6th Annual Medical Student Research Forum

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6th AnnualMedical Student Research ForumCelebrating the ResearchAccomplishments of our Medical StudentsMarch 13, 2021

Central Michigan University College of MedicineMount Pleasant, MichiganWelcome to the CMED 6th AnnualMedical Student Research Forum!The CMU College of Medicine Medical Student Research Forum serves toshowcase the impressive research that is performed by our undergraduatemedical students. This year we are excited to have received a total of thirtyone abstracts. These abstracts represent a broad spectrum of basic sciencedisciplines, medical disciplines, population health, and case studies, whichwere completed at research sites within our own university as well as otherinstitutions nationally. A committee of faculty and students selected eightabstracts to be highlighted as oral presentations to take place live as a virtualevent on March 13, 2021 from 10:00 am-12:30 pm. Oral presentations, inaddition to all abstracts with poster presentations can be searchForum.aspx. A recording of the oral presentations will be added to thiswebsite following the live event. Thank you to our faculty, staff, andstudents who helped organize this forum, and to the student trainees andtheir mentors who have done so much to advance the research mission ofour institution. We are incredibly proud of our student investigators, andwe are delighted that this forum will give them the spotlight that theydeserve.

CMED Medical Student Research Forum 2021AcknowledgementsFaculty OrganizersEdward McKee, PhDSenior Associate Dean, ResearchCentral Michigan University College of MedicineMichael J. Conway, PhDAssociate ProfessorCentral Michigan University College of MedicineNeli Ragina, PhDAssociate Professor and Director Students and Residents Clinical ResearchCentral Michigan University College of MedicineAssociate Meeting OrganizersMelanie ZalewskiAdministrative SecretaryCentral Michigan University College of MedicineAngela StillwagonExecutive Office SpecialistCentral Michigan University College of MedicineMichael MolterAssociate Director Healthcare IT OperationsCentral Michigan University College of MedicineJudging PanelistsOral Presentations:Rosemary Poku, PhDAssistant Professor, Central Michigan University College of MedicineSethu Reddy, MDProfessor and Chair Discipline of Medicine Central Michigan University College of MedicineTina Thompson, PhDSenior Associate Dean of Academic Affairs, Central Michigan University College of Medicine

CMED Medical Student Research Forum 2021AcknowledgementsJudging Panelists (continued)Poster Presentations:Sanjay BalijepalliMedical Student, Central Michigan University College of MedicineMichael J. Conway, PhDAssociate Professor, Central Michigan University College of MedicineUtibe Effiong, MD, MPHPhysician, MidMichigan HealthMichael Elftman, PhDAssistant Professor, Central Michigan University College of MedicineUte Hochgeschwender, MDProfessor, Central Michigan University College of MedicineRasha JawadMedical Student, Central Michigan University College of MedicineGabrielle KennelleyMedical Student, Central Michigan University College of MedicineD. Stave Kohtz, PhDProfessor, Central Michigan University College of MedicineRobert Petersen, PhDProfessor, Central Michigan University College of MedicineNeli Ragina, PhDAssociate Professor and Director Students and Residents Clinical Research, Central MichiganUniversity College of MedicineJulien Rossignol, PhDAssociate Professor, Central Michigan University College of MedicineStephen Zyzanski, PhDEmeritus Professor of Family Medicine, Case Western Reserve University

Oral and PosterPresentationsSorted alphabetically by Submitting Author. Use email links to reach out with questions.

