Department Of Chemical And Biological Engineering .
Department ofChemical and Biological EngineeringUndergraduate HandbookAcademic Year 2020-2021Revised: September 2020
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Table of ContentsWHAT IS CHEMICAL AND BIOLOGICAL ENGINEERING? .2THE EDUCATION OF A CHEMICAL AND BIOLOGICAL ENGINEER.3CERTIFICATE PROGRAMS. 19INDEPENDENT WORK . 20GRADUATION REQUIREMENTS . 24ACADEMIC HONORS. 24HONOR SOCIETIES, AWARDS, AND PRIZES. 25ADVISING . 28EXTRACURRICULAR ACTIVITIES . 29POST GRADUATION PLANS . 30THE FACULTY . 31LABORATORY SAFETY INFORMATION . 34THE REINER G. STOLL UNDERGRADUATE SUMMER FELLOWSHIP IN CHEMICALENGINEERING . 35MISCELLANEOUS REMARKS . 361
WHAT IS CHEMICAL AND BIOLOGICAL ENGINEERING?Chemical engineering is pollution control, pharmaceuticals, semiconductors, adhesives, biopolymers,artificial kidneys, oil refineries, solar panels, and ceramics. The American Institute for Chemical Engineers(AIChE) defines a chemical engineer as someone who uses science and mathematics, especially chemistry,biochemistry, applied mathematics and engineering principles, to take laboratory or conceptual ideas andturn them into value added products in a cost effective and safe (including environmental) manner.Chemical engineering is an applied science. While a chemist might discover a new compound in the lab,this compound would be nothing more than a laboratory curiosity unless a chemical engineer used his orher knowledge to quantify, scale up, test and produce the compound as a final product. In 2010 thedepartment changed its name to Chemical and Biological Engineering to reflect research interests of thefaculty and the growing influence of the life sciences in chemical engineering.So where do Princeton graduates go with their chemical and biological engineering degrees?Post Graduate plans for the last five graduating classesClass of 2016 – Class of 2020Graduate School in Engineering24%Other Endeavors16%Consulting12%Business School, Healthcare Industry,Arts & Entertainment, Sports Industry10%Pharmaceutical Industry9%Chemical Industry8%Finance Industry8%Food and Personal Products4%Medical School4%Electronic Industry, Information Technology3%Start-up Companies1%Non-profit Organizations1%2
THE EDUCATION OF A CHEMICAL AND BIOLOGICAL ENGINEERTo prepare for the kinds of diverse career options mentioned above, one needs a solid foundation inengineering and chemistry, as well as the freedom to take specialized courses in areas of interest. This isprovided in the chemical and biological engineering curriculum by having a core of common technicalcourses and then program electives tailored to the career objectives for each individual student. Theprogram electives explore areas including biotechnology/life sciences, environmental sciences, materialsand product engineering, entrepreneurship and management, systems engineering and informationtechnology and engineering science. The senior thesis provides students with the vital experience ofintegrating their training on an independent research project.General Notes and Comments on the Four-Year CurriculumThe University requires engineers to successfully complete 36 courses over four years for graduation.(Many students take more than the required 36.) Most students choose to take four 4-course semestersand four 5-course semesters. These 36 courses include:University, SEAS & Departmental RequirementsSchool of Engineering and Applied Science (SEAS) Requirements:Mathematics4 CoursesPhysics2 CoursesGeneral Chemistry1 CourseComputer Proficiency1 CourseWriting Requirement:1 CourseHumanities & Social Sciences Electives:7 Courses (EM req’d. Must satisfy 3 other areas)Chemical and Biological Engineering Core:9 Courses (including senior thesis)Advanced Science & Math Requirements:Differential Equations1 CourseChemistry or Biology (300 level or above) 1 CourseOrganic Chemistry1 CourseMolecular Biology1 CourseProgram Electives*:Area of Concentration3 CoursesBreadth2 CoursesFree Electives**:2 CoursesTotal36*At least two of the Program Elective courses must be engineering topic (ET) courses as designated on theapproved list in the Area of Concentrations. The advanced CBE course can also be satisfied within theProgram Electives.**The number of free electives will vary depending on course selection where students can double countcourses, as well as AP credit received.3
