VIRTUAL IMMUNOLOGY2021TM

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CALL FOR ABSTRACTSVIRTUALIMMUNOLOGY2021TMMore science, more time, your wayAAI ANNUAL MEETING MAY 10–15, 2021A FULLY ONLINE EXPERIENCEWWW.IMMUNOLOGY2021.ORG1 CALL FOR ABSTRACTSWWW.IMMUNOLOGY2021.ORG

PRESIDENTS’ PROGRAMSDue to the cancellation of IMMUNOLOGY2020TM, bothDr. Ting and Dr. Boss will have a president’s program atVirtual IMMUNOLOGY2021TM.2021 AAI President’s AddressThe All-Encompassing Importance ofInnate ImmunityJenny P. Ting, Univ. of North Carolina, Chapel HillAAI President (2020–2021)IntroductionJeffrey A. Frelinger, Univ. of Arizona and Univ. of NorthCarolina, Chapel HillJenny P. Ting2021 AAI President’s SymposiumThe Impact of Immunology on Health andDiseases: As Far as the Eye Can SeeChairJenny P. Ting, Univ. of North Carolina, Chapel HillAAI President (2020–2021)SpeakersEtty (Tika) N. Benveniste, Univ. of Alabama,BirminghamNeutrophil involvement in autoimmuneneuroinflammationEtty (Tika) N. BenvenisteMary N. CarringtonBlossom A. DamaniaLaurie H. GlimcherMary N. Carrington, NCI, NIHThe impact of immunogenetic variation on functionalcharacteristics of the immune responseBlossom A. Damania, Univ. of North Carolina, Chapel HillModulation of host immunity by human herpesvirusesLaurie H. Glimcher, Dana Farber Cancer Inst.Stressed out: a novel approach to cancer immunotherapy2 CALL FOR ABSTRACTSWWW.IMMUNOLOGY2021.ORG

PRESIDENTS’ PROGRAMS2020 AAI President’s AddressThe Regulation of ImmunityPresentation of AAI Lifetime Achievement Award toMarc K. JenkinsJeremy M. Boss, Emory Univ. Sch. of Med.AAI President (2019–2020)IntroductionPeter E. Jensen, Univ. of Utah2020 AAI President’s SymposiumGenes and Genomes in Healthy andAutoimmune LymphocytesJeremy M. BossPresentation of AAI Excellence in Mentoring Award toJeffrey A. BluestoneChairJeremy M. Boss, Emory Univ. Sch. of Med.AAI President (2019–2020)SpeakersMichael S. Krangel, Duke Univ. Med. Ctr.RAG expression and TCR repertoire formation in doublepositive thymocytesFrances E. Lund, Univ. of Alabama, BirminghamInflammatory cytokine-mediated control of effectormemory B cell development and functionMichael S. KrangelFrances E. LundEugene M. OltzMax D. CooperEugene M. Oltz, The Ohio State Univ. Col. of Med.Wiring schemes for innate and adaptivelymphoid cellsMax D. Cooper, Emory Univ. Sch. of Med.The evolution of T and B cells3 CALL FOR ABSTRACTSWWW.IMMUNOLOGY2021.ORG

DISTINGUISHED LECTURESThe 2021 Distinguished Lectures Program is dedicated to the memory of Dr. Wendy Havran. Dr. Havran was selectedas a Distinguished Lecturer for IMMUNOLOGY2020TM but she unfortunately died after a brief illness in January 2020.A tribute to her exemplary service to AAI, and to her life and work, may be read at www.aai.org/tribute.Michael P. CancroUniv. of Pennsylvania PerelmanSch. of Med.A tale of two subsets: rethinking B cellselection, homeostasis, and memoryDario A. A. VignaliUniv. of Pittsburgh Sch. of Med.Immune inhibitory mechanismsin cancerDonna L. FarberColumbia Univ. Med. Ctr.Human immunity in space and timeCAREER AWARDSEach year AAI recognizes the extraordinary professional achievements and career promise of its members. The followingare the recipients of the 2020 AAI Career Awards being presented at Virtual IMMUNOLOGY2021TM.AAI LifetimeAchievement AwardAAI DistinguishedService AwardAAI Excellence inMentoring AwardPresented prior to Dr. Boss’sPresident’s AddressPresented at theBusiness MeetingPresented prior to Dr. Boss’sPresident’s SymposiumRecognizes a member for acareer of extraordinary scientificachievement and exceptionalleadership and service to AAIRecognizes a member for outstandingservice to the AAI community and thefield of immunologyRecognizes a member for exemplarycareer contributions to a futuregeneration of scientistsJuan Carlos Zúñiga-PflückerUniv. of Toronto and SunnybrookRes. Inst., CanadaJeffrey A. BluestoneUniv. of California, San Francisco,and Sonoma BiotherapeuticsMarc K. JenkinsUniv. of Minnesota Ctr.for Immunology4 CALL FOR ABSTRACTSWWW.IMMUNOLOGY2021.ORG

