Interpersonal Psychotherapy: Recent Indications Beyond .

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Original article Articolo originaleInterpersonal psychotherapy: recent indications beyond major depressionLa psicoterapia interpersonale: recenti indicazioni oltre la depressione maggioreS. Bellino, C. Rinaldi, C. Brunetti, F. BogettoCentro per i Disturbi di Personalità, Clinica Psichiatrica 1, Dipartimento di Neuroscienze, Università di TorinoSummaryObjectivesInterpersonal psychotherapy was proposed in 1984 by Klerman and colleagues. It is a time-limited psychotherapy (1216 sessions/a week), diagnosis-focused, based on a medicalmodel, according to which the patient has a treatable illnessthat is not his/her fault. Psychiatric symptoms develop in aninterpersonal context, acting on which it is possible to induceremission and prevent subsequent relapses. IPT seeks the resolution of the interpersonal crisis improving social functioningand psychiatric symptoms, too.At first it was aimed to treat major depression, not psychoticor bipolar. Later IPT has been applied to a growing number ofpsychiatric disorders, because of their frequent and predominant interpersonal dimension. However, specific adaptationsof IPT have been required to consider the different clinicalcharacteristics of the disorders and to satisfy patient’s needs.This review will present and comment the results of the available studies of IPT adapted to mental disorders different frommajor depressive disorder.MethodsOpen-label and controlled studies concerning the use of IPTin Axis I and II disorders different from major depression weresystematically searched for and commented.ResultsChronic depressions, as dysthymic disorder, have usuallybeen considered more difficult to treat with IPT, because theirsymptoms are more commonly egosyntonic and it is not possible to identify a life event at the onset of the current episode.The IPT-D, a model of IPT structured in at least 24 sessions,was so developed to treat dysthymia. It proposes a iatrogenicrole transition as a recent interpersonal problem to work onwith.The close correlation among life events, regularity of circadianrhythms and mood regulation, particularly in bipolar patients,has contributed to the development of the interpersonal andsocial rhythms psychotherapy (IPSRT). IPSRT is an interpersonal and psycho-educational intervention that considersthese three factors and prevents pathological mood shifts firstof all by the stabilization of patients’ social rhythms.The frequent comorbidity between substance abuse and mooddisorders has also encouraged the use of IPT in the treatmentof addictions. In particular, IPT has been used in subjects withalcohol, cocaine, and opiates dependence.The IPT has also found a promising field of application in eating disorders, particularly bulimia and binge-eating-disorder.It doesn’t directly address the pathological eating behavior,but it focuses on the interpersonal problematic areas. Theseproblems are related to a difficult managing of emotions, thattriggers binges. The IPT aims to stop the use of food as a coping strategy that is called “emotional eating”.Because of the interpersonal nature of their symptoms, alsoanxiety disorders are potential indications for IPT. In the treatment of social phobia, modified IPT (IPT-SP) focuses on themost problematic interpersonal area in these patients: the roletransition. Preliminary data on the application of this therapyin panic disorder are now available. Finally, the IPT has beentested in post-traumatic stress disorder (IPT-PTSD). The IPTPTSD first addresses, in a flexible way, relational and socialconsequences of the trauma and aims to reinforce the patient’ssocial network. Secondary, a well developed social supporthelps to understand and deal with the trauma.To date, among Axis II disorders, only borderline personalitydisorder (BPD) has been a focus of IPT. The frequent comorbidity with mood disorders and the relational problems dueto BPD core symptoms are the main reasons for the proposalof an adapted model of IPT: the IPT-BPD. This is an intervention of longer duration than traditional IPT (34 sessions in 8months), adding to the problematic areas “the image of theself”. It’s designed to take into account the chronicity of BPDand the poor therapeutic alliance and high risk of suicide ofthese patients.ConclusionsBoth classical model of IPT and several specific adaptationshave been recently used to treat an increasing number of AxisI and II disorders. Initial results are overally promising, but onlylimited data are available for each indication. At the moment,a slightly larger number of studies has been performed for bipolar disorders and eating disorders, but replication of resultsin well-designed investigations is generally required.Key wordsInterpersonal Psychotherapy Dysthymic Disorder Bipolar Disorders Substance Abuse Bulimia Binge Eating Disorder Social Phobia Panic Disorder Post Traumatic Stress Disorder Borderline Personality DisorderCorrespondenceSilvio Bellino, Centro per i Disturbi di Personalità, Clinica Psichiatrica 1, Dipartimento di Neuroscienze, Università di Torino, via Cherasco 11,10126 Torino, Italy Tel. 39 011 6634848 Fax 39 011 673473 E-mail: silvio.bellino@unito.itJournal of Psychopathology 2012;18:359-375359

