WE’VE ALWAYS HAD THE NOW WE HAVE ANOTHER

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Pay as little as 25 or save up to 200per Saxenda prescription.Check your prescription coverage first! See back cover for more details.When it comes to losing weight and keeping it offWE’VE ALWAYS HAD THENOW WE HAVE ANOTHERActor Portrayals.Managing obesity like the long-term disease it is requiresmore than willpower alone. Adding Saxenda to a reducedcalorie meal plan and increased physical activity may helpyou lose weight and keep it off.Indications and UsageWhat is Saxenda ?Saxenda (liraglutide) injection 3 mg is an injectable prescriptionmedicine that may help some adults with excess weight (BMI 27)who also have weight-related medical problems or obesity (BMI 30)lose weight and keep the weight off. Saxenda should be used with areduced-calorie meal plan and increased physical activity Saxenda is not for the treatment of type 2 diabetes Saxenda and Victoza have the same active ingredient, liraglutide,and should not be used together Saxenda should not be used with other GLP-1 receptor agonistmedicines Saxenda and insulin should not be used together It is not known if Saxenda is safe and effective when taken withother prescription, over-the-counter, or herbal weight-loss products It is not known if Saxenda changes your risk of heart problems orstroke or of death due to heart problems or stroke It is not known if Saxenda can be used safely in people who havehad pancreatitis It is not known if Saxenda is safe and effective in children under18 years of age. Saxenda is not recommended for use in childrenPlease see additional ImportantSafety Information throughout andPrescribing Information, includingMedication Guide, at http://www.novo-pi.com/saxenda.pdf

WHY IS IT SO HARD TOLOSE WEIGHT?Changes in your appetitehormone levels make it difficultto lose weight and keep it offObesity needs to be treatedseriously, just like any otherchronic diseaseWhen you lose weight, your body’s natural responseincludes an increase in a key hunger hormone anda decrease in fullness hormones, undermining yourability to lose weight and keep it off. Losing weight and keeping itoff requires a long-term planAPPETITE HORMONES AFTER WEIGHT LOSSHUNGERFULLNESSEssentially, your body works againstyou as you lose weight—making youfeel hungrier and less full.2 A reduced-calorie meal planand increased physicalactivity are critical, butbecause of your body’snatural response toweight loss, you mayrequire medicalintervention

WHERE AM I IN THEWEIGHT LOSSCYCLE?Change your approach1 Defining Moment:I’ve made up my mind. It’s time to do this.2 Consideration:I’m feeling determined. I’m ready toconsider the options I have available. I’llchoose the one to help me reach my goal.3 Momentum:I see a difference in my weight and sodo others. I can do this.4 Plateau:It’s getting harder and I’m not losing weightanymore. Life is getting in the way. This isreally frustrating.NOTE:This is often where people find ithard to follow their plans and canrevert back to old ways.5 Collapse:I’m tired of this. I can’t keep it up, so I’m notgoing to and it’s a relief to stop trying so hard.6 Fatigue:I feel exhausted and sad. I don’t even wantto think about my weight right now.4It’s no longer about finding a quick fix—it’sabout focusing on your ongoing weight lossand weight management.Increasing your physical activity and building alow-calorie meal plan that fits your lifestyle are keyto reducing your weight, but you may need more.Your body’s naturalreaction to weight lossDo you know what is the body’s typicalnatural response to weight loss?When calorie intake is reduced, metabolismbegins to slow down. The body then adjusts,decreasing feelings of fullness and increasingfeelings of hunger, also known as appetite.When it comes to weight loss,change starts with small steps: Choose what you are willing to do Make it a part of your daily routine Take it 1 day at a timeMake a PlanQuick FactWorking with your health care provider to create,monitor, and adjust your plan over time is an importantpart of weight management. Tell your health careprovider where you are in the weight loss cycle.Did you know losing 5% to 10% of yourweight is clinically significant?Source: Ethnographic Weight-Loss Patient Journey Study.Novo Nordisk Inc. Custom Research January 2015.Taking off weight and keeping it off may helpimprove some weight-related health conditions.

