Ithildin Proposer's Day Brief - Iarpa.gov

Program FocusIthildin goal is development of a broad “toolkit” ofnew sorbent capabilities that can enable many ICapplications in the chemical sampling / sensing /collection domainMetrics are geared to maximize innovation and technicaladvancement, not to target a specific applicationIC applications are always the core motivation for IARPAprograms, but new science can also enable DoD andcommercial applicationsThe following slides provide a few notional applicationsbased on Ithildin capabilities – not prescriptive or inclusiveINTELLIGENCE ADVANCED RESEARCH PROJECTS ACTIVITY (IARPA)27

What Could Ithildin Enable?Scenario 1: Passive sequentially timed sample collectionA set of small sorbent canisters or tubes can be deployed together tosequentially sample at timed intervals over hours/days/weeks,followed by collection and analysis of the samples to examine the timestamped record of captured samples. Provides inexpensive, low-profiledetection of temporally varying signatures without deploying an activesensor. Possible applications include: Detection of narcotics production or purification Process monitoring for product quality & release levels Fine-grained hazard monitoring to determine spread and return-to-safeafter a chemical attack or toxic chemical releaseINTELLIGENCE ADVANCED RESEARCH PROJECTS ACTIVITY (IARPA)28

What Could Ithildin Enable?Scenario 2: Large area monitoring / protectionPassive sorbent canisters/tubes distributed throughout airports / trainstations / stadiums / shopping areas remain inactive until exposed totarget chemicals. Upon exposure, sorbent releases a tracer orundergoes a conformation change that is detected by a single central“monitor” unit. The passive sorbent canisters are cheap, long-lived,require no power, and can be easily configured/reconfigured to adaptto the area to be protected.INTELLIGENCE ADVANCED RESEARCH PROJECTS ACTIVITY (IARPA)29

What Could Ithildin Enable?Scenario 3: Safe sampling & decontaminationSorbent activates on exposure to target chemical(s), then stronglybinds & reencapsulates targets, or catalytically converts chemicals tostable, non-toxic materials via deterministic pathways. Potentialapplications include: Capability to sample toxic materials, then safely transport to analysisfacility for identification. Self-decontaminating protective clothing Capture and storage of short-lived toxic compounds of interest as stable,deterministic non-toxic products for forensic analysisINTELLIGENCE ADVANCED RESEARCH PROJECTS ACTIVITY (IARPA)30

What Could Ithildin Enable?Scenario 4: Smart filtersSorbent material remains inactive until exposed to target chemical(s).Upon exposure it activates, preferentially adsorbing targets to extenduseful life of filter. Potential applications include gas masks, filtermasks used in industrial manufacture and paint/chemical jobs,scrubber filters, HEPA filters, etc.INTELLIGENCE ADVANCED RESEARCH PROJECTS ACTIVITY (IARPA)31

BAA Definitions: Sorbent TaxonomyDefinitions for THIS solicitation:Selectivity:What is sorbed, and “how much” are certain chemicals preferredCaptureWhat fraction of the analyte that interacts with the sorbent is captured by the sorbentRetentionDo sorbed analytes “stick” in the sorbent over time (bumping)StabilizationHow well does the sorbent store the analyteCapacityHow much analyte can the sorbent collectReleaseHow much of the sorbed analyte can be removed and analyzedINTELLIGENCE ADVANCED RESEARCH PROJECTS ACTIVITY (IARPA)32

Development Scale - MolecularreversibleAffinity/interaction/binding of sorbent to sorbateControlled by sorbent chemistry, surface functionalization &coatingExamples:irreversibleLondon dispersion forcesDipole-dipoleDipole-induced dipolePi – Pi stackingHydrogen bondsCovalent bondC-CINTELLIGENCE ADVANCED RESEARCH PROJECTS ACTIVITY (IARPA)33

