Translational & Molecular Imaging Institute

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Translational & Molecular Imaging Institutetmii.mssm.eduSpring 2018THE POWER OF IMAGINGThe Imaging Research Center is the backbone of the Translational & Molecular Imaging Institute at the MountSinai Health System. Housed on three floors of Mount Sinai’s Leon and Norma Hess Center for Science andMedicine, the Center enhances the use of seamless diagnostics and treatment methods for our patients. Builtwith strategic growth in mind, the space is designed to be flexible. It contains today’s leading-edge research andclinical equipment while providing room for the evolution of clinical and research platforms as new technologiesemerge in the coming years.Many scientists study changes in the world. Our scientists create changes in the world.The Center serves as a research catalyst for a new generation of translational and molecular imagingmethodologies. As a service to the Mount Sinai community, the Center applies and validates imaging modalities,in both pre-clinical basic science and clinical research settings, to: Improve diagnostic accuracyIncrease the understanding of disease mechanismsMeasure therapeutic efficacyProvide education and training opportunities for students and postdoctoral research and clinical fellowsAn essential component of the vision of Valentín Fuster, MD, PhD, Dean Dennis Charney, MD, and BurtonDrayer, MD, the Imaging Research Center offers bold technology and challenges our definition of what ispossible. Led by renowned scientist Zahi A. Fayad, PhD, the Imaging Research Center provides physicians withpreviously unavailable images of patients’ internal organs, necessary for non-invasive diagnostics to treat cancer,brain, and cardiovascular diseases.Leon and Norma Hess Center for Science and Medicine1470 Madison AvenueNew York, NY 10029

THE NEXT STAGE OF EVOLUTIONOn the lower levels of the Hess Center, the Imaging Research Center has an extensive and expanding inventory ofimaging facilities and equipment, including related patient exam rooms, laboratories, and testing rooms. Physicianscientists who work in this space have a major impact on the science of imaging and its ongoing refinement—from thedevelopment of new visualization technologies to improved contrast agents that help investigators see noveltherapeutics at work.The Imaging Research Center has recruited several top-notch faculty members in cardiovascular imaging,neuroimaging, cancer imaging, and nanomedicine to parallel the expansion of translational medicine at Mount Sinai.Consequently, we have created one of the finest, most innovative imaging programs in the world.3T SkyraVevo2100 MicroUltrasound SystemBruker Micro MRI7TMR SimulatorUtilizing technology that allows us to look deeper into the human body than ever before, our physician-scientists arestudying disease models to improve the early detection and treatment of cancer and developing non-invasive methodsthat allow for the early detection, prevention, and treatment of cardiovascular disease.Low ResolutionHigh Resolution7T3T3T7TCombination PET/MRI: Used for heart, brain, and cancer imaging Completely non-invasive, whole body, dual system Enables scientists to develop novel methods for targeted imaging and drugdelivery to improve the diagnosis and treatment of a range of diseases7 Tesla ultra-high field MRI: The next generation of human MRI that offersspecial resolution Allows physicians to detect early brain disease orcancerous tumors Physicians can assess diseases non-invasively atnever-before-seen resolution and magnification No other institution in the United States is workingwith a 7 Tesla for cardiovascular diseaseSomatom Force CT: A novel dual-source Somatom Force CT for faster and lower dose imaging The system is available for human and large animal researchThese high performance systems are critically important for ongoing research and they enable us to support increasingnumbers of imaging projects from around the Mount Sinai community. Such advanced technologies also help usmaintain our competitive edge in the recruitment of the very best scientists and clinicians to Mount Sinai. But mostimportantly, they are invaluable tools for refining our ability to provide the best patient care available.Leon and Norma Hess Center for Science and Medicine1470 Madison AvenueNew York, NY 10029

IMAGE ANALYSIS CORECurrently, we have over 50 members with expertise in all aspects of translational imaging research. OurBiomedical and Electrical Engineers and Radiologists are leading experts in their fields. Our highly skilled staffprovides a full suite of support services for image acquisition, image analysis, scheduling, and performance ofthe proposed experiments.TMII provides image analysis support through the Image Analysis Core. This Core consists of IT personnel,software engineers, imaging physicists, research assistants, and other support personnel. Expert consultation forresearch projects including protocol design, specialized pulse sequences, special image acquisition hardware(coils), and custom-made functional MRI stimulus hardware are all supported.Comprehensive project-based image analysis is also provided, as well as image analysis training for thoseresearchers who want to learn more about image analysis in general. Training ranges from regular classroombased graduate coursework taught by TMII faculty to hands-on training on the use of specific software packages.The image analysis room is equipped with a large viewing display and more than 15 high performanceworkstations are open for researchers to learn or perform image analysis.A PICTURE OF DISEASEFigure 1.1:MetabolicsyndromesFigure 1.2: Neovascularization—StrokeFigure 1.4:MultipleSclerosisFigure 1.3: Lung TumorLeon and Norma Hess Center for Science and MedicineFigure 1.5: Alzheimer’s disease1470 Madison AvenueNew York, NY 10029

