Data Supplement To Chan Et Al. Predicting Suicide .

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Data supplement to Chan et al. Predicting suicide following self-harm: systematic review of risk factors and risk scales. Br J Psychiatry doi:10.1192/bjp.bp.115.170050Table DS1 Search strategiesReview areaRisk and protective factorsSearch construction[(Self-harm terms) AND (Risk andprotective factor terms) AND(Observational study filter)]Study designObservational studies*[(Self-harm terms) AND (SR studyfilter)]Risk assessment, needs assessmentand psychosocial assessmentSystematic reviewsObservational studies[(Self-harm terms) AND (Riskassessment, needs assessment,psychosocial assessment terms) AND(Observational study filter)][Self-harm terms) AND(predictive/repetition terms) AND(diagnostic accuracy filter terms)AND (named assessment tool terms)]N/A – no study design limit*[(Self-harm terms) AND (SR studyfilter)]Systematic reviewsPopulation search termsa) Self-harm – population search termsMEDLINE – Ovid SP interface1Database/ date rangeCINAHL, EMBASE, MEDLINE,PsycINFO [inception of databases upto February 2014]CINAHL, EMBASE, MEDLINE,PsycINFO [January 1995 up toFebruary 2014]CINAHL, EMBASE, MEDLINE,PsycINFO [inception of databases upto February 2014]CINAHL, EMBASE, MEDLINE,PsycINFO [inception of databases upto February 2014]CINAHL, EMBASE, MEDLINE,PsycINFO [January 1995 up toFebruary 2014]

1. overdose/ or self-injurious behavior/ or self mutilation/ or suicidal ideation/ or suicide/ or suicide, attempted/2. (autoaggress or auto aggress or automutilat or auto mutilat or cutt or overdose or (self adj2 cut ) or selfdestruct or self destruct or selfharm or self harm or selfimmolat or self immolat or selfinflict or self inflict or selfinjur or self injur or selfmutilat or self mutilat or selfpoison or selfpoison or suicid ).ti,ab.3. or/1-2Risk and protective factorsMEDLINE – Ovid SP interfaceWhat are the risk and protective factors (internal and external) amongst people who self-harm that predict outcomes?1. risk factors/2. (risk adj2 relative).ti,ab.3. ((predict or protect or risk ) adj2 (associat or attribute or correlate or determinant or factor or variable )).ti,ab.4. or/1-35. ((predict or risk ) adj2 (ongoing or recur or re cur or reattempt or re attempt or recur or repeat or repetit )).ti,ab.6. prospective repetit .ti,ab.7. ((associat or attribute or correlate or determinant or factor or variable ) adj8 (ongoing or recur or re cur or reattempt or re attempt or recur or repeat or repetit ) adj8 (autoaggress or aggress or automutilat or cutt or destruct or dsh or episode or harm or immolat or inflict or injur or mutilat or overdose or (self adj2 cut ) or poison or selfdestruct or selfharm or selfimmolat or selfinflict or selfinjur or selfmutilat orselfpoison or sh or suicid )).ti,ab.8. or/5-79. resilience, psychological/10. (buffer or cope or recovery or resilien ).ti,ab.11. or/9-1012. or/4,8,11Risk assessment, needs assessment and psychosocial assessmentMEDLINE – Ovid SP interfaceFor people who self-harm, does formal risk assessment, needs assessment and psychosocial assessment improve outcomes?1. (checklist/ or geriatric assessment/ or interview/ or interview, psychological/ or mass screening/ or nursing assessment/ or "outcome and process2

