Psychiatric Issues In Traumatic Brain Injury - Nbia.ca

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Psychiatric Issues inTraumatic Brain InjuryEstablishing a Differential Diagnosis andIdentifying Effective Treatment for Individualswith TBI and Behavioral Health ProblemsRolf B. Gainer, PhD, Dip. ABDANeurologic Rehabilitation Institute, Brookhaven Hospital, Tulsa, OK(800) 927-3974 www.brookhavenhospital.com

Objectives Explainthe scope of problemsexperienced by traumatic brain injury(TBI) patients, including behavioralhealth issues Discuss effective strategies fordiagnosing neurological impairment,psychiatric illness, and co-morbidity Review conditions created by TBI thatcan exacerbate underlying psychiatricconditions10/21/2004Brookhaven Hospital2

Objectives Examineclinical presentation ofpersons with a dual diagnosis, whichincludes TBI Examine treatment/rehabilitationimplications for individuals with dualdiagnosis10/21/2004Brookhaven Hospital3

Psychiatric Issues inIndividuals with TBI Behavioralcomponents of TBI whichresemble psychiatric illness Effects of brain injury on individuals withpre-existing conditions Issues of co-morbidity Diagnostic skills10/21/2004Brookhaven Hospital4

Facts About Brain Injury Everyday nearly 6,000 Americans sustaina brain injury (www.biausa.org) 400,000 individuals with moderate andsevere brain injuries in the USA arehospitalized each year10/21/2004Brookhaven Hospital5

Causes of Brain Injury MotorVehicle Accidents 50% Falls21% Assaults12% Sports/Recreation10% Other7%10/21/2004Brookhaven Hospital6

Physical Effects of BrainTrauma in Closed Head Injuries DirectImpact Coup and Contra Coup Injuries Rotation and Shearing Swelling Bleeding Neurochemical Changes Secondary Effects10/21/2004Brookhaven Hospital7

TBI Severity Distribution Injury Mild Moderate Severe Mortality10/21/2004Rate85%10%5%11%Brookhaven Hospital8

Assumptions about TBI Physiologicalimpairment Disruption of sensorium Disinhibition Arousal and attention problems Unstable mood states Problems in learning and organization10/21/2004Brookhaven Hospital9

Behaviors in Early Recovery Disorientation ParanoidIdeation Depression Hypomania Confabulation10/21/2004Brookhaven Hospital10

Behaviors in Early Recovery Restlessness Agitation Combativeness EmotionalLability Confusion Hallucinations10/21/2004Brookhaven Hospital11

In the early phase ofTBI recovery, somebehaviors canresemble a psychiatricillness.10/21/2004Brookhaven Hospital12

Biological Aspects of InjuryFurther Psychological Problems Seizuredisorder may include irritability andbehavior dyscontrol Cognitive problems, especially memory,affect, emotional response Denial of deficits may affect capacity toreceive help Previously effective medications may notwork or may exacerbate injury-relatedproblems Depression may prevent participation10/21/2004Brookhaven Hospital13

The Basic Person Doesn’t Change Theinjury alters specific aspects of theperson’s psychological, cognitive andemotional function Specific personality traits or styleremain10/21/2004Brookhaven Hospital14

TBI Affects All Aspects of Life Previouslycompetent individuals mayshow symptoms of psychiatric disease Coping skills are stressed Behavioral controls are lost10/21/2004Brookhaven Hospital15

TBI Affects All Aspects of Life Socialskills and rolesare affected Insight into TBI-relatedchanges may be limited Previously self-managedsymptoms may becomeout of control Relationships/supportsystems are stressed10/21/2004Brookhaven Hospital16

Positive Predictors ofRecovery Outcome Focalvs. Globalized injury Aggressive early intervention andtrauma care Work history10/21/2004Brookhaven Hospital17

Positive Pre-Injury Predictors Levelof severity, coma duration Natural recovery and return of functions Medical/behavioralcomplications Pre-injury achievement level Learning, school and workhistory Extroverted personality Positive social history10/21/2004Brookhaven Hospital18

