PERIYAR UNIVERSITY SALEM B.Sc., BIOCHEMISTRY (CBCS
1PERIYAR UNIVERSITYSALEMB.Sc., BIOCHEMISTRY(CBCS SYLLABUS)(For candidates admitted from 2008-09 onwards)
2SCHEME OF EXAMINATIONSEMESTER PART COURSEIIIIIIICore IAllied ISBEC ITITLE OF THE PAPERTamil IEnglish IBio-organic chemistryAllied Chemistrypharmaceutical biochemistry3333100100100100Tamil II33100100English IITools of biochemistryAllied ChemistryCore practical IAllied practical IEnvironmental StudiesTamil III3336333100100100100100100100English IIIEnzymesBiostatisticsPlant biochemistry and Medicinal Plants333333100100100100100100Clinical biochemistry3336333100100100100100100100VAL EDUIIIIIIIIIIIIIIIIIIVCore IIAllied IICore practical IAllied practical IEnviron.,ScienceCore IIIAllied IIISBEC IINMEC IIIIIIIDURATION MARKS3100Tamil IVEnglish IVIntermediary metabolismComputer application in biologyCore practical IIAllied practical IIVCore IVAllied IVCore practical IIAllied practical IINMEC IICore VVICore VICore VIIElective ISBEC IIISBEC IVCore VIIIMolecular biologyphysiologyBiomedical InstrumentationGenetic engineeringClinical pathologyImmunology333333100100100100100100Core IXElective e IIISBEC VSBEC VICore practical IIICore practical IVNutritional biochemistryMicrobial biochemistryBasic bioinformaticsIndustrial biochemistryCore practical IIICore practical IVTOTAL MARKS -4000
3Course of studySEMESTERPARTCOURSE CODE COURSEHrsCREDIT MARKSLecture T/PICIA EA TOTALI08UFTA01Tamil I632575100II08UFEN01English I632575100III08UBC01Bio-organic chemistry45257510008UCA01Allied I54257510008UBCP01Core practical I2----08UCAP01Allied practical I2----SBEC Ipharmaceutical 0Val EDUSEMESTER PART COURSE CODECOURSEHrsCREDIT MARKSLecture T/PIICIA EA TOTALI08UFTA02Tamil II632575100II08UEN02English II632575100III08UBC02Tools of biochemistry65257510008UCA02Allied II53257510008UBCP01Core practical I33406010008UCAP01Allied practical I33406010008UES01Environ.,Science122575100
4SEMESTERPART COURSE CODECOURSEHrsCREDIT MARKSLecture T/PIIIIIIIIICIA EA TOTALTamil III632575 100English III632575 100Enzymes652575 100Allied Biostatistics532575 10008UBCP02Core practical II3---08UBCS02Plant biochemistry222575 100NMECNMEC I222575 10008UFTA0308UFEN0308UBC03-SEMESTER PART COURSE CODE COURSEHrsCREDIT MARKSLecture T/PCIA EA TOTALIVI08UFTA04Tamil IV632575 100II08UFEN04English IV632575 100III08UBC04Intermediary metabolism452575 100Computer application in biology 442575 100Core practical II344060 100Allied practical II334060 100Value education222575 100NMEC II222575 10008UBCP02NMEC
5SEMESTER PART COURSE CODE COURSEHrsCREDIT MARKSLecture T/PCIA EA TOTALV08UBC05Clinical biochemistry552575 10008UBC06Molecular biology552575 10008UBC07physiology552575 10008UBCE01Biomedical Instrumentation 552575 10008UBCS03Genetic engineering222575 10008UBCS04Pathology222575 10008UBCP03Core practical III3----08UBCP04Core practical IV3----SEMESTER PART COURSE CODE COURSEVIHrsCREDIT MARKSLecture T/PCIA ogy55257510008UBCE0255257510008UBCE03Nutritional biochemistryMicrobial biochemistry 55257510008UBCS05Basic bioinformatics22257510008UBCS06Industrial biochemistry22257510008UBCP03Core practical III34406010008UBCP04Core practical IV3440601001---14010902910 4000Extension activity180
6PAPERS GIVEN BY THE BOARD AS NON –MAJOR ELECTIVE COURSESEMESTER –IIIBIOCHEMISTRY IN DIAGNOSISCLINICAL NUTRITIONSEMESTER -IVCELL BIOCHEMISTRY AND HUMAN PHYSIOLOGYBIOCHEMISTRY AND HEALTH
