I Semester: Courses Offered By Department Of Organic Chemistry

3y ago
139 Views
27 Downloads
398.73 KB
17 Pages
Last View : Today
Last Download : 2m ago
Upload by : Konnor Frawley
Transcription

UNIVERSITY OF MADRASDEPARTMENT OF ORGANIC CHEMISTRYSCHOOL OF CHEMICAL SCIENCESGUINDY CAMPUS, CHENNAI-600 025Dr. A. K. MOHANAKRISHNAN, M. Sc., Ph.D.,Phone No.22202813/22202815Associate Professor & Head i/cEmail: mohanakrishnan@unom.ac.inM. Sc ORGANIC CHEMISTRY SYLLABUSCHOICE BASED CREDIT SYSTEM (CBCS)I Semester: Courses Offered by Department of Organic ChemistryCourse CodeCHE C201Course TitleStereochemistry and OrganicReaction MechanismCore/ElectiveCoreCredits3Unit I: Stereochemistry (20 h)Chirality, Symmetry elements, Asymmetric and Dissymmetric chiral molecules.Calculation of number of optical isomers. Stereochemistry of mono and di-substitutedcyclopropane, cyclobutane, cyclopentane and cyclohexane. Stereochemistry of trisubstituted cyclopentane, tri-substituted pentane and tetra-substituted hexane.Description of various types of optically active compounds including allenes,cumulenes, spiranes, biphenyls, trans-cyclooctene.Compounds containing two asymmetric centres-Erythro and threo isomers.Conversion of Fischer projection into perspective forms. Erythro and Threo-Interconversion of Fischer to Sawhorse and Newman projections. Zig-Zag representation ofglucose. Interpretation of homotopic, enantiotopic and diastereotopic atoms and faces.Prochiral chiral carbon. R & S nomenclature of simple compounds, allenes, spiranes andbiphenyls. Stereospecific and Stereoselective reactions. Asymmetric Synthesis-Cramsrule. Conformational analysis of cyclohexane. Conformational analysis of di-substitutedcyclohexanes.

Unit II: Aliphatic Nucleophilic Substitution (20 h)Mechanism of nucleophlic substitution reaction: SN1, SN2 and SNi mechanisms.Solvent and leaving group effects and neighbouring group participation (NGP).Substitution at carbonyl, vinylic and bridgehead system. Substitution with ambidentnucleophiles- “O” Vs “C”alkylation. Role of LDA, crown ethers and phase transfercatalysts (PTC) in nucleophilic substitution reactions.Generation of enolates, enolate selectivity (Kinetic Vs Thermodynamic),alkylation of enolates and stereochemistry of enolate alkylation. Mechanism of esterester hydrolysis (only BAC2, AAC2 and AAL1). Alkylation of active methylenecompounds. Asymmetric alkylation (Evans, Enders and Meyers procedures).Preparation and synthetic utility of enamines, Finkelstein reaction Wurtz coupling.Unit III Aromatic electrophilic and nucleophilic substitution (20 h)Aromatic electrophilic substitution: mechanism of nitration, sulfonation, FriedelCrafts alkylation and acylation reactions. Synthesis of di- and tri-substituted benzenesfrom benzene or mono-substituted benzenes. Hammett and Hammett-Taft equation.Haworth reaction (for naphthalene), Scholl reaction, Vilsmeier-Haack formylation,Gattermann reaction, Reimer-Tiemann and Bischler-Napieralski reactions.Aromatic nucleophilic substitution in aryl halids by Meisenheimer complexmechanism and benzyne mechanism. Various methods of benzyne generation andreactions of benzynes (inter and intramolecular). Reactions of aryldiazonium salts.Zeigler alkylation, Vicarious Nucleophlic Substitution (VNS), Chichibabin andSchiemann reactions.Reference books:1. Stereochemistry of Organic compounds-E. N. Eliel2. Stereochemistry and Mechanism through solved problems-Kalsi. A3. Organic Reactions: Stereochemistry and Mechanism-Kalsi. A4. Stereochemistry of Organic Compounds-Eliel & Wilen5. Stereochemistry of Organic Compounds: Principles and Applications-NasipuriEliel & Wilen

