, execution andanalysis, statistics, using the literature, grant writing, manuscript preparation, oral presentations, andlaboratory management. The focus of the doctoral research is tailored to the student's interests, goalsand abilities and typically requires four to five years to complete.Student Learning Objectives To enhance your knowledge in molecular biology, genetics, biochemistry, cell biology,physiology and pharmacology To understand the scientific method, formulate hypotheses and set up controlled experiments To learn a broad array of techniques to tackle multidisciplinary research questions To familiarize the student with ethics in science To develop a critical mind To work independently with minimal supervision in a collaborative environment To develop manuscript and grant writing skills and effectively communicate ideas and resultsContactsDean J. Burkin, Ph.D.Professor of PharmacologyDirector, Cellular and Molecular Pharmacology and Physiology (CMPP) ProgramCenter for Molecular Medicine,University of Nevada School of MedicineTel: 775-784-6288Fax: 775-784-1620Email: dburkin@medicine.nevada.edu2. Degree RequirementsThe minimum requirement for a Ph.D. are set by the Graduate School at 72 graduate units including atleast 48 units in course work. A maximum of 24 units of course work (with grades of "B" or better)from a master's degree program may be allocated toward the doctoral degree. (A Credit TransferEvaluation Request Form available online from the Graduate School must be approved by the student'sadvisory committee, the Graduate Program Director and, the Dean of the Graduate School.)

The minimum CMPP Graduate Program requiresCMPP Core Curriculum47 required course units (see below)Electives1 electives (700 level)Dissertation24 unitsTotal units required72 unitsThe specific program of study will be determined by the student and his or her Advisory / ExaminationCommittee (see below).The following courses (46 units) are required by the CMPP Graduate Program unless waived by thestudent’s Advisory / Examination Committee and the Executive Committee.BCH 705 Molecular Genetics3 units - offered every FALLCMB 710 Molecular Cell Biology4 units - offered every SPRINGPCB 711 Systems physiology7 units – offered every SPRINGPHAR 710 Molecular Pharmacology3 units - offered every FALLPHAR 725 Ethics and Scientific Research 2 units - offered FALL odd yearsCSH 780: Biostatistics in Public Health3 units - offered every FALLCMPP 740 Neuroeffector Pharmacology3 units – offered every 3rd FALLCMPP 770 Research Rotation6 unitsCMPP 790 Seminar6 unitsCMPP 794 Journal Club-Colloquium6 unitsCMPP Independent Study/Qualifying Exam 3 unitsCMPP 795 Comprehensive Exam1 unitsIn addition to these courses, a CMPP Ph.D. student must take at least 2 graduate units of electivesselected by the student and the Advisory / Examination Committee.Recommended Electives for CMPP (highlighted), although any elective may be chosen3BCH 613 Molecular BiophysicsPHAR 750 Molecular Mechanisms of ExcitabilityPHAR 730 Intro to Imaging & OpticsPHAR 770 Reproductive Pharmacology33 - offered every 3rd FALL3 - offered every 3rd FALL3 - offered every 2nd FALLOther ElectivesBCH 704 BiochemistryBCH 706 Functional GenomicsBCH 740 EnzymologyBME 730: Introduction to Imaging & OpticsMICR 700: Biotechnology Today & TomorrowMICR 780: Intro Cellular ImmunologyMICR 784: Molecular Mech Virus3333233See Section 4 for an Example Plan of StudyA full-time graduate student may not register for more than sixteen (12) graduate units in any semester,or more than six (6) graduate units in any six-week summer session. Graduate assistants may notregister for more than twelve (12) graduate units per semester. More than 12 credits requires anoverload memo from the director.2