assessment (health care)"/ or "outcome assessment (health care)"/ or exp personality assessment/ or exp psychiatric status rating scales/ or exppsychological tests/ or questionnaires/)2. (form 1 or checklist or check list or index or indices or interview or instrument or inventor or item 1 or measure or psychometric or psychometric or question or scale or score or scoring or self report or subscale or test or tool ).ti,ab.3. 1 or 24. "predictive value of tests"/ or recurrence/ or risk .hw.5. (predict or ongoing or recur or re cur or reattempt or re attempt or recur or repeat or repetit or risk ).ti,ab.6. 4 or 57. area under curve/ or exp sensitivity and specificity/8. ((area under adj2 curve) or auc or (diagnostic adj2 odds ratio ) or ((false or true) adj negative) or ((false or true) adj positive) or (likelihood adj3 ratio )or ((pretest or pre test or posttest or post test) adj2 probabilit ) or (predict adj3 value ) or receiver operating characteristic or (roc adj2 (analy or curv or plot )) or sensititiv or specificit ).tw.9. 7 or 810. and/3,6,911. needs assessment/ or risk assessment/12. ((client or clinical or consumer or need or patient or psychiatric or psychological or psychosocial or psycho social or risk or service user ortherapeutic) adj2 (assess or evaluat )).ti,ab.13. (((assess or predict or risk ) adj2 (form 1 or checklist or check list or index or indices or interview or instrument or inventor or item 1 ormeasure or psychometric or question or scale or score or scoring or self report or subscale or test or tool )) or (comprehensive adj (assessment or evaluation ))).ti,ab.14. (adult suicidal ideation questionnaire or asiq or (beck depression inventory or bdi) or (beck hopelessness scale or bhs) or ((beck scale adj2 suicideideation) or bsi) or ((brief reasons adj2 living inventory) or brfl) or (brief symptom inventory or bsi) or ((college student reasons adj2 living inventory) orcsrli or csr li) or ((edinburgh risk adj2 repetition scale) or errs) or (firestone assessment adj2 self-destructive thoughts) or ((global clinical assessment) orgca) or ((hamilton depression rating scale) or hdrs) or ((hamilton rating scale adj2 depression) or hamd or ham d or hrsd or hrs d) or ((intersept scale adj2suicidal thinking) or isst) or lethality scale or (life satisfaction scale or ls scale) or lifetime parasuicide count or ((linehan reasons adj2 living inventory)or lrfl) or ((manchester self harm rule) or mshr) or ((modified scale adj2 suicide ideation) or mssi) or (parasuicide history interview or phi) or ((quiz adj2depression adj2 suicide adj2 later life) or qdsll) or (reasons adj2 living inventory) or ((reasons adj2 living scale adj2 older adult questionnaire) or rfloa orrfl oa) or ((reasons adj2 living scale adj2 younger adult questionnaire) or rflya or rfl ya) or risk rescue rating or ((scale adj2 suicide ideation) or ssi) or(self-inflicted injury severity form or siisf or sii sf) or (self-monitoring suicide ideation scale or smsis of sms is) or (suicidal behaviors interview or sbi) or(suicidal ideation questionnaire or siq) or (suicidal ideation screening questionnaire or sisq or sis q) or (suicidal intent scale or sis) or ((suicide3

assessment scale) or suas) or (suicide behaviors questionnaire or sbq) or (suicide intervention response inventory or siri) or (suicide opinionquestionnaire or soq) or (suicide potential rating scale or suicide lethality scale or spls or spl s) or (suicide probability scale or sps) or (suicide status formor ssf) or ((symptom driven diagnostic system adj2 primary care) or sddspc or sdds pc) or ((positive adj2 negative suicide ideation inventory) orpansi)).ti,ab.15. or/11-1416. and/6,9,1417. or/10,15-16Systematic review search filter – adapted from a filter designed by the Health Information Research Unit of McMaster University, Ontario, Canada.MEDLINE – Ovid SP interface1. meta-analysis/or meta-analysis as topic/2. meta-analysis.pt.3. ((evidence or quantitative or systematic ) adj2 (overview or review)).ti,ab.4. (((bibliographic or electronic) adj database ) or bids or cochrane or embase or index medicus or isi citation or medline or psyclit or psychlit or pubmedor scisearch or science citation or (web adj2 science)).ti,ab. and review.pt.5. (metaanal or meta anal or metasynthes or meta synthes ).ti,ab.6. ((pool or combined or combining) adj2 (data or trials or studies or results)).ti,ab.7. or/1-6Observational study filter – developed in-house.MEDLINE – Ovid SP interface1. case-control studies/2. cohort studies/3. cross-sectional studies/4. epidemiologic studies/5. follow-up studies/6. longitudinal studies/7. prospective studies/8. retrospective studies/9. (cohort 1 or cross section or crosssection or followup or follow up or followed or longitudinal or prospective or retrospective ).ti,ab.4

