Simulating Brain Cancer On Chip

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Public Relations & Information DepartmentSultan Qaboos UniversityThursday,27 February 2020Issue #019Simulating BrainCancer on ChipThoughts on SocialResponsibility in ELTRole of Social Mediaon Self-HarmIP Rights and Enforcementin the GCC

A Step ForwardFrom about 1920 to 1945, radio developed into thefirst electronic mass medium, monopolizing “theairwaves” and defining, along with newspapers,magazines, and motion pictures, an entire generation of mass culture. About 1945, the appearanceof television began to transform radio’s contentand role. Broadcast radio remained the most widely available electronic mass medium in the world,though its importance in modern life did not matchthat of television, and in the early 21st century itfaced yet more competitive pressure from digitalsatellite and Internet-based audio services.Editorial SupervisionJamal Al-RiyamiEditor in ChiefHilal Al-BadiSenior EditorSanthosh KunhiveettilEditorsNasebah Al MuharramiSara Al GhailaniFatema Al AjmiDesign & LayoutAhlam Al-WahaibiNajah Al HarthiIbrahim Al HajriGeneral ServicesSalim Al-SadairiKhalifa Al-SalehiPhotographyCentre for Educational Technologyimprint@squ.edu.omC 2020 Sultan Qaboos University.Radio is an attractive medium among the variousmass communication media because of its specialcharacteristics. It continues to be as relevant andpotent as it was in the early years despite the emergence of more glamorous media. Radio is the mostportable of the broadcast media, being accessibleat home, in the office, in the car, on the street orbeach, virtually everywhere at any time.Despite the presence of a plethora of media, thereis room and scope for each medium. Experience hasrevealed that ‘new technologies add things on butthey don’t replace’. Each medium reinvents itselfin the context of changes in the communicationenvironment. In the changed media scenario, radiois reorienting itself with more innovative programsand formats.An interesting fact is that majority of car users preferAM/FM radio as the main source of infotainmenton their cars. Despite the technological advancesthat are making the car a digital hub on wheels, theconsumer’s love affair with AM/FM radio remains.A new poll by the firm IPSOS confirms that whilesome consumers are demanding changes to thecar’s infotainment system, consumers want AM andFM radio to remain the heart and soul of their carentertainment.Similar to the scenario in any other country, radiois still one of the most significant mass media inOman. Now, there is good news for radio listenersin Oman. Oman FM broadcasts “Within SQU”, aweekly radio program that sums of the activities ofSultan Qaboos University in teaching, research andcommunity service fields. “Within SQU” is broughtto the listeners by the Public Relations and Information Department at SQU in association with OmanFM every Wednesday after the 6PM news. So, tuneto Oman FM for Within SQU and enjoy! The audiolink to the program is available on SQU news portalAnwar as well.

SpotlightCelebration ofReadingOman Convention & Exhibition Centre will host Muscat InternationalBook Fair from 22 February to 2 March 2020. Any book fair brings together publishers, distributors, retailers and book lovers together on asingle platform. For authors, it is a platform to meet their readers andfoster stronger relationships with people and publishers.In this digital age, most of the book fairs across the world are still flourishing, in terms of the quality of visitors to the fair. Book fairs are noweducational and cultural events. There are seminars, panel discussions,presentations, author meet-ups, etc. to keep the exhibitors and visitorsengaged and to spread knowledge.Amita J SanghviThe true valentine of a readeris their book. If books are whatyou love, you will have a hugewave of joy surge from withinto know that the Muscat BookFair is soon coming!If you are in love with books,and love a book affair, be at theMuscat Book Fair that sees exhibitors coming in from severalcountries near and far, and anever ending list of books foryou are right there, at the stallsto browse, buy, read and relish!Having a few hours set out tobe there with your children andbringing them to this fascinating world of imaginationand seeing them engrossed inbooks, is any day a very goodway to get them onto to theirjourney of learning and discovering the world of fancy, fantasyand facts.Oman prides itself in having thebiggest fair in the region at thesprawling and the most beautiful Oman Convention & Exhibition Centre that is a must visitfor one and all. Not only is theexhibition very helpful in exploring books and cultures throughreading, what makes it special isLive performances of Music andPoetry and Societies of Omanthe Environment Society and theWriters Society also display theirbooks and latest publicationsand journals, inviting the visitorsto join the bandwagon.It only gets better! You havetrolleys and assistants helpingyou while you move aroundfrom one stall to another, lostin the world of words. It goeswithout saying that you will pileup your trolley and be a veryhappy bunny with your insatiable thirst for knowledge beingmet.To discover the world throughbooks, is a travel through culture and land of faraway timesand lost worlds of antiquity;to dream and to discover, toconfirm and to consider whatyou think, what you chooseto explore, and what you find– all under one roof, is a treatindeed.So, choose many Valentines,not just one, and these bookswill always enhance your worth:Love reading, Love BOOKS!3

