Msrd 2015 - Uab

Group GG-1Bares, Jennifer (MS3)Intermediate TermComparing Incoming Residents’ Inpatient and Outpatient Oral Presentation StructuresMentor: Dr. Ryan KraemerG-2Bouldin, John (MS4)Short TermThe Use of a Sports Metrics App in the Recording of In-Situ Mock Code DataMentor: Dr. Marjorie Lee WhiteG-3Colon, Chad (MS4) (Not Presenting)Intermediate TermComparing High Risk Exposure disclosure among medical students and residents followingintervention between 2002-2015Mentor: Dr. Craig HoesleyG-4Cox, Kathryn (MS2)Long TermExperiences that Strengthen and Weaken Enthusiasm for Primary Care in First Year MedicalStudents: A Nominal Group Techniques EvaluationMentor: Dr. Carlos EstradaG-5Davis, Ann (MS3)Intermediate TermImproving Cardiopulmonary Resuscitation by Implementing First Five Minute TrainingMentor: Dr. Nancy TofilG-6Love, Ashley (MS4)Short TermPediatric Cardiology Simulation: When to Give Fluids and Oxygen and When NotMentor: Dr. Leslie RhodesG-7Rana, Amaad (MS3)(Not Presenting)Long TermKaizen-UME: Utilization patterns and educational outcomes of a software application to improvemedical knowledge among medical students.Mentor: Dr. James WilligG-8Smith, Walter (MS2)Short TermUsing Medical Students as Hypertension Patient Educators in the Emergency DepartmentSettingMentor: Dr. Charles KhouryG-9Sweeney, Mary Katherine (MS2)Short TermWhat Do Primary Care Physicians Offer that Others Do Not?: A Nominal Group TechniqueMentor: Dr. Carlos Estrada

Group HH-1Chung, Sebastian (MS2)Short TermHospital Adherence to Evidence-Based Severe Traumatic Brain Injury Management GuidelinesMentor: Dr. Leslie HayesH-2Craig, Carolyne (MS4)Short TermDevelopment and Implementation of a Standardized Sedation Weaning Guidelines in aPediatric ICUMentor: Dr. Leslie HayesH-3Hoepfner, Lauren (MS2)Intermediate TermValidity of the Braden Scale in Grading Pressure Ulcers in Trauma and Burn PatientsMentor: Dr. Jeffrey KirbyH-4Junkin, Elizabeth (MS4)(Not Presenting)Intermediate TermPrimary Care towards Patient-Centered Medical Home Qualifications through a Diabetes SelfManagement ProgramMentor: Dr. Lea YerbyH-5Kasanagottu, Koushik (MS2)Intermediate TermDevelopment and Assessment of a Video Health Education ProgramMentor: Dr. Monika SaffordH-6Kennel, Tim (MSTP-GS1)Intermediate TermAn OpenInfoButton and I2B2 Merger: Bringing Buttons to the translational research tool I2B2Mentor: Dr. James CiminoH-7Lewis, Justin (MS2)Short TermLiving Well with DiabetesMentor: Dr. Monika SaffordH-8Riley, William (MS2)Short TermMedical Students as Diabetes Educators in the Emergency Department SettingMentor: Dr. Todd PetersonH-9Sheets, Ryan (MS4) (Not Presenting)IntermediateGetting on the Bandwagon Improving Code Status IdentificationMentor: Dr. Winter Williams

H-10 Payne, Alaina (MS3)Intermediate TermAn analytical study of the Alabama Rural Physicians Tax Credit LawMentor: Dr. William Coleman