Positive Pre-Injury Predictors Perseveranceand motivation Strong social and familynetwork and support Absence of pre-injurypsychiatric symptoms Absence of substance abuse “Goodcharacter” and self control Strong-willed, determined personality10/21/2004Brookhaven Hospital19

Negative Predictors Poorresponse to psychiatric medications Poor response to “talking” therapies Failure in behavioral programs requiringmemory and problem-solving Social network failure: divorce, separation10/21/2004Brookhaven Hospital20

Negative Predictors Failureat work Involvement in thecriminal justicesystem Persistence ofchronic pain andheadache symptoms Lack of supportsystem10/21/2004Brookhaven Hospital21

Lateralization Issues ofBehavior Deficits RightHemisphere: unable to respond,flat affect Left Hemisphere:depression,agitation, anxiety Diffuse: attention,concentration,arousal, response10/21/2004Brookhaven Hospital22

TBI and Psychiatric DiseaseTraumatic Brain Injury can mimicpsychiatric symptomsExamples: memory problems, behavioraland emotional control problems, mooddisorders10/21/2004Brookhaven Hospital23

Biological Brain Changes canMimic Psychiatric Disease Biologicalchanges canexacerbate a preexisting psychiatricdisease Executive Syndromecan resemble a thoughtdisorder Behavioral features canresemble otherconditions10/21/2004Brookhaven Hospital24

TBI and Psychiatric DiseaseTBI can mask psychiatricsymptomsExample: Frontal systemdamage can produceexpressiveaposody/blunting,which may reduce theperson’s ability toexpress sadness10/21/2004Brookhaven Hospital25

Risk Factors Associated withPsychiatric Diagnosis (Lishman, 1988) Organicfactors Psychosocial factors (socio-economics,pre-morbid personality) Past history of psychiatric illness Family history of psychiatric illness Male Emergence of problems one year postinjury10/21/2004Brookhaven Hospital26

Research HighlightsLocalization of injury (Fann, 1995) Noradrenergic and serotonergic projectionsare sites of contusion (Rosenthal, 1998) Individuals withdepression andanxiety perceivethemselves asmore ill (Fann,1995) 10/21/2004Brookhaven Hospital27

Research Highlights Reactionto failure (Alexander, 1975,1992) Right hemisphere damage (Silver,1992) Pre-morbid factors and socialadjustment (Robinson & Jorge, 1993) Biochemical response (Robinson &Jorge, 1993)10/21/2004Brookhaven Hospital28

Brain Injured Patients withPsychiatric Disorders (Van Reekum, 2003)The level of severity ofthe person’s braininjury relates to thepotential for theemergence ofpsychiatric disordersin the first 24 monthspost-injury10/21/2004Brookhaven Hospital29

Personality DisturbancesAfter Brain InjuryAnxiety or “catastrophicreaction” Emotional lability/disinhibition Paranoia and psychomotoragitation Denial Depression Social withdrawal Amotivation/abulia 10/21/2004Brookhaven Hospital30

Distinguishing Brain Injuryfrom Psychiatric Problems Physicalinjury to the brain Cognitive and behavioral deficits Emotional and personality change Attention, concentration,arousal, filtering Memory problems Seizure problems Self regulation10/21/2004Brookhaven Hospital31

Psychological Syndromes canCo-occur or Predate Injury Whendid the symptoms emerge,before or after the TBI? What were persons like before injury? What were their coping styles? How have they adjusted to disability? What new symptoms/behaviors havedeveloped?10/21/2004Brookhaven Hospital32

Problems in DiagnosingPsychiatric Illness in TBI Timingbetween injury and emergenceof symptoms In mild cases lackof documentationof extent/severityof injury Pre-morbidpersonality traits Pre-injury issues10/21/2004Brookhaven Hospital33

Rate of Psychiatric IllnessOne Year Post Brain Injury 21.7%of individuals with TBI had ICD9 diagnosis vs 16.4% of generalpopulation (1998) Paststudiesfocused onindividuals withTBI who wereseen in psychiatrichospitals10/21/2004Brookhaven Hospital34

