Siste Nytt Fra EPoS Newsletter - Med.uio.no
Siste nytt fra EPoSNewsletterNewsletter from the European Polyp Surveillance trialSeptember 2017Patients included in EPoSas of September 17th, 2017Board Meeting in TromsøFrom the EPoS Board meeting in Tromsø, Norway in November 2016.We are proud to present the first European Newsletterof the EPoS trial. Our aim is to share the latest newsand updates from all EPoS centres, including thelatest inclusion numbers. The Newsletter provides tipsand tricks for data management from Frontier Science,and useful information based on experience from theEPoS centres.The EPoS community is growing bigger, and nowentails seven countries. A large number of healthprofessionals in Europe are working every day forPhoto: Siv Furholm.the success of the EPoS trial. Sharing information,experiences, and knowledge will help you at theparticipating centres to achieve our overarchinggoal of conducting a high-quality study which willchange clinical practice and improve patient care.This month, our special focus is on the new eligibilitycriteria for patients, please see the new flowchart onpage 2. Please share useful information about theEPoS trial by distributing this newsletter to your coworkers and other relevant hospital staff.Har du spørsmål om EPoS-studien?Kontakt anita.aalby@medisin.uio.nowww.eposstudy.org
EPoS NEWSNew Eligibility Criteria for EPoS PatientsVersion 10 of the EPoS protocol is approved in all participating countries (except Portugal). The protocolchanges are implemented in the EPoS randomisation system.Patients eligible for EPoS III according to the new critria, have already been moved to the correct studyby Frontier Science. Please consider advising the patient(s) about the changed surveillance intervals.Please note; this only applies to patients moved from EPoS I, group 2, with surveillance scheduled after10 years. After migration to EPoS III, they are now scheduled for an additional surveillance colonoscopyafter 5 years.Eligibility Criteria FlowchartEPoS I: Low risk adenoma 1 or 2 tubular adenomas 10 mm 1 or more adenoma 10 mmorand 1 or more serrated polyps 10 mm (prox. or dist. colon) 1 or more serrated polyps 5 mm in the prox. colon(proximal to the splenic flexure) SSA/P with dysplasia or TSA, all sizes and locations1 or more adenoma withhigh grade dysplasiawith low grade dysplasiaEPoS III: Serrated polyps(Serrated polyp SSA/P, TSA or HP)3 to 10 adenomasorboth EPoS II: High risk adenomaor 1 or more adenoma with tubulovillousor villous growth patternEPoS III: (Serrated polyp)No adenomasEPoS IIIEPoS III: (Serrated polyp)EPoS I: (Low risk adenoma)EPoS IIIEPoS III: (Serrated polyp)EPoS II: (High risk adenoma)EPoS IIMissing polyps: EPoS I and EPoS III: none. EPoS II: Only 1 polyp 10 mm may be missing.Do you need a full-size flowchart in your clinic?Contact: anita.aalby@medisin.uio.no
EPoS INFO1 Polyp – 1 ContainerWe sometimes lose patients for inclusion in EPoS because more than one polyp is put in the samecontainer for histology. Please remember to always use one container per polyp.Segment – not cm from SphincterOne of the important variables is colon segment; where the polyp was found. Using cm from the analsphincter is not a good description of anatomic site, and it leads to unspecific and incorrect data. Therefore,please encourage all endoscopists to include a clear description of which colonic segment each polyp wasfound in the endoscopy report.Tips and Tricks from Frontier Science Remember to mark the CRF as complete when all data have been entered.Fill out the Error Report Form and send to Frontier, if errors are made at randomisation.Two or more baseline colonoscopies: The FINAL baseline colonoscopy is registered in the «BaselineData».Previous baseline colonoscopies are registered in «Previous Baseline Colonoscopy», see image below.Polyps are registered in the associated colonoscopy CRF. Click «Detected in previous colonoscopy» inthe Final baseline colonoscopy if polyps were left in situ previously.There is a link in Open Clinica which will guide you to support documentation, se image below.First Paper from the EPoS TrialWe hope the EPoS trial will generate many papers in the future. The firstpaper has already been published.Title: Rationale and design of the European Polyp Surveillance (EPoS) trials.Journal: EndoscopyAuthors: Rodrigo Jover, Michael Bretthauer, Evelien Dekker, Øyvind Holme,Michał F. Kaminski, Magnus Løberg, Ann G. Zauber, Miguel A. Hernán, IrisLansdorp-Vogelaar, Annike Sunde, Eleanor McFadden, Antoni Castells,Jaroslaw Regula, Enrique Quintero, Maria Pellisé, Carlo Senore, MetteKalager, Mario Dinis-Ribeiro, Louise Emilsson, David F. Ransohoff, Geir Hoffand Hans-Olov Adami.Click on the image for access if you are reading this newsletter electronically.
European EPoS CentresCentres: 14Country PI: Rodrigo JoverSites: Alicante, Barcelona (2 centres),Zaragoza, Vigo, Ourense, Tenerife,Seville, Bilbao, Valladolid, Oviedo,Valencia, Aranda de Duero and Murcia.Centres: 13Country PI: Michael BretthauerSites: Oslo (2 centres), Moss, Kalnes,Lørenskog, Tønsberg, Skien, Kragerø,Kristiansand, Trondheim, Stavanger,Tromsø and Bærum.Centres: 2Country PI: Michał F. KaminskiSites: Warsaw and Cracow.Centres starting up in Gdansk andSzczecin.Centres: 1Country PI: Hans-Olov AdamiSites: Karlstad.Centre in Stockholm pending.Centres: 5Country PI: Evelien DekkerSites: Amsterdam (2 centres),Rotterdam, Alkmaar and Deventer.Centres: 3Country PI: Rune ErichsenSites: Herning, Horsens and Viborg.Centres: 1Country PI: Mario Dinis-RibeiroSites: Porto.
EPoS Accruals and ProgressionAccruals Europe: 6643 patientsProgression Europe
Siste nytt fra EPoS Newsletter Newsletter from the European Polyp Surveillance trial www.eposstudy.org September 2017 Board Meeting in Tromsø We are proud to present the first European Newsletter of the EPoS trial. Our aim is to share the latest news and updates from all EPoS centres, including the latest inclusion numbers.
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