NIH For GRANTS And CONTRACTS

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- NIH GUIDEfor GRANTSand CONTRACTSUs. DEPARTMENT OF HEALTH, EDUCATION, AND WELFARENo. 14, November 29, 1971WNT OF AND ACCOUNTWIP N TACWRFD u " I HITY FORGRANTS (NIH 56Q2)A N N 0 U N C E M E IJ TThe effective date of NIH Guide f o r Grants and Contracts Issuance No. 9 , pages 1through 6 , July 29, 1971 , subject as above, i s changed from July 1 , 1971 t oJuly 1 , 1972.*ulJConsequently, submission of NIH Forms 1754, Equipment Acquired w i t h NIH GrantFunds - Accountability and Disposition, will not be required until a f t e rJuly 1 , 1972.III k s GUIDE i s published a t irregular i n t e r v a l s t o provide p o l i c y , p r o g m , anda c h i n i s t r a t i v e information t o individuals and organizations who need t o be 'ieptinformed of requirements and changes i n grants and contracts programs a h i n i steredby the National I n s t i t u t e s of Health.

N [ H Guide f o r Grants and Contracts, No.14, November 29, 1971Page ThreeW&PORTINGOF INVENTIONS SUPPORTFD8-kJ&&BY','\SEARCH\ \ \ \ \ \ \ \ \ \ \ \ \ \ \ \ \;PROCEDURE NOTICE:TRAINING GRANTS1. Applicants f o r c o n t i n u a t i o n o r renewal support of N I H research career awards,(Form PHS 2557-2) , research career development awards, (Form PHS 2557-Z) , andresearch t r a i n i n g grants, (Form PHS 2499-2) need no 13nger submit the AnnualInventions Statement (PHS 3945). U n t i l such time as the proper a p p l i c a t i o n formsare revised, the f o l l o w i n g c e r t i f i c a t i o n i s being stamped on the f i r s t page o feach a p p l i c a t i o n form:a"Inventions (See Special I n s t r u c t i o n )6. [3 YES Not p r e v i o u s l y r e p o r t e dNOAC.YES - Previously reported"u4-2. Each a p p l i c a n t should check the appropriate box. If the answer i s "No," t h i se n t r y on the o f f i c i a l , signed a p p l i c a t i o n c o n s t i t u t e s a c e r t i f i c a t i o n t h a t noinventions were conceived o r f i r s t a c t u a l l y reduced t o p r a c t i c e during t h e courseof the work under t h i s p r o j e c t . I f the answer i s "Yes," and t h e i n v e n t i o n s weren o t p r e v i o u s l y reported t o the Department o f Health, Education, and Welfare, l i s tthe t i t l e s o f a l l such i n v e n t i o n s , and the names o f i n v e n t o r s on a separate sheetand submit w i t h t h e a p p l i c a t i o n .3. A l l references t o t h e requirement f o r Annual I n v e n t i o n Statements i n i n s t r u c t i o n s f o r c o m p l e t i n g a p p l i c a t i o n forms should be d i s r e g a r d e d and t h e procedureso u t l i n e d h e r e i n should be followed.4. This procedure does n o t preclude t h e requirement f o r t i m e l y submission o fOS Form 489, Final I n v e n t i o n Statement, a t the c l o s e o f the p r o j e c t period.

