Welcome To The 2 Sino-German Symposium - Adlershof
Welcome to the 2nd Sino-German SymposiumWe are very pleased to welcome you to the 2nd Sino-German Symposium on Singletoxygen and photodynamic effects.About 27 scientists from PR China, 22 from Germany, one special speaker from USA,one from Ireland and two from Brazil will report about their latest results in singletoxygen research.The symposium is dedicated to different aspects of singlet oxygen research, startingwith fundamental questions of photosensitized generation and direct detection ofsinglet oxygen. We devote particular attention to the question of 2nd and 3rd generationphotosensitizers for clinical use. This time, amongst clinical aspects, two sessions arededicated to the photodynamic inhibition of microorganisms. The exciting topic ofusing singlet oxygen luminescence as a tool for optimization of photodynamic treatment in situ will be discussed on the symposium, too.We would like to thank all of the participants – including our excellent students – fortheir substantial contribution towards making the symposium successful.We hope that by experiencing the open atmosphere of this meeting you will get newinsights and learn more about the fascinating new prospects of using the photodynamic effect. This 2nd symposium should give all of us new impulses, inspirations andthe basis for new scientific and social contacts to create and develop new networks.We will spare no effort to make the symposium informative and inspiring for you andhope, that you will have an enjoyable week in Berlin.Prof. Beate RöderGerman ChairHumboldt-Universität zu BerlinProf. Buhong LiChinese ChairFujian Normal University
Chinesisch-DeutschesZentrum nts1-Schedule8-Participants21 -Contact Information24 -About Berlin
Second Sino-German Symposium on Singlet Molecular Oxygen and Photodynamic EffectsSchedule29. May 2017: Registration30. May 20178:45 - 9:15Opening CeremonyBuhong Li, Fujian Normal University, ChinaBeate Röder, Humboldt-Universität zu Berlin, GermanyNorbert Koch, Director of the Department of Physics, Humboldt-Universität zu Berlin9:15 - 9:45Hans-Peter BerlienHistory of PDT - from an ancient technique to thefutureSession 1Ev. Elisabeth-Klinik,LasermedizinSinglet OxygenChairs: Ying Gu, Alexander Greer9:45 - 10:10Jan SchlothauerProspects and limits of singlet oxygen luminescencedetectionInstituto de Química, Universidade de São Paulo10:10 - 10:35Steffen HackbarthSinglet oxygen luminescence parameters in heterogeneous environment and in vivoHumboldt-Universität zuBerlin, Institut für Physik10:35 - 11:05Coffee Break11:05 - 11:30Martina MeinkeEPR detection of singlet oxygen induced ROS in skinCharité-UniversitätsmedizinBerlin, Klinik für Dermatologie, Venerologie undAllergologie, Bereich Hautphysiologie11:30 - 11:55Angelika RückCorrelated FLIM and PLIM for cell metabolism andoxygen sensingCore Facility für konfokaleund Multiphotonen Mikroskopie, Universität Ulm N2411:55 - 12:20Michael KöhlProperties and usage of water after quenching ofsinglet oxygenDivision Solar Thermal andOptics,Fraunhofer-Institut für Solare Energiesysteme ISE12:20 - 12:45Maurício S. BaptistaPhotosensitization reactions at membranesInstituto de Química, Universidade de São Paulo12:45 - 13:45Group Photo and Lunch Break1
Chinesisch-DeutschesZentrum on 2Singlet Oxygen Generation and DetectionChairs: Pengfei Wang, Steffen Hackbarth13:45 - 14:10Beate RöderSinglet oxygen luminescence in cell suspensions asmeasure of the photodynamic effectHumboldt-Universität zuBerlin, Institut für Physik14:10 - 14:35Michael PfitznerTime resolved singlet oxygen measurements in CAMmodel and miceHumboldt-Universität zuBerlin, Institut für Physik14:35 - 15:00Tobias BornhütterTime resolved singlet oxygen luminescence measurements on surfaces with algae, bacteria and fungiHumboldt-Universität zuBerlin, Institut für Physik15:00 - 15:30Coffee BreakSession 3Photosensitizers and targeting carrier systems: part IChairs: Daxiang Cui, Wolfgang Bäumler15:30 - 15:55Rüdiger