Lewin’s GENES XII

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Jones & Bartlett Learning, 2017This item was created as a helpful tool for you, our valued customer,and is not intended for resale, dissemination, or duplication.Lewin’s GENES XIIIncludes Navigate 2 Advantage AccessJocelyn E. Krebs, PhD, University of Alaska, AnchorageElliott S. Goldstein, PhD, Arizona State UniversityStephen T. Kilpatrick, PhD, University of Pittsburgh at JohnstownISBN-13: 978-1-284-10449-3Hardcover with Access Code 992 Pages 2018Jones & Bartlett LearningSEE WHAT’S NEW TO THE TWELFTH EDITION!Contact Your Publisher’s Representative For More Information1-800-832-0034 info@jblearning.com www.jblearning.com

Jones & Bartlett Learning, 2017This Transition Guide outlines many of the changes and new content in theTwelfth Edition. Use this guide for an easy transition to the new edition.Long considered the quintessential molecular biology textbook, for decades Lewin's GENES hasprovided the most modern presentation to this transformative and dynamic science. Now in itstwelfth edition, this classic text continues to lead with new information and cutting-edgedevelopments, covering gene structure, sequencing, organization, and expression. Leadingscientists provide revisions and updates in their respective areas of study offering readerscurrent research and relevant information on the rapidly changing subjects in molecularbiology. No other text offers a broader understanding of this exciting and vital science or doesso with higher quality art and illustrations. Lewin's GENES XII continues to be the clear choicefor molecular biology and genetics.All chapters have been carefully and thoroughly revised and updated with the latest scientificand education research.A completely redesigned interior layout will draw in the reader and help to engage students inthe high-quality pedagogical features.CHAPTER OUTLINETable of Contents comparison to transition from the Eleventh to the Twelfth EditionGENES XIPart 1 Genes and ChromosomesChapter 1 Genes Are DNAChapter 2 Genes Encode RNAs andPolypeptidesChapter 3 Methods in Molecular Biology andGenetic EngineeringChapter 4 The Interrupted GeneChapter 5 The Content of the GenomeChapter 6 Genome Sequences and GeneNumberChapter 7 Clusters and RepeatsChapter 8 Genome EvolutionChapter 9 ChromosomesChapter 10 ChromatinPart 2 DNA Replication and RecombinationGENES XIIPart 1: Genes and ChromosomesChapter 1: Genes are DNA and Encode RNAsand PolypeptidesChapter 2: Methods in Molecular Biology andGenetic EngineeringChapter 3: The Interrupted GeneChapter 4: The Content of the GenomeChapter 5: Genome Sequences and EvolutionChapter 6: Clusters and RepeatsChapter 7: ChromosomesChapter 8: ChromatinPart 2: DNA Replication and RecombinationChapter 9: Replication Is Connected to the CellCycleChapter 10: The Replicon: Initiation ofReplicationContact Your Publisher’s Representative For More Information1-800-832-0034 info@jblearning.com www.jblearning.com

Jones & Bartlett Learning, 2017Chapter 11 Replication Is Connected to theCell CycleChapter 12 The Replicon: Initiation ofReplicationChapter 13 DNA ReplicationChapter 14 Extrachromosomal RepliconsChapter 15 Homologous and Site-SpecificRecombinationChapter 16 Repair SystemsChapter 17 Transposable Elements andRetrovirusesChapter 18 Somatic Recombination andHypermutation in the Immune SystemPart 3 Transcription and PosttranscriptionalMechanismsChapter 19 Prokaryotic TranscriptionChapter 20 Eukaryotic TranscriptionChapter 21 RNA Splicing and ProcessingChapter 22 mRNA Stability and LocalizationChapter 23 Catalytic RNAChapter 24 TranslationChapter 25 Using the Genetic CodePart 4 Gene RegulationChapter 26 The OperonChapter 27Chapter 28RegulationChapter 29Chapter 30Phage StrategiesEukaryotic TranscriptionEpigenetic Effects Are InheritedRegulatory RNAChapter 11: DNA ReplicationChapter 12: Extrachromosomal RepliconsChapter 13: Homologous and Site-SpecificRecombinationChapter 14: Repair SystemsChapter 15: Transposable Elements andRetrovirusesChapter 16: Somatic DNA Recombination andHypermutation in the Immune SystemPart 3: Transcription and PosttranscriptionalMechanismsChapter 17: Prokaryotic TranscriptionChapter 18: Eukaryotic TranscriptionChapter 19: RNA Splicing and ProcessingChapter 20: mRNA Stability and LocalizationChapter 21: Catalytic RNAChapter 22: TranslationChapter 23: Using the Genetic CodePart 4: Gene RegulationChapter 24: The OperonChapter 25: Phage StrategiesChapter 26: Eukaryotic TranscriptionRegulationChapter 27: Epigenetics IChapter 28: Epigenetics IIChapter 29: Noncoding RNAChapter 30: Regulatory RNAContact Your Publisher’s Representative For More Information1-800-832-0034 info@jblearning.com www.jblearning.com

