Brief Summary Of Findings On The Association Between Physical .
Brief Summary of Findings on the Association Between Physical Inactivity and Severe COVID-19 OutcomesPrepared and reviewed byAisha L. Hill, PhD, MS, Public Health Analyst II, St. George Tanaq CorporationGeoffrey Whitfield, PhD MeD, Team Lead, National Center for Chronic Disease Prevention and Health Promotion, Physical Activity and Health Branch,CDCMadelon Morford, MPH, Public Health Analyst, General Dynamics Information TechnologyDevon L. Okasako-Schmucker, MPH; Program Analyst; Eagle Global ScientificChristine N. So, MPH, Program Analyst III; Eagle Global ScientificMarwan Wassef, MPH; Data Analyst; Chenega CorporationMylaica Conner Henry, MPH; Communications Specialist/Technical Writer; Eagle Global ScientificTashika M. Robinson, MPH; Program Analyst III; Eagle Global Scientific, LLCJill K. Kumasaka; ORISE Fellow; Division of Healthcare Quality Promotion, National Center for Zoonotic and Emerging Infectious Diseases, CDCErin C. Stone, MPH, MA, Public Health Analyst; Division of Healthcare Quality Promotion, National Center for Zoonotic and Emerging Infectious Diseases,CDCJoanna Taliano, MA, MLS; Reference Librarian, Cherokee Nation AssuranceDavid A Siegel, MD MPH, Core Clinical Unit Lead, Clinical Disease and Health Services Team, Health Systems and Worker Safety Task Force, CDC COVID19 Response, CDCEmily Koumans, MD MPH, Clinical Disease and Health Services Team Lead, Health Systems and Worker Safety Task Force, CDC COVID-19 Response, CDCKanta Devi Sircar, PhD, MPH, Epidemiologist, Underlying Conditions, Core Clinical Unit, Clinical Disease and Health Services Team, Health Systems andWorker Safety Task Force, CDC COVID-19 Response, CDCContact: CDC Info contact us formDisclaimer: The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention.Page 1 of 63
Brief Summary of Findings on the Association Between Physical Inactivity and Severe COVID-19 OutcomesTwenty-five studies, 15 cohort, 5 cross-sectional, 4 ecological and one case-control, reported data on physical inactivity or physical activity and severeCOVID-19 outcomes and were included in this analysis. Physical activity is defined as any bodily movement produced by skeletal muscles that results inenergy expenditure. Physical inactivity is defined as the lack of physical activity. Both may vary, depending on the context. The data indicate an association between increased mortality1-12 and hospitalization8,13-18 due to COVID1-19 infection and physical inactivity, anda possible association between increased ventilation1,6,9 due to COVID1-19 infection and physical inactivity. Limited data is insufficient on theassociation between physical inactivity and ICU admission6,9. Limited data from only one study is insufficient to determine if there is anassociation between physical inactivity and intubation17. The data suggest an increased risk of mortality19-22 and hospitalization15,17,18,22-25 due toCOVID1-19 infection with decreased duration or frequency of physical activity.Disclaimer: The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention.Page 2 of 63
ContentsTable of Tables . 3List of Figures . 4A. Methods . 5A.1. Literature Search . 5A.2. Study Selection . 5A.4. Data Extraction and Synthesis . 7A.5. Aggregation of the Evidence . 7A.6. Reviewing and Finalizing the Systematic Review. 7B. Systematic Literature Review Results. 8B.1. Search Strategies and Results . 8B.2. Study Inclusion and Exclusion Criteria . 11B.3. Evidence Review: Physical Inactivity and Severe COVID-19 . 12B.3.a. Strength & Direction of Evidence. 12B.3.b. Extracted Evidence . 20B.3.c. Internal Validity Assessments of Extracted Studies . 51C. References. 60Table of TablesTable 1 Physical Inactivity / Activity Search Conducted August 26, 2021. 8Table 3 The Association Between Physical Activity / Inactivity and Severe COVID-19 Outcomes. . 12Table 4 The Association Between Physical Activity/ Inactivity and Risk Markers and Severe COVID-19 Outcomes. 17Table 5 The Association Between the Duration or Frequency of Physical Activity/ Inactivity and Severe COVID-19 Outcomes. . 18Table 6 Extracted Studies Reporting the Association Between Physical Activity/ Inactivity and Severe COVID-19 Outcomes. . 20Table 7 Internal Validity Assessments of Extracted Studies Reporting the Association Between Physical Activity / Inactivity and Severe COVID-19Outcomes. .
Disclaimer: The findings and conclusions herein are draft and have not been formally disseminated by the Centers for Disease Control and Prevention and should not be construed to represent any agency determination or policy. Page 1 of 63 Brief Summary of Findings on the Association Between Physical Inactivity and Severe COVID-19 Outcomes
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