AAI-BD Biosciences InvestigatorAward Presentation and LectureAAI-BioLegend HerzenbergAward Presentation and LectureRecognizes an early-career investigator who has madeoutstanding contributions to the field of immunologyRecognizes an individual who has made exemplaryresearch contributions to the field of B cell biologyErika L. PearceMax Planck Inst. of Immunobiology andEpigenetics, Germany; Bloomberg-Kimmel Inst.for Cancer Immunotherapy, Johns Hopkins Univ.(as of January 1, 2021)Metabolic regulation of T cell functionAAI-Thermo Fisher Meritorious CareerAward Presentation and LectureRecognizes a mid-career scientist for outstandingresearch contributions to the field of immunologyAlexander Y. RudenskyHHMI, Mem. Sloan Kettering Cancer Ctr.,Rockefeller Univ., and Weill Cornell Med.The virtue of restraint in adaptive immunity5 CALL FOR ABSTRACTSSusan K. PierceNIAID, NIHRegulators and influencers of B cell affinityAAI-Steinman Award for HumanImmunology ResearchPresentation and LectureRecognizes an individual who has made significantcontributions to the understanding of immuneprocesses underlying human disease pathogenesis,prevention, and therapiesMichael J. LenardoNIAID, NIHIdentification of novel gene defects leads to precisiontherapies for congenital immune diseasesWWW.IMMUNOLOGY2021.ORG

MAJOR SYMPOSIAMajor Symposium AMajor Symposium CModern World Influences of theMicrobiome and their Consequences forImmune-Mediated DiseasesImmunological Angle of the Brain and its DiseasesChairsCathryn Nagler, Univ. of ChicagoBarbara Rehermann, NIDDK, NIHSpeakersBarbara Rehermann, NIDDK, NIHNatural vs. laboratory world: wild mouse microbiotaimprove host fitness and preclinical modelsNoah Palm, Yale Univ.Illuminating the ‘dark matter’ of the bioactivemicrobiota metabolomeJune L. Round, Univ. of UtahMicrobe-immune interactions prevent obesityCathryn Nagler, Univ. of ChicagoIntestinal bacteria regulate allergic responses to foodChairsJonathan Kipnis, Washington Univ., St. LouisZsuzsanna Fabry, Univ. of Wisconsin Sch. of Med.SpeakersZsuzsanna Fabry, Univ. of Wisconsin Sch. of Med.Dendritic cells link neuroinflammation andlymphangiogenesis in the brainAntoine Louveau, Lerner Res. Inst.Regulation of brain maturation by the meningeallymphatic vasculatureIsaac M. Chiu, Harvard Univ.Role of neuro-immune interactions in bacterial host defenseAshley Moseman, Duke Univ. Sch. of Med.Coordinating CNS host defense following olfactoryneuroinvasionNeil Surana, Duke Univ.Microbiome engineering to treat inflammatory diseasesStanley Perlman, Univ. of IowaCoronavirus infections of the CNS and immunologicalresponsesMajor Symposium BBeth Stevens, Boston Children’s Hosp.Mapping microglia states to function in health and diseaseHost Immunity to Intracellular PathogensChairsPhillip A. Scott, Univ. of Pennsylvania Sch. of Vet. MedShabaana Khader, Washington Univ., St. LouisSpeakersPhillip A. Scott, Univ. of Pennsylvania Sch. of Vet. Med.Pathways promoting pathology: how CD8 T cell cytolysisinfluences disease outcome in cutaneous leishmaniasisMajor Symposium DInnate Immunity: The Good, The Bad, The UglyChairsClara Abraham, Yale Univ.Katherine A. Fitzgerald, Univ. of Massachusetts Med. Sch.Shabaana A. Khader, Washington Univ., St. LouisRole of innate lymphoid cells in tuberculosisSpeakersClara Abraham, Yale Univ.Modulation of innate immune responses by diseaseassociated genesJohn T. Harty, Univ. of IowaT cell immunity in tissuesKatherine A. Fitzgerald, Univ. of Massachusetts Med. Sch.Regulation of inflammation by nucleic acid-binding proteinsManuela Raffatellu, Univ. of California, San DiegoMucosal immunity to SalmonellaDaniel B. Stetson, Univ. of WashingtonInnate immune detection of intracellular DNAMelissa B. Lodoen, Univ. of California, IrvineInnate immunity and pathogenesis in the vasculatureduring Toxoplasma gondii infectionRaphaela T. Goldbach-Mansky, NIAID, NIHInnate immune dysregulation in autoinflammatory diseasesMaziar Divangahi, McGill Univ., CanadaHematopoietic stem cells: the target for vaccine or pathogen6 CALL FOR ABSTRACTSGregory F. Sonnenberg, Weill Cornell Med.Immune regulation of intestinal healthKodi S. Ravichandran, Univ. of VirginiaSoothing messages on the way out: apoptotic cellcommunication with the neighborhoodWWW.IMMUNOLOGY2021.ORG