10. (case adj2 (control or series)).ti,ab.11. or/1-105

Table DS2 Included study characteristics of risk factor reviewStudy IDCountryBergen et al (2012)24UKBjornaas et al (2009)25Study length,yearsnMedian: 27 female, 31maleMedian 3158.6Prior history of self-harmbefore index episodepresented at hospital, %4651Unclear1083Mean 3763UnclearPatients discharged from hospitalfollowing index episode of self-harmHospital record of 51UnclearUnclearSelf-harm records at hospital A&EA&EHospital admission following self-harmSelf-harm records at hospital A&E45172573600Mean 36Median 3035–39% age 21–30Median: 34 male, 32femaleMedian 4050% age 15–3438% age 35–5412% age 55Mean 37.6Age 15 or above54% age below 355558.4320 ( in 3 years prior to indexattempt (inclusion criteria))Patients admitted with self-harmPatients discharged from hospitalfollowing index episode of self-harm69635359%Unclear48Psychiatric emergency unitPresented to hospital following self-harmA&E830202Norway20946Chen et al (2011)26Taiwan6Chen et al (2013)27Cooper et al (2005)8Holley et al (1998)28Kuo et al (2012)29Taiwan – TaoyuanUKCanadaTaiwan – TaipeiMadsen et al (2013)30Miller et al (2013)31DenmarkUSAMonnin et al (2012)32Nordentoft et al (1993)33Suokas et al (2001)34FranceDenmarkFinlandA&E, accident and nt settingA&E

Table DS3 Included study characteristics for risk scales reviewStudy IDPopulationBeck et al (1985)37Psychiatric in-patientsBeck et al (1999)38Psychiatric out-patientsHarriss & Hawton (2005)39People presenting to hospitalfollowing self-harmNimeus et al (1997)40Patients being treated in a psychiatricintensive care unit following suicideattemptPatients being treated in a psychiatricintensive care unit following suicideattemptIndividuals who have attemptedsuicideIndividuals who have attemptedsuicideNimeus et al (2002)41Stefansson et al (2012)42Suominen et al (2004)43Follow-up(months)60180N used inanalysis165SSI 3701,BHSMean 144224365654 (mean)Not reported% of female758Reference standardDeaths judged as suicide by the Philadelphia (or other)medical examiner’s office/coroner’s officeSuicide ascertained by National Death Index (computerdatabase)Office of National Statistics for England and Wales, theCentral Services Agency in Northern Ireland and theGeneral Register Office for Scotland.Completed suicide ascertained by Lund Department ofForensic MedicineCompleted suicide ascertained by Lund Department ofForensic Medicine and Swedish National Central Bureauof StatisticsSuicide ascertained by Cause of death register; NationalBoard of Health and Welfare in SwedenData obtained from national statistics

Figure DS1 Study flow chart for (a) risk factors review and (b) risk scales review(a)102 full text risk factors articles excluded for the following reasons:8514 recordsidentified bydatabase search8400 citations and abstractsexcluded at screening stage asnot relevant114 articles reviewedby full text102 full text articles excluded12 studies includedin review andmeta-analysis18% case-control/ retrospective studies40% population does not fit our criteria (general/ with a specific mentalhealth disorder/ older adults/ adolescents in school/ with intellectualdisabilities/ with ideation only)4% mixed population (general plus those with self harm attempt)24% outcomes are not in the format that's extractable or outcomes arenot about repeated self-harm (eg/high levels of hostility andhopelessness scores associate with repetition)5% paper not in English or a language that researchers can find resourceto translate9% other reasons (couldn't find full text; conference abstract; unrelated(b)105 full text risk scales articles excluded for the following reasons:10076 recordsidentified bydatabase search112 articles reviewedby full text7 studies9964 excluded atscreening stage asnot relevant105 full text articles excluded.- 26% were excluded due to reference standard not meeting our criteria('no data on completed suicide')- 56% excluded for not providing relevant data to be included in thereview ('not possible to populate 2x2 table')-18% excluded as not a relevant population8

