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DIANOTECH - Microsoft

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Products SchematicFluorescence Quantitative AnalyzerMinimum detection limit : full range signal value is 0.05%Stability : after 10 tests, TC/CV 0.5%Signal-to-Noise Ratio : 0.01% (1:10,000)Supported Data Connection : LAN, GPRS, COMTechnical parametersUser interface : 7 inches, capacitive touch screen displayStorage : 100,000 Patient Test ResultItem identification : Intelligent identification of 1200 items and batches0102

Products Listcanine C-Reactive Protein (cCRP)Product nameAbbreviationRapid detection kit for canine C-Reactive ProteincCRPRapid detection kit for feline Serum Amyloid AfSAARapid detection kit for canine ProgesteronecProgRapid detection kit for canine Cystatin CcCys-CRapid detection kit for feline Cystatin CfCys-CRapid detection kit for feline N-terminalpro-brain natriuretic peptidefNT-proBNPRapid detection kit for canine N-terminalpro-brain natriuretic peptidecNT-proBNPRapid detection kit for caninePancreas-Specific LipasecPLRapid detection kit for felinePancreas-Specific LipasefPLInflammatory MarkerReproductive MarkerKidney Disease MarkerMyocardium MarkerDigestive Tract MarkerRapid detection kit for canine CortisolcCortisolEndocrine MarkerRapid detection kit for canine Total ThyroxineThrombus MarkercTT4Rapid detection kit for canine D-DimercD-DimerRapid detection kit for canine Distemper Virus IgGantibodyCDV IgGRapid detection kit for canine Parvovirus IgG antibodyCPV IgGRapid detection kit for feline Parvovirus IgG antibodyFPV IgGAcute phase proteinSynthesized by hepatocytes in the liverIn response to inflammation cause bymicrobial invasion or tissue damageTriggered by various cytokines30100Increases with acute and chronic30000Change in Plasma Concentration(%)Item categoryinflammation、tissue injur y、700C-reactive protein600500CDVRapid detection kit for canine ParvovirusCPVRapid detection kit for canine CoronavirusCCVRapid detection kit for feline ParvovirusFPVRapid detection kit for feline CalicivirusFCVRapid detection kit for feline HerpesvirusFHVRapid detection kit for canine Parvovirus/canineCoronavirusCPV/CCVIncreases signifecantly 4-6h fromSerum amyloiod A400onset, reach to peak within 24-48h300HaptoglobinFibrinogen200100Drops rapidly afterC3recorvery (half life 19h),reach to0TransferrinAlbumin07Rapid detection kit for canine Distemper virusmalignant tumorsnormal after 3-7d1421Time after Inflammatory Stimulus (days)Viral infectiousdisease Tests03Result interpretationnormal 10mg/L10mg/Lmild inflammation40mg/L04systemic inflammation 40mg/L

Specification and parameterfeline Serum Amyloid A (fSAA)Species : CanineDetection range : 5mg/L-240mg/LSample types : whole blood, serum or plasmaSample volume : 5 μL serum, plasma or 10 μL whole bloodDetection time : 5minSAA introductionSAA is an acute phase protein used to evaluate the level of inflammation in the body.Storage temperature : 4-30 Bacterial infection, most viral infection, surgical injury or malignant tumor can lead toShelf life : 18 monthsthe increase of SAA and the increase of SAA is positively correlated with the number ofnecrotic cells and tissues.CRP and WBC comparisonSAA can reach its peak within 4 6 hours after the occurrence of systemic inflammationand SAA level will be reduced or return to normal after the disease is treated or cured.C-reactive protein(CRP)The rate ofresponse toinflammationInfluencefactorsActivityof relateddiseasesIdentifybacterial orviral infectionsWhite blood cell(WBC)CRP increases significantly 4 6hours after inflammation. It peaksat 48h (up to 100 to 1000 foldscompared to the normal value)and drops rapidly when infection iscontrolled.WBC responses slowly with anupward trend as long as 36 hours.After treatment, it decreases slowlywith the elimination of inflammatorystimulation.It is independent of individualdifferences, body states andtherapeutic drugs.It is influence by age, diurnal changes,body resistance, drug therapy andother confounding factors.The increase during bacterialinfection is rapid while the increaseduring virus infection is notobvious.The base value range of WBC is wide.The base number of WBC in animalsare different due to difference in breed,age and other factors and the slightincrease will not exceed the upper limitof the normal range.The extent of the increase ispositively correlated with thedegree of bacterial infection.Yes (significant difference)In the case of chronic bacterialinfection, the WBC count will notincrease in time and the count andclassification index will not changesignificantly.Difficult (some differences are notsignificant)Not a reliable indicator05Clinical significanceSensitive marker of inflammation and tissue damageContinuous detection of SAA can monitor the progress of the diseaseMonitor surgical proceduresGuide and monitor the efficacy of antibioticsPrognostic marker of diseases06