4SimulatingBrain Canceron Chip

ScopeCancer is one of the majorcauses of death and a threatthat takes lives unsparinglyalong with taking its toll on theglobal economy. In the GulfCooperation Council (GCC)region, blood cancer, colorectal cancer, breast cancer, thyroidcancer, prostate cancer and lungcancer are the common typesof cancer affecting the population. Studies have shown thatcancer-related deaths are oftencharacterized by their ability tometastasize, and develop a secondary tumor, which makes itdeadly with more than 90% ofdeaths worldwide. During metastasis, epithelial cancer cellsdetach from the primary tumorand intravasate into the vascular system. Intravasation is theinvasion of cancer cells throughthe basement membrane into ablood or lymphatic vessel. Oncein circulation, cancer cells travelin the body and colonize in tissues away from the primary site.Studies have showed that 2040% of metastatic lung, melanoma, colon, kidney and breastcancers occur in the brain.The blood-brain barrier (BBB) isa highly selective semipermeable border that separates thecirculating blood from the brainin the central nervous system(CNS) and acts as a protectionwall against the transfer of cancer cell to the brain tissue.The terms metastatic brain tumor, brain metastasis or secondary brain tumor refer to cancer that begins elsewhere in thebody and spreads to the brain.The BBB protects the brain from"foreign substances" inthe blood and acts as an interface to control molecularand cellular exchange betweenblood stream and brain. The keycomponents of BBB are braincapillary endothelial cells (insidethe capillary vessel), astrocytes,pericytes and neuronal cells (inthe brain tissue). Endothelialcells in BBB form tight junctionswhich play a vital role in pre-venting the migration of cancercells to brain tissue. Currently, investigations pertinent tothe mechanism of transfer ofcancer cells across the BBB inhuman or animals is extremely challenging. Models of theBBB developed in laboratoriescould provide useful informationabout the mechanism of migration of cancer cells in capillariescarrying blood to the brain tissue. Among different availableBBB models, organs-on-chip canmimic cell-to-cell interactions aswell as manipulate cancer cellmetastasis through BBB. Thisis a multi-channel environmentat small scale that simulatesactivities, mechanics and physiological response of real organs;a type of artificial organ.The Department of MechanicalEngineering at Sultan QaboosUniversity, in collaboration withLaboratory for Stem Cell Research & Regenerative Medicineat University of Nizwa, is takinga leading role in developing anovel hydrogel based microfluidic BBB model for studiesof cancer metastasis in brain.After several challenges encountered during this research, anexperimental setup has beendeveloped that is capable ofvisualizing cancer metastasis inthe brain. The research teamis using a microfluidic modelreplicating the brain-vascularinterface. The model allows realtime imaging and quantificationof cancer cells crossing BBB.The system will allow separationof different types of cells whileallowing their direct communication at the surface of barrier.Currently, the model is characterized to study cell migrationand interaction between them.The model has been tested toinvestigate drug permeabilitythrough the barrier and targetcancer cells. The model willallow testing several existingand new drugs to target criticaltumor pathways as well as studyon drug resistance at the BBB.5The development of suchplatforms for simulation of realenvironment of migration ofcells in BBB can be useful forseveral commercial applications.Outcome of this research studycan lead to several publications in high impact journals ofinternational repute. Successfultesting of the model may alsolead to further progress in fabrication of models in laboratoriesfor studies on brain cancer. Thedeveloped system can open-uppossibilities of collaboratingwith various local, regional andinternational universities andresearch institutions conducting cutting edge research oncancer. The outcomes of thisstudy will explore techniques fornovel target therapies. Throughsuccessful completion of thisproject, Oman can become oneof the leading countries in conducting challenging research oncancer. The research study willenrich research on treating cancer and bridge the gap betweenengineering and medicine. Theinnovative nature of the projectcan also help in developing newpostgraduate programs in thefuture.The research team consists oflead principal investigator Dr.Khurshid Alam (College of Engineering), Dr. Mamun Abdullah(College of Engineering), Dr.Anwarul Hasan (Qatar University), Mr. Saeid Vakilian (Universityof Nizwa), Dr. Fatemeh Jamshidi-adegani (University of Nizwa),Juhaina Al-Kindi (University ofNizwa), Dr. Sulaiman Al-Hashmi(University of Nizwa), Prof. Vadim Silberschmidt (LoughboroughUniversity UK), Dr. Jamal Umer(Loughborough University UK),Dr. Ikram Ali Burney (senior consultant oncology SQUH) and Dr.Mushtaq Khan (National University of Sciences and TechnologyPakistan).