Jones & Bartlett Learning, 2017IMPORTANT CHAPTER UPDATESIn addition to the key updates made to all chapters, the authors have provided more detailednotes on significant changes in certain chapters.Chapter 1 Previously Chapters 1 & 2 in EleventhEdition Added more information about theHershey-Chase and Meselson-Stahlexperiments Updated information about mutations Expanded discussion of RNAs and RNAsplicingChapter 2 Previously Chapter 3 in Eleventh Edition Addition of section on genome editing,including TALENs, ZPNs, andCRISPR/Cas9Chapter 3 Previously Chapter 4 in Eleventh Edition Updated information on large genes Added referencesChapter 4 Previously Chapter 5 in Eleventh Edition Updated information about genomemapping Added content about genome-wideassociation studies to detect genesassociated with human phenotypes Updated discussion of transposonsChapter 5 Previously Chapters 6 & 8 in EleventhEdition Updated whole genome sequenceinformation, genome sizes, and genenumbers for some organisms Updated discussion of pseudogenesChapter 6 Previously Chapter 7 in Eleventh Edition Updated discussion of DNA profilingChapter 7 Previously Chapter 9 in Eleventh Edition Added and updated information onbacterial nucleoid structure anddynamics, including the role of NAPs(nucleoid associated proteins) Added and updated information oneukaryotic centromere and telomerestructure and function, Included new information onchromosome territories and replicationdomainsChapter 8 Previously Chapter 10 in EleventhEdition New information on topologicallyassociated domains (TADs) and updatesthroughoutChapter 9 Previously Chapter 11 in EleventhEdition Major modification to section on shapeand spatial organization of a bacteriumduring chromosome segregation andcell division Major modification to section on minand noc/slm genes regulating thelocation of the septum Major modification to section onseparation of the chromosomes Major modification to chromosomalsegregation requiring site-specificrecombinationChapter 10 Previously Chapter 12 in EleventhEdition Updated referencesContact Your Publisher’s Representative For More Information1-800-832-0034 info@jblearning.com www.jblearning.com

Jones & Bartlett Learning, 2017Chapter 11 Previously Chapter 13 in EleventhEdition Updated referencesChapter 12 Previously Chapter 14 in EleventhEditionChapter 13 Previously Chapter 15 in EleventhEditionChapter 14 Previously Chapter 16 in EleventhEdition Expanded discussion of repair bymethyltransferases Updated information on pathways ofdouble strand break repair Expanded discussion of repair in thechromatin context, including PARylationChapter 15 Previously Chapter 17 in EleventhEditionChapter 16 Previously Chapter 18 in EleventhEdition Extensive updates and reorganizationthroughout New section on epigenetics andnoncoding RNAs in V(D)Jrecombination, CSR and SHMChapter 17 Previously Chapter 19 in EleventhEdition Updated section on interactionsbetween sigma factor and core RNApolymerase during promoter escape Updated section on stalled RNApolymeraseChapter 18 Previously Chapter 20 in EleventhEdition New material on enhancer RNAs (eRNA) Update references New material on Pol/DNA binding,clearance, and pause buttonmechanismChapter 19 Previously Chapter 21 in EleventhEdition Updated information about histonemRNAs Added referencesChapter 20 Previously Chapter 22 in EleventhEditionChapter 21 Previously Chapter 23 in EleventhEdition Added information about syntheticribozymes and synthetic inteins,taxonomic distribution of Group Iintrons, and the splicing mechanism forGroup II introns Added referencesChapter 22 Previously Chapter 24 in EleventhEdition Updated information about ribosomaltranslocation and about mRNA stability Added referencesChapter 23 Previously Chapter 25 in EleventhEdition Added information about variations togenetic code Added referencesContact Your Publisher’s Representative For More Information1-800-832-0034 info@jblearning.com www.jblearning.com