6. Organic Chemistry Vol 2: Stereochemistry and the Chemistry of Natural productI. L. Finar7. Advanced Organic Chemistry –Jerry March8. Advanced Organic Chemistry-Part A and B-F. Carey & R. J. Sundberg9. Advanced Organic Chemistry–Smith & March10. Organic Chemistry–Clayden, Greeves & Warren11. Organic Chemistry–M. B. Smith12. Principles of Organic Synthesis-Norman & Coxon13. Organic Synthesis-Stuart WarrenCourse CodeCHE C202Course TitleOrganic Chemistry Practical II.Core/ElectiveCoreCredits3Single Stage Preparations (50 h)Preparation of p-benzoquinone, 2, 5-ditertiarybutylhydroquinone, 4,6dimethylcoumarin, dibenzyllidene acetone, 2,4-dinitrotoluene and benzhydrol.II.Double Stage Preparations (50 h)Preparation of p-bromoacetanilide, p-nitroacetanilide, m-nitrobenzoic acid,symmetric tribromobenzene and 2,4,6-tribromo iodobenzeneReference book:Vogel’s Text book of Practical Organic ChemistryCourse CodeCHE E201Course TitleName Reactions in OrganicChemistryCore/ElectiveElectiveCredits3Unit ICarbon-Carbon bond formation reactions-Perkin, Knovenagel, Wittig, WittigHorner, Vislmeier Haack, McMurray, Glacer, Mannich, Pschorr, Simmons-Smith andThorpe reactions.

Unit IIHeterocycle forming reactions-Paal-Knorr synthesis of pyrroles; Hantschsynthesis of pyridines, Madelung, Reissert and Bischler synthesis of indole; Skraup,Friedländer , Doebner-Miller and Konard-Limpatch synthesis of quinoline. PomerantzFritsch synthesis of isoquinoline.Unit hibabinreaction,Eschweiler Clark reaction, Polonowski reaction, Reissert reaction, Sommlett reactions,Mitsunobu reaction, Leukart reaction, Bucherer reaction, Willegerodt reaction andWillegerodt-Kindler reaction.Reference books:1. Advanced Organic Chemistry –Jerry March2. Advanced Organic Chemistry-Part A and B-F. Carey & R. J. Sundberg3. Advanced Organic Chemistry–Smith & March4. Organic Chemistry–Clayden, Greeves & Warren5. Organic Chemistry–M. B. Smith End of I Semester II Semester: Courses Offered by Department of Organic ChemistryCourse CodeCHE C203Course TitleOrganic Reaction MechanismCore/ElectiveCoreCredits3UNIT – I: Addition and Elimination reactions (20 h)Electrophilic addition to carbon–carbon double and triple bonds. Nucleophilicaddition to carbon–carbon multiple bonds. Generation and addition of carbenesMichael addition and Robinson annulation.Nucleophilic addition to –C O bond- A study of Mannich, benzoin, Darzen’sglycidic ester, Stobbe and Knovenegal condensation reactions-Wittig, Wittig-Hornerolefination reaction- Julia & Peterson alkene synthesis.

