M Sc – Ph D (Biomedical Sciences)
Syllabus(Revised on 29-6-2009)M.Sc.inBiomedical Sciences(Four Semester Course)Dr. B.R. Ambedkar Center for Biomedical ResearchUniversity of Delhi, Delhi-110 007Master of ScienceBiomedical ScienceTWO YEAR FULL TIME PROGRAMMERules, Regulations and Course ContentsDr. B.R. Ambedkar Center for Biomedical Research(Faculty of Science)University of DelhiDelhi-110 007
University of DelhiExamination BranchDate:Course:30th June, 2009M.Sc. in Biomedical ScienceCheck List of New Course Evaluation for AC Programme StructureCodification of PapersScheme of ExaminationsPass PercentagePromotion CriteriaDivision CriteriaSpan PeriodAttendance RequirementsCourse content for each paper along with reading listStatus2
MASTER OF SCIENCE(Biomedical Science)TWO YEAR FULL TIME PROGRAMMEAFFILIATIONThe proposed programme shall be governed by the Dr. B.R. Ambedkar Center for BiomedicalResearch, Faculty of Science, University of Delhi, Delhi-110 007.PROGRAMME STRUCTUREThe M.Sc. Programme is divided into two parts as under, each part will consist of two Semesteras given below.First YearSecond YearPart IPart IISemester – OddSemester – ISemester – IIISemester-EvenSemester – IISemester – IVEach semester would consist of five papers and one practical through Semester I and II (Part I)and semester III. Semester IV (Part II) would comprise of Optional Papers from which each student has toselect two papers and undertake Dissertation work. Selection of papers in Semester IV would be basedon merit (performance in the Part I Examinations), choice and other specific guidelines as outlined below.It is mandatory for each student to complete a Dissertation, assigned at the end of 2nd Semester andcomplete at the end of 4th Semester. It would comprise of bench work.The schedule of papers prescribed for various semesters shall be as follows:CLASSIFICATION OF PAPERSPart I: Semester – IS.No.123456CodeMBS 101MBS 102MBS 103MBS 104MBS 105MBS 106SubjectOrganic Chemistry-IBiochemistryCell BiologyMedical MicrobiologyGeneticsPracticalsTotalMaximum ganic Chemistry-IIMolecular Biology and BiotechnologyApplication of Statistics & Mathematics forBiologyImmunologyHuman Physiology-IPracticalsTotalMaximum Marks100100100Credits44410010010060044424Part I: Semester – IIS.No.123CodeMBS 201MBS 202MBS 203456MBS 204MBS 205MBS 2063
Part II: Semester – IIIS.No.123CodeMBS 301MBS 302MBS 303456MBS 304MBS 305MBS 306SubjectHuman Physiology-IIPrinciples of Medicinal ChemistryAnalytical and Biomedical Techniques &InstrumentationMolecular OncologyToxicology & PharmacologyPracticalsTotalMaximum ionGenome Biology (Compulsory)Special Paper I ryZoologyInterdisciplinaryZoologyPart II: Semester – IV123MBS 401MBS 402MBSSpecial Papers* being offered (based on choice cum merit basis)123456MBS 403MBS 404MBS 405MBS 406MBS 407MBS 408Concepts in drug discovery and mechanismAdvanced Medicinal ChemistryRadiation BiologyTopics in Clinical ResearchAdvanced Toxicology & PharmacologyAdvanced ImmunologySCHEME OF EXAMINATION1.2.3.English shall be the medium of instruction and examination.Examinations shall be conducted at the end of each semester as per the Academic Calendarnotified by the University of Delhi.Each course will carry 100 marks and will have two components: Internal assessment (25 marks)and end of semester examination (75 marks)Theoryi.Internal Assessment30 marksa.b.AttendanceTest / Assignments05 marks25 marksii.End of semester examination70 marksEnd Semester Examination (Practicals)100 marks4