Group II-1Allen, Sarah (MS4)(Not Presenting)Intermediate TermUse of Multiple Antihypertensive Agents to Achieve Blood Pressure Control Associated withAdverse Pregnancy Outcomes?Mentor: Dr. Lorie HarperI-2Antipenko, Sergey (MSTP-GS3)Long TermThe Effect of Inflammation on Cardiac Stem CellsMentor: Dr. Tim TownesI-3Berry, Ryan (MSTP-GS3)Long TermDifferential tissue and time-of-day response to hGH in C57 Black 6 male miceMentor: Dr. Stuart FrankI-4Bray, Alexander (MSTP-GS4)Long TermMitochondrial Genetic Background Influences Susceptibility to AtherosclerosisMentor: Dr. Scott BallingerI-5Chiu, Sherwin (MS2)Short TermIs Pulse Pressure in the Early Postoperative Period a Predictor of Morbidity After the NorwoodProcedureMentor: Dr. Jeffrey AltenI-6Dowla, Shima (MSTP-GS2)Short TermDoes Providing Fresh Fruits and Vegetables to Children and Adolescents ReduceWeight? Designing a Randomized Control TrialMentor: Dr. Tapan MehtaI-7Erwin, William Clinton (MS2)Short TermDoes arterial-venous CO2 gradient correlate with other known markers of low cardiac output?Mentor: Dr. Leslie RhodesI-8Hackney, Andrew (MS2)Short TermMAP Management and Acute Spinal Cord InjuriesMentor: Dr. NewayI-9Ives, Chris (MS2)Short TermEstrogen reduces inflammation in postmenopausal women through modulation of macrophagephenotypeMentor: Dr. Suzanne Oparil

I-10McMonigle, Ryan (MSTP-MS1)Short TermMitochondrial Influence on Gene ExpressionMentor: Dr. Scott BallingerI-11Pepin, Mark (MSTP-GS1)Long TermThe Diabetic Heart: GABA signaling and Heart FailureMentor: Dr. Adam WendeI-12Reddy, Alex (MS2)Short TermBiotinylation: Novel Mechanism Linking the Cardiomyocyte Circadian Clock to CardiacMetabolismMentor: Dr. Martin YoungI-13Youngstrom, Mallory (MS4)(Not Presenting)Long TermOutcomes in Women with a History of Chronic Hypertension by Normal Blood Pressures inPregnancyMentor: Dr. Lori Harper

Group JJ-1Crowson, Cole (MS2)Short TermInduction of Immunosuppression Regimen and the Odds of Acute Rejection by Race inPediatric Kidney Transplant RecipientsMentor: Dr. Jayme LockeJ-2Deas, Dale (MS2)Short TermInterleukin-6 and interleukin -8 as acute kidney injury biomarkers in cardiac surgery in infantsMentor: Dr. David ClevelandJ-3Fox, Brandon (MSTP-GS3)Intermediate TermEndothelial-Derived Endothelin-1 Contributes to Renal Dysfunction and Mortality in Sickle CellMiceMentor: Dr. Jennifer PollockJ-4Hu, Muhan (MSTP – GS1)Short TermMechanisms of TGFβ signaling critical for C. elegans fertilizationMentor: Dr. Michael MillerJ-5Lever, Jeremie (MSTP-GS1)Short TermCharacterization of renal inflammation in a model of ischemic Acute Kidney Injury Leading toChronic Kidney DiseaseMentors: Dr. Anupam Agarwal and Dr. James GeorgeJ-6Ma, Elizabeth (MSTP-GS3)Intermediate TermUrinary F2-Isoprostanes Do Not Reflect Oxidative Stress Operative in Human InsulinResistance, but are correlated with Lean Mass and Serum LipidsMentor: Dr. Tim GarveyJ-7Mosher, Zachary (MS2)Short TermRenal function during and after prophylactic peritoneal dialysis after cardiopulmonary bypasssurgery in infantsMentor: Dr. Santiago BorasinoJ-8Neu, Matthew (MSTP-MS2)Short TermDe novo variant analysis in whole genomesMentor: Dr. Greg Cooper

J-9Smith, Burke (MS1)Short TermDosing eculizumab for antibody mediated rejection in kidney transplantation: a case reportMentor: Dr. Jayme LockeJ-10 Turner, Eric (MS2)Intermediate TermValidation of Bosniak Classification for Contrast Enhanced Ultrasound and Introduction of aNew Classification SystemMentor: Dr. Jessica ZarzourJ-11 West, Janelle (MS4)Intermediate TermThe Use of Contrast-Enhance Ultrasound in the Diagnosis of Indeterminate Small RenalLesionsMentor: Dr. Jessica ZarzourJ-12 Zou, Sylvia (MS2)Short TermMacrophage polarization in acute kidney injury: macrophage differentiation into M2 phenotype inIL-4 and IL-13 knockout miceMentor: Dr. Raymond Harris