7SEMESTERICORE COURSE -IBIO-ORGANIC CHEMISTRYUNIT-ICarbohydrates: Introduction, classification, monosaccharide-structure, stereo isomers and structuralisomers, mutarotation, and chemical reactions. Oligosaccharides-Dissaccharides -structure and importanceof sucrose, Lactose, maltose, cellobiose. Polysaccharides-structure and importance of homopolysaccharidesand heteropolysaccharides.UNIT-IIAmino acids and Proteins: Amino acids-classification, structure and properties. Protein classificationsand properties. Primary, secondary, tertiary structure of Proteins.UNIT-IIILipids: Introduction classification physical properties, and chemical properties of fats and oils.Structure and importance of saturated and unsaturated fatty acids, phospholipids and sterolsUNIT-IVNucleic acids: Introduction, chemistry of nucleic acids, nucleoproteins, double helical structure andproperties of DNA, RNA –types structure and functionsUNIT-VVitamins: Introduction Structure ,properties, functions and deficiency diseases of fat soluble and watersoluble Vitamins.RECOMMENDED BOOKS Lehninger’s Principles of Biochemistry (2000) by Nelson, David l. and Cox, M.M. Macmillan/worth,.NYFundamentals Of Biochemistry (1999) by Donald Voet, Judith G.Voet and Charlotte W Pratt, JohnWiley & Sons, NYBiochemistry 3rd (1994) by lubert stryer, W H freeman and co, Sanfrancisco.Biochemistry 4th edition (1988) by Zubay G L , W M C Brown Publishers.Principles of Biochemistry (1994) Garrette & Grisham, Saunders college publishingOutlines of Biochemistry (1987) by Eric E.Conn, P.K. Stumpf, G.Brueins and Ray H.Doi, JohnWiley & Sons, NYText book of biochemistry (1997) 4th edition Thomas M devlin, A John Wiley, Inc publication, Newyork.
8SKILL BASED ELECTIVE COURSE - IPHARMACEUTICAL BIOCHEMISTRYUNIT IDrugs: History of Drugs Classification of drugs, routes of drug administration, absorption and distributionof drugs, factors influencing drug absorption and elimination of drugs.UNIT IIDrug-Receptor interactions involvements of binding forces in drug receptor interaction, drug action notmediated by receptors.UNIT IIIDrug metabolism: Mechanism of phase I and II enzyme reactions, biochemical importance of xenobioticmetabolism.UNIT IVCancer: Cancer and principles of cancer chemotherapy, mode of action of anti cancer drugs,antimetabolites, antibiotics, alkylating agents and other agents,UNIT VAdverse drug reactions and drug induced side effects, biological effects of drug abuse and drugdependence, drug tolerance and intolerance.RECOMMENDED BOOKS The Pharmacology volume I and II –Goodman and GillmanBasic Pharmacology –Foxter CoxOxford text book of Clinical Pharmacology and Drug Theraphy ,D.G Grahme SmithandJ.K.AronsonPharmacology and Pharmatherapeutics – R.S.Satoskar,S.D.BhandhakarandEssentials of Pharmacotherapeutics ,Barav.F.S.KLippincotts illustrated review Pharmacology ,Mary.J.Mycek,Richards ,Pamela
9SEMESTER IICORE COURSE –IITOOLS OF BIOCHEMISTRYUNIT-IGeneral principles of Biochemical investigation ,in vivo and invitro studies-organ and tissue slice techniques,buffersolution and media for tissue homogenization and separation ,methods of cell disruption ,basic principles of cellculture ,cryopreservation ,cell sorting ,counting.UNIT-ICentrifugation techniques: Basic principles of sedimentation, types of centrifugation, types of centrifuges. Types ofrotors-swinging bucket fixed angle, vertical tube and zonal rotor. Differential and density gradient centrifugationwith applicationsUNIT-IIIChromatographic techniques: Principles, materials, sample preparation, methods and applications of paper,column, ion exchange, gel filtration , affinity chromatography, GLC,TLC & HPLC.UNIT-IVElectrophoresis techniques: Principles techniques and applications of agarose, PAGE,SDS-PAGE, cellulose