4.The system of evaluation shall be as follows:4.1Internal assessment will be broadly based on attendance in theory (5 marks), assignments andtests in the theory component (20 marks). These criteria are tentative and could be modified bythe faculty members associated with teaching of a paper based on guidelines approved by theacademic council.4.2The scheme of evaluation for dissertation shall be as follows:5.4.2.1Dissertation will formally begin from end of Semester II and will consist of bench work.4.2.2Dissertation work will consist of internal evaluation by the concerned supervisor based ongeneral performance, written assignments, student seminar, in-class examination duringthe duration of the dissertation (100 marks), Project work (200 marks) and viva-voce (100marks) the last two being evaluated by a board comprising of all teachers in theDepartment and /or external experts.Examinations for courses shall be conducted only in the respective odd and even Semester asper the Scheme of Examinations. Regular as well as Ex-students shall be permitted to appear /re-appear / improve in courses of Odd Semesters only at the end of Odd Semesters and coursesof Even-Semesters only at the end of Even Semesters.PASS PERCENTAGEMinimum marks for passing the examination in each semester shall be 40% in each paper and45% in aggregate of a semester.However, a candidate who has secured the minimum marks to pass in each paper but has notsecured the minimum marks to pass in aggregate may reappear in any of the paper/s of his choice in theconcerned semester in order to be able to secure the minimum marks prescribed to pass the semester inaggregate.No student would be allowed to avail of more than two chances to pass a paper inclusive of thefirst attempt.PROMOTION CRITERIASemester to Semester: Students shall be required to fulfill the Part to part Promotion Criteria. Within thesame part, students shall be promoted from a semester to the next semester, provided she/he haspassed at least three out of the five theory examinations of the current semester. However passing inpractical is mandatory for promotion from one semester to next. There shall not be anyrepeat/improvement allowed for practical examination.Part I to Part II: Admission to Part II of the programme shall be open to only those students who havesuccessfully passed at least 6 theory papers out of papers offered for the Part I courses comprising ofSemester-I and Semester-II taken together and two practical papers. However, she/he will have to clearthe remaining papers while studying in Part-II of the programme.5
DIVISION CRITERIASuccessful candidates will be classified on the basis of combined results of Part-I and Part-IIexaminations as follows:Candidates securing 60% and aboveCandidates securing between 50% and 59.99%All others between 40-49.99%:::I DivisionII DivisionPassQUALIFYING PAPERSNoneSPAN PERIODNo students shall be admitted as a candidate for the examination for any of the Parts/Semestersafter the lapse of four years from the date of admission to the Part-I/Semester-I of the M.Sc. in BiomedicalProgramme.ATTENDANCE REQUIREMENTNo student shall be considered to have pursued a regular course of study unless he/she iscertified by the Head /Director of the Dr. B.R. Ambedkar Center for Biomedical Research, University ofDelhi, to have attended 75% of the total number of lectures and seminars conducted in each semester,during his/her course of study. Provided that he/she fulfils other conditions, the Head/Director, Dr. B.R.Ambedkar Center for Biomedical Research may permit a student to the next Semester who falls short ofthe required percentage of attendance by not more than 10% of the lectures and seminars conductedduring the Semester.COURSE CONTENT FOR EACH COURSEIs Enclosed.LIST OF READINGSThe latest editions of each book will be referred to the class. List is enclosed at the end of each paper.6