6Thoughts on SocialResponsibility in ELTVictoria Tuzlukova, Anfal Alwahaibi, Zainab Al Belushi & Pooja SanchetiCentre for Preparatory StudiesThe concept of social responsibility has been given special importance and value in21st-century business practice.In business, it is commonlyappealed to as corporate socialresponsibility that is related tokeeping up with change andinvolves economic responsibility, direct philanthropic giving,environmental sustainabilityinitiatives, and ethical businesspractices. However, the conceptof social responsibility is notalienated from single humanbeings since it is also recognizedas individuals’ ability to affectchange through a variety ofsocially responsible actions, suchas volunteering, participatingin community-based initiatives,etc. Therefore, instilling thesense of social responsibility isone of the perspectives, principles, standards and the new vision of 21st-century education.Similar to other countries,more effective readiness ofyouth for changing businessand professional practices is anurgent need in the Sultanate ofOman, and the country is eagerto be in the forefront in train-

Vistaing socially responsible youngOmanis who are able to meetthe needs of the present without compromising the abilityof future generations to meettheirs. Consequently, there havebeen adaptations and changesin the country’s educationalpolicies, community initiatives,classroom methodologies,teaching methods and instructional approaches to supportstudents’ learning and theirdevelopment as socially responsible individuals who are able topursue innovative ideas with thepotential to benefit the community. For example, Nama Groupand the Environment Society ofOman (ESO) had just recentlyinitiated a Green InnovationECO-Thon aimed at encouraging Omani youth to tackleenvironmental challenges in theSultanate through working oninnovative solutions comprising applications, software andprojects focused on such issuesas waste management, carboncapture and alternatives, andenergy and water efficiency. Inaddition, many institutions ofhigher education in Oman haveinitiated a number of community-based projects that are aimedat influencing the developmentof social responsibility andsustainable behavior throughteaching and learning.Some illustrations of such projects include multiple opportunities students are provided withto learn more about Oman’s environmental challenges, charitywork, social entrepreneurship,just to name a few. For example, in one of the English forBusiness courses offered by theCentre for Preparatory Studiesof Sultan Qaboos University, social responsibility, and social entrepreneurship approaches areintegrated into the curriculum.In the context of the course,these concepts are applied tonon-profit charity organizationsthat students develop while implementing solutions to social,cultural, or environmental issuesand discovering more efficientways and methods of Englishlanguage learning and practice. Doing business for a socialcause also engages studentsin constructing logical writtenarguments supported by thesource material, data analysis,information synthesis, and authentic knowledge application.The main principles that governteaching and learning practicein implementing student projectwork include collaborative, constructive, contextual and self-directed learning as its integralparts. Here, collaboration, oneof 21st century skills, implies encouragement of mutual respectand interaction, willingness tolisten and adjust thinking toa commonly agreed goal andadvance a shared understandingof issues related to becominga responsible citizen throughgiving, sustainability, and volunteerism. The activities related toreal-world social, cultural andenvironmental problems engagestudents in intellectual collaboration, critical analysis of thespecific situations and solutionsthrough the services offered bythe charity, and consequentlyenhance their skills furnished inmore engrossing, meaningfuland challenging contexts fortheir application.In the academic space of theproject, self-directed learning is another