Cutting Out The Chromosomes Simulation Booklet

Cutting Out the ChromosomesGenotype to PhenotypeSimulation BookletStep #1Step #2Cut out eachpair ofchromosomeson the solidline thatsurroundseach pair.Fold along thedotted linebetween thepair ofchromosomes.Step #3Step #4Glue/tape thefolded pairtogether, pressuntil they areperfectly flat.Watch forundried gluesqueezing outfrom betweenthechromosomes;they may stickwith otherchromosomes!Bring yourchromosomesto school in anenvelopestored in oneof yourbooks. keepyour pairedchromosomesCombining germ cells to createa new baby humanflat!Name: Period:

Making A Face: Genetic SimulationAssessmentPlease assess your own work and fill in your scores on thissheet. This sheet must be attached to your work when youturn it in.TaskOutstandingGoodPoorData Sheet20: Complete,fully filled in,neat25: Complete,thoughtfulanswers, correct10: Partially filled in;sloppy0: Blank or missing15: Fully answered;answers short,inaccurate, and/orincomplete20: Mostly complete,mostly accurate, incolor, some creativity0: Blank or missingQuestionsDrawing ofFaceCooperationAnd FocusGrade Sheet35: Complete,accurate, in color,neatly done,creative10: Workeddiligently,cooperativelywith partner10: Filled in andtotaled by student5: Lack of focus, notworkingcooperatively all thetime3: Partially filled in,not totaledTotal Score (100 possible):Comments:11.After looking at the pictures of all the “children” in your class, how is there somuch variation in the way they look if they come from the same parents?0-15: Incomplete,partiallyinaccurate, not incolor0: disruptive,distracted, and/ordid not workcooper-atively withpartner0: not doneExtra Credit12.Explain why people that had the genotype "ll" had to skip the rest of the chincharacteristics.(25)

7. What does epistatis mean? Explain and give an example.8. Hair color is polygenic. What does this mean?(24)9. How is it that there are so many colors of skin?10.This exercise was a simulation. How much like real human genetics doyou think this was, and why?

Making A Face:A Genetic SimulationConverting Genotype Into Phenotype bySimulating Meiosis and FertilizationCongratulations, you are going to simulate creating a baby!After this simulation, you should be able to answer the following questions: How many chromosome pairs does each human parent have? How many chromosomes does each parent "donate" to the nextgeneration? Are some genes and gene characteristics expressed over others.are dominant and recessive genes responsible for how a babylooks? What is the difference between Genotype and Phenotype? Do some traits require more than one gene to be fully expressed? What are sex-linked traits? How is there so much variation in the way children look even ifthey come from the same parents? What is epistasis? What is a polygenic inheritance?You have been given a pink set of chromosomes if you are going torepresent the mother, and a blue set of chromosomes if you are going torepresent the father. We are asking the question. What would your babylook like if both(1)

you and your classmate (who will simulate the other parent) have onedominant gene and one recessive gene for each of the facial featuresillustrated on the following pages? This, of course, is not the way it reallyis, but this is a simulation. Each of you will be heterozygous (hybrid) foreach trait.Making A Face: Genetic Simulation Questions1. Why did you cut out the chromosomes in pairs?To determine the facial appearance of your child, you and your spouse willdrop your 23 pair of chromosomes to the floor to simulate germ cellformation. This "dropping your chromosomes" will determine which one ofthe pair of chromosomes will enter the successful germ cell. Each parent,mom and dad, donate one and only one of each of their 23 pairs ofchromosomes. Therefore, they each donate 23 chromosomes. Since genesride in the DNA of the chromosomes, each child will end up with a pair ofgenes for each trait, one from the dad and one from the mom.2. When you folded the pair of chromosome and dropped them, what did thatrepresent?3. What is the significance of only one of the pair of chromosomes ending its randomjourney facing up?After you drop your own chromosomes and line them up according to size,then you will pair with your partner by pushing the chromosomes one at atime toward one another until they are side by side. This represents theestablishment of pairs of chromosomes. When you are done you shouldhave twenty three pairs of chromosomes again. The mathematics of sexis. one of each pair from the mother.Plus. one of each pair from thefather equals a pair of each kind for the baby! You essentially will supplyone gene and the other parent will supply one gene for each characteristic.The resulting two genes that are paired up will produce the genotype.Record the genetic contributions from each parent on the chart provided.Translate the genetic information into the phenotypic information (whatwill your baby look like). A mother and father will produce one child only.Then, each student will produce a drawing of his or her child 15 years laterwhen he or she is in high school! Write your own name only on the back ofyour drawing -- we want to see if we can match the mother’s and father’sdrawings of their children. Don't collaborate with your partner on thedrawing assignment. In addition, answer the questions on the Questionsheet.5. When you and your partner pushed the like pairs of chromosomes together, whatwas the number of chromosomes before and after you pushed them together?4. What does this have to do with sex cell formation?6. What is it called when two genes are in a cell and one gene's phenotype isexpressed and one is not? Explain and give an example of when this happened.(2)(23)