CMED Medical Student Research Forum 2021Saturday, March 13, 202110:00 am-12:30 pmSchedule of Live Oral Presentations10:00 am – 10:05 pmOpening Remarks – Dr. Edward McKee, Senior Associate Dean for ResearchModerator – Dr. MJ Conway, PhD10:05 am – 10:20 amAn Assessment of COVID-19 Misinformation Among Patients in Rural Michigan presented byVivian Wang and Samantha Liu (Chin-I Cheng, PhD and Neli Ragina, PhD, Mentors)10:20 am – 10:35 amTeaching End-of-Life Preparations to African American Patients presented by Megan Reillyand Michael Mastrogiovanni (Delicia Pruitt, MD and Neli Ragina, PhD, Mentors)10:35 am – 10:50 amLipid Gene Regulation and Metabolism Is Altered in Diabetic Retinopathy presented by EhsenAbdul-Kabir (Patrice E. Fort, Mentor)10:50 am – 11:05 amImpact of in Utero Marijuana Exposure on Newborn Outcomes: How Timing of Use AffectsGrowth presented by Haley Kopkau (Dr. Beth Bailey, Mentor)Moderator – Dr. Neli Ragina, PhD11:05 am – 11:20 amCMU-CARES: Crisis Preparedness Toolkit for Rural Older Adults Using a Modified DelphiAnalysis presented by Brenda Maricela Varriano (Dr. Jyotsna Pandey, Mentor)11:20 am – 11:35 amBioconjugation of Anti-EAAT1 Antibody with PAMAM Dendrimers Using Copper Free ClickChemistry presented by Bradley Miller (Dr. Ajit Sharma and Dr. Julien Rossignol, Mentors)11:35 am – 11:50 amThe Difference in Mortality Rates in Urban Versus Rural Counties of Michigan presented byMichael Mastrogiovanni and Gabriel Swenson (Dr. Beth Bailey, Mentor)11:50 am – 12:05 pmThe Role of Socioeconomic Status and Life Stressors in Postpartum Depression: A crosssectional analysis using the PRAMS database presented by Molly Stanford and BrendaVarriano (Dr. Beth Bailey, Mentor)12:10 am – 12:30 pmClosing Remarks and Awards – Dr. MJ Conway, PhD

CMED Medical Student Research Forum 2021Oral and Poster Presentations(Sorted alphabetically by Submitting Author. Use email links to reach out with questions.)Author(s)Abstract TitleMentor(s)Patrice E. FortAbstractNumber3PageNumber9Ehsen Abdul-KabirLipid Gene Regulation And Metabolism Is Altered InDiabetic RetinopathyHaley Kopkau, Katherine Nadolski,Phoebe Dodge, Kaya Forrestal, VictoriaZablocki, Beth BaileyImpact of in Utero Marijuana Exposure on NewbornOutcomes: How Timing of Use Affects GrowthDr. Beth Bailey410Bradley Miller1,2,3., Gretchen Holtgrefe4.,Abhiraami Kannan-Sundhari1,2,5., BhairaviSrinageshwar1,2,3., Gary Dunbar1,2,5,6., AjitSharma4*., Julien Rossignol1,2,3*Bioconjugation of Anti-EAAT1 Antibody withPAMAM Dendrimers Using Copper Free ClickChemistryDr Ajit Sharma, Dr JulienRossignol611Teaching End-of-Life Preparations to AfricanAmerican PatientsDelicia Pruitt, MD, NeliRagina, MD212Affiliations:1 College of Medicine, Central Michigan University, MountPleasant, MI 48859, USA.2 Program in Neuroscience, Central Michigan University,Mount Pleasant, MI 48859, USA.3 Field Neurosciences Institute Laboratory for RestorativeNeurology, Central Michigan University, Mt. Pleasant, MI48859, USA4 Department of Chemistry and Biochemistry, CentralMichigan University, Mount Pleasant, MI 48859, USA.5 Department of Psychology, Central Michigan University,Mount Pleasant, MI 48859, USA.6 Field Neurosciences Institute, St. Mary's of Michigan,Saginaw, MI 48604, USADelicia Pruitt, MD, Neli Ragina, MD,Megan Reilly, Michael Mastrogiovanni