Increase range of SAA in different diseasescanine Progesterone (cProg)Marked increaseFungal or bacterial infectionsModerate to severe elevationRenal failure, viral infection, tissue damage, cachexia, autoimmune disease, arthritis,Progesterone is the most sensitive clinical indicator for the optimal mating periodmyocardial injury, vasculitisVaginalCornificationModerate elevationUrinary tract infections, tumor, diabetes, local inflammationThe low level of SAA indicates no serious tissue injury or bacterial infection.0-1-9-8-7 -6-5-4Proestrus 9 days-3 -2-1 s 1utrEs32456Estrus 9 daysFertile PeriodgrotEsOvulationenEnteritis, oral and liver diseasesMaturationLHNo elevationProgesterone78D9 s1rustie234DiestrusResult interpretationHormone changes during estrus in dogs2mg/Lnormal 2mg/L10mg/LMild inflammationModerate to severe inflammationProgesterone levels in female dogsSpecification and parameterOvulationSpecies : felineProgesteroneLH peak : 2ng/mLDetection range : 0.5mg/L-200mg/LSample types : whole blood, serum or plasmaSamplevolume : 5μL serum, plasma or 10μL whole bloodDetection time : 5minOvulation : 5-10 ng/mLEstrogenMetestrus : 15-80 ng/mLWhelping : 3 ng/mL /- 2ng/mLAnestrus : 1ng/mLStorage temperature : 4-30 5-10 ng/mlLH9DaysProestrusShelf life : 18 strus

Result interpretationN-Terminal pro-Brain Natriuretic Peptide (NT-proBNP)The progesterone value in unestrous dogs is less than 2ng/mL.The progesterone value increases slowly after oestrus. The dog begins to ovulate whenprogesterone value is at about 5ng/mL and the progesterone value increases rapidlyafterwards;When progesterone value is 15-40ng/mL, it is the best mating period.NT-proBNP is recognized as the best marker for heart failure with high accuracy, goodstability and strong objectivity.When the progesterone value is higher than 70ng/mL, dogs will enter the later stage ofestrus and mating is not recommended.The increase of progesterone is related to the breed, size and age of the dog.Clinical significanceOptimal biomarkers for the diagnosis and exclusion of heart failure;Specification and parameterPrognostic assessment, risk classification and therapeutic effect monitoring of heartSpecies : Caninefailure;Detection range : 0.5ng/mL -80ng/mLImportant prognostic factor of coronary heart disease;Sample types : serum or plasmaMonitoring tools before, during and after cardiac surgery.Sample volume : 50μL serum or plasmaDetection time : 10 minStorage temperature : 2-8 Specification and parameterShelf life : 18 monthsDIANOTECHcProg09Product parametercNT-proBNPfNT-proBNPNormal reference value800pmol/L150pmol/LDetection range150pmol/L-6000pmol/L50pmol/L-1000pmol/LSample typeserum or plasmaserum or EDTA anticoagulantplasmaSample volume50μL100μLDetection time10min10minStorage temperature4-30 4-30 Shelf life18 months18 months10