Jones & Bartlett Learning, 2017Chapter 24 Previously Chapter 26 in EleventhEdition Updated references Updated material on how transcriptionfactors slide on DNAChapter 25 Previously Chapter 27 in EleventhEdition Added referencesChapter 26 Previously Chapter 28 in EleventhEdition Added references Expanded discussion of the functionalinteractions between chromatinremodeling complexes and histonemodifying complexes and histonemodificationsChapter 27 Previous Chapter 29 in Eleventh Editiondivided into two and reorganized Expanded discussion of epigenetic driftand transgenerational epigeneticinheritanceChapter 28 Previous Chapter 29 in Eleventh Editiondivided into two and reorganized Updates on dosage compensation andimprintingChapter 29 Previously Chapter 30 in EleventhEdition Updated referencesChapter 30 NEW chapter on Interfering RNAsORGANIZATIONAL NOTE & CUSTOM PUBLISHINGINFORMATIONFor instructors who prefer to order topics with the essentials of DNA replication and geneexpression followed by more advanced topics, the following chapter sequence is suggested:Introduction: Chapter 1Gene and Genome Structure: Chapters 4–6DNA Replication: Chapters 9–12Transcription: Chapters 17–20Translation: Chapters 22–23Regulation of Gene Expression: Chapters 7–8 and 24–30Other chapters can be covered at the instructor’s discretion.Jones & Bartlett Learning offers Custom Publishing! If you would prefer this alternateorganization, or a different organization we can print a custom version for your course. Also, ifyou know there are certain chapters you will not cover, Jones & Bartlett Learning can createcustom versions that only contain the content you want that will often provide a cost saving foryour students. Custom Publishing is easier and less expensive than you think! Your AccountManager will be happy to assist you with designing your custom text, or you can learn more athttp://customsolutions.jblearning.com/.Contact Your Publisher’s Representative For More Information1-800-832-0034 info@jblearning.com www.jblearning.com

Jones & Bartlett Learning, 2017TEACHING TOOLS - SUPPORT FOR INSTRUCTORSThe Publisher will provide a variety of Teaching Tools to assist instructors with preparing forand teaching their courses. These resources are available via digital download and multipleother formats. Lecture Slides in PowerPoint format Test Bank Materials Online Image Bank Animations Navigate 2 platform with an interactive eBook and course management tools, includingan Assessment center with prepopulated quizzes, exams, and Study Tools for yourstudentsEACH NEW PRINT BOOK COMES WITH NAVIGATE 2ADVANTAGE ACCESSEach new print book now comes packaged with access to Navigate 2 online learning solution atno extra cost. Navigate 2 delivers unbeatable value to students and instructors alike. Some ofthe great features include: A complete and interactive eBook including links to useful websites and other uniquefeatures A virtual Study Center with Practice Activities and other learning tools for students An Assessment center with prepopulated quizzes and tests for instructors to assign A dashboard that reports actionable data on student use and progress to instructorsPRICE BREAK! Students can also purchase “standalone” access to Navigate 2 Advantageincluding the interactive eBook for just half the price of the print book.Contact your Publisher’s Representative for a demo today!Contact Your Publisher’s Representative For More Information1-800-832-0034 info@jblearning.com www.jblearning.com

Introduction: Chapter 1 . Gene and Genome Structure: Chapters 4–6 . DNA Replication: Chapters 9–12 . Transcription: Chapt

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