CMED Medical Student Research Forum 2021Oral and Poster Presentations(Sorted alphabetically by Submitting Author. Use email links to reach out with questions.)Author(s)Abstract TitleMentor(s)Molly Stanford, Hannah Hyaduck, BrendaVarriano, Joseph Fullmer, AhmadKhasawneh, David J. Miller, Ruoxi LuThe Role of Socioeconomic Status and Life Stressorsin Postpartum Depression: A cross-sectional analysisusing the PRAMS databaseBeth BaileyVarriano BM, Beatty A, Ragina N, Lu R,Long JL, Dickinson AM, Mouzoon RL,Pandey JCMU-CARES: Crisis Preparedness Toolkit for RuralOlder Adults Using a Modified Delphi AnalysisMegan Reilly, Haley Kopkau, Ehsen Abdul- The Difference in Mortality Rates in Urban VersusKabir, Michael Mastrogiovanni, JoshuaRural Counties of MichiganRichmond, Gabriel Swenson, Cody Hall,Alexis VicenziVivian Wang, Samantha Liu, Renee FullerMD, Chin-I Cheng PhD, Neli Ragina PhDAn Assessment of COVID-19 Misinformation AmongPatients in Rural MichiganAbstractNumber8PageNumber13Dr. Jyotsna Pandey514Dr. Bailey715Dr. Neli Ragina; Dr.Cheng116

Abstract #3Ehsen Abdul-Kabir, Submitting AuthorAbstract Title:Lipid Gene Regulation And Metabolism Is Altered In Diabetic RetinopathyAuthor(s):Ehsen Abdul-KabirAffiliation:Central Michigan University;University of Michigan;Abstract Category: Basic & Translational ScienceMentor(s): Patrice E. FortBackground: Diabetic Retinopathy (DR) is characterized clinically by microvascular damage to retinal vesselsleading to vision loss and ultimately blindness. Much research on disease progression of DR to date hasfocused on aberrant glucose metabolism. However, we employed a transcriptomic and lipidomic approachto analyze modification of lipid encoding genes in retinal tissue in diabetic donors with and without DR, aswell as nondiabetic retinas.Methods: Tissue samples were dissected from three areas of the retina: peripheral retina (PR), central retina(CR), and macula (MAC). Among several genes affected by DR were GBA (which encodes betaglucocerebrosidase) and DEGS1 (which encodes delta[4]-desaturase). These genes are involved withmetabolism and synthesis of ceramide, respectively, a lipid molecule shown to have apoptotic effects in theretina and CNS.Results: GBA expression was increased in the CR and MAC in diabetic samples with and without DRcompared to non-diabetic samples. In the PR, DR samples showed increased expression of GBA compared todiabetic and non-diabetic samples. We also found that DEGS1 expression was increased in PR but decreasedin CR samples with DR compared to diabetic and non-diabetic samples. Interestingly, subsequent lipidomicanalysis showed varying levels of ceramides depending on disease progression. Cer[EODS] and Cer[NS] weretwo ceramide species that were significantly increased in the retina of DR samples compared to nondiabetic and diabetic without DR samples. Higher levels of both were found in the CR and PR.Conclusion: These results show clear alterations of lipid metabolism in DR. While this study is preliminary,our next steps are to complement this study by further investigating the mechanisms of different lipidproducts and pathways.

Abstract #4Haley Kopkau, Submitting AuthorAbstract Title:Impact of in Utero Marijuana Exposure on Newborn Outcomes: How Timing of UseAffects GrowthAuthor(s):Haley Kopkau, Katherine Nadolski, Phoebe Dodge, Kaya Forrestal, VictoriaZablocki, Beth BaileyAffiliation:Central Michigan University;Abstract Category: Population Health/Quality Improvement/Clinical Mentor(s): Dr. Beth BaileyBackground: Findings are mixed on whether prenatal marijuana exposure is linked to birth outcomes, withinconsistencies potentially linked to failure to consider exposure timing. With recent legalization, marijuanause in pregnancy is more prevalent, increasing the need for research.Objective: The goal was to examine if in utero marijuana exposure predicts birth outcomes and whethertiming of exposure plays a role.Methods: Electronic health records at an academic obstetric practice identified eligible pregnant women.Study groups included 100 randomly-selected controls with no self-reported or biochemically-verifiedsubstance use and 66 with marijuana use only. Marijuana users were divided between exposure only 14weeks (n 26) and throughout pregnancy (n 40). Records were manually reviewed for study variablesincluding birth weight, length, and head circumference percentiles for gestational age.Results: Marijuana users were more likely than non-users to be younger, unmarried, have no education pasthigh school, have Medicaid/no insurance, and have a greater gestational age at delivery. After controllingfor these differences, marijuana exposure throughout gestation significantly predicted decreased birthweight, length, and head circumference. Early exposure predicted decreased head circumference but to alesser degree. Marijuana exposure was unrelated to other outcomes (length of newborn hospital stay, NICUadmission, Apgar scores).Conclusions: Exposure to marijuana throughout pregnancy predicted significant fetal growth, while onlyearly exposure predicted smaller deficits and only for head circumference.Significance: Marijuana use throughout pregnancy may predict newborn size, but not other markers ofnewborn health. With marijuana legalization, investigation of effects of gestational exposure is increasinglyimportant. Findings may inform advice to patients, recognizing that even with early exposure, quittingmarijuana use later in pregnancy will have benefits.