Group KK-1Bevans, Stephanie (MS2)Short TermFluorescence guided surgery in aggressive odontogenic tumors using Cetuximab-IRDye800Mentor: Dr. Jason WarramK-2Brinkley, Garrett (MSTP-MS2)Short TermFollowing treatment with bortezomib, myeloma cells secrete exosomes with altered proteinscomposition that enhance chemoresistance and tumor proliferationMentor: Dr. Ralph SandersonK-3Dussaq, Alex (MSTP-GS3)Long TermMechanistic parameterization of the kinomic signal using PamGene peptide arraysMentor: Dr. Christopher WilleyK-4Etikala, Deepa (MS2)Short TermThe Identification of FOXP3 Isoforms in Human Cancer Cell LinesMentor: Dr. Lizhong WangK-5Griswold, Gage (MS2)Short TermFrequency of skeletal surveillance in primary carcinomas at high risk for metastasis to boneMentor: Dr. Nichole BehnkeK-6Harris, David (MS3)Intermediate TermThe Importance and Risks of CBCT Alignment for Prostate Cancer RadiotherapyMentor: Dr. John FiveashK-7LeGrand, Jason (MSTP-GS5)Long TermIdentification of Cytogenetically Normal Human CD34 CD34- Hematopoietic Stem/ProgenitorCells from inv(16 ) Leukemic Bone MarrowMentor: Dr. Christopher KlugK-8McCaw, Tyler (MSTP-GS1)Short TermSolid Tumor Targeting with T cells, Linker Proteins, and Precise Gene EditingMentors. Dr. Troy Randall and Dr. Tim TownesK-9Prince, Andrew (MS2)Short TermDual-Modality Approach to Improving Surgical Intervention in Head and Neck Cancer Usingand IRDye800 Labeled PanitumumabMentor: Dr. Jason Warram89Zr

K-10 Ramesh, Tushar (MS2)Intermediate TermEvaluation of optical imaging agents in a fluorescence-guided surgical model of head and neckcancerMentor: Dr. Jason WarramK-11 Singireddy, Ramya (MS2)Short TermVitamin D receptor polymorphism status and the association of osteopontin and vitamin Dreceptor expression in skin tumorsMentor: Dr. Nabiha YusufK-12 Weaver, Alice (MSTP-GS3)Long TermActivation of Notch signaling pathway is associated with poor prognosis in oral cavity squamouscell carcinomaMentor: Dr. Eddy Yang

Group LL-1Birchall, Betsy (MS2)Short TermImaging and Analysis of Dendritic SpinesMentor: Dr. Jeremy HerskowitzL-2Eustace, Nicholas (MSTP-GS2)Intermediate TermMARCKS has a critical role in the growth and proliferation of Glioblastoma multiformeMentor: Dr. Christopher WilleyL-3Evans, John (MS4)Intermediate TermFractional tumor burden calculation using perfusion MRI can predict progression-free survivaland overall survival in glioblastoma multiforme patients treated with bevacizumabMentor: Dr. Asim BagL-4Figge, David (MSTP-GS4)Long TermRole of Dynamic DNA Methylation in Levodopa-Induced DyskinesiaMentor: Dr. David StandaertL-5Gragg, Stephen (MSTP-GS1)Short TermCDC42, ID2, and SIRTs are promising targets for regulation of microRNA-31Mentor: Dr. Tika BevenisteL-6Guzman Karlsson, Mikael (MSTP-GS5)Long TermGenome-wide transcription profiling in an APP mouse model of Alzheimer’s disease.Mentor: Dr. David SweattL-7Hardigan, Andrew (MSTP)Long TermBlocking of targeted microRNAs from next-generation sequencing librariesMentor: Dr. Richard MyersL-8Pacl, Hayden (MSTP-MS1)Short TermEffects of Alzheimer’s Disease Risk Factor BIN1 on Amyloid Plaque Deposition in a MouseModel of Alzheimer’s DiseaseMentor: Dr. Erik RobersonL-9Patel, Bhavika (MS2)Short TermAssessing binocular function in glaucomaMentor: Dr. MiYoung Kwon

L-10 Patterson, Kelsey (MSTP-GS2)Long TermMotor and Behavioral Phenotypes in a Novel Rate Model of Rett SyndromeMentor: Dr. Michelle OlsenL-11 Raman, Fabio (MSTP-MS2)Short TermUnraveling Mechanisms and Treatment Options of Glioblastoma Multiforme ProgressionPatterns: A Computational AnalysisMentor: Dr. Hassan Fathallah-ShaykhL-12 Stoyka, Lindsay (MSTP-MS2)Short TermG2019SLRRK2 May Lead to Increased Alpha-Synuclein Aggregation in Parkinson’s DiseaseMentor: Dr. David Standaert