NIti Guide f o r Grants and Contracts, No.14, November 29, 1971Page Fivev-The National Cancer I n s t i t u t e (NCI), National I n s t i t u t e s o f Health, i s seekingresearch and development sources q u a l i f i e d t o design, c a r r y out, and analyzeepidemiological s t u d i e s on U.S. Blacks and Spanish Americans r e l e v a n t t o t h e i rspecial r i s k s f o r cancer o f t h e l a r g e bowel. The incidence o f t h i s disease i nBlacks was once o n l y about 60 percent o f t h a t of Whites but now has r i s e n abovew h i t e r a t e s i n some p o p u l a t i o n groups. I t i s expected t h a t r a t e s i n t h e SpanishAmerican population a r e undergoing t h e same s h i f t s . Contracts are contemplatedt o determine t h e r e l a t i o n o f d i e t a r y and o t h e r environmental f a c t o r s t o t h i schanging r i s k and t o t e s t hypotheses about s p e c i f i c causal factors. Contractorsw i l l be expected t o be responsible f o r t h e study design and c r e a t i o n and v a l i d a t i o n o f t h e questionnaires, t a k i n g i n t o account p r i o r i t y items f u r n i s h e d by N C Is t a f f . Information submitted must be p e r t i n e n t and s p e c i f i c f o r the f o l l o w i n g :(1) Experience: submit evidence o f a b i l i t y t o handle p r o j e c t i n c l u d i n g o u t l i n e o fwork p r e v i o u s l y performed; (2) Personnel : Name, professional q u a l i f i c a t i o n s , ands p e c i f i c experience o f s c i e n t i s t s and t e c h n i c a l personnel who would be assignedt o the p r o j e c t ; (3) F a c i l i t i e s : Population sources , ( s i z e , c h a r a c t e r i s t i c s ,s u i t a b i l i t y ) cooperating groups, data processing c a p a b i l i t i e s ; (4) Existence o fp r e t e s t e d questionnaires and/or o t h e r resources t h a t might speed t h e mu1t i p l e OMBclearances required f o r development and use o f governmental questionnaires ; typesof i n f o r m a t i o n t h a t could and would be gathered. I n case o f c o l l a b o r a t i v e e f f o r t sthe i n f o r m a t i o n t o be f u r n i s h e d s h a l l i n c l u d e evidence t h a t agreement has beenreached t o make a v a i l a b l e the necessary personnel o r f a c i l i t i e s . This synopsis i sn o t a request f o r proposal and responses s h a l l n o t s t a t e any proposed p r i c i n g b u tshould i n d i c a t e conceptual design t h i n k i n g . Only those sources deemed f u l l y q u a l i f i e d f o r the s p e c i f i c requirement under consideration w i l l be i n v i t e d t o submitproposals when Requests f o r Proposals are issued.Ten copies o f resume: o f experience and c a p a b i l i t i e s must be submitted t oM r . George Brandner, Chief, Research Contracts Branch, O f f i c e o f the D i r e c t o r ,National Cancer I n s t i t u t e , National I n s t i t u t e s o f Health, Bldg. 31 , Room 10-A-11,Bethesda, MD 20014, so as t o be received no l a t e r than the c l o s e of business,5:OO p.m. l o c a l time a t the place designated f o r r e c e i p t o f resumes, December 15,1971. Telephone i n q u i r i e s w i l l n o t be honored and a l l i n q u i r i e s must be d i r e c t e dt o the o f f i c e l i s t e d above.

Page SixA rJ FJ 0 U f4 C E M E II TThe National I n s t i t u t e of Arthritis and Metabolic Diseases (NIAMD) i s interestedi n organizations having a capability and i n t e r e s t i n the preparation and assayof non-comnercially available vitamin D analogs a n d metabolites. Of immediatei n t e r e s t i s the compound, 1,25 - dihydroxy cholecalciferol (1,25 - DHCC). Otheranalogs and metabolites of vitamin D may be within the scope of future i n t e r e s t .Resumes are i n v i t e d from organizations having the above c a p a b i l i t i e s .Resumes should contain information which will : 1 ) establish the organization'squalifications, experience and achievements i n the area, 2 ) provide backgroundon personnel avai 1able f o r the project, 3) describe equi pment and faci 1i tiesavailable f o r the project, 4) outline the approach t o be used f o r preparation of1 ,25 - DHCC.I t i s emphasized t h a t expression of i n t e r e s t must r e l a t e t o this specific project.Compi 1ation of organizational reports, C. V. ' s , and general expression of capabi 1 i t i e s will n o t suffice.T h i s synopsis i s n o t a request for a proposal. Only those sources deemed f u l l yqualified f o r t h i s project will be considered when requests f o r proposals ares o l i c i t e d . The decision t o request proposals f o r the conduct of the project willbe based on evaluation by NIAMD s t a f f and consultants of the responding organiza t i o n ' s prior experience in t h i s f i e l d and the f e a s i b i l i t y of t h e i r outlinedapproaches. Other respondents will not be notified of the r e s u l t s of the evalu ation.Five copies of the resume of experience and c a p a b i l i t i e s s h o u l d besubmitted to:Contract OfficerNational I n s t i t u t e of A r t h r i t i sand Metabolic DiseasesBuilaing 31, Room 10A52National I n s t i t u t e s of HealthBethesda, Mary1 and 20014before close of business, no l a t e r t h a n 15 days from date of t h i s publication.--