S. Bellino et al.Interpersonal psychotherapy (IPT)Interpersonal psychotherapy developed from an ideaby Harry Stack Sullivan 1, an American psychiatrist whofocused on psychoanalytical theories that see man as a‘product of his interpersonal relations, and cultural andenvironmental interactions’ 2. This conception was influenced by the psychobiological theories of Adolf Meyerand is based on the clinical observation of a primary social group and the immediate involvement of the subjectwith one or more significant persons. Interpersonal intervention is centred on the intimate relations of the patient,starting with the conception of self as a result of the continuous of the ego with reference individuals. The individual is therefore supported and continuously defineedby the relations that are established and by the social rolethat the individual plays. Interpersonal psychotherapy(IPT) starts with the biunivocal relation between the psychopathology and a social role, and between symptomsand the interpersonal dimension.Klerman et al. 3 defined the methods and techniques ofthis psychotherapeutic approach, which consist of briefpsychotherapy sessions (12-16 weekly sessions lasting 1hour each), generally for treatment of patients with majordepression who are not psychotic and without bipolardisorder. The intervention has a distinct medical settingbased on the formulation and communication of a diagnosis 4, and on the transitory attribution of the phenomena of illness to the patient 5. Such an approach removesresponsibility from the patient regarding guilt and frustration for their emotional experience, and at the sametime defines the symptoms in a syndromic context thatis known and therefore curable. This pragmatic modelof IPT 6 highlights how depression develops in an interpersonal context, and by acting on this it is possible toinduce remission of symptoms. Thus, IPT has the aim ofresolving on-going relational crises, improve social functionality and relieve depressive symptoms. It also has theobjective of preventing recurrence of major depression.It is structured in three successive phases. The first phase(1-3 sessions) is concentrated on analysis of interpersonal relations of the patient, present and past, in order toformulate a correct diagnosis and identify the relationsthat are associated with a problematic interpersonal core:inability to mourn a death, interpersonal contrasts, roletransitions or interpersonal deficits. This approach is particularly effective in major depression, which allows thepossibility to relate interpersonal problems with the onsetof the on-going depressive episode. In the next phase,focus is placed on analysis of previously-identified issues.Beginning with emotionally relevant events that emergeduring each session, the emotional experience of the patient is analyzed: the objective is to substitute relationalstyles based on emotional and cognitive dysfunctions of360oneself and others with more adaptive models, withoutmaking the psychodynamic assumptions of IPT explicit.The final phase starts with a comparison of predeterminedobjectives with the observed improvements in order toplan the end of treatment: on one hand, the therapy recognizes the physiological sadness induced by the end oftherapy, a moment of separation and transition, and onthe other emphasizes a sense of dependence associatedwith the end of the psychotherapy.The efficacy of IPT in treatment of major depression iswell-established, and a recent meta-analysis has confirmed its utility in both monotherapy and in associationwith pharmacotherapy. It was also suggested that IPTshould be included among treatments recommended inguidelines as its efficacy is based on clinical evidence 7.Studies comparing various psychotherapies have demonstrated that IPT is superior to supportive psychotherapy(SP) and has an efficacy similar to cognitive-behaviouraltherapy (CBT) in improving global depressive symptoms.It is interesting to highlight that IPT is one of the most effective psychotherapies for improving relational dynamics and social integration 4 8. The superiority of combinedtreatment over pharmacotherapy or psychotherapy alonehas not been demonstrated, even if there is such evidencein severe depression.Over the years, IPT has been applied to other psychiatric disturbances, beginning with the changes in interpersonal functioning. Among Axis I disorders, IPT has beenstudied in dysthymia, bipolar disorder, substance abuse,post-traumatic stress disorder, social phobia, panic disorder and eating disorder. Among Axis II disorders, IPT hasbeen used in treatment of borderline personality disorder.Mood disordersOriginally proposed for treatment of unipolar depression,IPT was later used with promising results in treatment ofbipolar I and II disorder (BP-I and BP-II) and dysthymia.The chronic nature of affective symptoms (characteristicof dysthymia and even BP, the frequency of episodes andpresence of residual symptoms in the so-called symptomfree intervals) leads to difficulty in identifying a recentlife event that is associated with the onset of symptoms.Thus, IPT must be modified to render it appropriate forthe treatment of these disorders.Bipolar I and II disordersIPT, in the IPSRT version (interpersonal social rhythmtherapy) 9 11, has been used together with pharmacotherapy in the treatment of BPD-I, and as monotherapyin BP-II. IPRST correlates life events, variations in circadian rhythms and alteration in mood. At present, it is wellknown that stressful socio-environmental factors (sleep