Of these 36 courses no more than 4 may be taken on a Pass/D/Fail basis unless a course is given only onthis basis; in this case the maximum of 4 is increased by one for each such course. Any elective courseabove the required 36 may be taken Pass/D/Fail. For additional details about the University Pass/D/Failpolicy, refer to the Undergraduate Announcement.Advanced Placement does not reduce the course load required for graduation. Only if a student qualifiesfor and chooses Advanced Standing is the course load reduced. Students eligible for advanced standingwill be contacted by Dean Bogucki in the first year.School of Engineering and Applied Science RequirementsAll engineering students take a common core of courses in mathematics, chemistry, and physics.Advanced placement can satisfy some requirements and allow for more technical or humanities/socialscience electives.Mathematics RequirementsMath 103 and 104 — CalculusMath 201 (or 203 or 218) and 202 (or 204 or 217) — Multivariable Calculus and Linear AlgebraPhysics RequirementsPhysics 103 (or 105) and 104 (or 106) — General PhysicsComputer Proficiency RequirementComputer Science 126, 217, or 226Chemistry RequirementsChemistry 201 or 207 — General Chemistry IWriting RequirementThe ability to write English clearly and precisely is a University requirement that must be satisfied bycompleting, during the first year, a one-semester course that fulfills the writing requirement.Humanities and Social Sciences (HSS) ElectivesThe liberal arts component of the students’ education is implemented through the Humanities and SocialSciences requirements established by the University. Humanities and Social Science courses taken by CBEstudents must include at least one course in ethical thought and moral values (EM), which also satisfies theABET societal impact requirement, and one course in three of the following five areas: epistemology andcognition (EC), foreign language (FL), historical analysis (HA), literature and the arts (LA), and social analysis(SA). The remaining three required Humanities and Social Sciences courses, for a total of seven, may betaken in any field in the social sciences and humanities.4
Advanced RequirementsChemical and biological engineers are distinguished from other engineers by their knowledge of chemistryand life sciences. All CBE majors must complete a full year of General Chemistry, at least one semester ofOrganic Chemistry, and one semester of Molecular Biology.CHM 202 – General Chemistry IICHM 301 — Organic Chemistry IMOL 214 – Introduction to Cellular and Molecular BiologyPlease note that CHM 337 can satisfy the CBE organic chemistry requirement; however, it is important tokeep in mind that CHM 337 does not provide appropriate preparation for CHM 302 or CHM 304; CHM 301and CHM 337 cannot both be taken for credit; and students interested in being pre-meds need to consultwith the Health Professions Advising office concerning enrollment in CHM 337.Two additional (separate) approved advanced courses are required, one with advanced chemistry orbiology content and one with advanced CBE content.Advanced Chemistry or Advanced Biology ContentStudents must take one advanced chemistry or biology course at the 300-level or above (excludingindependent work courses, and student elected PDF courses). The list below provides