Cystatin C (Cys C)Pancreatitis specific lipase (cPL, fPL)PancreatitisCys C is cleared by glomerular filtration, which is an ideal endogenous marker reflectingchanges in glomerular filtration rate (GFR) and an early evaluation index of renal functionPancreatitis is one of the most common digestive diseases in both dogs and cats withinjury with high specificity, accuracy and sensitivity.acute and chronic forms as well as pancreatic tumors. Both acute pancreatitis andCystatin C is superior to creatinine and urea nitrogen and is not affected by gender, age,chronic pancreatitis have complicated clinical manifestations and the specific diagnosisheight, muscle mass, dietary structure, drugs and disease status of the body. Even in theis difficult.state of inflammation, its production rate does not change.Laboratory enzyme testing for pancreatitis includes amylase, lipase and pancreatitisspecific lipase (PL). PL is an endopeptidase secreted by the pancreas. It is pancreas-Clinical significancespecific and is not affected by exogenous lipase of pancreas.cPL and fPL are currently the most sensitive (87%-94%) and specific (81%-88%)Most sensitive marker for renal function evaluationlaboratory diagnostic biomarker for diagnosis of pancreatitis in dogs and cats. TheEarly diagnosis of chronic kidney disease and acute renal impairmentsensitivity of PL is lower for chronic pancreatitis than for acute pancreatitis.Monitoring renal function recovery and evaluate therapy efficacyResult interpretationResult /mL)Interpretation 200normal 3.6normalcCys CfCys CInterpretation200 - 399gray zone3.6 - 5.3gray zone 1.2mg/L 7mg/dLNormal400 - 599positive5.4 - 14.9positive1.2mg/L-1.5mg/L7mg/dL-10mg/dLSuspected renal injury 600strongly positive 15.0strongly positive 1.5mg/L 10mg/dLSuggested renal injurySpecification and parameterSpecification and parameterProduct parameterscPLfPLProduct parameterscCys CfCys CDetection range50ng/mL-1000ng/mL2ng/mL-50ng/mLDetection range0.1mg/L-10mg/L3mg/dL-30mg/dLSample typesserumserumSample typesserum or plasmaserum or plasmaSample volume50μL50μLSample volume10μL10μLDetection time10min10minDetection time10min10minStorage temperature2-8 2-8 Storage temperature4-30 4-30 Shelf life18 months18 monthsShelf life18 months18 months1112

canine D-DimerTotal Thyroxine (TT4)D-Dimer is increased in any condition resulting in the formation and breakdown of fibrin;T4 is a type of thyroxine and a hormone synthesized and secreted by thyroid folliculartherefore, it is not specific for thromboembolic disease.cells, which is released into the blood circulation in a free form and rapidly binds to plasmaD-Dimer is a by-product of fibrinogen degradation and is an evidence of hypercoagulabilityproteins.in dogs with various thromboembolic diseases, including parvoviral enteritis, immune-Hypothyroidism of dogsmediated hemolytic anemia and Heartworm disease.D-Dimer concentrations are increased in dogs after surgical procedures and in dogs withObesity, skin disease, lethargy, mental dullness, weak and feeble, frigolabileimmune-mediated hemolytic anemia, cancer, liver disease, heart failure, renal failure, orHyperthyroidism of catsinternal hemorrhage.Weight loss, excessive excitement, mental disorders, dry hair, more hair or excessive hairloss; unilateral or bilateral enlargement of the thyroid gland may be observedNormal valueCitrated plasma 20μL 0.55mg/LDetection rangeDetection time0-10mg/L10min20y 1.0478x-0.0907Low T4R² 0.984815(mg/L)D-dimer test results of DianotechSampleHypothyroidism, low TBG level (nephrotic syndrome, chronic liver disease, protein-loss10bowel disease), hypohypopituitarism, hypothalamic disease.5High T400510Test results of imported reagent(mg/L)15Hyperthyroidism, high TBG level (pregnancy, oral estrogen and birth control pills, familyhistory), acute thyroiditis, subacute thyroiditis, acute hepatitis, obesity, eating thyroid organswith rich thyroid hormones during the using of thyroid hormones.1314