Elimination reactions: E1, E2, E1cb and Ei-elimination. Conformation ofmechanism; solvent, substrate, leaving group effects-Saytzeff’s Vs Hoffman elimination;Chugaev and Cope elimination.UNIT – II: Molecular Rearrangements and Name reactions (20 h)A study of mechanism of the following rearrangements: Beckmann, Curtius,Hoffmann, Schmidt, Lossen, Wolff, Pinacol, Wagner Meerwin, Demyanov, DienonePhenol, Favorski, Benzidine, Claisen, Cope, Sommlet-Hauser, Pummerer and VonRichter rearrangements.A study of the following name reactions: Dieckmann cyclization, HoffmannLoffler Freytag reaction, Shapiro reaction, Eschenmoser-Tanabe and Ramburg-Backlundreactions.UNIT – III: Oxidation and Reduction reactions (20 h)Oxidation with Cr and Mn reagents; Oxidation with LTA, DDQ and SeO2;Oxidation using DMSO either with DCC or Ac2O or Oxalyl chloride; Oxidation usingDess Martin reagent. Hydroxylation of olefinic double bonds (OsO4, KMnO4);Woodward and Prevost oxidation. Epoxidation using peracids including Sharplessepoxidation, Ozonolysis.Reduction with NaBH4, LiAlH4, Li(tBuO)3AlH, DIBAL-H, Red-Al, Et3SiH andBu3SnH; Reduction using selectrides, Birch reduction.Hydrogenation (homogenous and heterogeneous), hydration of carbon-carbon doubleand triple bonds.Asymmetric reduction of carbonyl functions (Corey’s procedure).Reference books:1. Advanced Organic Chemistry –Jerry March2. Advanced Organic Chemistry-Part A and B-F. Carey & R. J. Sundberg3. Advanced Organic Chemistry–Smith & March4. Organic Chemistry–Clayden, Greeves & Warren5. Organic Chemistry–M. B. Smith6. Principles of Organic Synthesis-Norman & Coxon

7. Organic Synthesis-Stuart Warren8. Modern Organic Synthesis-H. O. House9. Oxidation in Organic Synthesis-V. K. AhluwaliaCourse CodeCHE E203Course TitleFunctional Group Transformation inOrganic ChemistryCore/ElectiveElectiveCredits3Unit I-Functional group transformations using oxidizing reagentsUse of Chromium reagents (CrO3, K2Cr2O7, CrO2Cl2, PCC, PDC and PFC). Use ofManganese reagents (KMnO4, MnO2, CTAP). Use of RuO4, KBrO3, DMSO, NCS, NaIO4,peracids and boranes.Unit II-Functional group transformations using reducing reagentsUse of NaBH4, NaCNBH3, LiAlH4 and Bu3SnH; Use of Sn/HCl, Zn/HCl,Hydrazine, Li-NH3, Na/alcohol, Pd/H2 and Raney Ni.Unit III-Functional group transformations using miscellaneous reagentsUse of SOCl2, PBr3, PPh3-CCl4, LiBr, NaI, NBS, PPh3-X2, Lawesson’s reagent,Mitsunobu reagent, CH2N2, TMSCHN2 and Barbier-Weiland degradation. Conversionof aldehyde to ketone and vice versa; Conversion of aldehyde to cyanide, Conversion ofcyanide to ester, Conversion of ketone/aldehyde to phenol; conversion of ketone toenone.Reference books:1. Advanced Organic Chemistry –Jerry March2. Advanced Organic Chemistry-Part A and B-F. Carey & R. J. Sundberg3. Advanced Organic Chemistry–Smith & March4. Organic Chemistry–Clayden, Greeves & Warren5. Organic Chemistry–M. B. Smith End of II Semester