Group MM-1Black, Ryne (MS2)Short TermActivation of neurons within PVN in Wistar and Wistar-Kyoto rats following the forced swim testMentor: Dr. Ilan KermanM-2Bolis, Ramy (MS2)Short TermA Predictive Algorithm of Citalopram EfficacyMentors: Dr. Nita Limdi and Dr. Richard SheltonM-3Cohen, Joshua (MSTP-GS3)Long Term12 Things you didn’t know about high responder/low responder rats, stress coping, andmicroRNA in the dorsal raphe. Number 5 will blow your mind!Mentor: Dr. Sarah ClintonM-4Duke, Corey (MS2)Short TermExperience Dependent Epigenomic ReorganizationMentor: Dr. Jeremy DayM-5Ramaker, Ryne (MSTP-GS2)Intermediate TermComparative transcriptomic and metabolomic profiling of psychiatric disorders across threebrain regionsMentors: Dr. Sarah Cooper and Dr. Rick MyersM-6Souder, Paige (MSTP-MS2)Short TermExpression and Function of Astrocyctic Connexin-43 in a Model of Pediatric Traumatic BrainInjuryMentor: Dr. Michelle OlsonM-7Webb, William (MSTP-GS2)Long TermHistone methylation and NKcortex during memory formationMentor: Dr. Farah Lubin-lysine signaling in the hippocampus and entorhinalM-8Zipperly, Morgan (MSTP-MS2)Short TermAssessment of Neuronal Activity in Reward-Associated Behavioral CircuitsMentor: Dr. Jeremy Day

Allen, Heather ElizabethProject Length: LongPrior Research Experience: YesSource of Funding: NIH MSTPFaculty Advisor: David G StandaertAbstract Approved: YesCo-Authors: Heather E Allen Reish, Ashley S Harms, PhD, David G Standaert MD PhDTitle: C3 is not required for alpha-synuclein-induced neuroinflammation and neurodegenerationin the AAV-SYN model of Parkinson diseaseParkinson disease (PD) is a common neurodegenerative movement disorder that inducesselective dopaminergic neuron loss in the substantia nigra (SN). There is no knownneuroprotective treatment. Pathologic and genetic studies indicate a causal role for the proteinalpha-synuclein in the pathogenesis of PD. However, how alpha-synuclein mediates its toxiceffects on dopaminergic neurons is still unclear. One leading hypothesis is the induction of toxicneuroinflammation by aggregated or otherwise abnormal forms of alpha-synuclein. Here, wehypothesized that complement component 3 (C3) was required for the neuroinflammation andneurodegeneration induced by alpha-synuclein in PD.Wildtype and C3-/- mice were stereotaxically injected with an adeno-associated virus thatselectively overexpresses alpha-synuclein in the substantia nigra (AAV-SYN) or a control virus(AAV-GFP). To assess neuroinflammation, mice were sacrificed 4 weeks post-injection. Brainswere either processed for qPCR or sectioned and stained for C9, MHCII, and IgGimmunofluorescence. Sections were scored by blinded rating. To assess neurodegeneration,wildtype and C3-/- mice were sacrificed at 4 weeks and 6 months post-injection; brains weresectioned and stained for tyrosine hydroxylase (TH) and counted using unbiased stereology.C3 mRNA was upregulated 4.7 fold, and C9 deposition was significantly increased in AAV-SYNinjected mice, indicating an upregulation of complement system components in the AAV-SYNmodel 4 weeks post-injection. Surprisingly, deletion of C3 did not ameliorate AAV-SYN-inducedMHCII microglial activation or IgG deposition 4 weeks post-injection. Furthermore, deletion ofC3 did not prevent AAV-SYN induced neuron loss. At 6 months post-injection, AAV-SYNinduced an 18% TH neuron loss din both wildtype and C3-/- mice, indicating no role for C3 ineither the neuroinflammatory or the neurodegenerative pathway of the AAV-SYN model of PD.Together these results indicate that although alpha-synuclein induces C3 expression, C3 is notinvolved in the downstream neuroinflammatory or neurodegenerative pathways of the AAV-SYNmodel of PD.