Abstract #6Bradley Miller, Submitting AuthorAbstract Title:Bioconjugation of Anti-EAAT1 Antibody with PAMAM Dendrimers Using Copper FreeClick ChemistryAuthor(s):Bradley Miller, Gretchen Holtgrefe, Abhiraami Kannan-Sundhari, BhairaviSrinageshwar, Gary Dunbar, Ajit Sharma, Julien RossignolAffiliation:Central Michigan University;Abstract Category: Basic & Translational ScienceMentor(s): Dr Ajit Sharma, DrJulien RossignolBackground:Drug delivery to the brain faces many barriers, including the blood brain-barrier (BBB), target specificity, andtoxicity. Polyamidoamine (PAMAM) dendrimers are a promising drug/biomolecule delivery vehicle. Mixedsurface G4 90/10 [OH/NH2] dendrimers are less toxic than amine-surface dendrimers and can cross the BBB.Dendrimer specificity toward astrocytes has been sought for treating brain pathologies involvinginflammation. Delivering biomolecules/drugs to astrocytes specifically would allow for altering cellcomposition during stroke recovery or in brain cancer (glioblastoma). Previous studies have shown thatexcitatory amino acid transporter 1 (EAAT1) is an astrocyte-specific surface transporter that is upregulated incertain disease states, such as in glioblastoma cells. Therefore, as a proof-of-concept we have designed ananti-EAAT1 antibodies conjugated to our dendrimers (d-Ab) to target astrocytes in vitro.Objective:To achieve specificity of G4-70/30 dendrimers through bioconjugation with anti-EAAT1 antibodies to allowastrocyte-specific targeting in vitro in a neuron-astrocyte culture.Methods:G4-70/30 PAMAM dendrimers were obtained from Dr Ajit Sharma, Department of Chemistry andBiochemistry, CMU. G4-70/30 dendrimers were conjugated to anti-EAAT1 antibodies through a strainpromoted azide-alkyne cycloaddition (SPAAC). FITC was added to the D-Ab to create a D-Ab-FITC complex.Optimization of the SPAAC was performed at different time-points (30min, 60min, 120min, and 8hr) and atantibody:dendrimer ratios (1:9, 1:3, and 1:1.1). SDS-PAGE and nanodrop assays were used to confirmsuccessful bioconjugation of SPAAC and FITC.Results:SDS-PAGE shows D-Ab bands distinct from antibody bands showing successful bioconjugation of thedendrimers with the antibody. UV imaging shows FITC present in the D-Ab-FITC bands.Conclusions:Bioconjugation of cell-specific antibodies to mixed-surface dendrimers can be used to achieve astrocytespecific targeting of dendrimers with drugs/biomolecules in vitro and in vivo.Significance:To continue dendrimer-antibody research in vitro and in vivo and use of d-Ab may allow for delivery ofdrugs to astrocytes for more precise therapeutic options.