Development Scale - NanoscalePore size & shapeRigidityViscosityThickness/path lengthCapacityRetentionKineticsSurface areaCapacityKineticsHeterogeneous structures enable mixed chemistryINTELLIGENCE ADVANCED RESEARCH PROJECTS ACTIVITY (IARPA)34

Development Scale - MesoscaleEncapsulated sorbent material activatedby physical action or chemical exposure FrictionLightHumidityExposure to target (or other compound) and then deactivated after a finiteelapsed timeIndication of target sorption provided bymeasurable change in sorbentphysical/chemical properties, or release ofa “tracer” substanceINTELLIGENCE ADVANCED RESEARCH PROJECTS ACTIVITY (IARPA)35

Brainstorming Timed Sorption:Some “Start” ApproachesSorbent is encapsulated inan outer coating that isbreached by:Mechanical force/frictionExposure to radiation(UV/visible/IR)Exposure to electric ormagnetic fieldWater soluble (humidity)Exposure to targetchemical/chemical class orother compoundINTELLIGENCE ADVANCED RESEARCH PROJECTS ACTIVITY (IARPA)36

Brainstorming Timed Sorption:Some “Stop” ApproachesBimodal sorbent adsorbscompound of interest andanother common moleculesuch as water, so poisonsafter a finite timeSelf healing encapsulationReagents co-encapsulatedwith sorbent that reacts toshut it down, or healencapsulationINTELLIGENCE ADVANCED RESEARCH PROJECTS ACTIVITY (IARPA)37

Brainstorming Remote Indicators:Some Possible ApproachesTracer molecule(solid/liquid/gas) andsorbent in same outerencapsulation that fails onexposure to targetCompetitive binding oftarget displaces boundindicatorSorbent heterostructurechanges color orreflectivity on exposure totargetINTELLIGENCE ADVANCED RESEARCH PROJECTS ACTIVITY (IARPA)38

Ithildin BAA OverviewDr. Kristy DeWitt, Program ManagerIntelligence Advanced Research Projects Activity

Program StructureDuration: 18 MonthsThrustAreaSelective AdsorptionEnhancementClutter RejectionTemporal FidelityRemote IndicatorsGoalsPreferential adsorptionof target chemicals orchemical classes orinterest, while retainingthe capability to collectbroad-spectrumbackground.Preferential rejection ofhigh-abundance cluttermaterials, such as wateror hydrocarbons.Capability toactivate/deactivate thesorbent material basedon mechanical, physicalor temporal triggers.A remotely detectablesignature indicative ofadsorption of a specifictarget or target class.Program goal is development of a “toolkit” of smart sorbent options that would beuseful for many different scenarios, not a solution to a particular application.INTELLIGENCE ADVANCED RESEARCH PROJECTS ACTIVITY (IARPA)40

BAA HighlightsOfferor team must address all of program requirements withina thrust area; no partial proposals, such as development ofspecific component technology, will be acceptedThe Government anticipates that proposals submitted underthis BAA will be unclassifiedMultiple awards are expectedForeign participants and/or individuals may participate to theextent that such participants comply with any necessary NonDisclosure Agreements, Security Regulations, Export ControlLaws and other governing statutes applicable under thecircumstancesINTELLIGENCE ADVANCED RESEARCH PROJECTS ACTIVITY (IARPA)41

Acceptable Thrust Area CombinationsFour Areas SelectiveSorptionEnhancement ClutterRejection TemporalFidelity RemoteIndicatorsACCEPTABLEThree Areas SelectiveSorptionEnhancement TemporalFidelity RemoteIndicators SelectiveSorptionEnhancement ClutterRejection RemoteIndicators SelectiveSorptionEnhancement ClutterRejection TemporalFidelityTwo Areas SelectiveSorption Rejection TemporalFidelity UNACCEPTABLETwo AreasOne Area SelectiveSelectiveSorptionSorptionEnhancement Enhancement ClutterRejectionClutter nRemoteIndicators TemporalFidelityRemoteIndicatorsTemporal FidelityRemote IndicatorsINTELLIGENCE ADVANCED RESEARCH PROJECTS ACTIVITY (IARPA)42