Allen, Sarah ElizabethProject Length: IntermediatePrior Research Experience: YesSource of Funding: OtherFaculty Advisor: Dr Lorie HarperAbstract Approved: YesCo-Authors: Tita, Anderson, Nadeau, Biggio, HarperTitle: Is Use of Multiple Antihypertensive Agents to Achieve Blood Pressure Control Associatedwith Adverse Pregnancy Outcomes?While requiring multiple antihypertensive agents to achieve a normal blood pressure (BP) is asurrogate marker of chronic hypertension (HTN) severity, it is unclear whether the number ofagents required to achieve BP control is associated with adverse pregnancy outcomes. Weassessed whether requiring 1 medication for BP control is associated with adverse pregnancyoutcomes.The study is a retrospective cohort of all singletons complicated by HTN at UAB from 20002014. Subjects initiated on 1 agent were compared to those on 1 agent 20 weeks gestationage. Because BP is tightly linked to pregnancy outcomes, only subjects achieving a BP 140/90mmHg were considered. Subjects with major medical comorbidities, baseline renal disease andfetal anomalies were excluded. The primary maternal outcome was preeclampsia (PE).Secondary maternal outcomes were severe PE, cesarean delivery (CD) and antepartumhospitalizations to rule out PE. The primary neonatal outcome was small for gestational age(SGA). Secondary neonatal outcomes were preterm birth (PTB, 35 weeks) and a composite ofperinatal death, assisted ventilation, umbilical cord pH 7, 5-minute Apgar 3 and neonatalseizures. Exposure groups were compared with Student’s t-test and χ2; logistic regressionadjusted for confounding variables.Of 634 women, 122 (19.2%) used 1 agent. Among women with BP 140/90 mmHg, those on 1 agent had similar odds of PE (AOR 1.3, 95% CI 0.7-2.5), severe PE (AOR 1.4, 95% CI 0.62.9) and CD (AOR 0.9, 95% CI 0.5-1.6). Women on 1 agent had increased risk of antenataladmission to rule out PE (AOR 3.2, 95% CI 1.6-6.6). Neonatal outcomes were similar betweengroups. When comparing those with BP 140/90 mmHg, requiring 1 agent was not associatedwith increased risk for any outcome studied. Initiation of 1 antihypertensive agent prior to 20weeks was not associated with an increased risk of adverse outcomes when a normal BP isachieved.

Alley, Wilson EdwardProject Length: ShortPrior Research Experience: YesSource of Funding: T35Faculty Advisor: Hui HuAbstract Approved: YesCo-Authors: Jianlin Geng, Hairong Wei, Xueri Luo, Hui HuTitle: Generating Improved Breadth and Potency of Antibodies Against Weak HIV ImmunogensHIV evades the host immune system by gene mutation and genetic diversity, and many HIVpotential targets are weak antigens. Creating antibodies to a given weak antigen by host cellmanipulation may help overcome the evasiveness of the virus towards host humoral responses.T20 is one such conserved peptide located on the GP41 region of HIV. Foxp1 is a negativeregulator of follicular T helper cells (Tfh), and downregulation of this gene is necessary forgerminal center b-cell function. When Foxp1 is deleted, naïve T cells preferentially differentiateinto Tfh cells augmenting antibody production, isotype switching, and increased kinetics. Ourgoal was to use a foxp1 conditional knock out mouse model to create antibodies to T20, whichwould serve as a proof of principle that manipulation of Foxp1 can improve breadth and potencyof B cell responses. The foxp1 cko mice were inoculated with OVA (ovalbumin) - T20 and serumwas collected. This serum was then analyzed for antibody production with both an enzymelinked immunosorbant assay (ELISA) and a viral inhibition assay. The ELISA revealed positiveantibody production to ovalbumin; however, T20 antibody production was negative. The HIVviral inhibition assay was done using a serial dilution of mouse serum on a human CUCY cellline. This test showed sustained viral inhibition with all serum concentrations including thecontrol mou

11:00 - 11:15 am Anna Joy Graves Rogers (MSTP-GS3)* Barriers and enablers to repeat HIV testing during pregnancy in Kenya: A quantitative study . Mentor: Dr. Sherry Collawn D-6 Patel, Fenil (MS3) Intermediate Term Racial Disparities in Length of Stay Among Patients Undergoing Lower Extremity