SuggestedsolutionsforChapter28(
asicone- eaminationOH2N analysisOH 2N Na(CN)BH4or undcanbemadebytheaddition- dthatcanbemadebydirectnitration.
sisHNNH2C–NCl O2NNO2nucleophilic aromaticsubstitutionO2 ns.Weprefernottoaddthet- st.ClnucleophilicsubstitutionO icthantheOHgroup.nucleophilicsubstitution xercisesinbasicone- ‐groupC–Cdisconnections.
lysisPh leadstoashortersynthesis.analysisC–CMeCO2Et 2xMgBrOHsynthesis1. Mg, Et2OBr2. synthesis.3
whatwearereallytryingtomake.OOOHacetalOH 1,1-diXMeOOMeOacetalOHCHO 2 MeOH1,1-diXOHThediolhasa1,3- etones,oresters.OH3OH2FGIOHOHCHO ncinaReformatskyreaction.OH3BrO2CO2EtCO2Et1CO2Et1. Zn2. EtCHOOHCO2Etuse Li enolateor Zn enolate1. LiAlH42. Me2COacidOOIftheketo- symmetricalketo- ‐estermadebyaClaisenestercondensation.
connection AOOCO2EtCO2EtOEtDisconnection isthatthesynthesisinvolvesasimpleself- esultingketo- tiongivesthetargetmolecule.OOEtOOEtO1. EtOCO2Et1. LiAlH4CO2Et2. MeI2. Me2CO,H Theothercompoundhasa1,5- veanaldehydesowechooseanesterfortheotherone.5 CHO435 CHOFGI21OH431,5-diOCHO12 CO Me2 eenolatetoavoidself- HONR2CHOR2NHCO2Me1. MeOHacidCO2Me 2. LiAlH4targetmoleculeOOtarget molecule
efirstcompoundisanα,β- atoms!Oaldol OOspecific enol(ate)equivalent asilylenolether,oraβ- ton.
vea1,5- 5-diCOEtO2oCfusing Thestrategybdecarboxylationofaβ- cule.EtO2COCO2EtOEtOEtO2CCO2EtONaBH4 EtO C2O
HOHPhOClCO2MeOCO2MeMeOMeOHOHO ertoformtheenolateofthechloro- ‐ester.
ineoraβ- ‐ketoester.OOMeOCO2MeClMeOHCO2MeOMeClR2NHR 2NClCO2MeOCO2Meaqueous acidwork-uptarget 2 dcase,thecyclopentanonehasself- seaspecificenolate,suchastheeasilymadeβ- ‐keto- ‐esterbelow.Thesix- rolysisanddecarboxylation.CO2MeCO2MeMeOCO2Me OOOOOCO2MeMeOHH2OOCO2MeClOOOtarget molecule 3O
nections.BrMgFGIBr1,1-diXOO1,3-diXHOacetalOOBrHBr eacid- ‐catalysed.BrHOBrMgMgOHOCHOacroleinHBrOOEt2OO
ldalsobefine. HFGIaldolCHOCHO CHOCHOd3 synthon
lationships.SuggestedsolutionThefirstisanα,β- oletherlookthebest.analysisFGICO2HaldolCO2EtCHO CO2EtsynthesisPh3P1. EtOCO2Et 2. r CNsynthesisNaCNBrHOCNH carboxylation.
Et1. EtO2.CO2EtBr1. NaOH, H2OCO2EtCO2H2. H , atheimine(notusuallyisolated).analysisHNFGINC NiminesynthesisOH2N NaB(CN)H3or Li(AcO)3BHH2N hylformateoroncetothecyclohexanealdehyde.13
ysis OHCHOC–CBrMgBrFGI synthesisBr1. Mg, Et2O2. HCO2EtBrTM1. Mg, Et2Oor2. RCHOR t.analysisCO2HBrC–C alkylationEtO2CCO2EtBr CO2HsynthesisEtO2CCO2Et1. EtO2. RBr(excess)EtO2CRCO2Et 1. NaOHRR cyclohexyl2. H , )H3RR cyclohexylNH4OAc1. TsClpyridine2. NaN33. H2, Pd/C ROHR
icroute.SuggestedsolutionThethreediketoneshave1,3- ‐,1,4- ‐,and1,5- hechemistryisverydifferentineachcase.The1,3- OO1,3-diCOspecific enol(ate)RR equivalent samedisconnectiononthe1,4- nenolate)andrequiresanenamineasthespecificenol.15
ysisOOR eededsynthesisOONR2R2NHR BrEt3NROOThe1,5- lequivalentisneededtostopself- O1. EtOCO2Et2.OCO2Et1. NaOHORR2. H , heattarget molecule
Suggested(solution efer!the!one!not!to! . CEt CO2Et O CO2Et O Disconnection A Disconnection B! . Methylation! of! the! resulting! keto?ester! followed! by reduction! to the diol! and! acetal! formation!gives!the!target!molecule.!! O OEt
Apprendre à accorder la guitare par vous même. Laguitaretousniveaux 11 Se familiariser avec le manche Ce que je vous propose ici, c'est de travailler la gamme chromatique, pour vous entraîner à faire sonner les notes. C'est un exercice qui est excellent pour cela, ainsi que pour s'échauffer avant de jouer. Le principe est très simple, il s'agit de placer consécutivement chaque doigt sur .
In recent years technologies like Artificial Intelligence (AI) is been proved immensely valuable to SCM. As the name suggests AI defined as the ability of a computer to independently solve problems that they have not been explicitly programmed to address. The field of AI came to existence in 1956, in a workshop organized by John McCarthy (McCarthy Et al., 2006). In successive years the .
2 AUDITING ARTIFICIAL INTELLIGENCE CONTENTS 4 Potential Impact of Artificial Intelligence on Organizations 4 Why Should Auditors Care About AI? 4 / Challenges for the Auditor 6 / Mapping COBIT to Strategy: A Visual Representation of How to Apply COBIT 2019 in the Auditing of AI 8 / Challenges and Solutions for the AI Auditor 9 Conclusion 10 Resources and References for Auditing AI 12 .
Billionaire Case Studies. Who are the Billionaires? You’ve Never Heard of Most Billionaires Pierre Bellon French Food Services - 4.4B Dmitry Rybolovlev, Russian Fertilizer - 7.7B Harry Stine, Agriculture - 3.5B The U.S. has 540 billionaires, more than any other country in the world. It’s followed by mainland China with 251 (Hong Kong has another 69) and Germany with 120. Russia .
The Communications Officer will be responsible for developing ways to capture and present this work digitally, ensuring consistency in communications across the programme. An additional hub is also envisaged for the Gulf region, as part of a separate project to
The COMPASS system provides English language arts placement tests in reading, writing skills, and writing production. In addition, the system includes three (3) reading
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* Les points de vue et opinions exprimés dans la présente publication sont ceux des auteurs et ne reflètent pas nécessairement la position officielle de la Banque interaméricaine de développement ou de ses pays membres.