FaustPhotosensitization with TiO2/phthalocyanine-hybridsUniversität Kassel, FB10Mathe-matik und Naturwissenschaften, Institut fürChemie15:55 - 16:20Pengfei WangCarbon dots based phototheranostic agentsTechnical Institute of Physicsand Chemistry of the Chinese Academy of Sciences16:20 - 16:45Thomas GenschFlavin binding fluorescent proteins as geneticallyencoded photosensitizersInstitut für Komplexe Systeme 4, Zelluläre Biophysik,FZ Jülich16:45 - 17:10Gang LiuBiomimetic synthesis of nanoliposomes as cancertheranosticsSchool of Public Health,Xiamen University17:10 - 17:35Guangjun NieNanotechnoligcal approaches for improved photodynamic therapyNational Center for Nanoscience and Technology,China19:30 - 21:30Dinner2
Second Sino-German Symposium on Singlet Molecular Oxygen and Photodynamic Effects31. May 2017Session 4Photosensitizers and targeting carrier systems: part IIChairs: Zhihua Ding, Rüdiger Faust8:35 - 9:00Jürgen LademannProtection of antioxidants against destructive actionof reactive oxygen species (ROS) in human skinCharité Berlin, Klinik fürDermatologie, Venerologieund Allergologie, BereichHautphysiologie9:00 - 9:25Mathias SengeReversible singlet oxygen binding dyes as theranostic agentsBiomedical Sciences Institute, SFI Tetrapyrrole Laboratory, Trinity College Dublin9:25 - 9:50Tymish Y. OhulchanskyyNonlinear Upconversion of Near-Infrared Light toEnable Cancer TherapyCollege of OptoelectronicEngineering, ShenzhenUniversity9:50 - 10:15Yueqing GuUpconversionalnanoplat for deep tissue PDTSchool of Engineering,ChinaPharmaceutical University10:15 - 10:40Xiaolong LiuSmart Nanomaterials for synergistically enhancingphotodynamic therapy efficiencyMengchao HepatobiliaryHospital of Fujian MedicalUniversity10:40 - 10:55Coffee BreakSession 5Photosensitizers and targeting carrier systems: part IIIChairs: Yueqing Gu, Mathias Senge10:55 - 11:20Daxiang CuiMultifunctional nanoprobes for targeted photoacoustic imaging and therapyShanghai Jiaotong University/Institute of Nano Biomedicine and Engineering11:20 - 11:45Yanchun WeiNano-photosensitizer for precisely Controlled photodynamic therapyMOE Key laboratory of LaserLife Science, College ofBiophotonics, South ChinaNormal University11:45 - 12:10Zhenxi ZhangMetal Nanomaterial - Photosensitizer conjugates forPDTSchool of Life Science andTechnology, Xi’an JiaotongUniversity12:10 - 12:35Jianzhang ZhaoPreparation of new Photosensitizers and Study ofthe Photophysical PropertiesState Key Laboratory of FineChemicals / School of Chemical Engineering, DalianUniversity of Technology12:35 - 13:00Jing XinThe effective ways to improve the anti-proliferativeactivities of AlPcS4 by photodynamic therapy ingastric cancer cellsSchool of Life Science andTechnology, Xi‘an JiaotongUniversity13:00 - 14:00Lunch Break3
Chinesisch-DeutschesZentrum on 6PDI of microorganisms: part IChairs: Guangjun Nie, Arno WieheTim Maisch14:00 - 14:25The impact of absorbed photons by differentphotosensitizers relating to the efficacy of PDIof microorganismsYing Wang14:25 - 14:50Selective killing effect of helicobacter pyloriby a novel pyridyl cationic-modified benzylidenecyclopentanone photosensitizerAnnegret Preuß14:50 - 15:15Cationic phosphor corrols - universal agents forPDI against microorganisms15:15 - 15:45Coffee BreakSession 7Antimicrobial PDT and ColdPlasma Klinik und Poliklinikfür Dermatologie UniversitätR egensburgDepartment of Laser Medicine, Chinese PLA GeneralHospitalHumboldt-Universität zuBerlin, Institut für PhysikPDI of microorganisms: part IIChairs: Dan Zhu, Tim Maisch15:45 - 16:10Wolfgang BäumlerNatural photosensitizer molecules for antimicrobialPDTKlinik und Poliklinik fürDermatologie, UniversitätRegensburg16:10 - 16:35Arno WieheConjugates of porphyrins and hyperbranchedpolyglycerol for the photodynamic inactivation ofbacteriaBiolitec AG16:35 - 17:00Jakob PohlPDI of phototrophic micro-organisms - from planctonic cells to biofilmsHumboldt-Universität zuBerlin, Institut für Physik17:00 - 17:25Alexander MüllerPDI of microorganisms via functionalized microfiltration membranesHumboldt-Universität zuBerlin, Institut für Physik17:25 - 17:50Nedaa ShamaliTowards photodynamic treatment of onychomycosis:photodynamic inactivation of dermatophytesHumboldt-Universität zuBerlin, Institut für Physik17:50Laboratory Tours19:30 - 21:30Dinner4
