Macromolecules Carbohydrates

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MacromoleculesCarbohydratescarbohydrates, lipids, proteins, nucleic acids Monomers and Polymers– dehydration reactions Carbohydrates– Sugars and starches Lipids– Fats and oils– Phospholipids– How soap works Start proteins, if time10 Sept. 2021Aldoses(Aldehyde Sugars)Sugars(Understand, but don tmemorize structures)Ketoses(Ketone Sugars)MonosaccharidesTrioses: three-carbon sugars (C3H6O3)GlyceraldehydeDihydroxyacetonePentoses: five-carbon sugars (C5H10O5)RiboseGlucoseRibuloseHexoses: six-carbon sugars (C6H12O6)RiboseGlucose GalactoseFigure 5.2(a) Dehydration1Fructosereaction: synthesizing a polymer2Simple sugars can be linked byDehydration reactions3Dehydration removes a watermolecule, forming a new bond.123H 2OCH2OHO H1OH4(b) Hydrolysis: breaking down a polymerGlucose123Hydrolysis adds a watermolecule, breaking a bond.1234CH2OHO2HHOCH2OHFructoseCH2OHO H1CH2OHO2OH 2OCH2OHSucroseSucrose is a commondisaccharide:Glucose FructoseH 2OH1

Other common disaccharidesCellulose10 µm0.5 µmCellulosemoleculesDo notmemorizeβ GlucosemonomerSmall difference in structure,big difference in function.Fig. 5-8Lipids (fats and JPGFried dough with lard . . . .Fats or triglyceridesFATS(glycerol 3 fatty acids)SolidGlycerolOCOHHCOHCOHHCHOHOCHCHOFat moleculeHCOCHCHOHCHFigure HCHHDehydration reactionOHCCHHHOILS Fatty ilic or hydrophobic?SaturatedUnsaturated orPolyunsaturatedLikeFig 5-122

Polar(charged)HeadWhat are trans fats?Fatty Acids“Amphipathic”VeryHydrophobicTailIn waterthey canform a“micelle”-- why? PhospholipidsWhy soap works– Glycerol 2 fatty acids phosphateHydrophilic headHydrophilic headsHydrophobic tailsGreasy mess onplateCH2O Grease is attracted to the interiorof the miceleFigure 5.13O– N(CH )3 3CholinePhosphateOCH2CHOOCO CCH2GlycerolHow willphospholipidsbehave in water?OFatty acidsHydrophobic tailsSoap miceleCH2OPHydrophilic headHydrophobictails(a) Structural formulaPhospholipid BilayerProteinsFormBoundariesWhat are some ofthe functions ofproteins?3

Nonpolar Side ChainsPolymers of Amino Acids Amino Acids differ only by their R group 20 kinds of amino acids– Same chasis, different cargoNonpolarOilPolarOHChargedSHGlycine(Gly or G)Alanine(Ala or A)Valine(Val or V)Leucine(Leu or L)Isoleucine(Ile or I)R5DuracellCan Keep addingto the endPolar Side ChainsMethionine(Met or M)Phenylalanine(Phe or F)Tryptophan(Trp or W)Proline(Pro or P)Charged Side ChainsBasic (positively charged)Acidic (negatively charged)Serine(Ser or S)Threonine(Thr or T)Cysteine(Cys or C)Aspartic acid Glutamic acid(Asp or D)(Glu or E)Tyrosine(Tyr or Y)Asparagine(Asn or N)Lysine(Lys or K)Arginine(Arg or R)Histidine(His or H)Glutamine(Gln or Q)The amino and acid groupscouple the monomers together4 Levels of StructurePrimary Structure:Amino acid sequence Can make polymers that are 100s or 1000s of aminoacids longR5R1R2R3R4Tertiary Structure:3-D shape of onepolypeptideCan Keep addingto the endSecondary Structure:Local foldingα helix and β sheetQuaternary Structure:Assembly of severalpolypeptides to formone functional protein4

Stopped hereNucleic AcidsATPNucleotidesNucleotides have three components Sugar Base PhosphateUse dehydration reactions toconnect these molecules32Carbons in the sugar arenumbered with primesPurinesA, GPyrimidinesThe bases each have a polar edge forhydrogen bondingThymineAdenineCytosineGuanineC, T, U5

The nucleotide ATP is a commonenergy carrierPolynucleotide (DNA, RNA)chains are assembled by yetanother type of dehydrationreaction5endThese are high-energy phosphate bonds Link the -OH on the 3 carbonof one nucleotide to the phosphate on the 5carbon of the next.Also GTP, CTP, etc.RNA3endDNADNA copyingis the basisof heredityThesequences ofbases is thehereditaryinformationFlow of informationStopped hereDNA -- RNA -- Protein6

If actively growing cells are fed 14C-labeledglucose, what macromolecules will becomeradioactive first?A.B.C.D.proteinsstarchnucleic acidsfatty acidsMacromolecules Carbohydrates Lipids Proteins Nucleic Acids7

carbohydrates, lipids, proteins, nucleic acids Monomers and Polymers - dehydration reactions Carbohydrates - Sugars and starches Lipids - Fats and oils - Phospholipids - How soap works Start proteins, if time 10 Sept. 2021 Carbohydrates Sugars Aldoses (Aldehyde Sugars) Ketoses (Ketone Sugars)

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