Quality By Design: A Primer
Quality By Design: A PrimerZia AbdullahFebruary 19, 2020
Feedstock Conversion to ProductsIs Designed to Process Multiple InputsConversion TechnologiesWoody BiomassFeedstockGrasses AgriculturalResidues Energy Crops Forest Resources Organic Waste AlgaeIntermediatesProducts Sugars IntermediateChemical BuildingBlocks Bio-Oils Gaseous Mixtures Fuels Chemicals MaterialsMSWCrop ersion-technologiesNREL 2
Feedstock Variability InducesSignificant Processing Challengeswww.123rf.comForest Residue PileResidue ChipsFresh Corn StoverStored Corn StoverClean Pine ChipsDeteriorated Corn StoverNREL 3
2016 Biorefinery Optimization Workshop Identified FeedstockFlowability and Feedstock Variability as Key ChallangesNREL 4
BETO Has Set Up the FCIC Consortium to AddressFeedstock Related Issues with BiorefineriesObjective: To develop first-principles basedknowledge and tools to understand andmitigate the effects of biomass feedstockand process variability on biorefineriesPrincipal Investigator: Ed WolfrumEd.Wolfrum@nrel.govProgram Manager: Amie SluiterAmie.Sluiter@nrel.govNREL 5
FCIC Uses the Quality by Design (QbD) Approach OriginallyDeveloped for the Pharma IndustryCritical Process ParameterProcess parameter that impacts a CQAQuality Target Product ProfileProduct characteristics required toobtain desired quality of productCPPCMAInputMaterialCritical Material AttributeProperty of input material that is necessary toobtain desired quality of productQTPPProcess UnitOperationCQAOutputMaterialCritical Quality AttributeProperty that must be achieved to obtaindesired quality of productNREL 6
Quality by Design Approach Can Be Analogousfor Biorefinery OperationCPPsCQAsCMAsOutputMaterials nCQAsOutputMaterials orProductExample: Blending/Mixing of Medical TabletExample: Jet Fuel ProductionCMA: Particle Size DistributionCMA: Lignin Content, H2 ContentCPP: Mixer Load LevelCPP: Process Design and OperationCQA: Blend UniformityCQA: Aromatic Content 25%Sustainable JetFuel Compliantwith ASTMD4054NREL 7
Quality by Design for Biomass Value aterialsHandling MonomericMoisture contentsugar contentFurfural,Bale integrityHMF contentInorganicsCarbohydrate(e.g.contentNa, K) tingstrategy (e.g. single-pass,AerationmethodBale arrangementmulti-pass)TemperatureStorage tempUseof balewrapFeedingstrategyStoragetimeHarvesterheight yieldNREL 8
Quality by Design Approach May Be Useful To Process MunicipalSolid Waste With High VariabilityHighVariabilityCMA . . . LowerVariabilityPreprocessingProductCMACQA . Conversion . L 9
Thank youwww.nrel.govAcknowledgements:Ed WolfrumAmie SluiterJun QuGeorge FenskeJim KeiserAllison RayBryon DonohoeYidong XiaTroy SemelsbergerKevin KennyJim CollettRachel EmersonVicki ThompsonRick ElanderDanny CarpenterJim ParksPhil LaibleAkash NaraniSteve PhillipsErin WebbMike ReschChenlin LiStaff from the Bio Energy Technology OfficeThis work was authored by the National Renewable Energy Laboratory, operated by Alliance for Sustainable Energy,LLC, for the U.S. Department of Energy (DOE) under Contract No. DE-AC36-08GO28308. Funding provided by U.S.Department of Energy Office of Energy Efficiency and Renewable Energy Bioenergy Technologies Office. The viewsexpressed in the article do not necessarily represent the views of the DOE or the U.S. Government. The U.S.Government retains and the publisher, by accepting the article for publication, acknowledges that the U.S.Government retains a nonexclusive, paid-up, irrevocable, worldwide license to publish or reproduce the publishedform of this work, or allow others to do so, for U.S. Government purposes.
Quality by Design: A Primer Author: Zia Abdullah Subject: Quality by Design: A Primer presentation by Zia Abdullah, National Renewable Energy Laboratory, at the Advancing the Bioeconomy: From Waste to Conversion-Ready Feedstocks Workshop held February 19-20, 2020 in Arlington, VA. Created Date: 2/24/2020 10:21:06 AM
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