A WORLD OF POSSIBILITIESImagine a world where we can detect a heart attack before it strikes.We can. Cardiovasculardisease is the leading cause ofdeath worldwide, mostlybecause of the widespreadlack of recognition andtreatment of individuals withrisk factors for atherosclerosis,a thickening of the arterial wall of the heart that decreases blood supplyleading to heart disease and strokes.The Cardiovascular Imaging Research Program is developing andapplying new imaging approaches that allow the assessment not only ofthe structure of blood vessels, but also of the composition of the vesselwalls—enabling abnormalities in the arteries to be observed down tothe cellular and molecular level.Imagine a world where we can find a cancer before it’s malignant.We can. Primary liver cancer has significantlyincreased in incidence over the last 10 years inthe United States. In New York City the incidencerate is much higher. 17 out of 100,000 men inNYC are affected, compared to 5 out of 100,000men in North America.The Cancer Imaging Research Program isdeveloping new imaging methods that will allowclinicians not only to see where a tumor islocated in the body, but also to visualize theexpression and activity of specific molecules thatinfluence tumor behavior and/or response totherapy.Imagine a world where we can see the injured tissue at the onset of Alzheimer’s disease.We can. The living brain is one of the last frontiers of research. Far more complexand mysterious that any other organ, the brain’s 100 billion nerve cells formhundreds of trillions of nerve connections. Yet we cannot examine it by touch withoutrisking significant damage.The Neuroimaging Research Program is developing novel imaging techniques toelucidate changes in brain structure, metabolism, and function in the presence ofdisease. This method is so effective that 90% of brain research has come to rely onadvanced imaging for new discoveries.Leon and Norma Hess Center for Science and Medicine1470 Madison AvenueNew York, NY 10029

SCIENTISTSFayad LabZahi A. Fayad, PhDProfessor of Radiology and Medicine (Cardiology)Director, Translational and Molecular Imaging InstituteDirector, Cardiovascular ImagingDr. Fayad’s laboratory is dedicated to the detection and prevention of cardiovascular diseaseand conducts interdisciplinary and discipline bridging research, from engineering to biology,which includes pre-clinical and clinical investigations. The focus of this lab is to develop and useinnovative multimodality cardiovascular imaging including to study, prevent and treatcardiovascular disease, including: Magnetic Resonance Imaging (MRI), computed tomography(CT), and positron emission tomography (PET), as well as molecular imaging andnanomedicine. Dr. Fayad’s focus at Mount Sinai is on the noninvasive assessment andunderstanding of atherosclerosis.Claudia Calcagno, MD, PhDFayad LabDr. Calcagno is an Instructor at the Translational and Molecular Imaging Institute at MountSinai. She holds an MD from the University of Genova, Italy (2004) and a PhD in ComputationalBiology from New York University/Mount Sinai. Her research is focused on the developmentand validation of non-invasive, quantitative imaging techniques in animal models (mice, rabbits,pigs) of cardiovascular disease. More specifically, her expertise is in dynamic contrastenhanced (DCE) MRI to measure microvasculature/permeability, and PET imaging to measureinflammation, two of the hallmarks of high-risk atherosclerotic plaques.Her current projects are focused on the development of 3 dimensional (3D) imaging combined with cutting edge fastimage acquisition and reconstruction methods for the accurate, extensive quantification of these parameters in largevascular territories.Balchandani LabPriti Balchandani, PhDAssociate Professor of RadiologyDirector, Advanced Neuroimaging Research ProgramDr. Priti Balchandani is an Associate Professor in the Department of Radiology andNeuroscience at the Icahn School of Medicine at Mount Sinai. She also serves as the Director ofthe The Advanced Neuroimaging Research Program (ANRP) at the Translational and Molecularimaging institute. The mission of ANRP is to develop novel imaging technologies and apply themto diagnosis, treatment and surgical planning for a wide range of diseases, including epilepsy,brain tumors, psychiatric illnesses, multiple sclerosis and spinal cord injury.For her primary research, Dr. Balchandani’s team focuses on novel radio frequency (RF) pulse and pulse sequencedesign as well as specialized hardware solutions such as parallel transmission. These techniques are ultimately appliedto improve diagnosis, treatment and surgical planning for a wide range of neurological diseases and disorders. Someclinical areas of focus for Dr. Balchandani’s team are: improved localization of epileptogenic foci; imaging to reveal theneurobiology of depression; and development of imaging methods to better guide neurosurgical resection of braintumors.Lazar Fleysher, PhDImaging CoreOwing to his diverse training in physics and mathematics, Dr. Fleysher has made significantcontributions in the fields of MR data acquisition, image reconstruction, experiment design,protocol optimization, post-processing and statistical data analysis. Accordingly, he is a coauthor on 40 scientific peer-reviewed publications and two patents.More recently, .Fleysher developed an MRI sequence, acquisition and reconstruction protocol forintracellular sodium imaging. This method, implemented for brain imaging on human 7.0 Teslascanners, has been applied to the study of healthy subjects and patients with multiplesclerosis. It has the potential to provide clinicians and scientists with a tool to investigate andmonitor pathological processes and treatment response at a cellular level.Leon and Norma Hess Center for Science and Medicine1470 Madison AvenueNew York, NY 10029