some examples ofapproved courses:CBE 415/CHM 415/MSE 425CBE 421/CHM 421/ENE 421CHM 302 or 304CHM 305/PHY 305/ELE 342CHM 306CHM 403CHM 406CHM 407CHM 408CHM 470/GEO 470EEB 309EEB 320/MOL 330EEB 325EEB 327/MOL 327/GHP 327EEB 328/ GHP 328GEO 353/ENV 333/CEE 353GEO 360GEO 363/CHM 331/ENV 331GEO 417GEO 418MOL 310/NEU 301MOL 340MOL 342MOL 345/CHM 345MOL 348PolymersGreen and Catalytic ChemistryOrganic Chemistry IIQuantum Mechanics/ Quantum Theory/ Quantum EngineeringPhysical Chemistry: Thermodynamics and KineticsAdvanced Organic ChemistryAdvanced Physical ChemistryInorganic Chemistry IInorganic Chemistry IIEnvironmental Chemistry of SoilsEvolutionary BiologyMolecular Evolutionary GeneticsMathematical Modeling in Biology & MedicineImmune Systems: From Molecules to PopulationsEcology and Epidemiology of Parasites and Infectious DiseasesOil to Ozone: Chemistry of the EnvironmentGeochemistry of the Human EnvironmentIntroduction to Environmental GeochemistryEnvironmental MicrobiologyEnvironmental Aqueous GeochemistryCellular NeurobiologyMolecular and Cellular ImmunologyGeneticsBiochemistryCell and Developmental Biology5
MOL 380Modern MicrobiologyMOL 411/CBE 411Antibiotics: From Cradle to GraveMOL 415Modern Biophysics and Systems BiologyMOL 425/WWS 355/GHP 425 Infection: Biology, Burden, PolicyMOL 431Regulatory Mechanisms in DevelopmentMOL 433/CBE 434/GHP 433 BiotechnologyMOL 455/QCB 455/COS 455 Introduction to Genomics and Computational Molecular BiologyMOL 459/GHP 459Viruses: Strategy and TacticsMOL 485/QCB 485Mathematical Models in BiologyMOL 490/QCB 490Molecular Mechanisms of LongevityAdvanced Math RequirementMany processes in chemical and biological engineering are described by differential equations. All studentsin Chemical and Biological Engineering must complete a course in differential equations (MAE 305 or MAT427 or APC 350) by the end of the fall term of the junior year.Advanced Chemical and Biological Engineering ContentStudents must take one advanced CBE course from any 300/400/500-level CBE courses for a grade.Independent work courses, CBE 351, CBE 352, CBE 451, and CBE 452, cannot be used to fulfill thisrequirement.Chemical and Biological Engineering Core CoursesTo qualify for a Chemical and Biological Engineering degree, students must take a core of 9 departmentalcourses. This is required by ABET and Princeton University. The following nine courses are required:CBE 245CBE 246CBE 250CBE 341CBE 346CBE 441CBE 442CBE 454Introduction to Chemical and Biochemical Engineering PrinciplesThermodynamicsSeparations in Chemical Engineering and BiotechnologyMass, Momentum and Energy TransportChemical and Biological Engineering LaboratoryChemical Reaction EngineeringDesign, Synthesis, and Optimization of Chemical ProcessesSenior Thesis (counts as two)Students may petition to substitute a 1-semester independent work project (CBE 451 or CBE 452) plus anapproved CBE elective for the 2-semester senior thesis. To be eligible for departmental honors one mustcomplete a 2-semester senior thesis.Chemical and Biological Engineering Program ElectivesProgram Electives are used to satisfy requirements for areas of concentration and breadth. These arediscussed in detail in the following pages.6
Integrated Science CurriculumThe integrated science program is intended for students with a strong interest in quantitative biology whoare considering concentrating in the sciences or engineering. It provides an alternative path into theDepartments of Chemistry, Computer Science, Molecular Biology, and Physics. ISC/CHM/COS/MOL/PHY231, 232, 233, 234 can be taken in the first year; ISC 231 and ISC 232 in the fall term and ISC 233 and ISC234 in the spring term. These courses can be substituted for CHM 201-202, PHY 103-104 or 105-106, MOL214, and COS 126 in the first year. ISC/CHM/COS/MOL/PHY 235, 236 can be taken in the sophomore