Interpersonal psychotherapy: recent indications beyond major depressiondeprivation, work shifts, insomnia) can cause alterationsin circadian rhythms 12 13 and favour the development oftransitory somatic and cognitive symptoms. In individuals subject to affective disturbances, such variations canlead to significant mood alterations 14-16. This is especiallytrue for sleep deprivation and the consequent appearanceof an expansive episode on BP 17 18. To prevent and treatthymic variations in these patients, it is this necessary toprioritize regulation of circadian rhythms, maintaininga constant equilibrium between the loss of “Zeitgebers”or “time givers” 19 (socio-environmental factors that synchronize vital rhythms), and the presence of “Zeitstorers”or factors that alter regularity 12. IPSRT, an interventionwith is also psychoeducational, behavioural and interpersonal, has the objective of resolving interpersonalcrises, thymic stabilization and especially normalizationof circadian rhythms. It is used in the acute phase withcurative intent and in the maintenance phase with prophylactic intent. It is modular and can be modulated 10 11,and is divided into four phases.In the first phase, through anamnesis of the patient, lifeevents are correlated with alterations in circadian rhythmand mood. Psychoeducational intervention is also carriedout to increase awareness of the disease and compliance.It is important to combine evaluation of circadian rhythms,using the Social Rhythm Metric (SRM, 20), with interpersonal relations, through administration of the InterpersonalInventory. A problematic interpersonal area is then chosenon which to focus. The next phase is characterized byinterpersonal intervention, aimed at resolving on-goingsocio-relational crises, and by behavioural interventionto normalize circadian rhythms. The maintenance phasereinforces the newly-acquired social abilities and sustains aconstant daily cycle. The last phase concerns autonomization of the patient by reducing the frequency of sessions,initially bi-weekly then monthly, to prepare the individualfor interruption of treatment. One can also opt for continuedsessions with reduced frequency.In an initial study 21, the efficacy of IPRST was evaluatedin combination with pharmacotherapy in the acute treatment of patients with BP; 42 patients were enrolled andtreated with either combined IPSRT therapy (n 21) ora clinical approach called Clinical Status and SymptomReview Treatment (CSSRT) (n 21). Once stabilized,patients then entered a continuation and maintenancephase that lasted at least 2 years. The results showed amoderate efficacy of IPSRT, but not in the acute phase,with a limited ability to reduce the time of remission ofan episode. The investigators thus stressed a prophylacticrole for IPSRT. However, these discouraging results havebeen questioned in later studies 9 22-24.A second RCT 22 studied a cohort of patients with BP thatwas treated in the acute and maintenance phases withcombined therapy consisting in pharmacotherapy andIPSRT or a psychoeducational intervention, namely Intensive Clinical Management (ICM). After stabilization,patients were randomly reassigned to one o

Interpersonal psychotherapy (IPT) Interpersonal psychotherapy developed from an idea by Harry Stack Sullivan 1, an American psychiatrist who focused on psychoanalytical theories that see man as a ‘product of his interpersonal relations, and cultural and environmental interactions’ 2. This conception was influ-enced by the psychobiological .

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