Major Symposium EMajor Symposium GMolecular Mechanisms of Tumor ImmunityB Lineage Signals in Protective vs. MaladaptiveAntibody ResponsesChairsThomas F. Gajewski, Univ. of ChicagoLisa H. Butterfield, Parker Inst. for CancerImmunotherapySpeakersThomas F. Gajewski, Univ. of ChicagoMechanisms of cancer immunotherapy efficacy vs.resistanceLisa H. Butterfield, Parker Inst. for CancerImmunotherapyCancer vaccines and what does and doesn’t matterWeiping Zou, Univ. of MichiganMetabolic impact on cancer immunity and therapyJennifer A. Wargo, Univ. of Texas MD AndersonCancer Ctr.The role of the microbiome in response and toxicity to therapyArlene H. Sharpe, Harvard Med. Sch.Discovery of new immuno-oncology targets leveragingCRISPRChairsMark R. Boothby, Vanderbilt Univ. Med. Ctr.Roberta Pelanda, Univ. of Colorado, DenverSpeakersRoberta Pelanda, Univ. of Colorado, DenverMolecular control of central B cell tolerance: is it one for all?Julie Zikherman, Univ. of California, San FranciscoNegative feedback regulation of normal andautoimmune B cell responses.João P. Pereira, Yale Univ.B cell circuits in homeostasis and diseasePamela L. Schwartzberg, NIAID, NIHModulation of B cell responses by PI3K-deltaMark R. Boothby, Vanderbilt Univ. Med. Ctr.Imag(in)ing a fusion of nutrients, metabolism, andfunction as B cells effect antibody responsesMichel C. Nussenzweig, HHMI, Rockefeller Univ.Human antibody responses to viral pathogensMajor Symposium FMajor Symposium HEngineering ImmunityStromal Cells Underpinning Immune CellDevelopment and FunctionChairsDennis Burton, Scripps Res.Benjamin A. Youngblood, St. Jude Children’s Res. Hosp.SpeakersDennis Burton, Scripps Res.Neutralizing antibodies, neutralization, and vaccinesChairsSusan R. Schwab, New York Univ. Grossman Sch. of Med.Juan Carlos Zúñiga-Pflücker, Univ. of Toronto andSunnybrook Res. Inst., CanadaLaura M. Walker, Adimab, LLCBroad and potent neutralizing antibodies to combatviral threatsSpeakersJuan Carlos Zúñiga-Pflücker, Univ. of Toronto andSunnybrook Res. Inst., CanadaThymus stromal cells are plasticDarrell J. Irvine, MITThe impact of vaccine kinetics on humoral immunityMark S. Anderson, Univ. of California, San FranciscoMaintenance of immune tolerance by thymic stromal cellsAlexander Marson, Univ. of California, San FranciscoReprogramming human T cells with CRISPRBurkhard Ludewig, Kantonsspital St. Gallen, SwitzerlandFibroblastic reticular cells: subsets and functionsBenjamin A. Youngblood, St. Jude Children’s Res. Hosp.Epigenetic reprogramming of CD8 T cell differentiationpotentialSusan R. Schwab, New York Univ. Grossman Sch. of Med.Exit strategies: S1P and immune cell migrationAnjana Rao, La Jolla Inst. for ImmunologyTranscriptional and epigenetic regulation in anti-tumorresponsesTheresa T.-S. Lu, Hosp. for Special Surgery Res. Inst.Langerhans cells and stromal regulation in lupusMelody A. Swartz, Univ. of ChicagoAntigen presentation by lymphatic endothelial cells andT cell memoryAll session information is subject to change.7 CALL FOR ABSTRACTSWWW.IMMUNOLOGY2021.ORG