III Semester: Courses Offered by Department of Organic ChemistryCourse CodeCHE C601Course TitlePhysical Methods in ChemistryCore/ElectiveCoreCredits4Unit I (Analytical, Inorganic and Physical Chemistry)Unit II (Analytical, Inorganic and Physical Chemistry)Unit III-NMR (Organic Portion: 20 h)Origin of NMR spectrum-Nuclear spin states – NMR active nuclei – Nuclearmagnetic moment–Larmor equation – Absorption of energy and Resonance –Population density of nuclear spin states. Saturation phenomena – Relaxationmechanisms, Bloch equation (only significance and derivation not required).Comparison of CW and FT instrument–Chemical shift - Standards in NMR – Shieldingand Deshielding – Factors affecting chemical shift – electronegativity, hybridization,hydrogen bonding - anisotropic effect – double, triple bond, aromatic compounds andcarbonyl compounds. Spin-spin coupling – splitting origin and rules – factors affectingcoupling constant: cis, trans, gem, ortho, meta, para coupling – exchange withdeuterium. Vicinity of the proton, Long range coupling, Karplus equation and curve. 1J,2J, 3J, 4Jand 5J coupling in NMR, order of NMR spectrum. Spin systems: Two interactingnuclei: A2, AB, AX, AA’BB’, dd, pair of doublet, AB quartet. Three interacting nuclei:AMX, ABX, ABC systems (only pattern is required). 13C NMR – difficulties in recording13CNMR: Homo nuclear and heteronuclear coupling. Decoupling technique: SFORDand Off Resonance decoupled spectrum identification of various types of carbon using13CNMR. APT & DEPT spectrum (DEPT-45, DEPT-90 and DEPT-135).19FNMR – Precessional frequency and heteronuclear coupling. Identification oforganofluoro compounds (CF3CO2Et and CF3CH2OH) using NMR. 31P NMR – Chemical

shift and heteronuclear coupling. Identification of organo phosphorus compounds suchas (CH3)3P, (C2H5O)2P O and Ph3P. P-P bond in NMR.Unit IV (UV, IR and MS: 10 h)(Organic Portion only half of the unit and remaining half of unit by Inorganic Chemistry)Electronic absorption-Beer-Lamberts law, Types of electronic excitation.Chromophore and Auxochrome-Bathochromic and Hypsochromic shift. UV-vis spectraof simple organic compounds such as alkenes, phenols, anilines, carbonyl compoundsand 1,3-diketones.Infrared Spectra: Identification of functional groups in Organic Compounds,Finger print region. Inter and Intramolecular hydrogen bondingOrigin, basics and bloc diagram of Mass spectrum-Various types of Ionizationtechniques-Stability of Molecular ions, Meta stable ions. Base peaks and Isotope peaks.Fragmentation patterns of organic molecules such as benzenes, phenyl halides, phenols,benzyl alcohols, benzyl halides, aliphatic alcohols, aliphatic as well as agmentationpatternsofaliphatic/aromatic nitro and amine compounds. Fragmentation patterns of heterocycliccompounds (furan, pyrrole and pyridine only). McLafferty rearrangements of organicmolecules.Structural determination of Organic Compounds using UV, IR, NMR and MassSpectra.Reference books:1. Organic Spectroscopy–William Kemp2. Spectroscopy of organic compounds – P.S. Kalsi3. Spectrometric identification of Organic compounds-Silverstein, Bassler & Morrill4. Spectrometric identification of Organic compounds-Silverstein & Webster5. A complete introduction to NMR Spectroscopy-Roger S. Macomber6. Organic Spectroscopy Principles & Applications-Jag Mohan7. Introduction to Spectroscopy-Pavia, Lampman and Uriz

Course CodeCHE C204Course TitleOrganic Chemistry Practical IICore/ElectiveCoreCredits3Double Stage Organic Preparations (120 h)Course CodeCHE C205Course TitleOrganic Chemistry Practical IIICore/ElectiveCoreCredits3Multi-Stage Organic Preparations (120 h)Course CodeCHE E601Course TitleBiological ChemistryCore/ElectiveElectiveCredits3Unit I (Organic Chemistry: 20 h)Studies in Carbohydrates: Hexoses : Glucose and Galactose and amino sugars;Disaccharides : Maltose, Sucrose, Cellulose structure; Polysacharides : Starch, Cellulose,Glycogen structure; Glycoaminoglycans: Hyaluronic acid, Dermatan sulphate,Chondratin Sulphate, Heparin; Glyco Proteins: N-Linked and O-Linked glycoproteinsLipids and Membranes: Molecular structure of lipids. Fatty Acids, TriglyceridesTypesof membrane lipids, Membrane Structure-Fluid Mosaic model of membranes.Transport in membranes- Passive, Facilitated and Active Transport.Proteins: Amino acids. Protein structure, Disulphide bond determination. Analysis ofN-terminal and C-terminals in a polypeptide. Sanger method, Edman degradation,Enzymatic analysis etc.Primary, secondary and teritiary structure of proteins. Peptide bond. Synthesis of polypeptides and the importance of protecting groups. Structure of collagen, myoglobin andhaemoglobin.Nucleic Acids: Nucleoside and nucleotide. Nucleo bases and hydrogen bonding.Double helical structure, Types of RNA. Replication of DNA (Semiconservative),Transcription and