NIH Guide f o r Grants and Contracts, No.14, November 29, 1971Page SevenThe National Blood Resource Branch supports contract research i n blood bankingsystems, thrombosis and hemorrhagic disease, and s i c k l e c e l l disease. In addition,the c l i n i c a l evaluation of promising drugs and treatments i s occasionally undertaken by the Branch as a d i r e c t operation. In the blood banking area the Branchhas supported studies of the f e a s i b i l i t y of automated systems f o r tracking bloodinventory and d i s t r i b u t i o n i n large metropolitan areas. Other work is aimed a timproving the technology of blood fractionation, prolonging the storage period ofblood and blood components, and eliminating safety hazards i n blood transfusion,particularly the transmission of h e p a t i t i s . Recently, i n recognition of thefragmented nature of the nation's blood industry, the Branch has i n i t i a t e d amanagement study which i s intended t o identify and describe the key operationalaspects o f blood banking i n this country.Thrombosis i s a major public health problem and hemorrhagic diseases place greatdemand on the nation's blood supply. Since thrombotic and hemorrhagic processesoften are an inseparable tandem, the National Blood Resource Branch supports andconducts research i n both areas. Current research i n thrombosis includes c l i n i c a lt r i a l s of thrombolytic ( c l o t dissolving) agents i n pulmonary embolism and acutemyocardial infarction, studies i n the epidemiology of venous thrombosis and i n thestandardization of t e s t s t o detect venous thrombosis. Studies of agents which mayprevent thrombosis are envisioned. Work on hemorrha.gic processes centers on hemo philia. Current research i s aimed a t standardizing the cryoprecipitate method ofextracting c l o t t i n g factor VI11 from blood and a t improving methods of obtaininghigh-purity f a c t o r VI11 i n h i g h yield. Clinical studies are envisioned to assessthe value of prophylactic treatment and self-treatment w i t h f a c t o r VIII.Present studies i n s i c k l e c e l l disease are designed t o evaluate several regimensi n the treatment of painful s i c k l e " c r i s i s . " Support will be forthcoming f o r morefundamental studies of t h e s i c k l e cell and of the pathophysiological eventssurrounding the sickle " c r i s i s . "

Page EightThe objectives of the Myocardial Infarction Program are the planning and supportof research leading t o a reduction of death o r d i s a b i l i t y from acute myocardialinfarction, chronic coronary heart disease, and sudden cardiac death. I t includesinvestigations on disease detection, pathophysiological mechanism, and prophy1 a c t i c , acute, and rehabi 1i t a t i ve therapy.The Program was established i n 1966. In 1967 five large, c l i n i c a l l y focused, multidisciplinary groups were established f o r a comprehensive investiation of the patho physiology and therapy of acute myocardial infarction. There are now nine suchMyocardi a1 Infarction Research Uni t s . They use certain protocol s i n comnon, b u tthe bul k of t h e i r research represents individual projects. Relevant fundamentalstudies support the c l i n i c a l investigations. Techniques for c l i n i c a l investigationare being developed in these MI Research Units; i n addition, in response t o aseparate s o l i c i t a t i o n , techniques are being developed f o r quantifying the extento f ischemic or infarcted myocardium sui table f o r c l i n i c a l use.A program o f research on sudden cardiac death was i n i t i a t e d i n 1970 and expandedin 1971. Four groups are working on the comprehensive, clinical-pathologicalcorrelation of sudden cardiac death. Five groups are investigating the earlytherapy of patients w i t h suspected myocardial infarction, u s i n g atropine and/orlidocaine. About a dozen additional projects attack a variety of topics d i r e c t l yo r fundamentally related t o sudden cardiac death. The goals of these studiescollectively include the development of methods f o r identifying those chronicallya t h i g h risk, the recognition of b e t t e r premonitory warning signs, the elucidationof possible precipitating factors and pathophysiological processes, and thedevelopment and assessment of very early therapy of acute myocardial infarction ando f chronic prophyl a c t i c therapy.Research on chronic coronary heart disease w i 11 encompass the development andassessment of pharmacological, surgical, and other techniques f o r the prevention ofacute coronary heart disease and/or the amelioration o f symptomatic chronic heartdisease.Physiological and biochemical processes fundamental t o new therapeutic methods areunder investigation. The present six projects focus upon characterizing theseprocesses i n ischemic myocardium and designing interventions to prevent theprogression of ischemic t o i r r e v e r s i b l e damage. Future topics might include inves tigation of myocardial s c a r formation, the fundamental problems of arrhythmiasassociated w i t h coronary heart disease, non-occl usive pathophysiological mechanisms,and the comparison of the pathophysiology and therapeutic response of atheroscler o t i c and non-atheroscleroti c animal s .Special programs have included the support of a symposium of research on myocardialinfarction; future symposia on broad and narrow topics are planned. In a d d i t i o n ,the development of large-scale data bases on myocardial infdrction are contemplated.-"