SPECIAL SESSIONSAnthony S. FauciLinda J. SaifCOVID-19 and the Science of Pandemics—Lessons LearnedCo-ChairsDavid Masopust, Univ. of Minnesota, AAI ProgramCommittee ChairM. Michele Hogan, Executive Director, AAISpeakersAnthony S. Fauci, Director, NIAID, NIHLinda J. Saif, Distinguished University Professor,The Ohio State Univ.De’Broski R. HerbertAAI Vanguard LecturePresented by an AAI member selected by the MinorityAffairs Committee for their scientific achievement andexemplary career success.ChairTonya J. Webb, Univ. of Maryland Sch. of Med., AAIMinority Affairs Committee ChairSpeakerDe’Broski R. Herbert, Univ. of Pennsylvania Sch. ofVet. Med.IL-33 regulates the balance between inflammationand immunosuppressionGUEST SESSIONS(Past Participants)American Society for Reproductive Immunology (ASRI)Japanese Society for Immunology (JSI)The American Society of Transplantation (AST)Korean Association of Immunologists (KAI) andThe Association of Korean Immunologist in America(AKIA)The American Society of Tropical Medicine and Hygiene(ASTMH)Australasian Society for Immunology (ASI)Canadian Society for Immunology (CSI)Center for Scientific Review (CSR, NIH)Chinese Society for Immunology (CSI)Chinese Society of Immunology, Taiwan (CSIT)European Federation of Immunological Societies (EFIS)German Society for Immunology (DGfI)International Complement Society (ICS)The International Cytokine and Interferon Society (ICIS)International Society of Developmental andComparative Immunology (ISDCI)8 CALL FOR ABSTRACTSNational Institute of Allergy and Infectious Diseases(NIAID, NIH)National Institute of Environmental Health Sciences(NIEHS, NIH)National Institute on Aging (NIA, NIH)The Obesity Society (TOS)Society for Immunotherapy of Cancer (SITC)Society for Leukocyte Biology (SLB)Society for Mucosal Immunology (SMI)Society for Natural Immunity (SNI)WWW.IMMUNOLOGY2021.ORG