Second Sino-German Symposium on Singlet Molecular Oxygen and Photodynamic Effects01. June 2017Optical monitoring techniques for photodynamic therapySession 8 and dosimetryChairs: Jianzhang Zhao, Beate Röder8:35 - 9:00Buhong LiOptical techniques for monitoring photodynamictherapySchool of Photonics andElectronic Engineering, Fujian Normal University9:00 - 9:25Dan ZhuIn vivo Tissue Optical Clearing:A Potential Technique for PDTWuhan National Laboratoryfor Optoelectronics9:25- 9:50Zhihua DingOptical coherence tomography for monitoring photodynamic therapyWuhan National Laboratoryfor Optoelectronics9:50 - 10:15Lisheng LinMonitoring blood flow responses for artery and veinduring vascular targeted photodynamic therapySchool of Photonics andElectronic Engineering, Fujian Normal University10:15 - 10:40Xianglian LiaoQuenching effects of EGCG on photosensitizedluminescence in the tissue simulating phantomSchool of Photonics andElectronic Engineering, Fujian Normal University10:40 - 11:00Coffee Break11:00 - 11:25Jing WangHyperspectral imaging for fluorescence dosimetry inPDTSchool of Life Science andTechnology, Xi‘an JiaotongUniversity11:25 - 11:50Ronald SrokaTheoretical considerations on self - shielding effectduring PDTLaser-Forschungslabor /LIFE-Zentrum, Klinikum derUniversität München, Campus Großhadern11:50 - 12:15Adrian RühmTherapy planning and monitoring of interstitial PDTSchool of Life Science andTechnology, Xi’an JiaotongUniversity12:15 - 12:40Huiyun LinAssessment of signal acquisition mode impact ontime-resolved sensitized singlet oxygen measurementSchool of Photonics andElectronic Engineering, Fujian Normal University12:40 - 13:45Lunch Break5
Chinesisch-DeutschesZentrum on 913:45 - 14:1014:10 - 14:35New aspects in clinical PDTChairs: Buhong Li, Hans-Peter BerlienAlexander GreerPointsource Photodynamic Therapy: Fiber Opticsand 3D Printed Sensitizer Tips for High PrecisionEradication of Cancer CellsHerbert SteppPDT response of cancer stem-like cellsDepartment of ChemistryCity University of New York,Brooklyn College, USALaser-Forschungslabor/LIFE-Zentrum, Klinikum derUniversität München, Campus Großhadern14:35 - 15:00Georg DaeschleinPDT in skin and wound antisepsis in the postantibiotic era: possible indications and clinical advantage15:00 - 15:30Coffee Break15:30 - 15:55Ying GuClinical treatment of port wine stainsDepartment of Laser Medicine, Chinese PLA GeneralHospital15:55 - 16:20Sijia WangLight-controlled delivery of Photo-immune conjugates for molecular targeted PDTSchool of Life Science andTechnology, Xi‘an JiaotongUniversity16:20 - 16:45Sviatlana KalininaOxygen sensing PLIM together with NAD(P)H-FLIMfor metabolic mapping in living cells and tissuesCore Facility für konfokaleund Multiphotonen Mikroskopie, Universität UlmN24/416:45 - 17:10Xuelin XuQuantitative evaluation of vasoconstriction by imageprocessing for vascular targeted photodynamictherapySchool of Photonics andElectronic Engineering, Fujian Normal University17:10 - 17:35Cuiping YaoNanoparticle aided PDTXi‘an Jiaotong UniversitySchool of Life Science andTechnology17:35 - 18:00Concluding Remarks – aspects of future collaborationBeate Röder, Humboldt-Universität zu Berlin, GermanyBuhong Li, Fujian Normal University, China19:30 - 21:30Dinner6Department of DermatologyUniversity of Greifswald
Second Sino-German Symposium on Singlet Molecular Oxygen and Photodynamic EffectsSanssouciNew Palace02. June 2017: Academic visiting andscientific discussion9:00Departure at the hotel (by bus)10:15Arrival in Portsdam, walk in the park of Sanssouci11:45Arrival at the New Palace12:00Walk in the New GardenLunch in the restaurant Meierei Potsdam14:30Departure back to Berlin (by bus)15:30Arrival at Alexanderplatz16:00Visit of the TV-Tower17:00Departure from Alexanderplatz (by bus)18:00Arrival at the ship Bon Ami on river Spree, Dinner21:00Departure to the hotel (by bus)03. June 2017: Departure dayTV-TowerShip Bon Ami on the river Spree7