HOW DOES SAXENDA WORK?Saxenda addresses your body’s naturalresponse to weight lossYour body naturally produces anappetite hormone that helpsregulate your hunger.FULLNESSHUNGERSaxenda works in a similar way,helping you to feel less hungry—and feel full with less food. Saxenda works by regulatingyour appetite, which can leadto eating fewer calories andweight loss Saxenda is not a stimulantThe exact way that Saxenda regulatesappetite is not fully understood.Start the conversation with your health care providerby completing the Weight Exploration Report atSaxenda.com/Anotherway.Print the report and take it into your health care provider.Important Safety InformationWhat is the most important information I should knowabout Saxenda ?Serious side effects may happen in people who take Saxenda , including:Possible thyroid tumors, including cancer. Tell your health careprofessional if you get a lump or swelling in your neck, hoarseness,trouble swallowing, or shortness of breath. These may be symptoms ofthyroid cancer. In studies with rats and mice, Saxenda and medicinesthat work like Saxenda caused thyroid tumors, including thyroidcancer. It is not known if Saxenda will cause thyroid tumors or a typeof thyroid cancer called medullary thyroid carcinoma (MTC) in people.Do not use Saxenda if you or any of your family have ever had MTC,or if you have an endocrine system condition called Multiple EndocrineNeoplasia syndrome type 2 (MEN 2).Who should not use Saxenda ?6Do not use Saxenda if: you or any of your family have a history of MTC you have MEN 2. This is a disease where peoplehave tumors in more than one gland in their bodyTell your health care provider aboutyour efforts to lose and keep weight off.Ask for FDA-approved Saxenda .Important Safety InformationWho should not use Saxenda ? (cont’d) you are allergic to liraglutide or any of the ingredients inSaxenda . Symptoms of a serious allergic reaction may include:swelling of your face, lips, tongue, or throat, fainting or feelingdizzy, very rapid heartbeat, problems breathing or swallowing,and severe rash or itchingTalk with your health care provider if you are not sure if you arepregnant or planning to become pregnant. Saxenda may harm yourunborn babyBefore taking Saxenda , tell your health care provider about allof your medical conditions, including if you: have any of the conditions listed in the section “What is the mostimportant information I should know about Saxenda ?” are taking certain medications called GLP-1 receptor agonists are allergic to liraglutide or any of the other ingredients in Saxenda have severe problems with your stomach, such as slowed emptyingof your stomach (gastroparesis) or problems with digesting foodPlease see additional ImportantSafety Information throughout andPrescribing Information, includingMedication Guide, at http://www.novo-pi.com/saxenda.pdf

HOW MUCHWEIGHT CAN I LOSE?85% of people taking Saxenda lost some weightaSaxenda was clinically tested and proven in astudy of more than 2,250 patients. In this study:3OUTOF 5Which means those patients lost an averageof 12 lb (from before they entered the study)1 3OUTOF people taking Saxenda achievedsignificant weight loss of 10% or moreb,c,dWhich means those patients lost an averageof 23 lb (from before they entered the study)6% people taking Saxenda achievedsignificant weight loss of 5% or moreb,c,dof people taking Saxenda achievedweight loss of 20% or moreb,c,dWhich means those patients lost an averageof 47 lb (from before they entered the study)Results were from a 56-week trial of 3,731 adults with body mass index(BMI) 27-29.9 with at least 1 weight-related condition, or BMI 30, notincluding adults with type 2 diabetes. Study participants had an averagestarting weight of 234 lb and an average BMI of 38. All were on areduced-calorie meal plan with increased physical activity and randomizedto receive once-daily Saxenda or placebo. On average, there were 27%of people (Saxenda ) and 34% (placebo) who did not complete the study.Significant weight loss was evaluated at 56 weeks, as per study design.bFor patients taking placebo: 5% or more weight loss was achieved by34% of patients, 10% or more weight loss was achieved by 15% ofpatients, and 20% or more weight loss was achieved by 3% of patients.c3 out of 5 62%; 1 out of 3 34%.dIndividual results may vary.aFind out how SaxendaCare can support your long-termweight management on pages 14-15.Important Safety InformationWho should not use Saxenda ? (cont’d) 8have or have had problems with your pancreas, kidneys or liverhave or have had depression or suicidal thoughtsare pregnant or plan to become pregnant. Saxenda may harmyour unborn baby. Tell your health care provider if you becomepregnant while taking Saxenda . If you are pregnant you shouldstop using Saxenda are breastfeeding or plan to breastfeed. It isnot known if Saxenda passes into your breastmilk. You and your health care provider shoulddecide if you will take Saxenda or breastfeed.You should not do both without talking withyour health care provider firstCheck your prescriptioncoverage first Before you go to the pharmacy, goto SaxendaCoverage.com or call1-888-809-3942 to check yourprescription coverage and find outyour co-pay for Saxenda Important Safety InformationWho should not use Saxenda ? (cont’d)Tell your health care provider about all the medicines you take,including prescription and over-the-counter medicines, vitamins,and herbal supplements. Saxenda slows stomach emptying andcan affect medicines that need to pass through the stomach quickly.Saxenda may affect the way some medicines work and some othermedicines may affect the way Saxenda works. Tell your healthcare provider if you take diabetes medicines, especially sulfonylureamedicines or insulin.Please see additional ImportantSafety Information throughout andPrescribing Information, includingMedication Guide, at http://www.novo-pi.com/saxenda.pdf