Abstract #2Megan Reilly, Submitting AuthorAbstract Title:Teaching End-of-Life Preparations to African American PatientsAuthor(s):Delicia Pruitt, MD, Neli Ragina, MD, Megan Reilly, Michael MastrogiovanniAffiliation:Central Michigan University;CMEP;Abstract Category: Population Health/Quality Improvement/Clinical Mentor(s): Delicia Pruitt, MD,Neli Ragina, MDBackground: Barriers to appropriate end of life care (EOL) care in minority populations have been welldocumented. This is often the result of lack of knowledge as well as differences in beliefs between physicianand patient, and limited and/or poorly timed communication (1-3). In 2018, the Central Michigan MedicalEducation Partners (CMEP) conducted a pilot study investigating the effects of an educational interventionon knowledge, understanding, and consideration of EOL care. The study indicated that the educationalintervention led to a statistically significant (p 0.05) increases in knowledge and consideration of EOL care.Objective: The goal of this study was to determine if targeted intervention can be used to educate theelderly African American (AA) population on EOL prior to need for critical care. Continuation of the pilotstudy program is in progress and aims to expand sample size and reach out to more participants throughvirtual format due to COVID. This expanded study also aims to discern actual execution of enrolleesintentions.Methods: Level of preparation for EOL in the AA community was determined through survey format beforeand after educational intervention. Paired-sample t test was used to assess changes understanding of EOLoptions and regressions analysis was used to assess changes while including demographics.Results: The pilot data indicates understanding as well as consideration of palliative and hospice care weresignificantly increased post survey (P 0.05).Conclusions: The pilot study showed evidence that educational intervention increases understanding andconsideration of EOL care in this population. This may be a useful tool in AA communities to increaseacceptance and understanding of EOL care while also decreasing morbidity.Significance: Intended impact is to increase knowledge of EOL care in high risk groups prior to terminaldiagnosis or critical emergency.

Abstract #8Molly Stanford, Submitting AuthorAbstract Title:The Role of Socioeconomic Status and Life Stressors in Postpartum Depression: A crosssectional analysis using the PRAMS databaseAuthor(s):Molly Stanford, Hannah Hyaduck, Brenda Varriano, Joseph Fullmer, AhmadKhasawneh, David J. Miller, Ruoxi LuAffiliation:Central Michigan University;Abstract Category: Population Health/Quality Improvement/Clinical Mentor(s): Beth BaileyBackground: Postpartum depression (PPD) is a complex mood disorder affecting women in theperiod following childbirth. PPD is common and affects as many as 13% of women, though remains poorlyunderstood and goes undetected. Previous research suggests a role for socioeconomic status (SES) andother social factors in the development of PPD; however, the strongest predictors remain undetermined.Objective: To investigate the relationship between indicators of SES or social stressors and PPD.Methods: We used the Phase 8 Pregnancy Risk Assessment Monitoring System (PRAMS) Questionnaire (datafrom 2016 and 2018) for this cross-sectional secondary analysis. Linear-regression analysis was conducted toinvestigate (1) SES (education, rural/urban status etc.) and (2) social stressors (divorce, partner in jail etc.) asindicators of PPD. Statistics were completed with SPSS software.Results: 37,541 women met inclusion criteria for this study, including 3,090 (8.2%) who met internal criteriafor PPD. Lower levels of paternal education were significantly associated with an increased risk of PPD(p 0.001), maternal education was not. Social stressors including frequent arguing (p 0.001), inability topay bills (p 0.001), family illness (p 0.05), maternal unemployment (p 0.05), and drug use (p 0.001) wereall significantly associated with an increased risk of PPD. Pre-existing depression was the strongest predictorof PPD in our sample (β -0.253; p 0.001). Clinical factors such as diabetes mellitus and hypertension wereassociated with a reduced risk of PPD (p 0.001 and p 0.008, respectively).Conclusions: We found that various stressors such as frequent arguing; pre-existing depression; and lowlevels of paternal education were positively correlated with the development of PPD.Significance: PPD can have devastating effects on maternal and child health and early intervention mayreduce the impact of PPD. Our research identified targets that can be used to develop future screeningtechniques.