MBS 101: Organic Chemistry – IReactive Intermediates in Organic ReactionsCarbocations, carbanions, Free Radicals their stability and applications to biological systems, benzynes,carbenes, radical cations and radical anions; their generations and reactions exemplified with suitablecase study leading to C-C bond formation.Stereochemistry of Organic CompoundsThe definition of the following terms with suitable examples; Elementary treatment of symmetric elements,Chirality, prochirality; (enantiomer, epimer,diastereomer). Absolute and relative configuration; r and snotation; enantiotopic and diastereotopic faces, endo and exo faces, Regioselective, enantioselective,stereoselective and stereospecific reactions, Confirmation of 2,3 dibromomutane, E & z notations,Cyclohexane diols.Mechanism and stereochemistry of following reactionsSubstitution, elimination and addition reactions; oxidation and reduction, Ester formation and esterhydrolysis, Aromaticity, aromatic and Nucleophilic substitution (with appropriate examples; WoodwardHoffman rules and photocyclization,Asymmetric synthesisCram and Prelog rule, Chiral synthesis (with suitable examples) asymmetric epoxidation.Heterocyclic ChemistryStructure, synthesis and reactivity of the following heterocycles and their significance in biology and drugsand materials: furan, pyrrole, thiophene, imidazole, oxazole, thiazole, azepine, thiazine, carbazole, indolepyridine, quinoline and isoquinoline, acridine, phenothiazine, pteridine, purines and pyrimidinesReading List123456March’s advanced organic chemistry: reactions, mechanisms and structure by Jerry March andMichael B. Smith; Ed.6th; Wiley-Interscience; 2007.Advanced organic chemistry: Part A: structure and mechanisms by Francis A. Carey andRichard J. Sundberg; Ed. 5th; Springer; 2008.Asymmetric synthesis: the essentials by Mathias Christmann and Stefan Brase; Wiley-VCH;2007.Organic chemistry by Thomas N. Sorrell; Ed.2nd; University Sceince Books, 2005Organic chemistry by Robert Thorton Morrison and Robert Neilson Boyd; Ed. 6th; Prentice Hallof India; New Delhi; 2002.Organic chemistry by T. W. Graham Solomons and Craig B. Fryhle; Ed. 9th; Wiley, 20077
MBS 102: BIOCHEMISTRYStructure Of ProteinSecondary and tertiary structure of protein: a helix, ß sheets, examples of proteins, Ramachandran plot,factors effecting secondary and tertiary structure (disulphide bonds, heat, organic solvents, detergents).Examples of some common structural motifs in proteins.Separation techniques for proteins: Ion exchange chromatography, dialysis, molecular sieving,polyacrylamide gel electrophoresis (determination of subunits and molecular weight), electrofocussingaffinity chromatography.Structure and function of hemoglobin: Conformational studies, binding of oxygen and its release, oxygensaturation curves. Methods of protein sequencing. Disorder of Amino Acid and protein metabolismEnzymologyIntroduction: General characteristics of enzymes, definition of coenzyme, holoenzyme, prosthetic groups,classification.Enzyme Kinetics: Substrate, active site, transition state, activation energy, equilibrium constant Km,Vmax, specificity, Michaelis-Menten equation.Reaction Mechanism: Acid-base catalysis and colvalent catalysis (giving examples). Regulation ofenzyme activity: Reversible and irreversible inhibition (non-competitive, uncompetitive) and their effectson Km and Vmax, effect of pH, heat, PMSF and other inhibitors.Allosteric enzymes: Models to explain their kinetic behaviour.Problems on enzyme kinetics: Determination of active sites and turnover number.DNA replication and its regulationConcept of origin of replication, semiconservative hypothesis.Mechanism of DNA Replication: Structure and function of DNA polymerases. Role of helicase, primase,gyrase, topoisomerase and other proteins in DNA replication in E.coli. replication of viruses andeukaryotes, initiation of replication, elongation and termination of DNA synthesis. DNA RepairRNA SynthesisTranscription in prokaryotes using E-coli as an example, Structure & function of RNA polymerases.Transcription initiation, elongation and termination.Transcription in eukaryotes–Structure of TFIID, and other transcription factors, enhancers, silencers,insulators, general concept of regulation of transcription (in brief). Post-transcritional modifications,Ribozymes–Structure and mechanism of action.TranslationTranslation in Prokaryotes-initiation: activation of amino acid, role of 30s and 50s ribosomal subunits,initiation factors) shine-dalgarno sequences. Elongation factors, peptidyl transferase termination signal,release factors. Inhibition of protein sunthesis - by antibiotics.Translation in eukaryotes – recent concept in initiation and termination, regulation of protein synthesis,comparison with prokaryotic system. Post translation modification – Methylation, glycosylation,phosphorylation, acetylation, proteolytic processing, addition of prosthatic groups, disulphide bond etc.protein degradation.Reading List1Harper’s biochemistry by Robert K. Murray and Daryl K. Granner and Peter A. Mayes and Victor W.Rodwell; Ed. 25th; McGraw-Hill; 2000.8
23456Biochemistry by Donald Voet and Judith G. Voet; Ed. 3rd; Wiley; 2008.Lehninger principles of biochemistry by David L. Nelson and Michael M. Cox; Ed. 5th; W.H.Freeman, 2004.Biochemistry by Christopher K. Mathews and Kensal E. van Holde and Kevin G. Ahern; Ed. 3rd;Prentice Hall, 1999.Textbook of biochemistry with clinical correlations by Thomas M. Devlin; Ed.6th; Wiley-Liss; 2005.Biochemistry by Jeremy M. Berg and John L. Tymoczko and Lubert-Stryer; Ed. 6th; W.H. Freeman,2008.9
MBS 103: CELL BIOLOGYBiomembranes: Basic structure, lipid and protein composition and their basic functions Transport ofmolecules across membranes. Passive and active transport across membranes. Factors regulating them,ion chanells, ABC pumps of bacteria.Organelles of eukaryotic cells – Introduction basic structure and function of various organelles, ER,golgi bodies, chloroplasts, mitochondria endosomes, lysosomes etc. separation and visualizationmethods of various cell organelles.Muscle & Nerve Cells.Nucleus and Chromosome StructureIntroduction: Prokaryotic and Eukaryotic genome and its organization, eukaryotic chromosome. Basicstructure of DNA; hairpins and cruciform, Z-DNA, triple helix.DNA Supercoiling: Histones, nonhistone proteins, topoisomerases and telomerase and their functions inchromatin structure. Yeast artificial chromosome.The CytoskeletonCytoskeleton proteins, Cell motility and shape, protein sorting, Transport of proteins. Microfilaments andactin filamentsECM Proteins and Cell AdhesionCell-cell interaction, Cell junctions, Adhesion proteins, Cell matrix interaction, Integrins, Functional role ofadhesion proteins.Eukaryotic Cell CycleCell cycle and its control: Loss of cell regulation by viral infection, checkpoints in cell cycle regulation.Cell to Cell SignalingCell surface receptors, G-protein mediated signaling, camp, receptors tyrosine kinases, secondmessengers.Cell deathApoptosis, Necrosis, Proapoptotic and Antiapoptotic proteins and mechanism of action Autophagy,Senescence, Cell death mechanisms in health and diseases.Cell DifferentiationCellular Stress ResponseStress response proteins and pathways, Post translational modifications in stress response, Generalresponses to hyperthermia nutritional deprivation and other stressors.Reading List1.2.3.4.5.Molecular biology of the cell by Bruce, Alberts and Alexander Johnson and Julian Lewis, andMartin Raff; Ed. 5th; Garland Science; 2008.Molecular biology of the cell: the problem book by John Wilson and Tim Hunt; Ed. 5th; GarlandScience; 2008.Molecular cell biology by Harvey Lodish and Arnold Berk, Chris A. Kaiser, and Monty Krieger;Ed. 6th; W H Freeman and Company; New York; 2008.Cell: molecular approach by Geoffrey M. Cooper and Robert E. Hausman; Ed. 4th; ASM Press;2007.Cell biology by Thomas D. Pollard and William C. Earnshaw; Ed. 2nd; Saunders; 2008.10