NIH Guide f o r Grants and Contracts, No.14, November 29, 1971WbllABORATIVF ( h R A C T )IO"6 1NICAlPage Nine&PI ICATI-,HFART AND LWG INSTITUTEThe C1 inical Applications Program undertakes research i n t o the etiological factorsre1 ating t o cardiovascular and respi ratory diseases i n general population groupsarid eval uates the therapeutic effectiveness of new drugs , products, o r measureswhich may have promise f o r the prevention o r treatment o f cardiovascular andrespiratory diseases. I t conducts o r cooperates i n clinical t r i a l s o r controlledtherapeutic evaluations of new agents o r measures f o r the prevention o r treatmento f cardiovascular and respiratory diseases; and following confirmation of effective ness, develops and demnstrates special techniques f o r preventive o r therapeuticappl i cations.The Clinical Applications Program u t i l i z e s grants, contracts, P.L. 480 counterpartcurrency, and d i r e c t funds t o s u p p o r t i t s a c t i v i t i e s . Three major segmentscomprise the program: the Epidemiology Branch, the Therapeutic Evaluations Branch,and the Biometrics Research Branch.The-Epidemiology Branch conducts a coordinated research program (U.S. and foreignpopulation studies) t o identify etiological factors which determine the r a t e s ofcardiovascular, cerebrovascular, and obstructive pulmonary disease i n natural popu l a t i o n s ; and conducts such f i e l d investigations i n t o the frequency, geographicd i s t r i b u t i o n , and other demographic characteristics of such diseases as may benecessary to evaluate r e l a t i v e significance of factors affecting the incidence andprognosis of parti cul a r cardi ovascul a r and pulmonary diseases. Such i nves ti gationshave been conducted by the branch f o r many years i n Framingham, Mass., and i nHonolulu, Hawaii, as d i r e c t operations, and in Puerto Rico, Israel , Yugoslavia,and Japan t h r o u g h other funding mechanisms.TheTherapeutic Evaluations Branch serves as a focal p o i n t f o r the evaluation ofnew diagnostic techniques, therapeutic measures, new drugs, and/or new deviceswh-ich have potential importance f o r the prevention or treatment of cardiovasculardisease; implements operational c l i n i c a l t r i a l s which require cooperative e f f o r t sof multiple centers; provides a final testing area f o r d r u g s , agents, or deviceswhich have passed t h r o u g h the preliminary evaluation procedures and warrant d e f i n i t etesting in large-scale c l i n i c a l t r i a l s ; and develops and demonstrates specialtechniques f o r application of new measures f o r the prevention o r treatment ofcardiovascular disease. Studies supported by t h i s branch include the HypertensionCliinical T r i a l s , a coordinated program f o r the detection and follow-up of hyperten sive persons i n the population a t l a r g e , i n an e f f o r t to determine the degree t owhich morbidity and mortality from hypertension can be reduced under specialregimens of management by anti-hypertensive drugs ; and the Coronary Drug Project,a c:oordinated program designed t o determine whether or n o t drugs which reduce thelevels of cholesterol and other blood l i p i d s will improve the survival r a t e of menw h o have coronary heart disease.Research Branch provi des a central resource f o r s t a t i s t i cal consul tation and other biometrical assistance t o a l l seqments of the National Heart andLung I n s t i t u t e ; i n collaboration w i t h the Epidemiology and Therapeutic EvaluationsBranches i n i t i a t e s studies of the s t a t i s t i c a l role of various biologic factors inthe incidence of and mortal i t y from cardiovascular and respiratory diseases , andundertakes responsibility f o r collection and analysis of data from such studies;collaborates w i t h intramural and extramural scientists i n the design and analysisof 1aboratory experiments, cl i n i cal investigations , and f i el d studies ; and conductstheoretical investigations leading t o new biometric methods of use i n medicalresearch.The Biometricsw