Psychiatric DiagnosisDistribution Following TBI Male- 21.6% Female – 11.3% Mild brain injury –17.2% Moderate andsevere brain injury– 23.3%10/21/2004Brookhaven Hospital35

Psychiatric DiagnosisFeaturesRelationship of psychiatric diagnosis to: Younger age Glasgow outcome scale score History of pre-injury ETOH use/abuse History of psychiatric illness Lower Mini Mental State score Fewer years of education (Deb, 1999) Not working before injury (Bowen, 1998)10/21/2004Brookhaven Hospital36

Psychiatric Issues in TBI Cases Male/female70%/30% more likely todevelop psychiatric symptoms Elevated risk for bi-polar affectivedisorder Seizures noted in 50% of cases withmania (Shukla, 1987) Limbic system lesions in 75% of maniccases (Starkstein, 1987) Family history of mood disorders10/21/2004Brookhaven Hospital37

Diagnostic Issues in BI Group Depressiveepisode13.9% vs. 2.1% Panic Disorder9.0% vs. 0.8% Generalized anxiety2.5% vs. 3.1% Phobic disorder0.8% vs. 1.1% Obsessive compulsive 1.6% vs. 1.2% Schizophrenia0.8% vs. 0.4% ETOH dependence4.9% vs. 4.7%10/21/2004Brookhaven Hospital38

Brain Injury and DepressionDepressionfollowing braininjury occurs at arate of 44.3% vs.5.9% in non-braininjured population10/21/2004Brookhaven Hospital39

Differential Diagnosis IssuesHow can the clinician determine the roleof injury and pre/post injury psychiatricfactors that contribute to behavioraldysfunction?10/21/2004Brookhaven Hospital40

Pre-existing PsychiatricDisorders Related to TBIDementia due to head injury Cognitive disorder Bipolar disorder (manic ordepressive types Mood disorders (depression,mania) Sleep disorder Anxiety disorders Intermittent explosive disorder 10/21/2004Brookhaven Hospital41

Pre-existing Conditions canAffect Recovery from TBILimited coping skills Impaired ability to managesymptoms Cognitive problems limitcapacity to manage disabilityand pre-existing condition Advent of new behaviors Prior medications mayincrease cognitive problems 10/21/2004Brookhaven Hospital42

Effect of TBI on UnderlyingPsychiatric Disease Reducedcapacity to self-managesymptoms Diminished impulse control leads toenhanced interpersonal problems Psychological defenses and copingskills fail to function Denial of deficits prevents person fromresponding to injury-related deficits10/21/2004Brookhaven Hospital43

Effect of TBI on UnderlyingPsychiatric Disease Interpersonalrelationships change Social role is altered Seizures anddyscontrol event aremisinterpreted Enhanced dependentneeds affectpsychological status10/21/2004Brookhaven Hospital44

Adjustment Difficulty due toEmotional & Behavioral Issues Emotionalchange Impaired perceptionof social interaction Impaired self control Increasedependency Behavioral rigidity10/21/2004Brookhaven Hospital45

Most Frequent Problems Citedby Family Members Slowness Irritability Impatience Depression Memory10/21/2004Brookhaven Hospital46

Co-Morbidity: PTSD & TBI(Arnon, 1998) 32%of motor vehicle accident victimsmeet diagnostic criteria for PTSD oneyear post-injury Those with PTSD have higher rates ofpre-morbid/co-morbid psychopathology(anxiety and affective disorders) Immediacy of PTSD symptoms is abetter predictor of later PTSD thaninjury severity10/21/2004Brookhaven Hospital47

Role of Prior Learning orAttentional Problems inOccurrence of PsychiatricDiagnosisPrior learning and attentionalproblems are enhanced Diminished filtering andstimuli selection Altered coping skills producedysfunctional responses 10/21/2004Brookhaven Hospital48

Psychiatric Issue orBrain Injury?Mania vs. Arousal problems Anxiety Denial Confusion Depression Cognitive problems Personality changes Intellectual changes Thought disorder vs. Thinking problem 10/21/2004Brookhaven Hospital49

Psychiatric Features of TBI Mania- Agitation Anxiety - Catastrophic Reaction(Goldstein) Denial - Inability to accept deficits Confusion - Disorientation and memoryproblems Depression – Withdrawal, abulia10/21/2004Brookhaven Hospital50

