Formulation And Evaluation Of Vanishing Herbal Cream Of .

www.ijcrt.org 2022 IJCRT Volume 10, Issue 1 January 2022 ISSN: 2320-2882Formulation and Evaluation of VanishingHerbal Cream of Crude DrugsMs. Mohini S. PohekarDepartment of Pharmaceutics, Dattakala College of Pharmacy, PuneABSTRACTThe purpose of the present research work is to formulate and evaluate vanishing herbalcream. Herbal cream offers several advantages over other synthetic creams. The majorityof vanishing creams prepared from synthetic origin (for e.g., acyclovir, triamcinolone,calcipotriene, triethanolamine, etc) gives extra fairness to face, but has several side effectssuch as itching, burning sensation and many other allergic reactions. Herbal creams do nothave such side effects and it gives natural fairness to skin. Methods carried out for thepreparation of herbal creams are very simple. Firstly, oil phase was prepared which was amixture of stearic acid (17%), potassium hydroxide (0.5%), sodium carbonate (0.5%)melted at 70 . Secondly, aqueous phase was prepared which was a mixture of alcoholicextract of crude drugs, including Chamomile, A. indica, Turmeric, Nutmeg, Cinnamon,Aloe was commercially available as extracts and are used either for cosmetic purpose orfor medicinal use. Glycerine (6%), perfume (0.5%), water (71%) heated at 71 . Thenaqueous phase was added in oil phase at 70 with continuous stirring. Once, the procedurewas completed it was allowed to cool at room temperature with continuous stirring.Perfume was added at last just before the product was transferred to suitable container. Theabove prepared herbal cream was evaluated and physical parameters such as pH,homogeneity by touch and visual, appearance, wash ability, consistency, patch test,irritancy test, accelerated stability studies were determined. Further studies are needed toinvestigate this formulation for its performance.KEYWORDS: - Crude drugs, Evaluation, Vanishing cream, Herbal extract.IJCRT2201353International Journal of Creative Research Thoughts (IJCRT) www.ijcrt.orgd195

www.ijcrt.org 2022 IJCRT Volume 10, Issue 1 January 2022 ISSN: 2320-2882INTRODUCTIONNow-a-days, herbal extracts are used inthe cosmetic preparations for augmentingbeauty and attractiveness. Herbalcosmetics are classified on the basis ofdosage form like- cream, powder, soaps,solutions, etc. and according to part ororgan of the body to be applied for like;cosmetics for skin, hair, nail, teeth andmouth etc. Creams are semisolidemulsions intended for application to theskin or mucous membrane. A low-fatmoisturizer that disappears into the skin iscalled as a vanishing cream. It softensskin, leaving nothing behind.Vanishing cream are o/w emulsionbased preparations containing aqueousphase and oil phase. Depending on theproportion of water to grease, cream canbe water miscible and washed away easilyor be thick and sticky. It is perhaps thecommonestprescribedtopicalmedicament. As it is less oily, messy andsticky, most patients find it more userfriendly.The traditional systemsofmedicine, evolved over centuries hadbeen responsible for safe guardinghealthcare of the world until the advent ofallopathic system of medicine. As thelatter system used knowledge of modernbiology and chemistry, for both discoveryand treatment, it found fast acceptabilityamong the users and now it occupiespredominant space in the area of healthcare. In-spite of this, the contribution ofthe traditional preparations, which arenormally polyherbal, is increasingdoes not cause any side effects oradverse reactions. The cream alsoacts as a fairness expert in day-to-daylife by removing aging signs. It alsoIJCRT2201353because of the general impression thatthese products are safe; while the singlemolecule based modern drugs used inallopathic system can have severe adverseeffects.The skin is the body’s first line ofdefense for external exposure. The signsof ageing are most visible in the skin.Although, ageing skin is not a threat to aperson, it can have a detrimental effect onthe psychology of a person. Much of thepremature ageing occurs as a direct orindirect result of skin’s interaction withthe environment. Exposure to sunlight is arecognized as a major factor in theetiology of the progressive unwantedchanges in the skin appearance. Photochemoprotective agents are capable ofpreventing the adverse effects ofultraviolet radiation on the skin, which arecaused by excessive generation of reactiveoxygen species.This herbal vanishing herbal creamconsists of various crude drugs includingChamomile (Matricaria chamomillafamily-Asteraceae) and A. indica(Azadirechta indica family-Meliaceae),Turmeric (Curcuma longa, familyZingeberaceae), Nutmeg (MyristicafragransfamilyMyristicaceae),Cinnamon (Cinnamomum zeylanicumfamilyLauraceae),Aloe(Aloebarbadensis family-Liliaceae).OBJECTIVEThe objective of this research work was toformulate the cream whichpossesses nutritional value whichprovided required nutrients to theskin.International Journal of Creative Research Thoughts (IJCRT) www.ijcrt.orgd196