EyelashesInstructionsLongMMLongMmShortmmMouth SizeWideQQAverageQqNarrowqqFollow the instructions to make the cut-out, folded chromosome models. Note that thetwo sides of each “chromosome” are different – each side carries a different version(allele) of each gene for this simulation.Lips: ThicknessThickJJThickJjThinjj2. Meiosis: Creating the Germ CellsDimplesDimplesKKDimplesKkAbsentkkNose SizeBigNNMediumNnSmallnnNose ShapeRoundedUURoundedUuPointeduuEarlobe Attachment FreeZZFreeZzAttachedzzHairy EarsPresentDDPresentDdAbsentddFreckles onCheeksPresent Present AbsentFreckles onForeheadPresent@@Present@@Absent @@1. Making the Chromosome ModelsHold your set of chromosomes high in the air above your head. Drop them one at atime to the floor. If they don't twirl then drop them again. When they have all droppedto the floor carefully pick them up without turning them over and find a lab tablewhere you can face each other, then organize them according to size. Your teacher willdemonstrate how they should line up. Equal sizes should be across from each other asyou face your partner. The sex chromosomes should be organized separately from the22 other (autosomal) chromosomes. Keep in mind that you begin this exercise with thechromosome pair above your head, dropping them so that they twirl down to the floorand finally land. Only one of each chromosomal pair faces up. The upward facingone of the pair represents the chromosome that ended up in the successful germ cellthat you have just produced. Yes, those 23 chromosomes that are all neatly lined uprepresent the contents your sperm or egg.3. FertilizationGently push the like-sized chromosomes toward each other at point halfway betweenyou, pairing them up according to size and number. This represents the moment whena new human potential is reached. A totally unique human is conceived!4. Determination of CharacteristicsDetermination of child's sex. After conception, parents are always interested indetermining the sex of their child. In this case the "father" has pushed either an "X"chromosome or a "Y" chromosome toward the middle (which ever dropped facing up)and matched it with the "mother's” "X" chromosome. If an "X", then you have abeautiful little girl, if a "Y", then a beautiful little boy! Record the information on yourdata sheet.(3)(22)Determination of various genotypes. Carefully read the genes on all of thechromosomes and circle the resulting genotypes and phenotypes on your data sheet.These are the genes that make up the new baby’s genotype.

Light BlueFfBbPale BlueffbbRed HairRedPigmentGGLess RedPigmentGgNo RedPigmentggHair TypeCurlyWWWavyWwStraightwwPresentPpAbsentpp5. Envisioning the New PersonTime passes, you get older, your baby is growing up! What doesyour child look like when he or she is a teenager of about 15 yearsof age? Make a full page, color drawing of your teenager's faceusing your best drawing ability. Color is necessary; some of thegenes produce pigment!6. Envisioning the New PersonTime passes, you get older, your baby is growing up! What does your childlook like when he or she is a teenager of about 15 years of age? Make a fullpage, color drawing of your teenager's face using your best drawing ability.Color is necessary; some of the genes produce pigment!7. Understanding the Process of HeredityAnswer the questions about the traits of “your” child on the question sheet.Use the descriptions of the genes and chromosomes to help you with youranswers.(4)Eye ColorDark Brown Brown Brown DarkBrownBlueFFBB FFBb FFbb FfBB FfBbWidow’s Peak PresentPPEyebrow ThicknessThick Thick ThinTTTtttEyebrow PlacementApart Apart Touching in MiddleEEEeeeEye DistanceApartClose Less CloseOOOoFar ApartooEye SizeLarge MediumIIIiSmalliiEye Roundvv

Making A Face: Genetic SimulationData ce ShapeRoundRRRoundRrChin ShapeVery Prominent Very Prom.LLLlChin ShapeRoundIf LL or Ll only SSCleft ChinCleftIf LL or Ll only CCSkin ColorPolygenicSquarerrNot Prom.llRoundSsSquaressCleftCcNo CleftccVery,VeryDarkBrownAAAVery Dark Med. Light Light VeryDark Brown Brown Brown Light VeryBrownBrown LightBrownAAA AAA AAA AAA/aAAAAA/aaaaA/aa/aaa/aaaaaaaaaaaHair ColorPolygenicBlack Very DarkDark BrownBrownHHHH HHHH HHHHHHHH HHH/h hhhhBrown Light Honey BlondBrown BlondHHHH HHHH/ HHH/h HH/hH/hhh hhhh hhhh hhhhh(20)

Gender DeterminationFace and Chin DeterminationIf your dropping ofthe genes resultedin two "XX"chromosomesturning face up,then you are thevery lucky parentsof a little girl.The Momcontributed one"X" and the Dadthe other "X".If your dropping ofthe genes resultedin an "Xy"combination ofchromosomesturning face up,then you are thevery lucky parentsof a little boy.The Momcontributed one"X" and the Dadthe "y"chromosome.Its a Girl!Chromosome #1 contains the genetic information in agene we will call "R". This information determines thegeneral shape of the face. Place your baby's genotypefor face shape in the data table.Its a Boy!Chromosome #2 contains the chin shape gene "L." Thegenotype "ll" prevents the expression of the next twopairs of genes. Place your baby's genotype for chinshape in the data table. The control of one set of genes byanother is called epistasis. If you landed the genotype "ll"then skip the next two and start on Skin Color.(5)(6)