Neurologic andNeuropsychiatric Features Atypicalseizuredisorders Intermittent explosivedisorder (Yudofsky) Neurologic rage orlimbic-psychoticaggressive syndrome(Dorothy Lewis)10/21/2004Brookhaven Hospital51

Neurologic Rage Identifiers Suddenloss of behavioral control,“out of the blue” Inability to stop the behavior Seizure-like quality, unawareness of theindividual to the event Deficient memory of the event (DorothyLewis)10/21/2004Brookhaven Hospital52

Factors Leading toBehavioral Problems in TBI Primaryandsecondary aspectsof the physical injury Development ofemotional problems Development ofcognitive problems10/21/2004Brookhaven Hospital53

Two Type ofBehavioral Problems Behavioralexcess –too much Behavioral deficit –too little10/21/2004Brookhaven Hospital54

Neurobehavioral Issues Hyper/hypoarousal Level of response to externalevents/filtering Stimulus control vs. stimulus bound Denial Judgment Impulsivity vs. self-regulation Irritability and seizure-like events10/21/2004Brookhaven Hospital55

Neurobehavioral Features Impulsivity(lack of self-regulation) Level of motor agitation/restlessness Aggressivity andassaultiveness Apathy, abulia,lack of motivation Irritability,impatience10/21/2004Brookhaven Hospital56

Interpersonal/Psycho-SocialFactors of Behavioral Problems Impairedself-perception Emotional changes Egocentric thinking Impaired perception ofsocial issues Increased dependency Behavioral rigidity10/21/2004Brookhaven Hospital57

Interpersonal/Psycho-SocialFactors of Behavioral Problems Irritability Angercontrolproblems Mood instability Hypo/hyper sexuality Diminished drive/motivation Cognitive deficits10/21/2004Brookhaven Hospital58

Factors ofCognitive Problems in TBI Levelof arousal Sensorium disruption Concentration andfocus Filtering, stimulicontrol10/21/2004Brookhaven Hospital59

Factors of Cognitive Problems Orientationand confusion Memory, information retrieval Problem-solvinganddecision-making Language andcommunication10/21/2004Brookhaven Hospital60

Cognitive Problems Can LookLike Behavioral Problems Attentionand filtering problems Over/under arousal Concentration Memory Task learning Novel learning (old to new)10/21/2004Brookhaven Hospital61

The first step in making adiagnosis is to think of it.-- Thibault, 199210/21/2004Brookhaven Hospital62

Evaluate and SeparatePost-Injury from Pre-InjuryProblems10/21/2004Brookhaven Hospital63

Diagnostic Approaches Interviewwithindividual Comprehensivemedical andpsychiatric history Developmental and school history Neurological evaluation Neuropsychological assessment Medical file review10/21/2004Brookhaven Hospital64

Pre-Morbid IssuesPresence of known psychiatriccondition Level of adjustment, degree ofattainment (school, work,family) History of learning, behaviorand conduct problems History of substance problems Medical history School and vocational history 10/21/2004Brookhaven Hospital65

Post-Injury Effect on CopingSkills and Personality Responseto disabling condition(s) Cognitive deficits Neurobehavioral deficits External support system Motivation/initiative Substance use/abuse Engagement in meaningfulactivities10/21/2004Brookhaven Hospital66

Persistent Problems ofRecovery and Rehabilitation Irritability Impulsivity Egocentricity Lability Judgmentdeficits Impatience Tension/Anxiety Depression10/21/2004Brookhaven Hospital67

Implications forRehabilitation:Why Patients “Fail”10/21/2004Brookhaven Hospital68

Persistent Problems ofRecovery and Rehabilitation Hypersexuality Hyposexuality Dependency Silliness/Euphoria Aggressivity Apathy Childishness Disinhibition10/21/2004Brookhaven Hospital69

Why Patients “Fail”Strategy: Individual and Group PsychotherapyWhy? Can’t identify problems as shared byothers Difficulty maintaining behavioralalternatives10/21/2004Brookhaven Hospital70