N I H GUIDE FOR GRANTS AND CONTRACTSCUMULATIVE CONTENTSWGuideNo. 1, A p r i l 30, 1970Annual Increments f o r "Special!' S t i p e n d s Funded from N I HT r a i n i n g Grants (NIH 4801-1) ange-a -6ra Cee- sC C e - SR?s i?d?d.bY * -4382)S t a n d a r d s f o r S u b s t a n t i a t i o n of System f o r Budgeting andAccounting f o r S a l a r i e s Under N I H G r a n t s (NIH 5301)Information Requirements and I n s t r u c t i o n s f o r A p p l i c a t i o nf o r Research G r a n t , Form PHS-398 (NIH 4301)I n d i r e c t Cost C e i l i n g on T r a i n i n g G r a n t s ( N I H 4101-2).,. . .12345Guide No. 2 , June 1 9 , 1970. .P r e d o c t o r a l Research Fellowships (NIH 70-3)Ectension of P r o j e c t P e r i o d (NIH 4802)Release of Information on Research P r o j e c t s (NIH 4201)D i s p o s i t i o n of N I H Grant-Related Income ( N I H 5601)(See a l s o N O . 16)G uide No. 3 , August 14, 19701235. 1. 3. 5 I w t 5 - e e m f - X q x & t i - o e d - (RescindedW W hy) .Na. 13) 6S i g n a t u r e Requirements f o r Grant A p p l i c a t i o n s (NIH 4301-1) . . . . . . . . .8D i s t r i b u t i o n and A p p l i c a b i l i t y of N I H Grants P o l i c y Guide . . . . . . . . .9Dependency Allowances on N I H Fellowships (NIH 4801-2)Release of Information on T r a i n i n g P r o j e c t s (NIH 4202)Motion P i c t u r e P r o d u c t i o n s (NIH 1185)*u*r*GuideNo. 4 , December 1, 1970. . . . . ."Student Unrest" P r o v i s i o n s of HEW A p p r o p r i a t i o n Acts.Use of Grant Funds f o r t h e Payment of C o n s u l t a n t Fees (See No. 5 )P r o t e c t i o n of P r o p e r t i e s L i s t e d i n t h e N a t i o n a l R e g i s t e r ofH i s t o r i c Places (NIH 4103)Use of Government S e r v i c e s A d m i n i s t r a t i o n Sources of Supply. . . .and S e r v i c e s (NIH 4203)G uide. .I512346No. 6 , A p r i l 26, 1971. . . .NIIl Biomedical Research C o n t r a c t s ( N I H 6000-3-60.4).Change of Grantee I n s t i t u t i o n (NIH 5201)N I H Grant and Fellowship A p p l i c a t i o n Deadline Dates (NIH 4304)Research Grant Award Adjustments Related t o t h e Estimated and A c t u a l.Unexpended and Unobligated Grant Balances (NIH 5005),Annual Reports of T r a i n i n g Grants Expenditures (NIH 5804)W4No. 5, February 5 , 1971Duration of Research Career Development Awards (NIH 4505-1)Expanded Scope of N I H G r a n t s P o l i c y Guide ,,P r i n c i p a l I n v e s t i g a t o r on Research P r o j e c t s Supported by N I H (NIH 4205)U s e of Grant Funds f o r t h e Payment of Consultant Fees (NIH 5302)Record Retention Requirements f o r Grantee I n s t i t u t i o n s ( N I H 5803)Guide13Assoc. D i r . f o r Extramural Research and T r a i n i n gB u i l d i n g 1, Room 118Bethesda, Maryland 20014.134.5.7