acetate,capillary electrophoresis, isoelectric focusing ,Factors affecting electrophoresisColometric and spectroscopic techniques: Beer - Lambert's law, light absorption and its transmittance, principleinstrumentation and applications in enzyme assay and kinetic assay, protein and nucleic acid structural studies.UNIT-VRadioisotopic techniques: Atomic structure, types of radioactive decay ,negatron, positron, alpha particle andgamma particle ,rate of radioactive decay, units of radioactivity ,detection and measurement of radioactivity based onionization ,excitation properties and autoradiography and its applications.RECOMMENDED BOOKS Principles and techniques of practical Biochemistry,Keith Wilson and John Walker,1995.CambridgeUniversity Press.An Introduction to Spectroscopy for Biochemist, Brown. SB Academic Press.Introduction to Centrifugation, Ford T.C and Graham J.N., Bioscientific Publishers Ltd, Oxford.Biophysical chemistry Principles and Techniques- Avinash Upadhyaye and Nirmalendhe Nath , HimalayaPublishers. A Biologist Guide to Principles and Techniques of Biochemistry , Keith Wilson andGoulding, Edward Arnold publishers Tools of Biochemistry David CooperKenneth
10CORE PRACTICAL – II.II.Preparation of Buffers and Determination of pHQualitative Analysis.a. Analysis of carbohydratesb. Analysis of Aminoacidsc. Test for proteinsd. Test for lipids – cholesterolIII.Biochemical preparationa. Starch from Potatob. Casein from milkc. Lecithin from egg yolkIV.Quanitative Analysisa. Reducing Sugar – Benedict’s methodb.c.d.e.V.Amino acid – formal titrationDetermination of Acid NumberDetermination of Saponification Number.Ascorbic acid – using 2,6 Dichloro phenol Indophenol method.Techniquesa. Separation of sugar & amino acid by Ascending paper chromatographyb. Separation of lipid by thin layer chromatographyc. Separation of plant pigments by column chromatographyd. Separation of serum proteins by paper electrophoresis.
11SEMESTER IIICORE COURSE –IIIENZYMESUNIT-IEnzyme : Introduction , IUB Classification and nomenclature of enzymes , holoenzymes ,apo enzymes , coenzymes,cofactors ,prosthetic group ,activators , inhibitors . Definition and examples of metalloenzymes and metal activatedenzymes.Active site –Characteristics, theories of ES complex –Lock and key, induced fit and substrate strain theory.Monomeric enzymes ,Oligomeric enzymes –definition with examples ,multienzymes complex ,enzyme specificityand enzyme units.UNIT-IIEnzyme Kinetics-, MM Equation, LB Plot, Eadie Hostsee Plot , Hanes Plot, . Factors affecting enzyme activity.Isoenzymes – definition, LDH & CPK, diagnostic importance of isoenzymes.UNIT-IIICoenzymes – definition , structure and functions of TPP , Nicotinamide, FMN , Coenzyme A , Lipoic acid, Biotin &Folate (Mechanism not required)Mechanism of action of chymotrypsin & lysozyme. Enzymatic catalysis, Acid base catalysis, Covalent catalysis,Metal ion catalysis.UNIT-IVEnzyme inhibition – Reversible inhibition, Competitive, Non competitive & Uncompetitive inhibition. Irreversibleinhibition , Feedback inhibition. Allosteric enzymes- properties, types, models, Aspartate transcarbamoylase.Covalent modification.UNIT-VMethods for isolation & purification , criteria of purity. Immobilised Enzymes- methods & applications.RECOMMENDED BOOKSooooooEnzymes By Dixon , E.C Webb, CJR Thorne and K.F. Tipton, Longmans , London.Fundamentals of Enzymology 2 ed., (1998) By Nicholas C.Price, Lewis Stevans, Oxford UniversityPress, First Edition (1990).Understanding Enzymes, Trevor Palmer, Ellis Horwood Limited, Third Edition(1991).Protein Biotechnology, Gary Walsh and Denis Headon, John Wiley and Sons,1994.Protein Biochemistry and Biotechnology, Gary Walsh and John Wiley and Sons Ltd.2002.Enzyme kinetics and Mechanism –Paul F.Cook