Result interpretationPet Infectious Disease(antigen detection)cTT4(nmol/L)Interpretation 13 *Low13 - 26 *Gray zone26 - 51Normal 51HighThe kits are used for rapid quantitative detection of canine Distemper virus, canineParvovirus, canine Coronavirus and feline Distemper virus.The kits can be used for epidemiological investigation of pet infectious diseases to provideGray zone: Suspected hypothyroidism; TSH should be tested in combination with the clinicalsymptoms of the dog.accurate disease information for the owners and doctors, and to take preventive ortherapeutic measures.fTT4(nmol/L)Interpretation 10Low10 - 30Normal30 - 60 *Gray zone 60 *HighClinical significanceEarly and latent infection of the virus can be detected during physical examinationWhen clinical symptoms appear, the pathogen can be identified quickly.Gray zone: Suspected hyperthyroidism; This should be combined with clinical symptomsTo eliminate and/or prevent infection quickly in cases which contacted with otherand other diagnoses for evaluation.infected pets.Specification and parameterProduct parameterscTT4fTT4Detection range6.4-90nmol/L6.4-90nmol/LSample typesserum or heparin lithiumanticoagulant plasmaserum or heparin lithiumanticoagulant plasmaResult interpretationSample volume100μL100μLIncubation time5min5min 10 10 10 10 10 10NegativeDetection rStorage temperature4-30 4-30 20-4020-4020-4020-4020-4020-40mild positiveShelf life18 months18 months 40 40 40 40 40 IU)16FCV(IU)FHV(IU)Interpretation

Specification and parameterPet Infectious Disease(IgG antibody detection)ProductparametersCDVDetectionrange5IU - 200IUCPVCCV5IU - 200IU 5IU - 200IUFPVFCVFHV5IU - 200IU5IU - 200IU5IU - 200IUThe kits are used for rapid quantitative detection of IgG antibody against canine Distempervirus, Parvovirus and feline Distemper virus .Sampletypeeye, mouthand nosedischargefaecesfaecesfaeceseye, mouthand nosedischargeeye, mouthand nosedischargeVaccination is one of the effective way to prevent infectious diseases in pets. Vaccinationcan not only reduce the susceptibility to infectious diseases but also improve the specificresistance of cats and dogs to infectious diseases.Successful immunization not only depends on the quality of vaccination, vaccination d immunization procedures and other external conditions but also depends on theimmune response ability of the body. Regular antibody measurement is important to thepet to maintain a healthy state.StorageTemperature4-30 4-30 4-30 4-30 4-30 4-30 Shelf life18 months18 months18 months18 months18 months18 monthsClinical significanceBefore vaccination :Timely detection of latent virus infection to ensure immunization safety;Determine titer of maternal source antibody to ensure immunization effect.After vaccination :Detect antibody titer to monitor immunization effect;Annual regular testing :Regular antibody titer test to ensure the safety and effectiveness of the immunobarrier.1718

Result interpretationCDV IgG(U) CPV IgG(U) FPV IgG(U) FCV IgG(U) FHV IgG(U) Grade 1.0 0.5 1.0 1.0 1.0Grade 01.0 - 2.00.5 - 1.01.0 – 1.51.0 – 1.51.0 – 1.5Grade 12.1 - 5.01.1 - 2.51.6 - 2.01.6 - 2.01.6 - 2.0Grade 25.1 - 10.02.6 - 5.02.1 – 2.32.1 – 2.32.1 – 2.3Grade 310.1 - 20.05.1 - 10.02.4 – 5.52.4 – 5.52.4 – 5.5Grade 420.1 - 50.010.1 - 20.05.6 – 8.05.6 – 8.05.6 – 8.0Grade 5 50.0 20.0 8.0 8.0 8.0Grade 6Interpretation- , Recommendimmunization , Insufficientimmunization,Recommendimmunization ,IgG antibodyexists , high titerIgG antibodySpecification and parameterProduct parametersCDV IgGCPV IgGFPV IgGFCV IgGFHV IgGDetection range1.0U - 50.0U0.5U - 20.0U1.0U - 8.0U1.0U - 8.0U1.0U - 8.0USample typeserum orEDTA orsodium citrateanticoagulantplasmaserum orplasmaSample volume10μL10μL10μL10μL10μLDetection 0 4-30 4-30 4-30 4-30 Shelf life18 months18 months18 months18 months18 months19serumserumserumor EDTAor EDTAor EDTAanticoagulant anticoagulant anticoagulantplasmaplasmaplasma

Rapid detection kit for canine Parvovirus Rapid detection kit for canine Coronavirus Rapid detection kit for feline Parvovirus Rapid detection kit for feline Calicivirus Rapid detection kit for feline Herpesvirus Rapid detection kit for canine Parvovirus/canine Coronavirus Rapid detection kit for