CAN I KEEPTHE WEIGHT OFF?In people taking Saxenda for 3 yearsCLINICAL STUDYachieved significantweight loss at year 1, andapproximately half ofthem maintainedweight loss at 3 years when takingSaxenda added to a reduced-calorie mealplan and increased physical activity,compared with people not on the drug.a56%In a 3-year study, 2,254 adults with pre-diabetes and BMI 30or 27 with one or more weight-related conditions were givenSaxenda (1,505 people) or placebo (749 people) added toa reduced-calorie meal plan and increased physical activity.The study looked at how many people lost 5% of their bodyweight. At year 1, 817 people on Saxenda (56%) lost 5% oftheir weight vs 182 patients on placebo (25%). After 3 years,747 people on Saxenda and 322 people on placebo remainedand had their weight measured. 391 of those people onSaxenda (26%) lost 5% of their weight at both the 1- and3-year marks vs 74 people on placebo (10%).aAt no cost to you, SaxendaCare providespersonalized support to help you make the mostof your weight management efforts with Saxenda .Check your prescription coverage and activatea Savings Card at SaxendaCoverage.com.Important Safety InformationHow should I use Saxenda ?Important Safety Information What are the possible side effects of Saxenda ? (cont’d) Inject your dose of Saxenda under the skin (subcutaneousinjection) in your stomach area (abdomen), upper leg (thigh), orupper arm, as instructed by your health care provider. Do not injectinto a vein or muscleNever share your Saxenda pen or needles with another person.You may give an infection to them, or get an infection from them What are the possible side effects of Saxenda ?Saxenda may cause serious side effects, including: possible thyroid tumors, including cancer inflammation of the pancreas (pancreatitis). Stop usingSaxenda and call your healthcare provider right away if you havesevere pain in your stomach area (abdomen) that will not goaway, with or without vomiting. You may feel the pain from yourabdomen to your back gallbladder problems. Saxenda may cause gallbladder problems,including gallstones. Some gallbladder problems need surgery.Call your health care provider if you have any of the followingsymptoms: pain in your upper stomach(abdomen), fever, yellowing of your skin oreyes (jaundice), and clay-colored stools10 low blood sugar (hypoglycemia) in people with type 2diabetes who also take medicines to treat type 2 diabetes.Saxenda can cause low blood sugar in people with type 2diabetes who also take medicines used to treat type 2 diabetes(such as sulfonylureas). In some people, the blood sugar may getso low that they need another person to help them. If you takea sulfonylurea medicine, the dose may need to be lowered whileyou use Saxenda . Signs and symptoms of low blood sugar mayinclude: shakiness, sweating, headache, drowsiness, weakness,dizziness, confusion, irritability, hunger, fast heartbeat, andfeeling jittery. You should check your blood sugar before youstart taking Saxenda and while you take Saxenda increased heart rate. Saxenda can increase your heart ratewhile you are at rest. Your health care provider should checkyour heart rate while you take Saxenda . Tell your health careprofessional if you feel your heart racing or pounding in yourchest and it lasts for several minutes when taking Saxenda Please see additional ImportantSafety Information throughout andPrescribing Information, includingMedication Guide, at http://www.novo-pi.com/saxenda.pdf

HOW DO I TAKE SAXENDA ?WHAT ARE THE POSSIBLESIDE EFFECTS?Saxenda is a once-daily medicine that comesin a prefilled penThe most common side effects of Saxenda are: You can self-inject your medicine each day at any time,with or without foodRecommended dosing schedule to minimizepotential side effects such as nausea:1STARTyour dose at0.6 mg23INCREASESTAYyour dose by0.6 mg each weekWEEK 1WEEK 2WEEK 3WEEK 40.6 mg1.2 mg1.8 mg2.4 mgwhen youreach 3.0 mgWEEK 5NauseaDecreased appetiteDiarrheaUpset ingStomach painLow blood sugar(hypoglycemia)Change in enzyme (lipase)levels in your blood Tell your healthcare provider if you have any side effects thatbother you or don’t go away The most common side effect you may experience when youfirst start Saxenda is nausea. This usually gets better as yourbody gets used to the medicine You should always tell your doctor if you think you are havingany side effect, including nausea. If you do experience nausea,here are some things that may help:––––FULL DOSEIf you experience side effects with the increased dose, callyour health care provider to see if you should adjust yourdosing schedule. Be sure to continue to the full 3.0-mg dose.Eat bland, low-fat foods, like crackers, toast, and riceEat foods that contain water, like soups and gelatinDon’t lie down after you eatGo outside to get some fresh airYou will know if Saxenda is workingfor you if you lose 4% of your body weightin 4 monthsCheck your prescription coverage first and activatea Savings Card at SaxendaCoverage.com.More details on back cover.Important Safety Information To continue receiving your prescription coverage, be sure t

Your body’s natural reaction to weight loss When it comes to weight loss, change starts with small steps: It’s no longer about finding a quick fix—it’s about focusing on your ongoing weight loss and weight management. Increasing your physical activity and building a low-calorie meal plan that fits your lifestyle are key

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