year.Students who take ISC 231-234 cannot also take MOL 214 for credit. These students can satisfy the CBE“Molecular Biology” requirement by taking another course offered by, or cross listed with, MolecularBiology at the 300-level and above (please note that any substitute for MOL 214 cannot be used to satisfyany other departmental requirement). For more information, consult the Undergraduate Announcementor www.princeton.edu/integratedscience.ABET AccreditationThe Chemical and Biological Engineering Program is accredited by the Engineering AccreditationCommission of ABET, http://www.abet.org.ABET requires CBE students to complete a minimum of 12 engineering topic courses. This is satisfied bycompleting the nine CBE core courses (including the double credit thesis), SEAS COS requirement, and atleast two program electives identified as ET on the approved list of courses in the Areas of Concentration.Program ElectivesThe program electives provide students with an introduction to the breadth of advanced areas of chemicaland biological engineering and to have the students pursue one area in greater depth. Six areas have beenidentified as areas of concentration and are listed in Table II along with courses that satisfy therequirements. New courses may be added to the lists and students can petition to have a course count inone of these six areas. Depth in an area of concentration is accomplished by taking three courses from aprescribed list in the same area of concentration. Students are required to take courses in two differentareas outside their concentration to provide breadth. Except under exceptional circumstances, technicalelectives cannot be taken anywhere but at Princeton University. Students must take a minimum of 5separate courses as Program electives.A number of courses in three of the areas of concentration can also satisfy the advanced chemistry oradvanced biology requirement, or the advanced CBE course requirement. By judicious choice of programelectives students can free up two electives within the 36-course requirement.Every course on the list that has been designated ET has been assessed to satisfy the engineering topiccontent requirement. ET courses can be added to the list if approved by the Undergraduate Committeebased on the course syllabus and an explanation of the engineering topic content in that course by theinstructor. Courses with ET designations will be re-evaluated approximately every five years to ensure thattheir contents continue to include engineering topics.7
Program electives may be used to partially or completely fulfill course requirements for the Universitycertificate programs. Certificate programs readily accessible to Chemical and Biological Engineers includeEngineering Biology, Engineering Physics, Environmental Studies, Materials Science and Engineering,Applied and Computational Mathematics, Sustainable Energy, Applications of Computing, Finance andEngineering Management Systems. For further information on certificate programs the student shouldconsult the appropriate certificate program handbooks or websites.Areas of Concentration for Chemical and Biological Engineering Majors Bioengineering and BiotechnologyEntrepreneurship and ManagementEnergy and Environmental TechnologyMaterials and Product EngineeringOptimization, Dynamics and Information TechnologyScience and Engineering for New TechnologiesApproved Courses in Areas of ConcentrationCourseCourse DescriptionAdditionalRequirementsEngineeringTopic ContentBioengineering and Biotechnology, Track 1CBE 411/MOL 411CBE 419CBE 433/ MSE424CBE 438/MOL 438CBE 439CBE 440CBE 447Antibiotics: From Cradle to GraveMAT 104 and MOL 214EnzymesIntroduction to the Mechanics andDynamics of Soft Living MatterBiomolecular EngineeringMOL 214ETETETQuantitative PhysiologyThe Physical Basis of Human DiseaseMetabolic Engineering8MOL 214ETETETET