SCIENTISTSMani LabVenkatesh Mani, PhDAssistant Professor of RadiologyDirector, Cardiovascular Imaging Clinical Trials Units (CICTU)As a TMII faculty member and CICTU Director, Dr. Mani works to translate novel multi-modalityimaging techniques for use in multicenter clinical trials. His main interests are in imaging ofcardiovascular diseases, specifically focusing on atherosclerosis, thrombosis and theircomplications using FDG-PET, CT and MRI. The CICTU is composed of clinicians, imageprocessing and programming experts, image analysts, data managers, IT personnel and researchcoordinators.It is a modern hybrid between a contract research organization and an imaging core lab. They undertake and manageall aspects of clinical trials, from scientific conduct to administrative management. CICTU’s tasks span from industry orfederally sponsored multicenter clinical trials to the support of individual investigators interested in using imagingendpoints for their work.Mulder LabWillem J.M. Mulder, PhDAssociate Professor of RadiologyDirector, NanomedicineThe Nanomedicine Laboratory’s mission is to develop and advance nanomedicinal approaches toallow a better understanding, identification and treatment of the most detrimental pathologiestoday: cardiovascular disease and cancer. The research projects range from fundamental,including nanotechnologies to better understand lipoprotein biology, to translational, with one ofthe developed nanotherapies being in clinical trials.Carlos Perez-Medina, PhDMulder LabDr. Perez-Medina’s work revolves around the development of radiolabeling strategies fornanoparticles with a view to evaluate their in vivo behavior and non-invasively visualize their biodistribution by positron emission tomography (PET) imaging. Thus far we have been able tosuccessfully radiolabel liposomal and high-density lipoprotein (HDL) nanoparticles with the longlived, PET-active isotope zirconium-89. We have tested both nanoparticles in different animalmodels of cancer and cardiovascular disease with outstanding results that warrant furtherinvestigation. We are currently working on PET imaging tools to evaluate nanotherapy in a noninvasive manner as well as novel ways to assess vascular inflammation in the context ofcardiovascular disease.Philip Robson, PhDFayad LabDr. Robson is an Instructor of Radiology in the Translational and Molecular imaging Institute andis a member of the Cardiovascular Imaging group. Dr. Robson’s research includes thedevelopment of hybrid positron emission tomography (PET) magnetic resonance (MR) imagingtechnology and its applications in cardiovascular disease, including coronary and carotid arterydisease, cardiac sarcoidosis and other cardiomyopathies. His work has led to some of the firstsuccessful applications of imaging the activity of micro-calcification and inflammation inatherosclerotic plaque in the coronary arteries using 18F-fluoride and 18F-FDG PET/MR imagingand the development of combined PET and MR protocols for evaluating cardiac sarcoidosisand amyloidosis. He is currently working on methods for MR-based motion correction of PET data, MR-basedattenuation correction and complementary anatomical and functional cardiac MR imaging for optimizing cardiac andcoronary PET/MR imaging. Dr. Robson’s research includes partnerships with clinical investigators in theCardiovascular Institute as well as national and international collaborators. Before joining Mount Sinai, Dr. Robsonworked as a postdoctoral fellow at Beth Israel Deaconess Medical Center and Harvard Medical School in Boston,MA. He was awarded doctoral and undergraduate degrees in Physics by the University of Cambridge, UK.Leon and Norma Hess Center for Science and Medicine1470 Madison AvenueNew York, NY 10029