Students who register for nine (9) graduate units or more in a semester are considered full-time. To beconsidered full-time for financial aid purposes, all graduate students, including those onassistantships, must be enrolled in at least nine (9) graduate units;A minimum of 72 graduate units is required, including at least 48 units in course work. At least 30units of 700-level courses beyond the bachelor’s degree, not including dissertation units, arerequired for the doctoral degree.Program Completion RequirementsGraduate School Academic Requirements:All graduate students must maintain a cumulative graduate GPA of 3.0. If their GPA drops below3.0 they are either placed on probation or dismissed. Undergraduate courses will not count towardsgraduate GPA.Probation: students whose cumulative graduate GPA is .1 to .6 points below that needed for a 3.0GPA are put on probation. Students are placed on academic probation for one semester. If they failto raise their cumulative GPA to 3.0 by the end of one semester, they are dismissed from theirgraduate program. Thesis, dissertation, S/U graded credits, and transfer credits have no impact on astudent’s GPA.Dismissal: students whose cumulative graduate GPA is .7 or more grade points below that neededfor a 3.0 GPA are dismissed. Dismissed students are no longer in a graduate program but may takegraduate-level courses as a Grad Special. Students wishing to complete their degree must obtainapproval to take graduate-level courses, raise their graduate GPA to at least 3.0 and then re-applyto a graduate program. Any courses taken to raise their GPA will be included in the graduatespecial/ transfer credit limitation (9 credits for master’s degrees).3. Transfer creditsThese are credits transferred from another institution. Credits completed at UNR in another program oras a graduate special do not need to be transferred. Transfer credit is requested on the Graduate CreditTransfer Evaluation Request form available on Graduate School l/GraduateCreditTransferEvaluationRequest.pdf. andmust be signed by the student, major advisor, and graduate director. Transfer credits applied to amaster’s program must comply with the time limitation on master’s work (6 years). Thus, if a studenttook a course five years prior to admission, they would have to complete the degree within one year forthe course to apply to the degree. Credits from a completed master’s degree will be exempt from the 8year time limitation for those students earning a doctoral degree.4. Timeline for degree completionA PhD in the CMPP graduate program typically requires four to five full years to complete. A samplecourse of study is listed below (note that some courses are not offered every year)Year 1 (Fall)BCH 705CSH 780CMPP 770CMPP 790CourseunitsMolecular GeneticsBiostatistics in Public HealthResearch RotationSeminar3Dissertation units3331

CMPP 794Colloquium/Journal clubTotal course unitsTotal graduate units11111Year 1 (Spring)CMB710Molecular Cell BiologyCMPP 770Research RotationCMPP 790SeminarCMPP 794Colloquium/Journal ClubTotal course unitsTotal graduate units431199Year 1 (Summer)CMPP 797ThesisCMPP 770Research Rotation (if necessary)Total course unitsTotal graduate units4 (2 units per summer term)344Year 2 (Fall)PHAR 725Ethics and Scientific ResearchCMPP 790SeminarCMPP 794Colloquium/Journal ClubCMPP 799DissertationTotal course unitsTotal graduate units211549Year 2 (Spring)PCB 711Systems PhysiologyCMPP 790SeminarCMPP 794Colloquium/Journal ClubCMPP 799DissertationTotal course unitsTotal graduate units7111910Year 2 (Summer)CMPP 797ThesisTotal course unitsTotal graduate units4 (2 units per summer term)44Year 3 (Fall)PHAR 710Molecular PharmacologyORELECTIVECMPP 794Colloquium/Journal ClubCMPP 790SeminarCMPP 799DissertationTotal course unitsTotal graduate units33114594

Year 3 (Spring)CMPP 790SeminarCMPP 795Comprehensive ExamCMPP 793Independent StudyCMPP 794Colloquium/Research RoundsCMPP 799DissertationTotal course unitsTotal graduate unitsYear 3 (Summer)CMPP 797ThesisTotal course unitsTotal graduate units56114 (2 units per summer term)44Year 4 (Fall)PHAR 710Molecular PharmacologyORELECTIVECMPP 797ThesisCMPP 799DissertationTotal course unitsTotal graduate units3334610Year 4 (Spring)CMPP 790SeminarCMPP 799DissertationCMPP 797ThesisTotal course unitsTotal graduate unitsYear 4 (Summer)CMPP 799113115349Dissertationif necessaryTotals66 course units90 graduate unitsIncludes 24 dissertation unitsDoctoral degrees: All course work must be completed within eight years preceding the awarding ofthe degree. Credits transferred into doctoral degree from a completed master’s degree are exempt fromthis eight-year limit.5. Committee selection guidelineFirst Year of Study - The Co-Directors of the Molecular Biosciences Program will advise studentsduring their first year of graduate study. First year students will enroll in CMPP 770 (ResearchRotation in the fall and spring of their first year). These rotations are intended to expose students tothe range of research in the Molecular Biosciences Program and to aid in the selection of an advisor.Students should rotate in a least two different laboratories. In the first two weeks of the first semester,5