OthersLiving aloneEducationSocioeconomic ubstanceabuseAnxietyK 1; N 974K 1; N 30202K 1; N 30202K 1; N 273adjusted for psychosocialassessment in last episode,relationship problem,financial problem,bereavement problem,consequence of previousabuse (K 1, N 30202)K 1; N 273K 1; N 273K 1; N 1018K 2; N 31220K 2; N 31220K 2; N 31174N/AK 1, N 273Adjusted hazard ratio 1.68[1.38, 2.05] (I² 19%)4 studies, N 012)PhysicalhealthproblemK 1; N 1080 (Somatic disease)SchizophreniaMethod ofself-harmSuicide intentPreviouspsychiatrictreatmentSuicide following self-harmGenderHistory k factorsPrevioushistory ofTable DS4 Adjusted confounds and risk of bias assessment in risk factors studiesadjusted for smokers,follow up care,current treatment(K 1, N 273)Risk of bias:Study sample – All studies met criteria (represents population of interest regard to key characteristics, sufficient to limit potential bias to results?)Loss to follow-up – None met criteria (whether loss to follow up is unrelated to key characteristics, sufficient to limit potential bias)Putative risk factor - All studies met criteria (adequately measured in study participants)Outcome of interest - All studies met criteria (adequately measured in study participants, sufficient to limit bias)Potential confound- None met criteria (important ones are appropriately accounted for, limiting potential bias with respect to prognostic factor of interest)Statistical analysis- All studies met criteria (is appropriate for design of study, limiting potential for presentation of invalid results)9

Risk of bias:Study sample – 3 of 4 studies met criteriaLoss to follow-up – None met criteriaPutative risk factor - 3 of 4 studies met criteriaOutcome of interest – All studies met criteriaPotential confound- 1 of 4 studies met criteriaStatistical analysis- All studies met criteria10OthersLivingaloneK 2; N 25495 (not living withclose relatives)EducationK 1, N 17527Socioeconomic statusK 2; N 47729EmploymentK 2; N 18403MaritalstatusK 2; N 47729PsychiatricdiagnosisK 3, N 48605SubstanceabuseK 4PhysicalhealthproblemAnxietyK 2, N 8844SchizophreniaK 1, 17527Method ofself-harmK 2, N 8844N/AK 2; N 31078K 1; N 302024 studies, N K 3; N 48605Adjusted hazardratio 1.27 [0.94,1.73] (I² 55%)K 1; N 7968 (avoideddiscovery)Previouspsychiatrict ttSuicideintentGenderSuicide followingself-harmAgePsychiatrichistory (pasthistory,treatments,admissionsfrom records,psychiatricoutpatient)Previoushistory ofOutcomeDepressivesymptomsRisk factorsadjusted for psychosocialassessment in last episode,relationship problem,financial problem,bereavement problem,consequence of previousabuse (K 1, N 30202)adjusted for clinical covariates-admissiondiagnosis, secondary diagnosis,personality disorder, private psychiatrist,private psychologist (K 1, N 17527)

Risk of bias:Study sample – All studies met criteriaLoss to follow-up - None met criteriaPutative risk factor – 2 of 3 studies met criteriaOutcome of interest – All studies met criteriaPotential confound- 1 of 3 studies met criteriaStatistical analysis- All studies met criteria11OthersEducationLivingaloneK 1; N 7968 (not living closewith relatives)K 1; N oeconomic statusSubstanceabuseN/AK 1; N 273PhysicalhealthproblemAnxietyK 1; N 7968SchizophreniaK 1; N 273Method ofself-harmK 1; N 7968 ntentK 2, N 8914K 1; N 946K 1; N 2733 studies, N 9187(COOPER2005,BJORNAAS2009,MONNIN2012)K 1; N 273Adjusted hazard ratio1.63 [1.00, 2.65] (I² 53%)K 2, N 8914GenderSuicide followingself-harmAgeAlcoholmisusePrevioushistory ofOutcomeDepressivesymptomsRisk factorsLevel of consciousness(K 1; N 946)adjusted for smokers,follow up care,current treatment(K 1, N 273)