12SKILL BASED ELECTIVE COURSE- IIPLANT BIOCHEMISTRY AND MEDICINAL PLANTSUNIT- IPlant cell – Structure and functions of subcellular organelles, plant cell wall, Mechanism of waterabsorption, Ascent of sap. Transpiration - types, stomatal opening, Mechanism and factors affectingtranspiration.UNIT-IIPhotosynthesis – Photosynthetic pigments, Photo synthetic apparatus, Light reactions, cyclic and non cyclicphosphorylation. Calvin cycle, Hatch – Slack cycle, CAM plants. Regulation of photosynthesis,Photorespiration.UNIT-IIICycles of elements – Nitrogen cycle, Biochemistry of symbiotic and non symbiotic nitrogen fixation,Sulphur cycle, Phosphorus cycle. Plant nutrition – Biological functions of micro and macro nutrients inplants and their deficiency symptoms.UNIT – IVPlant growth regulators – chemistry, biosynthesis, mode of action, distribution and physiological effects ofAuxins,Gibberllins, Cytokinins, ABA and Ethylene. Biochemistry of seed dormancy, Seed germination ,Fruit ripening and Senescence.UNIT- VMedicinal value of different parts of plants. Basic methods to identify the secondary metabolites. Role ofsecondary metabolites in Ayurvedha and Sidha treatment. Medicinal value of Amla, Stevia, Aswagandhaand Turmeric.RECOMMENDED BOOKS Plant physiology, Verma, 7th Revised edition, Emkay Publications 2001.Plant Physiology, S. N. Pandey and B.K. Sinha, Vikas Publishing House Pvt. Ltd, 3rd edition, 1999.Plant Biochemistry and Molecular Biology, Peter Jhea, Richard C. Leegood,Introduction to plant physiology, William. G.Hopkins, Norman. P.A. Hunger, 3rd editionA Handbook of Medicinal Plants –Prajapathi, Purohit,Sharma, KumarMedicinal Plants –a compendium of 500 species.Medicinal Plants –Chopra,Khana,Prasad,Malik,Bhutiani.
13SEMESTER IVCORE COURSE –IVINTERMEDIARY METABOLISMUNIT-ICarbohydrate metabolism: Introduction , glycolysis ,TCA cycle , and its energyproduction.Glycogen metabolism : Glycogenesis & Glycogenolysis ,Alternative pathways: HMP pathway ,gluconeogenesis , glucuronic acid pathway , glyoxylate cycle and its importance.UNIT-IILipid metabolism: Introduction , biosynthesis & degradation of fatty acids (alpha , beta , omegaoxidation ) . Degradation of lipids ,Biosynthesis of cholesterol and TG , Metabolism of ketone bodies .UNIT-IIIProtein metabolism : Degradation of proteins – Deamination , Transamination &Decarboxylation . Transport of ammonia. Urea cycle. Ketogenic & Glucogenic amino acidsUNIT-IVBiological oxidation : Introduction , Enzymes in biological oxidation , Redox potential ,Mitochondrial E.T.C. & its inhibitors , structure of ATPase complex , chemiosmotic theory , Oxidativephosphorylation & its inhibitors , Mitochondrial shuttle systemUNIT-VNucleic acid metabolism : Introduction , Biosynthesis & degradation of purine and pyrimidinenucleotides , inhibitors of nucleic acid metabolism .RECOMMENDED BOOKSoooooFundamentals of Biochemistry, J.L. Jain, S.Chand publications, 2004.Harper’s Biochemistry Robert K. Murray , Daryl K. Granner , Peter A. Mayes , Victor W.Rodwell, 24th edition , Prentice Hall International. Inc.Principles of Biochemistry , Geoffrey L. Zubay , 3rd edition William W. Parson, Dennis E.Vance, W.C. Brown Publishers, 1995.Principles of Biochemistry, David L. Nelson , Michael M.Cox, Lehninger, 4th edition, W.H.Freeman and company.Biochemistry, Lubert Stryer , 4th edition, W.H. Freeman & Co, 1995.