Chinesisch-DeutschesZentrum n ParticipantsBeate Röder is professor for experimental physics at the Department of Physics,Humboldt-Universität zu (HU) Berlin since 1992. She is leading the photobiophysics group and supervised about 20 PhD students. She received her PhD degree inExperimental Physics from HU Berlin in 1982 and the habilitation in 1986. Her research focuses on molecular photobiophysics, especially on fundamental research inthe field of photosensitization and artificial photosynthesis. Beside these topics herresearch was and is focused on the development of time-resolved optical methodsfor detection of very low light intensities. She works more than 30 years on directspectroscopic detection of singlet molecular oxygen, the last years in particular ontime-resolved luminescence detection. In 1986 she was awarded with the HumboldtResearch Price for her habilitation in the field of fundamental research on mechanisms in PDT. 1989 she was a visiting scientist at Bowling Green State University (USA)in the group of Michael Rodgers, one of the pioneers in singlet oxygen luminescence detection. In the 90is she also visited the Weizmann Institute in Israel (Prof. A.Scherz, Prof. Y. Salomon), In 2009 she was awarded with a Walton Professorship byScience Foundation Ireland.Volkhard May is Privatdozent for Theoretical Physics at the Department of Physics,Humboldt-Universität zu Berlin since 1997. He is the head of a group focusing on thetheory of charge and energy transport in molecular systems. About 15 PhD studentshave been supervised by him. His PhD degree in Theoretical Physics received fromthe Humboldt-Universität zu Berlin in 1981, and he got the habilitation in 1987 fromthe College of Education at Güstrow. His research focuses on Theoretical ChemicalPhysics, especially on photoinduced kinetic phenomena in nanosystems formed bymolecules, semiconductor nano-crystals and metal nano-particles. His actual interestis on different mechanisms to achieve an enhancement of singlet oxygen luminescence. In 1981 he was awarded by the Humboldt Price for his PhD thesis.Steffen Hackbarth received his Ph.D. degree in experimental physics from HU Berlinin 2000. Ever since, he was working in the field of time-resolved spectroscopy in thetime range ps to ms with a special focus at the triplet processes of photosensitizers.He is member of the photobiophysics group and scientist in charge for the singletoxygen lab and especially the highly sensitive singlet oxygen detection. He co-supervised one Ph.D. and several Master/ Diploma students. Since 2011 he is leader of theadvanced practical courses for the physics students at HU-Berlin. His research focuses on molecular photobiophysics, especially on fundamental research in the fieldof photosensitization and energy transfer processes in multi-chromophoric systemsdesigned for Photodynamic therapy as well as singlet oxygen luminescence detec-8
Second Sino-German Symposium on Singlet Molecular Oxygen and Photodynamic Effectstion at highest sensitivity.In 2012 he was awarded (together with his colleague, JanSchlothauer) with the innovation award of the SPIE Europe for the development of acompact time-resolved table-top singlet oxygen luminescence detection system.Annegret Preuß is scientific assistant in the photobiophysics group led by ProfessorBeate Roeder in the Department of Physics, Humboldt-Universität zu Berlin. Sinceher diploma in Biophysics 2007 she is working in this group in the field of in vitroexperiments for Photodynamic Therapy. She received her PhD degree in 2011 for invitro investigation of biodegradable nanoparticles as drug carrier for the Photodynamic Therapy. The PhD thesis was part of the German-Chinese joint research project“NanoCancer” funded by the German Federal Ministry of Education and Research.During her PhD she spend 6 month in the Group of Mathias O. Senge in the Instituteof Molecular Medicine at the Trinity College Dublin, Ireland. 