MBS 104 : MEDICAL MICROBIOLOGYBacteriologyIntroduction, Taxonomy, nomenclature and identification of bacteria, Reproduction and growth,Organization and ultrastructure of micro-organisms and various antibiotics, Antimicrobial used in clinicalpractical, Normal human flora, Pathogenesis and virulence factors of bacteria, Human diseases causedby bacteria in the following: Respiratory tract infections, Urinary tract infections, Genital tract infections,Gastrointestinal tract infections, Blood stream and CNS infections. Epidemiology of bacterial diseases.ParasitologyClassification of parasitic protozoa. Cellular organization of parasitic protozoa. Epidemiology of parasiticinfections. Immunology and immunopathology of parasitic infections, Control of parasites and parasiticinfections. Common parasitic disease: Trypanosomiasis, Leishmaniasis, Malaria, Opportunistic parasiticinfections, Helminths.Medical MycologyClassification, sis,Histoplasmosis,Coccidiomycosis,Clinical VirologyThe structure, components and classification of viruses. Viral multiplication cycle, effect of virus infectionon the host cell, cytopathic effects, inhibition of host cell cytopathic effects, inhibition of hostmacromolecular biosynthesis, changes in regulation of gene expression. Genetics of animal viruses.History, epidemiology, diagnosis, clinical features, treatment and prevention of small pox, herpes,adenoviruses, arboviruses, picornaviruses, myxoviruses.Reading List123456Microbiology by Lansing M. Prescott and John P. Harley and Donald Klein; Ed. 6th; McGraw-HillScience, 2004.Color ATLAS and textbook of diagnostic microbiology by Elmer W Koneman and Stephen D Allenand William M Janda and Paul C Schreckenberger and Washington C Winn; Ed. 6th; LippincottWilliams & Wilkins, 2005.Medical microbiology: a guide to microbial infections: pathogenesis, immunity, laboratory diagnosisand control by David Greenwood and Richard C. B. Slack and John F. Peuthere, ed. 17th Ed.Churchill Livingstone; 2007.Essentials of diagnostic microbiology by Lisa Anne Shimeld and Anne T. Rodgers; DelmarPublishers, 1999.Medical Microbiology by Geo. Brooks and Karen C. Carroll and Janet Butel and Stephen Morse; Ed.24th; McGraw-Hill Medical, 2007.Topley and Wilson's Microbiology and Microbial Infections by Leslie Collier and Albert Balows andMax Sussman; Ed. 9th; 6-Volume Set; A Hodder Arnold Publication, 2000.11
MBS 105: GENETICSSECTION AIntroduction to the Science of GeneticsGenetic terminology Impact of Genetics on other disciplines.Mendelian GeneticsMendelian Laws of inheritance, its application in animal Genetics, analysis ofby various methods.results of Genetic crossesChromosomal basis of inheritance and data analysisSex chromosomes in grasshopper, maize and co-linearity of genes on chromosomes, Non-disjunction inDrosophila and its role in deciphering chromosomal basis of inheritance. Analysis of patterns ofinheritance, Punnett square, statistical methods.Deviations from Mendelian Genetics ICodominance, incomplete dominance, RFLP markers, gene interactions, multiple alleles.Mutation and mutational analysisSpontaneous occurrence of mutations in bacteria Lederberg and Lederberg experiment, Types ofmutations i.e. point mutations, deletions, rearrangements, insertions, dynamic mutations (repeatexpansions) with appropriate examples, Chromosomal anomalies. Mutation mapping suing balancers,Clb technique in Drosophila.Linkage as a deviation from Mendelian GeneticsRecombination, Gene mapping using Drosophila as an example, experiments demonstrating physicalbasis of recombination, crossing over. Gene mapping using special systems, yeast and Neurospora.Bacterial geneticsTransformation, Conjugation, genetic map construction in E.coli. Phage genetics, fine structure of rIIregion, work of Seymour Benzer.Genetic VariationTransposition and its application in genetic studies. Extra chromosomal inheritance, chloroplast andmitochondrial inheritance, mitochondrial mutations in yeast, human genetic disorders related tomitochondrial inheritance.Deviations from Mendelian Genetics IIGenomic imprinting in mice, understanding molecular basis of epigenetic inheritance, human disordersrelated to imprinting, Prader Willi and Angelmen syndrome, Molecular basis of Epigenetic regulation in
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