N I H Guide f o r G r a n t s and C o n t r a c t s . Cumulative Contents (Continued)Guide No.7 . June 1 4 . 1971Guide No. 8 . June.136711.129 . 1971Awarding of I n d i r e c t Costs f o r N I H Research G r a n t s (NIH 5006)Guide No. 9. . . . .Submission of S a l a r y I n f o r m a t i o n i n Grant A p p l i c a t i o n s (NIH 4305)Care and Treatment of Laboratory A n i m a l s (NIH 4206)Proposed Implementation of N I H Copyright P o l i c y (NIH 4208)Programs of t h e N a t i o n a l Cancer I n s t i t u t eN I H Grant and Fellowship A p p l i c a t i o n Deadline Dates (NIH 4304)J u l y 29. 1971Management of and A c c o u n t a b i l i t y f o r Equipment Acquired UnderN I H Grants (NIH 5602).(See a l s o No 1 4 )Grant Support of S c i e n t i f i c Meetings (NIH 4105-1)Awards i n D i g e s t i v e Diseases and N u t r i t i o nC o l l a b o r a t i v e ( C o n t r a c t ) Programs i n P o p u l a t i o n Research.N a t i o n a l I n s t i t u t e of Child H e a l t h and Human DevelopmentC o l l a b o r a t i v e ( C o n t r a c t ) Programs. D i v i s i o n of B i o l o g i c s S t a n d a r d sC o l l a b o r a t i v e ( C o n t r a c t ) Programs of t h e N a t i o n a l I n s t i t u t e ofEnvironmental Health S c i e n c e sC o n t r a c t Announcement: I n t e r a c t i o n of O t o t o x i c Drug and NoiseExposure on Hearing Loss i n AnimalsContract Announcement: E f f e c t s of Noise on Drug Action and Drug Metabolism.19141517181920Guide No . 10. August 30. 1971.C o l l a b o r a t i v e ( C o n t r a c t ) Programs of t h e N a t i o n a l I n s t i t u t e ofAllergy and I n f e c t i o u s DiseasesSources Sought f o r Conduct of Research on Development of R e s p i r a t o r yS y n c y t i a l V i r u s and P a r a i n f l u e n z a VaccinesSources Sought f o r Conduct of C l i n i c a l E v a l u a t i o n of R e s p i r a t o r yS y n c y t i a l . P a r a i n f l u e n z a . and Other R e s p i r a t o r y V i r u s VaccinesSources Sought f o r Conduct of C l i n i c a l E v a l u a t i o n of Meningococcal andHemophilus I n f l u e n z a e Type B Vaccines i n Young C h i l d r e nSources Sought f o r C o n t r a c t S t u d i e s on MycotoxinsD i s p o s i t i o n of N I H Grant-Related Income (NIH 5601) Appendix D.134567Guide No. 11. September 1 7 . 1971Sources Sought f o r C o n t r a c t on E f f e c t s of EnvironmentalComponents on Reproduction and OntogenesisBasic Agreements t o b e E s t a b l i s h e d p;rith U n i v e r s i t y C o n t r a c t o r sC o l l a b o r a t i v e ( C o n t r a c t ) Programs i n A r t i f i c i a l Kidney .Chronic U r e m i aResearch. N a t i o n a l I n s t i t u t e of A r t h r i t i s and Metabolic D i s e a s e s"Student Unrest" P r o v i s i o n s of HEW A p p r o p r i a t i o n Acts.Guide No.13571 2 . October 1. 1971S e t t l e m e n t of I n d i r e c t Costs on P r o j e c t G r a n t s w i t h F i n a l NegotiatedRates (NIH 5007).Guide No . 13. October 27. 1971Sources Sought f o r Research S t u d i e s R e l a t e d t o P r e v e n t i o n of Dental C a r i e sNotice of D i s p o s i t i o n of Grant Unexpended Balance (NIH 5002)Sources Sought f o r V i r a l H e p a t i t i s S t u d i e sModel C i t i e s Resident Employment and T r a i n i n g Requirements1.ii1357

N I H Guide f o r Grants and C o n t r a c t s , Cumulative Contents (Continued)WGuide No. 1 4 , November 2 9 , 19711.lanagement of and A c c o u n t a b i l i t y o r Equipment Acquired UnderN I H Grants (NIH 5 6 0 2 )(See a l s o No. 9 ) .Reporting of I n v e n t i o n s Supported by Research Career Awards,Research Career Development Awards, and Research T r a i n i n g G r a n t s! ources Sought f o r Epidemiological S t u d i e s of CancerSources Sought o r P r e p a r a t i o n of Vitamin D M e t a b o l i t e sC o l l a b o r a t i v e ( C o n t r a c t ) Blood Resource Programs, N a t i o n a l Heart andLung I n s t i t u t eC o l l a b o r a t i v e ( C o n t r a c t ) Myocardial I n f a r c t i o n Programs, N a t i o n a lHeart and Lung I n s t i t u t eC o l l a b o r a t i v e ( C o n t r a c t ) C l i n i c a l A p p l i c a t i o n s Programs , N a t i o n a lHeart and Lung I n s t i t u t e. .iWWiii1356789

inventions were conceived or first actually reduced to practice during the course of the work under this project. If the answer is "Yes," and the inventions were not previously reported to the Department of Health, Education, and Welfare, list the titles of all such inventions, and

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