Risk of bias:Study sample –2 of 3 studies met criteriaLoss to follow-up – None met criteriaPutative risk factor - 2 of 3 studies met criteriaOutcome of interest – All studies met criteriaPotential confound- 1 of 3 studies met criteriaStatistical analysis- All studies met criteria12OthersEducationLivingaloneK 1; N 7968 (not living closewith relatives)K 1; N 876K 1, N 3299K 1; N oeconomic statusK 2; N 4175K 2 (alcohol misuse/ as afactor), N od ofself-harmSchizophreniaK 3(violent method, cutting)(avoided discovery)K 1; N 7968PreviouspsychiatrictreatmentSuicideintentK 2, N 8844GenderK 2; N 41753 studies, N 12143(HOLLEY1998,COOPER2005,CHEN2013)K 1; N 876Adjusted hazardratio 1.99 [1.16,3.43] (I² 29%)AgeSuicide followingself-harmK 1, N comorbidity)Previoushistory ofOutcomeDepressivesymptomsRisk factorsAdjusted for residence (urban vs rural);reasons for self harm – problem withromantic relation; problem with family(K 1, N 3299)

Risk of bias:Study sample – All studies met criteriaLoss to follow-up – 1 of 4 studies met criteriaPutative risk factor – All studies met criteriaOutcome of interest – All studies met criteriaPotential confound- None met criteriaStatistical analysis- All studies met gnosisMaritalstatusEmploymentSocioeconomic statusK 2; N 33501adjusted for psychosocialassessment in last episode,relationship problem,financial problem,bereavement problem,consequence ofprevious abuse(K 1, N 30202)K 2; N 33501SubstanceabuseK 1; N 30202 (alcohol in lastepisode)PhysicalhealthproblemAnxietyK 2; N 1080 (Somaticdisease) 3299K 3; N 11980K 1; N 1080K 2; N 31220K 4; N 421825 studies, N 013)K 2; N 31220Adjusted hazardratio 2.05 [1.70,2.46] (I² 0%)SchizophreniaMethod ntGenderSuicide followingself-harmAgeGender –MalePrevioushistory ofOutcomeDepressivesymptomsRisk factorsAdjusted for residence(urban vs rural);reasons for self-harm – problem withromantic relation; problem with family(K 1, N 3299)

talstatusEmploymentSocioeconomic hizophreniaMethod deintentRisk of bias:Study sample – All studies met criteriaLoss to follow-up –None met criteriaPutative risk factor – 1 of 3 studies met criteriaOutcome of interest – All studies met criteriaPotential confound- 1 of 3 met criteriaStatistical analysis- All studies met criteria14K 1, N 7968K 1, N 946K 2, N 8914K 2, N 8986N/AK 33 studies, N 9932(SUOKAS2001,COOPER2005,BJORNAAS2009)adjusted for level of consciousness (K 1,N 946)K 2, N 1964Adjusted hazardratio2.70 [1.91, 3.81](I² 0%)AgeSuicide followingself-harmPrevioushistory ofSuicideintentDepressivesymptomsOutcomeK 1, N 1018Risk factors

talstatusEmploymentSocioeconomic hizophreniaMethod ntGenderSuicide followingself-harmAgeUnemploymentPrevioushistory ofOutcomeDepressivesymptomsRisk factorsAdjusted for psychosocial assessment in lastepisode, relationship problem, financialproblem, bereavement problem,consequence of previous abuse (K 1,N 30202)Adjusted for Residence (urban vs rural);Reasons for self-harm – problem withromantic relation; problem with family(K 1, N 3299)Adjusted hazardratio 1.08 [0.65, 1.8](

14. (adult suicidal ideation questionnaire or asiq or (beck depression inventory or bdi) or (beck hopelessness scale or bhs) or ((beck scale adj2 suicide ideation) or bsi) or ((brief reasons adj2 living inventory) or brfl) or (brief symptom inventory or bs

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