COMMITTEE-SPONSORED SESSIONS AND EVENTSAAI Committees host symposia, workshops, lectures, and events that address the most recent advances in theirspecialty areas of immunology research, as well as issues in public policy and career development.Clinical Immunology CommitteeTransforming the Study of Human Disease throughSystems ImmunologyChair: Jennifer Anolik, Univ. of Rochester Med. Ctr.Committee on Public AffairsThe U.S. COVID-19 Response: Successes, Failures, andOngoing ChallengesChair: Ross M. Kedl, Univ. of Colorado Anschutz Sch. of Med.Committee on the Status of Women andEducation CommitteeCareers in Science RoundtablesChair: Laura A. Solt, Scripps Res.Education Committee Careers in Biotech Panel DiscussionChair: H. Kiyomi Komori, Arena Pharmaceuticals Immunology Teaching Interest GroupChairs: Edith Porter, California State Univ., LosAngeles, and Michelle A. Swanson-Mungerson,Chicago Col. of Osteopathic Med., Midwestern Univ.Minority Affairs CommitteeChair: Tonya J. Webb, Univ. of Maryland Sch. of Med. Panel Discussion: Minority Scientists’ Experiences:Challenging and Overcoming Barriers to EnhancingDiversity and Career Advancement Careers Roundtables AAI Vanguard LectureProgram CommitteeBack to School: A Review of Four Fast-Moving FieldsChairs: David Masopust, Univ. of Minnesota; andKimberly S. Schluns, Univ. of Texas MD AndersonCancer Ctr.Publications CommitteeHow to Write a Scientific Paper, Respond to Reviews, andDisseminate Your FindingsChair: Eugene M. Oltz, The Ohio State Univ. Col. of Med.,Editor-in-Chief, The Journal of ImmunologyVeterinary Immunology CommitteeZoonotic Pandemics—Immune Factors Contributing toPathogenesis and ProtectionChair: Crystal L. Loving, Natl. Animal Dis. Ctr., ARS, USDAFor session details and presentations, visit www.IMMUNOLOGY2021.org/scientific-program.CAREER DEVELOPMENT OPPORTUNITIESIn addition to committee-sponsored sessions, Virtual IMMUNOLOGY2021 will provide the following careerdevelopment programs. AAI will also sponsor a Jobs Board during the meeting.How to Convert Your CV into a RésuméSpeaker: Derek Haseltine, Career Development Ctr.,Baylor Col. of Med.; Hertz Foundation (as of January 2021)Interviewing for a JobSpeaker: Derek Haseltine, Career Development Ctr.,Baylor Col. of Med.; Hertz Foundation (as of January 2021)9 CALL FOR ABSTRACTSNIH Grants Workshop: Demystifying theGrant Application Submission, Review,and Funding ProcessesChair: Tina McIntyre, CSR, NIHHow to Have a Successful Postdoctoral ExperienceSpeaker: Lori Conlan, Office of Postdoctoral Services, NIHWWW.IMMUNOLOGY2021.ORG

ABSTRACTSBLOCK SYMPOSIAAAI invites the submission of abstracts that reportunpublished data from research developments in allareas of immunology. Abstracts are welcome fromscientists in all sectors—academia, government,and industry. To submit an abstract, please go towww.IMMUNOLOGY2021.org/abstracts. All accepted abstracts will be presented in virtualposter sessions. Authors will be present to discuss research resultsduring assigned poster times. These times will beunopposed by other sessions. First authors of abstracts must register for the meetingin order to present their work. (Details to follow withacceptance notifications.) Submitting an abstract is not the same asregistering for the meeting. To register, pleasevisit www.IMMUNOLOGY2021.org/registrationby April 20, 2021.Abstract Submission . . . . . . . . . . . . . . . . . Now OpenAbstract Submission Closes . . . . . . . . .January 26, 2021Abstract Submission FeesAAI Member 80Nonmember 115Abstract submission fees are non-refundable. Please notethat registration fees are additional.IMPORTANTFor submission guidelines and detailson abstract topic categories, visitwww.IMMUNOLOGY2021.org/abstracts.PUBLICATION OF ABSTRACTSAll successfully presented abstractswill be published in a supplement toThe Journal of Immunology. Outstanding abstracts will be programmed for oralpresentation in Block Symposia. (Assigned times willbe provided with acceptance notifications.) First authors will be required to upload theirpresentations. (Further instructions will be providedwith acceptance notifications.) Authors presenting in Block Symposia must alsopresent a poster in a designated poster session.POSTERS Posters will be available for viewing throughoutthe meeting. All poster presenters will be required to upload a PDFof their poster. (Further instructions will be providedwith acceptance notifications.) All poster presenters will be required to pre-recordand upload a short presentation of their poster. Thisshould act like a guided presentation for attendeesas they view a poster. (Further instructions will beprovided with acceptance notifications.) All poster presenters will be required to beavailable for a live Q&A session during an assignedtime. (Assigned times will be provided withacceptance notifications.)Please note: AAI cannot prevent screenshots ofposters or the photography/recording of posterpresentations in a virtual environment.TRAINEEABSTRACT AWARDSHundreds of AAI members are eligible to receiveTrainee Abstract Awards each year! To be eligible forthese awards, individuals must be members of AAIat the time of abstract submission. Details aboutVirtual IMMUNOLOGY2021 awards can be foundat www.aai.org/Awards. Join AAI or renew yourmembership and submit your abstract byJanuary 26, 2021.To renew or become an AAI member, visitwww.aai.org/membership/join.10 CALL FOR ABSTRACTSWWW.IMMUNOLOGY2021.ORG