students will attend presentations by CMPP faculty interested in recruiting students into theirlaboratory in order to become familiar with faculty research and available research opportunities.Selection of the Advisory/Examining Committee – Upon completion of the second rotation, eachstudent will select a Dissertation Advisor who will serve as chair of their Advisory/EvaluationCommittee. The Dissertation Advisor must agree to take the student on and will be responsible forsupporting the student’s research and providing a stipend consistent with CMPP guidelines. Studentswho are unable to identify a willing mentor at the completion of the second rotation will be advised bythe members of the Student Oversight Committee over the summer following the first year of study. Ifa mentor cannot be found, the Committee will provide the Program Director with a written summary ofthe student’s performance in course and research work and may recommend that the student bedismissed from the Ph.D. program. Once a mentor is chosen student should complete the declaration ofmentor form and submit to the Graduate school:Declaration of Advisor form - erThe Advisory/Examining committee will consist of at least five members of the Graduate Faculty: theCommittee Chair/Permanent Advisor, at least two members of the CMPP Graduate Program, at leastone faculty member from a department in a field related to the student's major, and at least onegraduate faculty member representing the university-at-large. (For doctoral students, the researchadvisor may be a different faculty member than the permanent chair.) Students may request theappointment of a qualified faculty member from another university or from a relevant discipline orprofession. Formal approval of the student's advisory/examining committee is made by the GraduateDean. The Advisory/Examination Committee will hold an initial meeting prior to or early in the fallsemester of the second year of study. The committee will approve the Qualifying Exam, the programof study, and the dissertation. It will also conduct the formal oral part of the doctoral dissertationdefense and serve in an advisory capacity to the student during his or her tenure in the CMPP program.The student and committee will meet annually to prepare a written progress report consisting of a listof the courses the student has taken, the courses proposed for the next year, and the tentative date forthe Qualifying Exam. The committee should review the students program of study which should besubmitted to the Graduate School:Program of Study form - am-of-study.pdfDoctoral Programs: Consist of a minimum of five graduate faculty members; the chair, at least twofaculty members from the student’s major department/program, at least one faculty member from adepartment in a field related to the student’s major, and at least one Graduate School representative.In case of interdisciplinary graduate programs, the Graduate School Representative cannot have aprimary appointment in the same department (or other appropriate major unit) as the student'scommittee chair.Formal approval of all student advisory committees is made by the Graduate Dean6. Comprehensive ExamsStudents must pass a Comprehensive Exam consisting of a written research proposal and oralexamination by the Advisory/Examination Committee in order to be a candidate for a Ph.D. degree.6