Metrics – All Thrust AreasForm FactorPowder plus one additional form factor of offeror’s choosingSorbent CapacityMinimum sorption capacity of 10% w/w of the sorbentSorbate Retention 10% mass loss under exposure to: 100 liter per minute N2 flow 90% relative humidity 72 hour ambient exposure 100 torr vacuumSorbate Stabilization 90% of sorbed material retains original chemical state or isderivatized upon sorption to a single predictable state (nodecomposition or catalytic reactions)Release Efficiency 90% sorbate desorption as usable analyteRelease MethodThermal desorption preferred, any other proposed release methodmust be compatible with conventional chemical separation andidentification techniquesINTELLIGENCE ADVANCED RESEARCH PROJECTS ACTIVITY (IARPA)43

Metrics – Selective Sorption EnhancementBroad Sorption CapabilityCapture efficiency from C4-C14 within 25% of average broadspectrum capture rateSelective SorptionCapabilityConcentration factor of 10 (threshold) / 100 (goal) over relativeambient exposure for 3 (threshold) / 8 (goal) of the followingcompounds: Ordinance Related Chemicals Nerve Agents & Simulants Blister/Choking Agents & Simulants Cholinesterase Inhibitors Blood Agents Chemical Agent Precursors Toxic Industrial ChemicalsINTELLIGENCE ADVANCED RESEARCH PROJECTS ACTIVITY (IARPA)44

Metrics – Clutter RejectionBroad Sorption CapabilityCapture efficiency from C4-C14 within 25% of average broadspectrum capture rateClutter RejectionConcentration reduction of 10 (threshold) / 100 (goal) over relativeambient exposure for 1 (threshold) / 3 (goal) of the followingcompounds: Water Hydrocarbons (aliphatic)INTELLIGENCE ADVANCED RESEARCH PROJECTS ACTIVITY (IARPA)45

Metrics – Temporal FidelityFast TemporalCharacteristics 90% of sorbent active within 2 minutes after trigger 5% of sorbent still active 12 minutes after triggerNo more than 10% performance change, tested at 10%, 50%, 90% RHSlow TemporalCharacteristics 90% of sorbent active within 1 hour after trigger 5% of sorbent still active 6 hours after triggerNo more than 10% performance change, tested at 10%, 50%, 90% RHINTELLIGENCE ADVANCED RESEARCH PROJECTS ACTIVITY (IARPA)46

Metrics – Remote IndicatorsGas Phase Tracer Release 0.1% tracer release per hour under ambient exposure, no target 90% tracer release within 5 minutes of tracer exposureSolid Phase Tracer Release 0.1% tracer release per hour under ambient exposure, no target 90% tracer release within 5 minutes of tracer exposurePhysical Change Tracer 0.1% of sorbent undergoes physical change per hour under ambientexposure, no target 90% of sorbent undergoes physical change within 5 minutes oftracer exposureINTELLIGENCE ADVANCED RESEARCH PROJECTS ACTIVITY (IARPA)47

Milestones and WaypointsMilestones are Government-defined progress metrics that must be met bythe end of each phaseWaypoints are offeror-defined, task-driven intermediate steps towards amilestoneDepending on an offeror’s specific approach, progress towards a milestone isnot expected to be linear in all areasWaypoints are how the offeror clearly explains to the Government thequantitative and timely progress that must be made for their overall concept tomeet the end-of-phase Milestones – performance against these waypoints isreviewed throughout programTechnical reviews held at months 3, 5, 8, 11, and 14 will quantify progressagainst the waypoints & assess whether course corrections are needed forsuccessINTELLIGENCE ADVANCED RESEARCH PROJECTS ACTIVITY (IARPA)48