opportunity toinvolve students in all aspectsof developing and enhancingsocial responsibility, and socialentrepreneurship skills. Here,self-directed learning refers toa process in which students areencouraged to take the initiativein determining their learningneeds, formulating learninggoals, identifying human andmaterial resources for learning,choosing and implementingappropriate learning goalsand objectives. Consequently,teaching strategies and methods that stimulate, develop andimprove students' aptitudesand competencies, respond to7their needs and further increasetheir personal, academic andprofessional growth are used tofurther support social responsibility, and social entrepreneurship approaches in English forBusiness course’s project work.Another example is English forScience course that effectivelymeets the widely supportedobjective of educating studentsto be socially responsible. Thetopics of the projects studentsare engaged within this courseto include social issues thatrelate to science, promote socialresponsibility and make studentsmore socially conscious. Forexample, such topics, as oceanmicro plastic pollution, high-energy consumption in buildings,ocean oil pollution, desertification, soil salinity, teach studentsto behave ethically and sensitively towards social, economic, and environmental issuesin Oman. Students spend thefull semester on their projects.They start with writing andpresenting a research proposal,and then do their research andpresent their recommendationsin a poster exhibition.In spite of an extensive teachingand learning practice, little hasbeen done to reflect and betterunderstand the role of Englishlanguage classrooms in developing social responsibility amongstudents in Oman and its valuefor future educational policiesand pedagogy. For example, theinstructional techniques that areinfluential to social responsibilityteaching and learning and inassisting the implementationof changes within the academic community have not beenestablished yet. Therefore, moreresearch is needed to developevidence-based guidelines forusing English language classroom as an effective learningenvironment for establishingan ethical framework of socio-cultural understanding thatsuggests societal and individualobligation and enthusiasm actfor the benefit of the society.

8Role ofSocial Mediaon Self-HarmMohammed Ghalib QutishatCommunity & Mental Health DepartmentCollege of NursingSelf-harm is a sign of emotional distress that adolescents andyouths use to relieve stress, anxiety or pain as a distraction fromtheir attention, or draw attentionor peers, to appear as enjoyablepeople, or to seek experienceand curiosity. Several factors playan important role in self- harmamong adolescents and youths,the majority of them associatedsometimes with eating disorders,personality disorder, post-traumatic stress disorder, neglect, sexual orphysical abuse, poor adjustment,and poor communication skills.Social networking sites haverecently played an essential role inthe spread of self-harming amongadolescents and youths throughthe Internet, called the phenomenon of electronic self-bullying,or self-harming; indeed, manyscientific studies indicated that 40percent of published content onsocial media among adolescentsare related to depression or deathand that 13.3 percent had explicitly written about their desire todie. These group of people tendsto disclose these thought in manysocial media platforms, whetherit is linked to each other or not,to create a content about suicideand share it anonymously, so theyappear happy and psychologicallystable in their regular accounts,while they are spreading importantnegative indicators of their mental health condition in other fakeaccounts.Posting messages of self-harmthrough various social media sites,especially when it comes to religious or spiritual rituals, helps theusers to reduce their social isolation since the process of interaction between them in cyberspaceenables them to express themselves easily and to communicateeffectively. Also, it helps to avoidstigmatization associated with

