2016 Arizona Opioid Report - Arizona Department Of Health .

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2016 ArizonaOpioid Reportazhealth.gov/opioid

The number of reported 2016 deaths directly attributed to opioids among Arizona residents, or nonresidents within Arizona, is 790. This represents a 16.3% increase in opioid deaths since 2015, and a 74%increase since 2012. Sixty-four percent of the growth in opioid deaths over the last four years, and nearly54% in the last two years have been heroin deaths. Heroin has increased from 11% of opioid deaths in2007 to 39% in 2016. Data also show increasing deaths due to prescription/synthetic opioids since 2014,reversing a declining trend since 2009. If current trends are sustained, by 2019 the number of annualopioid deaths in Arizona will exceed 1,000, of which nearly 50% will be due to heroin. These trends arenot explained by changes in the Arizona population since 2007. Due to well established factors delayingreporting, new opioid death reports continue to be received as of 6/1/2017, and the final count mayexceed 800 for 2016.Opioid death counts among Arizona residents and non-residents in Arizona from 2007to Prescription Opioids482532517All 2007200892201120122013201420152016Opioid average 10-Year death rate per 100,000 population by age group from2007 to 2016.18.114.114.112.28.03.71.70.10 to 1415 to 2425 to 3434 to 4445 to 5455 to 642016 Arizona Opioid Report65 to 7475 and olderazhealth.gov/opioid

Opioid deaths are not uniformly distributed among different population groups in Arizona. By age, opioiddeath rates rise beginning in the late teens until they peak at age 45-54. Above age 65 the opioid deathrate drops significantly. Deaths due to opioids among persons under age 55 have constituted 80% of allopioid deaths in Arizona during the last 10 years.Rate per 100,000 population of opioid death by race/ethnicity group in Arizonafrom 2007 to 2016.WhiteAmerican IndianAfrican AmericanHispanicAll Other02468101214Among different race/ethnicity groups, rates of death from opioids differ greatly. From 2007-2016 77.5%of all opioid deaths were among White non-Hispanics, among whom the rate of death is nearly twice thatof any other race/ethnicity group.2016 Arizona Opioid Reportazhealth.gov/opioid

Historical analysis has revealed significant trends and patterns among persons who died from opioids.Nearly 86% of all deaths directly resulting from opioids involved other non-opioid drugs. While 82% ofpersons who died from opioids had been seen by a hospital or emergency medical provider during the 5year period prior to their death, only 32% of those persons were seen for an opioid-related encounter.Hospital opioid unique encounter rates per 100,000 population - Primary causefrom 2007 to rescription 0201120122013201420152016200Opioids have a significant impact upon Arizona’s medical care system due to the volume of encountersinvolving opioids, and the costs of these encounters. Unique encounters are events for a single personinvolving either hospital admission, or an emergency department encounter without admission. Therate of unique encounters due to prescription opioids as the principal diagnosis, as shown above, hasdeclined since 2012, while the rate due to heroin has increased. However, this is only part of the fullburden that opioids present to the healthcare system. A comprehensive measure of burden upon thehealthcare system should also include the additional burden of encounters that are associated withopioids, but are not the principal diagnosis. Such encounters are referred to as ‘opioid-related’ events.When ‘opioid-related’ events are considered, an entirely different picture emerges.2016 Arizona Opioid Reportazhealth.gov/opioid

Hospital opioid-related unique encounter rate per 100,000 population from2007 to 2016.800741700604600539474500400489Prescription 92220072008200920102011201220132014201520160The full economic burden of opioids upon the healthcare system is difficult to precisely calculate, buta reasonable measure may be derived using hospital reported charges adjusted using national cost tocharges ratios provided by the Department of Health and Human Services. Using this approach the costof all ‘opioid-related’ encounters in Arizona from 2009 – 2015 has increased by 125%.*2016 Arizona Opioid Reportazhealth.gov/opioid