Anticipated Performance ScheduleMonths esign complete,selective adsorptionproof of conceptexperimentsDemonstrate selectiveadsorption at 50% of finalperformance parametersReady forGovernmentBenchmark testMeet allPhase 1MilestonesClutter RejectionDesign complete,clutter rejection proofof concept experimentsDemonstrate clutterrejection at 50% of finalperformance parametersReady forGovernmentBenchmark testMeet allPhase 1MilestonesTemporal Fidelity Design complete,temporal fidelity proofof concept experimentsDemonstrate temporalfidelity at 50% of finalperformance parametersReady forGovernmentBenchmark testMeet allPhase 1MilestonesRemoteIndicatorsDemonstrate remoteindicator trigger at 50% offinal performanceparametersReady forGovernmentBenchmark testMeet allPhase 1MilestonesDesign complete,remote indicator proofof concept experimentsINTELLIGENCE ADVANCED RESEARCH PROJECTS ACTIVITY (IARPA)49

List of DeliverablesKickoff meeting. Corrected slide package provided within 15 days after meetingdate.Washington metro area technical reviews. Corrected slide packages providedwithin 15 days after meeting date.On-site technical review. Corrected slide package provided within 15 days aftermeeting date.Benchmark testing at Government T&E Facility.Government Interaction Day.Demonstration of Phase 1 milestones per 1.B.5.System available for independent Government testing.Final report. Format provided upon contract award.Demonstration hardware (1 gram sorbent sample packaged in vacuum sealedcontainer).Monthly technical and financial reports.INTELLIGENCE ADVANCED RESEARCH PROJECTS ACTIVITY (IARPA)15, 1510141517171818Monthly, by10th day offollowingmonth.50

Schedule0DeliverablesTestReviewsMonth123456789 10 11 12 13 14 15 16 17 18KickoffTechnical ReviewsGovernment WorkshopBenchmark TestFinal ExamAlgorithm Training SetTraining SamplesMonthly ReportsFinal ReportSorbent SampleWashington Metro Area TIMSite Visit and ReviewINTELLIGENCE ADVANCED RESEARCH PROJECTS ACTIVITY (IARPA)51

ReferencesBibliography of example “smart” sorbents:Lei Cheng, Yao Jiang, Ni Yan, Shu-Feng Shan, Xiao-Qin Liu, and Lin-Bing Sun*, SmartAdsorbents with Photoregulated Molecular Gates for Both Selective Adsorption andEfficient Regeneration, ACS Appl. Mater. Interfaces 2016, 8, 23404 23411Yao Jiang, Peng Tan, Lei Cheng, Shu-Feng Shan, Xiao-Qin Liu and Lin-Bing Sun*,Selective adsorption and efficient regeneration via smart adsorbents possessingthermo-controlled molecular switches, Phys.Chem.Chem.Phys., 2016, 18, 9883J.W. Long, D.R. Rolison, and M.S. Logan, Magneto-Mechanical Deformations ofPorous Magnetic Iron Oxide, Nanoarchitectures, U.S. Patent #7,754,085Brian J. Melde, Brandy J. Johnson,* and Paul T. Charles, Mesoporous SilicateMaterials in Sensing, Sensors 2008, 8, 5202-5228Dmitry A Kozak, R. Andrew McGill, Todd H Stievater, Robert Furstenberg et al,Infrared spectroscopy for chemical agent detection using tailored hypersorbentmaterials, Proceedings of SPIE Volume: 9482, Article #: 94820E 2015. DOI:10.1117/12.2177571INTELLIGENCE ADVANCED RESEARCH PROJECTS ACTIVITY (IARPA)52

T&E Team Background PresentationsNaval Research Laboratory & Edgewood Chemical Biological CenterIntelligence Advanced Research Projects Activity

Doing Business with IARPAMr. Tarek Abboushi, Chief Acquisitions OfficerIntelligence Advanced Research Projects ActivityINTELLIGENCE ADVANCED RESEARCH PROJECTS ACTIVITY (IARPA)