14CORE PRACTICAL IIICOLORIMETRY1.2.3.4.5.6.7.IIEstimation of glucose – O T MethodEstimation of fructose –Seliwanoff’s MethodEstimation of Pentose – Bial’ s MethodEstimation of Protein – Biuret MethodEstimation of Urea – DAM MethodEstimation of Cholesterol – Zak’s MethodEstimation of Phosphorus – Fiske Subbarow Method.ENZYME ASSAYDetermination of activity, effect of pH, effect of temperature and substrate concentration ofa.b.c.d.Salivary AmylaseUreaseAcid phosphataseAlkaline phosphatase
15SEMESTER VCORE COURSE VCLINICAL BIOCHEMISTRYUNIT – IApproaches to clinical biochemistry: Concepts of accuracy, precision, sensitivity and reproducibility,quality control, fixation of normal range.Collection and processing of samples, anticoagulants,preservatives for blood and urine, transport of biological samples.UNIT – IIDisorders in carbohydrate metabolism: Introduction, blood glucose regulation, hypo and hyperglycaemia,renal threshold value. Diabetes mellitus : Types, Clinical features, metabolic effects, complications, GTT,galactosaemia, fructosuria, and glycogen storage diseases.UNIT – IIIDisorders in protein metabolism: Introduction, aetiology and clinical features of phenylketonuria,alkaptonuria, cystinuria, albinism and tyrosinemia, clinical significance of non – protein nitrogen – urea,uricacid and creatinine. Metabolism of bilirubin, types of jaundice and its clinical features.UNIT – IVDisorders in lipid metabolism: Introduction, hypertriacylglyceridemia, atherosclerosis – aetiology, clinicalfeatures and complication. Lipid storage diseases, fatty liver. Disorders in nucleic acid metabolism: Gout,types,aetiology and clinical features.UNIT – VLiver function tests: Detoxification and excretory function. Renal function test: Urea clearance and itsinterpretation. Enzymology: Clinical significance of SGOT, SGPT, ALP, ACP, CPK and LDH.RECOMMENDED BOOKSoooooText book of medical Biochemistry, M.N. Chatterjee and Rane SindeText book of Biochemistry with clinical correlation, Thomas M. Devlin, 3rd edition, A. JohnWiley-Liss Inc. PublicationPractical Clinical Biochemistry, Harold Varley, 4th edition, CBS Publication andDistributors, New Delhi.Principles of Internal Medicine, Harrison T.R. Fauci, Braunwald, Isselbacher 14th edition,MC-graw hill, Newyork. Volume I and IITietz Fundamentals of Clinical Chemistry- (5th edition) C.A. Burtis, E.R. Ashwood (eds)Saunders WB Co.
16CORE PAPER-VIMOLECULAR BIOLOGYUNIT – ICell: Structural organization of prokaryotes and eukaryotic cells and its functions, physical and chemicalstructure of DNA, DNA as genetic material, properties, organization of DNA, special base sequences, lefthanded DNA helices, structure of RNA.UNIT- IIDNA replication: Semiconcervative replication, experimental evidence for semiconservative replication,replication in prokaryotes and eukaryotes, enzymes involved in replication, mechanism of replication,inhibitors of DNAreplication. DNA damage and repair, types of mutationUNIT – IIITranscription: Basic features of RNA synthesis, E.Coli RNA polymerases, initiation, chain elongation andtermination of transcription, types of RNA and their processing.UNIT- IVTranslation: Genetic code and its features, tRNA and amino acyl tRNA synthetases. Initiation, elongationand termination of translation, post translational modifications. Differences in protein synthesis betweenprokaryotes and eukaryotes.UNIT – VRegulation of gene expression: General aspects, operon model in prokaryotes – lac operon, tryp operon andarab operonRECOMMENDED BOOKSoooooMolecular biology, 3rd edition, Herylodish et alGenes – IX , Benjamin Lewin, Oxford UniversityConcept of Genetics, 4th edition, William S. Klug and Micheal R. Cummings.Genetics, Peter J. Russell, 4th edition, Harper Collins College Publishers.Molecular biology of gene, James D. Watson, Nancy H.Hopkins, Jeffrey W. Roberts, JoanArgetsinger Steitz, Alan M. Weiner, 4th edition, The Benjammin Cummings PublishingCompany, Inc. 2002
17CORE COURSE VIIHUMAN PHYSIOLOGYUNIT –IDigestive System: Secretions of digestive tract, digestion, absorption, assimilation of carbohydrates,proteins, fats, nucleic acids, vitamins and minerals.UNIT – IIRespiratory System: Transport and exchange of gases between lungs and tissues, Blood composition,function, mechanism of blood coagulation.UNIT – IIIMuscles: Types, functions and physiology of muscle contraction, physiology of cardiac muscle, cardiaccycle and the regulation of heart pumping, E.C.G, and blood pressureUNIT – IVAnatomy of kidney: Mechanism of urine formation, outline of structure and function of the male andfemale reproductive organs, spermatogenesis, menstrual cycle, physiology of pregnancy, parturition andlactation.UNIT – VNeuron structure: Synaptic transmission, classification of nervous system, characteristics of sympatheticand parasympathetic function.RECOMMENDED BOOKS Human Physiology, Chatterjee.C. 11th edition Medical agency allied, Calcutta.Text book of medical physiology, A.C. Guyton 10 th edition.Human body, Atlas, Publication Garden cheersMammalian Biochemistry, White handler smithReview of medical physiology, William. F. Ganong, 14th edition, A Lange Medical book.