SCIENTISTSUltra-High Field Imaging inEpilepsyEpilepsy adversely affects almost 3million people in the United States.15%-30% of these individuals donot respond to medication and maybe candidates for surgicalintervention.High resolution T2 -weighted images of the brain. The cerebral cortex and hippocampus,where epileptogenic abnormalities are often located, are visualized in fine detail.Due to excellent soft tissue contrastand high-resolution visualization ofbrain anatomy, magnetic resonanceimaging (MRI) plays a vital role in thepreoperative localization andcharacterization of brainabnormalities for patient undergoingepilepsy surgery.Tang LabCheuk Y. Tang, PhDDirector, Neurovascular Imaging ResearchAssociate Director, Imaging Science LaboratoriesDirector, In-Vivo Molecular Imaging SRFDr. Tang’s lab is involved with the research and development of novel imaging strategies for thestudy of neuro-psychiatric diseases. The work consists of both hardware and softwaredevelopment. The lab develops novel image analysis software approaches to integrate functionaland structural connectivity using DTI, DSI and fMRI. The lab has also developed noveltechnologies (e.g. olfactory meter, real time fMRI) in use for the study of memory, OCD andmood-disorders.Taouli LabBachir Taouli, MDProfessor of Radiology and MedicineDirector, Cancer ImagingThe Quantitative Body Imaging Group develops, tests and validates quantitative MR imagingtechniques applied to body imaging. Our current research includes the optimization and validationof novel functional MRI techniques applied to diffuse and focal liver diseases, including diffusionweighted MRI, dynamic contrast enhanced MRI, MR Elastography, flow quantification,spectroscopy and multi echo Dixon methods.Xu LabJunqian Xu, PhDAssistant Professor, Radiology, NeuroimagingDr. Xu’s lab develops quantitative and functional magnetic resonance (MR) techniques andapplies them to study neurometabolism and neuropathophysiology. Our current projects are todevelop: (1) fast MR imaging and spectroscopy methods for quantitative neuroimaging, (2)reliable MR techniques for functional assessment of spinal cord, and (3) a “Connectomic” imagingapproach for tissue recovery, repair and clinical outcomes in multiple sclerosis.Leon and Norma Hess Center for Science and Medicine1470 Madison AvenueNew York, NY 10029

LEADERSHIPDr. Zahi A. Fayad is Director of the Imaging Research Center and the Translationaland Molecular Imaging Institute, Director and Founder of the Eva Morris FeldImaging Science Laboratories, and Director of Cardiovascular Molecular ImagingResearch at the Icahn School of Medicine at Mount Sinai. He is a world leader in thedevelopment and use of multimodality cardiovascular imaging including:cardiovascular magnetic resonance (CMR), computed tomography (CT), positronemission tomography (PET). He holds twelve U.S. and worldwide patents and/orpatent applications.Dr. Fayad is the recipient of multiple prestigious awards and was recently honoredwith the John Paul II Medal from the City of Krakow, Poland, in recognition of thepotential positive impact of his work on humankind and he holds the title of HonoraryProfessor in Nanomedicine at Aarhus University in Denmark.In 2013, he was elected Fellow of the International Society of Magnetic Resonance In Medicine, Magnetic ResonanceImaging, received a Distinguished Reviewer from Magnetic Resonance in Medicine, and was selected as an Academyof Radiology Research, Distinguished Investigator. In 2014 his alma mater, Bradley University, awarded him itshighest honor, the Centurion Society Award, for bringing national and international credit to his university.Dr. Fayad has authored more than 300 peer-reviewed publications, 50 book chapters, and more than 400 meetingpresentations. He is currently the principal investigator of four federal grants/contracts funded by the NationalInstitutes of Health’s National Heart, Lung and Blood Institute and the National Institute of Biomedical Imaging andBioengineering, with a recent large award from NHLBI to support the Program of Excellence in Nanotechnology. Inaddition, he serves as principal investigator of the Imaging Core of the Mount Sinai National Institute of Health(NIH)/Clinical and Translational Science Awards (CTSA).If you wish to make a donation to support the Translational & Molecular Imaging Institute, please contact:Cassandra Kamarck, Office of Development646.605.89794 or cassandra.kamarck@mountsinai.orgLeon and Norma Hess Center for Science and Medicine1470 Madison AvenueNew York, NY 10029

Director, Translational and Molecular Imaging Institute Director, Cardiovascular Imaging Dr. Fayad's laboratory is dedicated to the detection and prevention of cardiovascular disease and conducts interdisciplinary and discipline bridging research, from engineering to biology, which includes pre-clinical and clinical investigations.

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