Ithildin Proposers’ Day AgendaINTELLIGENCE ADVANCED RESEARCH PROJECTS ACTIVITY (IARPA)

Doing Business with IARPA - RecurringQuestionsQuestions and Answers (http://www.iarpa.gov/index.php/faqs)Eligibility InfoIntellectual PropertyPre-Publication ReviewPreparing the Proposal (Broad Agency Announcement (BAA) Section 4)Electronic Proposal Delivery (https://iarpa-ideas.gov) Organizational Conflicts of th-iarpa/iarpas-approach-to-oci)Streamlining the Award ProcessAccounting systemKey PersonnelIARPA Funds Applied ResearchRECOMMENDATION: Please read the entire BAAINTELLIGENCE ADVANCED RESEARCH PROJECTS ACTIVITY (IARPA)56

Responding to Q&AsPlease read entire BAA before submitting questionsPay attention to Section 4 (Proposal & SubmissionInformation)Read Frequently Asked Questions on the IARPA @http://www.iarpa.gov/index.php/faqsSend your questions as soon as possibleIthildin BAA: dni-iarpa-baa-17-04@iarpa.govWrite questions as clearly as possibleDo NOT include proprietary informationINTELLIGENCE ADVANCED RESEARCH PROJECTS ACTIVITY (IARPA)57

Eligible ApplicantsCollaborative efforts/teaming strongly encouragedContent, communications, networking, and team formation arethe responsibility of ProposersForeign organizations and/or individuals may participateMust comply with Non-Disclosure Agreements, SecurityRegulations, Export Control Laws, etc., as appropriate, asidentified in the BAAINTELLIGENCE ADVANCED RESEARCH PROJECTS ACTIVITY (IARPA)58

Ineligible OrganizationsOther Government Agencies, Federally Funded Research andDevelopment Centers (FFRDCs), University Affiliated ResearchCenters (UARCs), and any organizations that have a specialrelationship with the Government, including access to privilegedand/or proprietary information, or access to Governmentequipment or real property, are not eligible to submit proposalsunder this BAA or participate as team members under proposalssubmitted by eligible entities.INTELLIGENCE ADVANCED RESEARCH PROJECTS ACTIVITY (IARPA)59

Intellectual Property (IP)Unless otherwise requested, Government rights for data firstproduced under IARPA contracts will be UNLIMITEDAt a minimum, IARPA requires Government Purpose Rights(GPR) for data developed with mixed fundingException to GPRState in the proposal any restrictions on deliverables relating toexisting materials (data, software, tools, etc.)INTELLIGENCE ADVANCED RESEARCH PROJECTS ACTIVITY (IARPA)60

Pre-Publication ReviewFunded Applied Research efforts, IARPA encourages:Publication for Peer Review of UNCLASSIFIED researchPrior to public release of any work submitted for publication,the Performer will:Provide copies to the IARPA PM and Contracting Officer Representative(COR/COTR)Ensure shared understanding of applied research implications betweenIARPA and PerformersIARPA PM decides on approval for release or receiving courtesy copyINTELLIGENCE ADVANCED RESEARCH PROJECTS ACTIVITY (IARPA)61

Preparing the ProposalNote restrictions in BAA Section 4 on proposal submissionsInterested Offerors must register electronically IAW instructions on:https://iarpa-ideas.govInterested Offerors are strongly encouraged to register in IDEAS at least1 week prior to proposal “Due Date”Offerors must ensure the version submitted to IDEAS is the “FinalVersion”Classified proposals – Contact IARPA Chief of Secu

computing research funded by IARPA World's leading funder of quantum computing academic research, and quantum research cited as Science Magazine's "reakthrough of the Year" White House BRAIN Initiative, National Strategic Computing Initiative Dr. Craig Gentry named a MacArthur Fellow Although best known for quantum computing .