Why Patients “Fail”Strategy: Insight-Oriented ApproachesWhy? Can’t identify problem with self Problems with generalization10/21/2004Brookhaven Hospital71

Why Patients “Fail”Strategy: Didactic ApproachesWhy? Memory problems prevent use ofprevious learning10/21/2004Brookhaven Hospital72

Why Patients “Fail”Strategy: Milieu TreatmentWhy? Social deficits inhibit positive peer groupmembership10/21/2004Brookhaven Hospital73

Why Patients “Fail”Strategy: Cognitive-Behavioral TherapyWhy? Memory problems and difficulty withgeneralizations10/21/2004Brookhaven Hospital74

Why Patients “Fail”Strategy: Behavior ModificationWhy? Problems with impulse control Memory problems preventreinforcement strategy from beingeffective10/21/2004Brookhaven Hospital75

Why Patients “Fail”Strategy: Medication ManagementWhy? Some medications further cognitiveproblems or cause disinhibited behavior10/21/2004Brookhaven Hospital76

Why Patients “Fail”Strategy: Addictive Treatment/Self-Help GroupsWhy? Cognitive problems preventidentification with the speaker/groupprocess Individual cannot apply information toself10/21/2004Brookhaven Hospital77

Why Patients “Fail” Personcannot process “talkingtherapies” Limited insight New behaviors (e.g. impulsivity) arerelated to the brain injury Increased dependence Unable to relate to previously effectivesupport groups (e.g. AA, NA)10/21/2004Brookhaven Hospital78

Support System StressesIncrease Psychological Issues Highincidence of divorce or loss of primaryrelationship (50% in first two years postinjury) Adult children return to aging parents forphysical assistance Loss of friends and work High potential for substance use/abuse Loss of social role with family, friends andcommunity Cultural factors influence recovery10/21/2004Brookhaven Hospital79

Social Network IssuesComplicate Rehabilitation Socialnetwork failureseen 24-months postinjury (Burke andWeslowski. 1989) Psychological effect ofwithdrawal or loss ofsupports10/21/2004Brookhaven Hospital80

Social Network IssuesComplicate Rehabilitation Changingsocial role post-injury affectsself-image and self-worth Individual response to loss of functionsand social changes Recidivism and emergence ofpsychiatric symptoms commonly seen12-24 months post-injury10/21/2004Brookhaven Hospital81

Increasing Success inRehabilitation andTreatment:What Works!10/21/2004Brookhaven Hospital82

What Works?Early identification of problems Highly structured, social learning environment Repetitive “teaching” of behavioralalternatives External controls managed by staff, graduallytransferred to the individual Neurological approach to medicationmanagement Integrated rehab program, includingpsychiatric and substance abuse treatment 10/21/2004Brookhaven Hospital83

What Works? Emphasison learning and relearning ofsocial role Teaching “scripts” for social interaction Guided/supported attendance atAA/NA/self-help groups Use of “failures” within treatment toaddress denial and limited insight10/21/2004Brookhaven Hospital84

What Works?Focus on social role re-entry and response offamily, friends, co-workers, peers, and othersto the person Staff understanding of TBI-related behavioral,cognitive, emotional and psychological issues Understanding of adjustment to disability Teaching individual about consequences ofTBI Promoting return to work, avocational andrecreational activities 10/21/2004Brookhaven Hospital85

What Works?Consistent response from staff throughout theenvironment Use of behavioral analysis to understandbrain/behavior issues Avoidance of negative consequences forbehavior problems Focus on discharge engineering to assurethat the individual moves to a supportiveplacement with the solid transfer ofinformation and management techniques 10/21/2004Brookhaven Hospital86

Neurological RehabilitationInstitute (NRI)atBROOKHAVENTulsa’s Specialty 1/2004Brookhaven Hospital87

Psychiatric Diagnosis Features Relationship of psychiatric diagnosis to: Younger age Glasgow outcome scale score History of pre-injury ETOH use/abuse History of psychiatric illness Lower Mini Mental State score Fewer years of education (Deb, 1999) Not working before injury (Bowen, 1998)

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