VIRTUALEXHIBIT HALLVIRTUALEXHIBITOR WORKSHOPSLeading scientific companies and organizations willshowcase their products and services. Attendees willbe able to visit booths and learn more through productvideos and resources, engage through Live Chat and/orscheduled appointments, and attend workshops.Take advantage of the knowledge-building opportunitiespresented in Virtual Exhibitor Workshops. Theseworkshops explore the newest technologies, products,and services through presentations, demonstrations,and discussions.Plan which exhibits you wish to visit and learn more byviewing the interactive Virtual Exhibit Hall atwww.IMMUNOLOGY2021.org/exhibitors.Workshops are planned and conducted by exhibitors.These sessions do not constitute endorsement of anyproduct or service by AAI.Virtual Exhibit Hall HoursPlease note that all times listed are U.S. Eastern Time.Tuesday, May 1110:30 AM–8:00 PM(Unopposed) 7:00 PM–8:00 PMWednesday, May 129:00 AM–6:30 PM(Unopposed) 9:00 AM–10:00 AMThursday, May 1310:30 AM–8:00 PM(Unopposed) 7:00 PM–8:00 PMFriday, May 149:00 AM–6:30 PM(Unopposed) 9:00 AM–10:00 AMSaturday, May 1510:30 AM–5:30 PM(Unopposed) 1:00 PM–2:00 PM11 CALL FOR ABSTRACTSMEET THE EXHIBITORS ONLINE!Visit www.IMMUNOLOGY2021.org/exhibitorsto learn about all the exciting newproducts and services you will see atVirtual IMMUNOLOGY2021 .JOBS BOARDPost OnlineAAI offers career services to job seekers and employersthrough the Jobs Board—free for registrants and exhibitors.Jobs Board submission information will be availableonline in February 2021.WWW.IMMUNOLOGY2021.ORG

REGISTRATIONRegistration Now OpenEarly Registration Deadline: April 20, 2021The registration fee covers access to all scientific events, posters, exhibits, social events, and archived scientificprogram. Visit www.IMMUNOLOGY2021.org/registration for complete details.REGISTRATION CATEGORIES AND FEESMEMBERS*NONMEMBERS*Take advantage ofreduced rates bybecoming a memberor renewing beforeregistering.EARLY REGISTRATIONDecember 1–April 20REGULAR REGISTRATIONAfter April 20Regular, Associate,and Postdoc 395 495Emeritus 250 250Young Professionals 150 175Graduate Student 80 115Undergrad Student 55 75 egular, Associate,Rand Postdoc 595 695Young Professionals 250** 450**Graduate Student 225** 450**Undergrad Student 225** 450**High School Teacher 55**High School Student 55**There is a special registration rate for scientists from developing countries. Please contact meetings@aai.org to register.Cancellation Fee*Registrants must be a member at the time ofregistration to qualify for the lowest rates. Registrantswho renew or become members after registering forthe meeting will not be refunded the difference inrates. Visit www.aai.org/membership to join or directinquiries to members@aai.org.**Contact meetings@aai.org to register.JOIN US ONLINE MAY 10–15, 2021,FOR MORE SCIENCE, MORETIME, YOUR WAY!Visit www.IMMUNOLOGY2021.orgto view the full program.12 CALL FOR ABSTRACTS 75 up untilApril 20, 2021No refunds afterApril 20, 2021IMPORTANT DATESAND DEADLINESAbstract SubmissionAbstract SubmissionAbstract Submission ClosesNow OpenJanuary 26, 2021Trainee Abstract AwardsApplication cycleApplication deadlineNow OpenJanuary 26, 2021RegistrationRegistrationEarly Registration Discount EndsNow OpenApril 20, 2021WWW.IMMUNOLOGY2021.ORG

American Society for Reproductive Immunology (ASRI) The American Society of Transplantation (AST) The American Society of Tropical Medicine and Hygiene (ASTMH) Australasian Society for Immunology (ASI) Canadian Society for Immunolo

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