1. Organic Spectroscopy–William Kemp 2. Spectroscopy of organic compounds – P.S. Kalsi 3. Spectrometric identification of Organic compounds-Silverstein, Bassler & Morrill 4. Spectrometric identification of Organic compounds-Silverstein & Webster 5. A complete introduction to NMR Spectroscopy-Roger S. Macomber 6. Organic Spectroscopy .

Related Documents:

Texts of Wow Rosh Hashana II 5780 - Congregation Shearith Israel, Atlanta Georgia Wow ׳ג ׳א:׳א תישארב (א) ׃ץרֶָֽאָּהָּ תאֵֵ֥וְּ םִימִַׁ֖שַָּה תאֵֵ֥ םיקִִ֑לֹאֱ ארָָּ֣ Îָּ תישִִׁ֖ארֵ Îְּ(ב) חַורְָּ֣ו ם

2-semester project Semester 1 Semester 2 Semester 3 1-semester project Semester 2 Semester 3 BA to MA Student Semester 1 Semester 2 Select a faculty member to se rve as Project A dvisor Co m plete Project F orm #1, with A dviso r‘s signature, and file it with the Program Director Deve lop a wri tten Project Pr oposa l, and

Manajemen Akuntansi Keuangan Lanjutan 1 Taufan Adi K Muda Setia Hamid Aplikasi Perpajakan Uum Helmina C SEMESTER 5 A1 SEMESTER 5 A2 SEMESTER 5 A3 SEMESTER 5 A4 SEMESTER 5 A5 SEMESTER 5 A6 SEMESTER 5 A7 SEMESTER 5 A8 07.30-10.00 102 203 103 10.10-12.40 104 13.00-15.30 104 307 306 15.30-18.00 306 308 LTD 305 306

¾ Semester duration 16-18 weeks ¾ Semesters 8 ¾ Course Load per Semester 15-18 Cr hr ¾ Number of courses per semester 4-6 (not more than 3 lab / practical courses) Compulsory Requirements (the student has no choice) General Courses to be chosen from other departments Discipline Specific Foundation Courses

Last day to drop 1st 8-week courses with no grade reported on transcript. Last day for 50% refund for full semester courses. Last day to drop a full semester course with no grade reported on transcript. Last day for “W” final grade in full semester courses. 1st 8-week online courses end at 11:59 pm CS

Courses offered through IRSC's Virtual Campus online degree programs (Not all courses offered every semester. Courses subject to change.) Many other online courses are available for IRSC programs. 4 DEADLINE DATES SPRING 2014 Friday, December 20 - Spring deadline to pay IN PERSON by 5:00 p.m.

MASTER OF SCIENCE (M.Sc.) ZOOLOGY First Semester – Fourth Semester (2-year programme) I Semester Examination November 2007 II Semester Examination April 2008 III Semester Examination November 2008 IV Semester Examination April 2009 Syllabus applicable for the students seeking a

Modern Drama (127) BA, 3rd Semester Eng Lang thru Litt Section 2 # (122) 6 / SAT th BA, 5th Semester DSE: Modern Drama (127) BA, 3rd Semester Eng Lang thru Litt . BA, 3 d Semester English Fluency Section 1 (T) 5 / FRI st BA, 1 Semester Section B AECC – English (22) BA,