Students are required to enroll in CMPP 795 in the semester in which they plan to take theComprehensive Exam. Students are allowed 2 semesters to complete the Comprehensive Exam – signup for the class in one semester and finish in the 2nd semester, then a grade change form is submitted.Failure to complete the Qualifying Exam will result in an Incomplete in this course.The grant proposal of the Comprehensive Exam must be in the standard NIH format for a multi-yearRO1 grant as described in PHS form 398 8.html)It must include (suggested page limits):1. Abstract (1 page)2. Specific Aims (1 page)3. Research Strategy (12 pages)(a) Background(b) Significance(c) Innovation(d) Preliminary Studies (optional)(e) Approach4. Literature Cited5. Human Subjects or Vertebrate Animals (as appropriate) (3 pages)It should not include personnel, budget or facilities pages. Standard English grammar and spelling andaccurate citation to work by others are required.The topic must be approved by the Advisory/Examining Committee before the student begins writing.It can be an extension of the student's current research problem if it represents a significant advance ornovel approach to the problem. It cannot be the same as a research project described in any grantsubmitted by the advisor or collaborators. Resources that may be consulted include the library,PubMed, the Advisory / Examining Committee, other researchers and other students. The finisheddocument must be the student’s own work. The proposal should be sent out to the examiningcommittee at least two weeks prior to the date of the comprehensive examination to allow time for thecommittee to evaluate the proposal.The student's doctoral committee will formally examine the student orally on the grant. If the grantproposal is not considered acceptable, a revised grant proposal will be due two months from the date ofthe first examination. If the student fails the second examination he or she will be dropped from theprogram. This exercise is viewed as an important component of the student's training and education.To pass the exercise, students will need to be well-versed in the current literature in their field, and beable to formulate and defend their research plan and methodology. Students will also be expected toanswer questions about the principles and factual basis of the research being proposed as well as anyprinciples and facts of biomedical science that the committee feels the student should know to advanceto candidacy. This exam will introduce the student to the style, complexities and nuances of the grantproposal process and will begin to develop those skills necessary for obtaining extramural researchgrants and for defending their ideas before other scientists.In order for a student to pass the Qualifying Exam, the Advisory/ Evaluation Committee must reach aconsensus that the student has written an acceptable proposal and performed satisfactorily in the oralexamination. This consensus will be provided to the Program Director. If the Committee cannot reachsuch a consensus, they may offer the student the opportunity to revise the written proposal, to repeatthe oral examination, or both within a period determined by the Committee. Alternatively the7

Committee will provide the Program Director with a written summary of the student’s performance inQualifying Exam, course and research work and a recommendation that the student be dismissed fromthe Ph.D. program. The Program Director and Advisory/ Evaluation Committee will decide if thestudent’s work merits awarding a Master’s Degree or if the student should be dismissed from theCMPP Graduate Program. The final decision will be forwarded to the Graduate School. Per GraduateSchool policy, students cannot continue in the CMPP Ph.D. program without passing the QualifyingExam.7. Thesis requirementsDissertation and Final Examination Requirements - Prior to choosing a date for the final oralexamination, graduate students must submit a copy of their final dissertation for review by theirexamining committee. The dissertation does not have to be in its final form, but must containsufficient information to allow their committee to make an informed decision about the state ofcompletion of their studies. The purpose of the review is to discern whether a student has sufficientlycompleted their studies to schedule the public seminar and final examination.The format of the dissertation must meet the requirements of the Graduate School. If a student has firstauthor publications accepted in refereed journals, the student may solicit the committee to use thesepublications together with an appropriate introductory chapter in lieu of the standard dissertationformat. The committee may determine that additional chapters are required along with the publishedpapers. The thesis should be sent out to the examining committee at least four weeks prior to the dateof the thesis defense.Following acceptance of the dissertation by the Advisory/Examination Committee, all doctoralcandidates in the CMPP program will schedule and present a public research seminar on theirdissertation research. This seminar will constitute part of the final examination and must be presentedwhile the candidate is still in residence. Following the public seminar, the Advisory/ExaminationCommittee will conduct a final oral examination in closed session. This oral examination will beconducted in accordance with the examination requirements of the Graduate School. Doctoralcandidates may register for one credit of Independent Study during the semester in which this seminaris presented.8. Graduate AssistantshipsAll graduate students holding an assistantship (teaching GTA or GRA) are considered Nevadaresidents for tuition purposes. Non-resident tuition is only waived for the duration of the assistantship.To be eligible for an assistantship, students must be admitted to a degree-granting program and be ingood academic standing. The student must have an overall GPA of at least 3.0 and must becontinuously enrolled in at least 6 graduate level credits (600-700) throughout the duration of theassistantship.State-funded assistantships (GTA/GRA) may be held for a maximum of: three (3) years for master’sdegree students and five (5) years for doctoral degree students.For more information on graduate assistantships please refer to:General information: ships8

Graduate Assistantship handbook: e/hr/hrgraduate/GA handbook.pdf9. Health insuranceAll domesti

Center for Molecular Medicine, University of Nevada School of Medicine Tel: 775-784-6288 Fax: 775-784-1620 Email: dburkin@medicine.nevada.edu 2. Degree Requirements The minimum requirement for a Ph.D. are set by the Graduate School at 72 graduate units including at least 48 units in course work.

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