18ELECTIVE COURSE -IBIOMEDICAL INSTRUMENTATIONUNIT IClassification of Biomedical Equipment, Diagnostic, therapeutic and clinical laboratoryequipment.Introduction, types, merits, demerits, limitations, diagnostic and therapeutic application ofendoscope, laparoscope and cardio s
Lehninger’s Principles of Biochemistry (2000) by Nelson, David l. and Cox, M.M. Macmillan/ worth,.NY Fundamentals Of Biochemistry (1999) by Donald Voet, Judith G.Voet and Charlotte W Pratt, John Wiley &
PERIYAR UNIVERSITY PERIYAR PALKALAI NAGAR . 2 II Foundation- English- I 6 3 3 III Core Paper- I Fiction 5 4 4 III Core II- Grammar and Usage 5 4 5 III Allied-I Social History of England 5 5 6 IV Environmental Studies 1 - 7 IV Value Education 2 2 TOTAL 30 21 SEMESTER – II SL. NO PART COURSE HOURS CREDIT .
permission from his leader Periyar. Periyar was pleased to correct his script and saw it was published later on as small booklet in Tamil and many thousands of copies of the book sold. This book was reviewed in ‘The Hindu’, a famous English Daily. It compared Periyar to the “H.G.Wellsof the Twentieth century”.
PERIYAR UNIVERSITY PERIYAR PALKALAI NAGAR SALEM – 636011 DEGREE OF BACHELOR OF SCIENCE CHOICE BASED CREDIT SYSTEM . II English II 6 - 3 25 75 100 III Core II C Programming 4 - 4 25 75 100 III Practical II Programming in C - 3 4 40 60 100 III Allied II 4 - 3 25 75 100 .
PERIYAR INSTITUTE OF DISTANCE EDUCATION (PRIDE) Office of the Controller of Examinations PERIYAR UNIVERSITY, SALEM –11. List Of JAN 2014 (Calendar Year Dec 2013) PRIDE Examinations Centres for the Students Admitted through the Study Centres Situated at the States at Other States ALWAR Exam Centre No: 1048 Bal Vihar Senior Secondary School
PERIYAR UNIVERSITY, SALEM-636 011 CONTROLLER OF EXAMINATIONS Scheme of (July-2013) PRIDE Examinations for the Students Admitted through the Study Centres situated at the States in Tamilnadu,Pudhucherry and Other States SEMESTER (Academic Year 2001 – 02 Students only) I – Semester B.A. Economics Sl.
2Assistant professor, Dept of LIS , Periyar University, Salem . Tamilnadu, India. 3II-M. L. I. S , Periyar University, Salem . Tamilnadu, India. 2gomathi148@gmail.com Abstract The present stu dy may be useful for understanding the importance of research and . adopting English as the main language as this will increase citation counts and the .
Research Scholar,Periyar University,Salem Dr.B.J.Geetha , Asst.Prof.of English , Periyar University,Salem ABSTRACT The present research work is a study of the selected fiction of the Brazilian writer Paulo C
Periyar University, Salem 04 January- March 2016 Poverty and Food Security among scheduled caste and tribes Vol- 1, Issue No. 1,E- ISSN- 2347-756X, ISSN 2348-0653 Periyar University, Salem 05 Oct- Nov 2017 Role of Infrastructure in India : Importance and Issues. DBJC Jounal of busine