CHM 440/GHP 440EEB 309EEB 320/ MOL330EEB 325Drug Discovery in the Genomics EraEvolutionary BiologyMolecular Evolutionary GeneticsMathematical Modeling in Biology &MedicineEEB 327/ MOL Immune Systems: From Molecules to327PopulationsENE 318/ CBE Fundamentals of Biofuels318GEO 417Environmental MicrobiologyGEO 428Biological OceanographyISC 326/ EEBHuman Genomics: The Past, Present326/ MOL 326 and Future of the Human GenomeMAE 344Biomechanics and Biomaterials: FromCells to OrganismsMOL 340Molecular and Cellular ImmunologyMOL 342GeneticsMOL 345/BiochemistryCHM 345MOL 348Cell and Developmental BiologyMOL 410Introduction to Biological DynamicsMOL 415Modern Biophysics and Systems BiologyMOL 433/BiotechnologyCBE 434MOL 434Macromolecular Structure andMechanisms in DiseaseMOL 435Pathogenesis and Bacterial DiversityMOL 448/CHM 448MOL 457MOL 459MOL 423NEU 201/ PSY258NEU 202/ PSY259NEU 408/MOL 408/ PSY404Chemistry, Structure, and StructureFunctions of Nucleic AcidsComputational Aspect of MolecularBiologyViruses: Strategy and TacticsMolecular Basis of CancerFundamentals of NeuroscienceIntroduction to Cognitive NeuroscienceCellular and Systems Neuroscience2 terms of organicchemistryEEB 211 and MOL 214MOL 214 or any upperlevel MOL courseEnrollment by applicationEEB 211 and MOL 214ETCollege level Bio, CHM,PHYEEB 211 or MOL 214 orCOS 126 or ISC 231/2MAT 103/4, PHY103/4MOL 214MOL 214MOL 214 and CHM304/304BMOL 342 or MOL 345MAT 103 or equivalentMOL 342 or MOL 345MOL 345 or permissionfrom instructorMOL 342 or permissionfrom instructorOne 300-level MOL, CHMcourseMOL 342 or MOL 348 orpermission of instructorNEU 258/PSY 258MOL 214, PSY 258, MAT103, PHY 1049ET
NEU 437/ MOL Computational Neuroscience437/ PSY 437PSY 406PSY 407QCB 455/ COS455MOL 410 or basic linearalgebra, probability, MAE305Functional NeuroanatomyDevelopmental NeuroscienceIntroduction to Genomics andComputational Molecular BiologyPSY 208, 256 or 258Entrepreneurship and Management, Track 2CBE 260/ EGR260CEE 334/ WWS452/ ENV 334/ENE 334CEE 460CHV 331/WWS 372COS 432/ ELE432ECO 310ECO 311EGR 437/MAE 437/ ELE437EGR 491/ ORF491EGR 494EGR 495EGR 497GEO 366/ ENV339/ WWS451/ ENE 366ORF 245ORF 335Ethics and Technology: Engineering inthe Real WorldGlobal Environmental IssuesRisk Assessment and ManagementEthics and Public HealthInformation SecurityETAP chemistry, CHM 201, orpermission of instructorORF 245, MAT 202COS 217, 226Microeconomic Theory: AMathematical ApproachMacroeconomics: A MathematicalApproachInnovation Process LeadershipECO 100 & MAT 200 or201ECO 100 & ECO 101 &MAT 200 or MAT 201ETETETETHigh-Tech EntrepreneurshipETLeadership Development for BusinessSpecial Topics in EntrepreneurshipEntrepreneurial LeadershipClimate Change: Impacts, Adaptation,PolicyETETETFundamentals of Engineering StatisticsIntroduction to Financial MathematicsORF 360Decision Modeling in Business AnalyticsORF 435Financial Risk and Wealth ManagementWWS 373/CHV 373Welfare, Economics and ClimateChange Mitigation PolicyMAT 101/2, CHM 201/2or PHY 101/2, GEO 202ECO 102, MAT 104, ORF309ORF 245, ORF 307, ORF309 or approval byinstructorORF 245, ECO 202, 335, or465Not open to first y
CBE 245 Introduction to Chemical and Biochemical Engineering Principles . CBE 246 Thermodynamics . CBE 250 Separations in Chemical Engineering and Biotechnology . CBE 341 Mass, Momentum and Energy Transport . CBE 346 Chemical and Biological Engineering Laboratory . CBE 441 Chemical Reaction Engineering .
Chemical Formulas and Equations continued How Are Chemical Formulas Used to Write Chemical Equations? Scientists use chemical equations to describe reac-tions. A chemical equation uses chemical symbols and formulas as a short way to show what happens in a chemical reaction. A chemical equation shows that atoms are only rearranged in a chemical .
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