2010 she chose a newfocus for her research: The Photodynamic inactivation of microorganisms. Startingwith the Photodynamic inactivation of bacteria (PIB) the interest spread to variousmicroorganisms relevant in medical and environmental research. A special focus isthe investigation of Photodynamic inactivation of mold fungi and their conidia.Wolfgang Bäumler is professor for experimental dermatology at the Department ofDermatology, University Hospital of Regensburg in Germany since 2008. He studiedphysics at the University of Regensburg and graduated with a diploma 1987. Thetopic of his PhD thesis was spectroscopy of dye molecules using femtosecond lasers.After his PhD thesis he moved to the medical faculty in 1992 and is working in different fields of laser medicine and photodynamic therapy to date. He gained muchexpertise in detecting singlet oxygen by its very weak luminescence signal. Singletoxygen is a major species to kill tumor cells or pathogenic microorganisms. He iscollaborating with scientific partners in Germany, European countries and the United States. At present he focussed on the development of a sustainable antimicrobialphotodynamic therapy that kills pathogenic and multiresistant bacteria using naturalphotosensitizers.Tim Maisch studied Biology at the Univ. of Erlangen-Nuremberg, Germany. In 1997he received his diploma and achieved his Ph.D. with a thesis titled „Upregulationof protein expression on endothelial cells infected with human cytomegalovirus” in2001. Since 2002, he has been working as postdoctoral fellow at the Dept. of Dermatology, University Hospital of Regensburg on photodynamic inactivation of multi-resistant bacteria. Main objectives are to investigate the role of singlet oxygen andoxygen consumption in photodynamic inactivation of bacteria as well as the detectionof singlet oxygen directly by its luminescence. One focus is the development of newphotosensitizers for the photodynamic treatment of bacterial and fungal infections.9
Chinesisch-DeutschesZentrum fürWissenschaftsförderung中德科学中心A second focus in cooperation with the Max-Planck-Institute for Extraterrestic Physics (MPE) is the application of cold atmospheric plasma against microorganisms.He gained his Postdoctoral Habilitation in 2009 (venia legendi). He is a member ofthe American Society for Microbiology. Since 2006, he achieved several Awards tosupport the research interest in antimicrobial photodynamic therapy (e.g. “PDT-2006Award”to support the research interest in photodynamic therapy and fluorescencediagnosis of skin diseases and “9th Arnold-Rikli-Award” to support photo-biologicalresearch interests of light in relation to human medicine in the future).Hans-Peter Berlien graduatied from the faculty of medicine at the Freie UniversitätBerlin in 1976 and became medical assistant at the University Clinic Berlin Steglitzwhere he certified as a physician, started his surgical education and received his doctorate specializing in paediatric surgery in 1981. Since 1985 he is medical director ofthe Centre for Laser and Medical Technology Berlin (LMTB). After his postdoctorallecturing qualification he became professor for laser medicine at the Freie UniversitätBerlin in 1989. From 1996 to 2005 he has been head of department for laser medicineat the Klinikum Berlin Neukölln now belonging to Vivantes. As head of department,he transferred the whole department to the Elisabeth Klinik Berlin in 2005 where hestill is. He is aFellow of the National German Academy for Technical Sciences (acatech), Fellow of the New York Academy
Welcome to the 2nd Sino-German Symposium We are very pleased to welcome you to the 2nd Sino-German Symposium on Singlet oxygen and photodynamic effects. About 27 scientists from
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