www.ijcrt.org 2022 IJCRT Volume 10, Issue 1 January 2022 ISSN: 2320-2882MATERIALSAll crude drugs were collected from Dattakala College of Pharmacy, Pune.Table 1: Crude Drug InformationSr.No.1.Common NameBotanical NameMedicinal UseChamomileMatricaria chamomillaFamily: Azadirechta indicaFamily: MeliaceaeCurcuma longaFamily: ZingeberaceaeMyristica fragransFamily: MyristicaceaeCinnamomumzeylanicumFamily: LauraceaeAloe barbadensisFamily: LiliaceaeAntiinflammatory,Anti-fungal, xidant,Anti-bacterialAUTHENTICATIONThe plant material collected wasidentified and authenticated by Dr. VishalBharat Babar, PG Research, Departmentof pharmaceutical chemistry, Dattakalacollege of Pharmacy, Pune.METHOD OF PREPARATIONSteps carried out in the preparation ofvanishing herbal cream were as follows.Preparation of alcoholic extract ofcrude drugs:All above mentioned powdered crudedrugs of 5gms were taken into the conicalflask and then 100ml of ethanol was addedto it, then the conical flask was cappedwith aluminium foil. Then this mixturewas placed for maceration for 5 days.IJCRT2201353Preparation of oil phase:Stearic acid (17%), potassium hydroxide(0.5%), sodium carbonate (0.5%) wastaken into porcelain dish and this mixturewas melted at 70 .Preparation of aqueous phase:Alcoholic extract of crude drugsmentioned in step-1 (4.5%), Glycerine(6%), Water (71%) were taken intoanother porcelain dish and heated thismixture at 70 .Addition of aqueous phase to oil phase:The aqueous phase was added to the oilphase with continuous stirring at 70 .Now, once the transfer was completed itwas allowed to come at room temperature,all the while being stirred. Perfume (0.5%)was added at last just before the finishedInternational Journal of Creative Research Thoughts (IJCRT) www.ijcrt.orgd197

www.ijcrt.org 2022 IJCRT Volume 10, Issue 1 January 2022 ISSN: 2320-2882product was transferred to suitablecontainer. Then cream was evaluated forvarious physical parameters.EVALUATION OF CREAMDeterminationproperties:oforganolepticThe appearance of the cream was judgedby its colour, pearlescence and roughnessand graded.Determination of pH:The pH meter was calibrated andmeasured the pH by placing in the beakercontaining 20mg of the cream.Determination of homogeneity: Theformulations were tested for thehomogeneity by visual appearance and bytouch.Determination of spread ability:Spread ability may be expressed by theextent of the area to which the topicalapplication spreads when applied to theaffected parts on the skin. The therapeuticefficiency of the formulation also dependsupon its spreading value. Hence, it wasfound necessary to determine the spreadability of the formulation. In this method,500gms of cream was placed between twoslides. A weight of 100gm was placed onupper slide for 10mins. The weight wasremoved and extra formulation wasscrapped off. The lower slide was fixed onapparatus and upper slide was fixed withnon-flexible string on which 20gms loadwas applied. Time taken by upper slide toslip off was noted down. The spreadability (S) was calculated using theformula:S Spread abilitym Weight tied to upper glass slide.L Length moved on a glass slideT Time taken.The determinations were carried out intriplicate and the average of three readingswas recorded.Determination of Dye test:The test was done by mixing the creamwith red dye then place the drop of creamon a slide and cover it with cover slip,observed under microscope. If thedispersion phase appears in red colouredglobules the cream was o/w type. If thecontinuous phase appears red colour thecream was w/o type.Determination of Wetness:It was determined by applying cream onskin surface of human volunteer.Determination of homogeneity:The formulations were tested for thehomogeneity by visual appearance and bytouch.Determination of Patch Test:About 1-3gm of material to be tested wasplaced on a piece of fabric or funnel andapplied to the sensitive part of the skine.g., skin behind ears. The cosmetic to betested was applied to an area of 1sq.m. ofthe skin. Control patches (of similarcosmetic of known brand) were alsoapplied. The site of patch is inspected after24 hrs. As there was no reaction the testwas repeated three times. As no reactionwas observed on third application, theperson may be taken as nothypersensitive.𝑆 𝑚 𝐿/𝑇Where,IJCRT2201353International Journal of Creative Research Thoughts (IJCRT) www.ijcrt.orgd198

www.ijcrt.org 2022 IJCRT Volume 10, Issue 1 January 2022 ISSN: 2320-2882Determination of Appearance:The appearance of the cream was foundby observing its colour, opacity, etc.Determination of Smear type:The test was conducted after theapplication of cream on the skin the smearformed was oily or aqueous in nature.Determinationofemolliency:Emolliency, slipperiness and amount ofresidue left after the application of fixedamounts of cream was checked.Determination of viscosity:The viscosity determinations were carriedout using a Brookfield Viscometer (DVII Pro model) using spindle number S-64Acceleratedstabilitystudies:Accelerated stability studies wereperformed on all the formulations bymaintaining at room temperature for20 days with constant time interval.During the stability studies theparameterslikehomogeneity,viscosity, physical changes, pH andtype of smear were studied.at a 20 rpm at a temperature of 25 . Thedeterminations were carried out intriplicate and the average of three readingswas recorded.Determination of Wash ability:The removal of the cream applied on skinwas done by washing under tap water withminimal force to remove the cream.Determination of Irritancy:The cream was applied on left hand dorsalside surface of 1sq.cm and observed inequal intervals upto 24hrs for irritancy,redness and oedema.RESULTSDISCUSSIONSANDThe herbal vanishing cream wasprepared by using o/w emulsionmethod using mixture of alcoholicextract of crude drugs includingChamomile,Neem,Turmeric,Nutmeg, Aloe and Cinnamon and theextract were used and the cream wasformulated which pass all evaluationtests.Table 2: Evaluation ParametersSr. No.1.2.3.4.ParametersAppearanceOdourPhSpread ability5.Homogeneity By Visual By TouchDye test with scarlet redPatch testType of smear6.7.8.IJCRT2201353ObservationsYellowish greenSlightly aromatic6.4Uniform with a value of42 g.cm/secEasily spreadableHomogenousSmooth and consistento/w typeNot hypersensitivenessNon-greasyInternational Journal of Creative Research Thoughts (IJCRT) www.ijcrt.orgd199