In focustheir mental health conditionand find solutions or alternatives to their problems.Some websites and apps provided simplified instructions fortheir followers on how to harmthemselves for enjoyment. insome cases, the website maymanipulate its name throughsocial media platforms, thus,browsing the word "Suicide,"for example, maybe prohibitedfor the user, while the word"Suiciiideee" may allow themto do that easily, and here canimagine how many websiteswill become available for adolescents and children, not in thecontext of self-harm, but themeaning of sexual problems andpornography, extortion, substances, and othersSocial networking sites andsmartphone applications storesset some particular policies forsharing images, videos, andposts that contain contentsof self-harm such as cutting,scratching, burning, stop eatingand others, but indeed, it doesnot help to mitigate this contentas required due to the abilityof some to circumvent thesepolicies by creating fake sitesand accounts frequently, or touse some programs designed toallow the user to see banned ordangerous materials.Social media has contributed tothe dissemination of many teenagers pictures in which they tryto imitate socially and artistic celebrities, and engage in similarbehavior in some social challenges or tests after watchingit on social networking; thesechallenges can affect their bodies and contribute to many unnecessary accidents such as thechallenge of the ice bucket, thechallenge the cinnamon, or thechallenge of Kiki. Besides, therehave also been several electronic games that have promptedusers to think about self-harmor suicide, such as the game of"Mary," "Pokémon," and "BlueWhale." In Blue whale, for example, the user need 50 days toaccomplish many tasks startingby waking up at 4.am in themorning to watch a horror movie, then sculpt the words F57or draw a blue whale on thehand using a sharp tool, makingwounds on the arm, and standon the bridges, while the finalchallenge is to commit suicideby jumping from a high buildingor stabbing self with a knife.So what can we do? Here aresome tips for managing selfharm and attempted suicide incyberspace: Increase the awareness ofthe members of society in allsegments of the importanceand dangers of excessive useof the Internet and electronicdevices and social networkingplatforms. Monitor internet serviceproviders and urge them to takeresponsibility for what is published through their engines. Establish a suicide helpline(hotline) to report cases of selfharm or suicide attempts andto report its content to relevantauthorities. Activate cybercrime laws thatcontribute to reducing this phenomenon and its social effectson the family and society. Diagnosis, treatment, andearly care for people with psychiatric or substance use disorders, chronic pain, and acuteemotional disorders.9 Observe the pages or applications browsed by childrenafter exiting them, and noteany change in their behaviorand feelings such as the desirefor isolation, aggression, andloneliness. Provide psychological support to this group of peopleor contact a family member orfriends who can help them, andlimit the access of these individuals to the various means ofsuicide, such as guns, firearms,medicines, and others. Avoid maintaining the privacy and confidentiality of theinformation provided by thesuicidal provider if they requestthat, the person's life is at risk,so talk to the people concernedurgently such as specializedmedical care team or securitypersonnel, to preserve the life ofthe person and prevent furthercomplications. The appearanceof signs of self-harm should bemonitored and reported immediately, and should not beignored if a child or adolescentis exposed to a form of it.

10IP Rights andEnforcementin the GCCDavid Price is a Professor in Intellectual Property Law and International Law at Charles Darwin University, Darwin, Australia. His major areas of academic research and teaching are theintersection of intellectual property law, publicinternational law, and international trade law.He has published widely on intellectual property protection regimes in the Middle East andother developing regions, and the impact ofbilateral and regional trade agreements on domestic intellectual property protection. During1999-2001, he was principal of Sohar Collegefor Applied Sciences (now Sohar University),Sultanate of Oman. In October 2019, Prof.Price gave a talk on “Contemporary Issues inIP rights and Enforcement in the GCC” at SQU,which was organized by the Innovation & Technology Transfer Centre and the College of Law.In this interview, Professor Price discussed theimportance of IP rights and GCC IP initiatives.Can you define Intellectual Property (IP) inbrief and explain the importance of IP rightsin the backdrop of changes in the global economic environment?n very simple terms, intellectual property is theexpression of the creative forces of an individual’sintellect and inventiveness – the product of the‘sweat of the brow’.Intellectual property can cover a vast range ofsubject matter that is constantly growing and ex-panding as society and technological increase themeans of effective communication, and businessand trade expand the commercial exploitative opportunity of the range and types of subject matter. On occasion, advances, notably in the digitalenvironment, test the capacity of the currentintellectual property regimes to keep pace withthose advances. Hence, intellectual property, particularly the “big three” of copyright, patents andtrademarks, are subject to constant scrutiny andare thus constantly evolving.