In 2015 there were 41,434 unique ‘opioid-related’ encounters in Arizona hospitals, with an estimatedcost of 341.5 million. The average cost per opioid-related unique encounter was 8,241. In 2009 therewere 20,365 unique opioid encounters, with an estimated cost of 151.5 million and an average cost perencounter of 7,441. The net increase in ‘opioid-related’ encounter costs from 2009 – 2015 is primarilydriven by the doubling numbers of ‘opioid-related’ encounters, not rising medical service charges.The cost of all opioid-related encounters has increased125% from 2009 to 2015. 400,000,000 300,000,000 200,000,000 100,000,00020092010201120122013201420152016* Cost for encounters are calculated by applying the annual cost-to-charges ratio (produced by the Agency for Healthcare Research and Quality, Healthcare Cost Utilization Project) toreported encounter charges. This will estimate the actual cost paid to the provider for the healthcare services of the encounter. For this report, 2015 costs were estimated using the 20102014 average cost-to-charges-ratio by facility since 2015 and 2016 ratios were not available. When facility-specific ratios were not provided, the group ratio was used, or the state averageratio. These estimated costs are reasonable, estimates of actual cost, and are a more accurate measure than reported charges.2016 Arizona Opioid Reportazhealth.gov/opioid

Another significant impact which ‘opioid-related’ events will have upon the healthcare system has to dowith emergency response and care. Not all regions within Arizona have equal capacity for emergencyresponse and care, and deaths due to opioids show considerable regional variation as well.The greatest burden of death from opioids occurs within urbanized centers of Arizona. However, somerural communities also see significant death counts as well. Considering that resources are moredispersed outside of urbanized centers, the ratio of deaths to total unique hospital encounters willhighlight areas where persons experiencing opioid overdose would have the greatest risk of death. Adifferent picture emerges, demonstrating that the regional impact of the opioid epidemic is a complextapestry of regional variations in events, resources, and response strategies.2016 Arizona Opioid Reportazhealth.gov/opioid

2016 Arizona Opioid Reportazhealth.gov/opioid

Driven response strategies will vary between regions in response to different needs. These responsestrategies must involve elements of the medical, emergency medical services, and first-responder groups,including law enforcement. Many of these groups contribute data to the State EMS Registry, from whichdata important indicators are monitored to describe the size and nature of opioid overdose in differentregions. The number of patients receiving naloxone before arrival at a hospital is an important indicatorthat assists policy makers in describing the regional frequency of opioid overdose. Another importantindicator is the number of doses of naloxone a patient receives from EMS and Law Enforcementpersonnel.Naloxone works by displacing opioid drugs from the brain centers that control breathing and other vitalfunctions. Smaller doses of naloxone can displace drugs like morphine and heroin. Once administered,naloxone stays in the blood stream for a limited time. Morphine and heroin can sometimes stay in theblood for longer than naloxone. Even though an individual has received naloxone they may still be at riskof reoccurring overdose if the naloxone wears out before the other drug.Recently, synthetic opioids and opioids mixed with other powerful drugs like fentanyl have created largeclusters of overdose in a number of communities and states. The entrance of these powerful mixturesinto a community is signaled by an increase in overdose deaths in the active drug user community notaccustomed to a more potent formulation and by an increase in the number of patients who receivemultiple doses of naloxone by the EMS and Law Enforcement providers. Arizona is experiencing aworrisome increase in patients that require multiple doses of naloxone, possibly indicative of these morelethal mixtures. In January, 2016 18% of patients received multiple doses of naloxone by EMS and LawEnforcement personnel. That percentage has increased steadily, and as of 6/1/2017, 27% of patientsreceived multiple doses of naloxone during May.The number of patients who received naloxone by EMS or law enforcement in2017 ranged from 460 to 517.550500450400JanuaryFebruaryMarch2016 Arizona Opioid ReportAprilMayazhealth.gov/opioid

Almost a quarter of patients who received naloxone by EMS or lawenforcement needed multiple doses.EMS and law enforcement reported administering naloxone to patients in almost allArizona counties during the 1st five months of 2017.2016 Arizona Opioid Reportazhealth.gov/opioid

2016 Arizona Opioid Report azhealth.gov/opioid The full economic burden of opioids upon the healthcare system is difficult to precisely calculate, but a reasonable measure may be derived using hospital reported charges adjusted using national cost to charges ratios provided by the Department of Health

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