Face to FaceIntellectual property rights area major tool of world tradeand therefore a major tradeexport item for those countrieswhose citizens create or generate products that constitute“intellectual property”. Since1995 and the establishment ofthe World Trade Organisationand the adoption of the WTO’sAgreement on the Trade-Related Aspects of IntellectualProperty Rights (TRIPS Agreement), the nature of intellectualproperty law has largely beenshaped by global trade imperatives, in which the driving focusis on expansion, exploitativeprotection and enforcementof intellectual property rights.Intellectual property has becomeformalised as a major commodity in the world trade basket,and enforcement of intellectualrights has become a powerfulweapon in world trade. TheTRIPS Agreement has becomethe most significant multilateralagreement over the full range ofintellectual property rights.Can you explain the beginning of enactment of IP lawsin Oman?Development of Oman’s intellectual property rights protectionregime has been a fairly recentachievement, having really onlybeen established as part of itsmembership of the WTO in2000. But it has since developed one of the most sophisticated protection systems in theGCC, incorporating domesticlaws to the participation inconventions and internationaltreaties. Oman is a member ofseveral international treaties,conventions and protocolsincluding the Gulf Cooperation Council, The World TradeOrganization, The World Intel-lectual Property Organization,the Berne Convention, the ParisConvention, the Madrid Protocol and the Patent CooperationTreaty.In addition to the above international treaties and conventionslisted above, Oman has enacted a number of domestic lawsprotecting IP rights. In 2008it updated its laws coveringcopyright (Royal Decree No. 65),and what has become generallyknown as industrial property(Royal Decree No. 67 covering trademarks and patents inparticular, but also industrialdesigns, geographical indications, integrate circuits andplant breeders rights). Omanalso adopted the GCC UnifiedPatents Regulations in 2000,and the GCC Unified TrademarkLaw in 2017.How would you comment onGCC IP Initiatives and GCCPatent Regulation Acts?Consideration for a unifiedpatent regulation at GCC levelcommenced in 1987 and wasapproved in 1992. The Regulation was amended andre-issued in April 2000. TheGCC Supreme Council alsoestablished the GCC PatentOffice in Riyadh. This Regulationallows a GCC member to obtainprotection across all States bylodgment of a single patentapplication with the GCC PatentOffice. However, the Regulation is essentially a registrationstatute, and includes little byway of enforcement provisions,notably infringements, precautionary measures and sanctions,leaving these matters to eachState and their own domesticlaws. Currently all GCC member States have adopted the11Patent Regulation, but each alsohas retained its own domesticpatent law.The GCC approved a regionaltrademark regulation in December 2006. In 2014, the regulation was revised and reissuedas the GCC Unified TrademarkLaw. The primary objective ofthe Law is to replace much ofprovisions in the trademark lawsof each of the GCC memberStates, thereby introducing adegree of consistency in regional trademark protection. However, the Law does not offera unified filing system as doesthe GCC patent regulation andtrademark applications still needto be filed separately in eachState for protection.In your view what are theenforcement challenges forintellectual property infringements and offences?At judicial level, it is more aboutunfamiliarity with the status ofthe prevailing legislation. Localsocietal, cultural and commercial influences play a big rolein the enforcement of IP legislations. There exists a certainconservatism that questionsthe desirability and necessity tocomply with international andnational IP obligations. Societalattitude that holds ownershipof a good confers an unlimited right to use and disposal,including copying and resale is achallenge. The societies believethat protection of IP rights, particularly software and audiovisual goods, foreign-trademarkedconsumer goods and pharmaceuticals represents a protectionof western commercial interestsat the expense of local technology transfer for benefit of localmarkets and communities.

We will buildOman fora brightertomorrow

and love a book affair, be at the Muscat Book Fair that sees ex-hibitors coming in from several countries near and far, and a . Dr. Ikram Ali Burney (senior con-sultant oncology SQUH) and Dr. Mushtaq Khan (National Univer-sity of Sciences and Technology Pakistan). 6 The concept of social r

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