Abstract #5Brenda Varriano, Submitting AuthorAbstract Title:CMU-CARES: Crisis Preparedness Toolkit for Rural Older Adults Using a Modified DelphiAnalysisAuthor(s):Varriano BM, Beatty A, Ragina N, Lu R, Long JL, Dickinson AM, Mouzoon RL,Pandey JAffiliation:Central Michigan University;Abstract Category: Population Health/Quality Improvement/Clinical Mentor(s): Dr. Jyotsna PandeyBackground: The COVID-19 pandemic has challenged rural dispersed older adult (RDOA) uniquely. RDOAhave limited- finances, access to resources and additionally several health comorbidities. Crisis preparednessresources do not consider the vulnerabilities of RDOA. Thus, RDOA targeted resources are needed toaugment “crisis” preparedness.Objective: To develop an evidence-based “crisis” preparedness-toolkit that empowers RDOA self-relianceduring a disaster/crisis using their experiential knowledge from the COVID-19 crisis.Methods: Modified Delphi analysis (MDA) technique was employed due to its strength for qualitativeanalysis. 20 volunteer RDOA (age 65, and cognitively intact) participated in interviews based on WHOQuality of Life-BREF, using the “Empowerment Evaluation” model. Interviews determined hardships facedand level of preparedness for the pandemic. Interviews were recorded and analyzed using WebEx and NVivosoftware. Student panelists analyzed interview transcripts independently and as a group. A mediatoroversaw the process [JP]. Greater than 50% agreement was needed to “endorse” a theme.Results: Interviews revealed nine core-themes: Isolation and Interpersonal relationships, Impact/Concernsfor Others, Lifestyle Requirements, Medical Requirements, Technology Literacy, CommunityInvolvement/Fulfillment, Hobbies, Mood/Wellbeing and Information Gathering.Conclusions: MDA revealed the self-identified needs of RDOA; especially the importance of socializationduring crisis, which affects mental well-being. Additionally, access to reliable information supports mentalwell-being and helps RDOA navigate their community (how/when to access to food, healthcare etc.). Finally,training in technology can support digital socialization and allow for knowledge of crisis.Significance: No other research group has included RDOA in the design process of a crisis preparednesstoolkit. These self-identified needs will inform development of future crisis management resources. CMUCARES supports the mission of the College of Medicine to care for the rural underserved.

Abstract #7Alexis Vicenzi, Submitting AuthorAbstract Title:The Difference in Mortality Rates in Urban Versus Rural Counties of MichiganAuthor(s):Megan Reilly, Haley Kopkau, Ehsen Abdul-Kabir, Michael Mastrogiovanni, JoshuaRichmond, Gabriel Swenson, Cody Hall, Alexis VicenziAffiliation:Central Michigan University;Abstract Category: Population Health/Quality Improvement/Clinical Mentor(s): Dr. BaileyThe Difference in Mortality Rates in Urban Versus Rural Counties of MichiganMegan Reilly, Haley Kopkau, Ehsen Abdul-Kabir, Michael Mastrogiovanni, Joshua Richmond, GabrielSwenson, Cody Hall, Alexis VicenziCentral Michigan University College of MedicineBackground: There are numerous studies exploring healthcare discrepancies in rural vs urban areas aroundthe United States, but few in Michigan. Michigan’s diverse population, health challenges, and largeproportion of rural residents creates an ideal research setting.Objective: The goal was to determine whether there was a significant difference between all-cause andcause-specific mortality rates in rural and urban counties in Michigan and if the number of hospitals in thecounties played a role.Methods: Data was gathered from Michigan Department of Health and Human Services. Age-adjusted ratesfor the 11 most common causes of death from 2014-2018 were utilized. Counties were defined as urban orrural, as identified by the Michigan Department of Community Health, and grouped by the number ofhospitals they contained. Rural and urban county mortality rates were compared with two-tailedindependent samples t-tests in IBM SPSS Statistics 26. Mortality rates were compared to the number ofhospitals in each county using one-way ANOVA.Results: Independent samples T-test showed statistically significant increased death rate for cancer (P .015), chronic lower respiratory disease (CLRD) (P .016) and suicide (P .000) in rural vs urban counties.One-way ANOVA showed a significantly higher suicide death rate in counties with 0 hospitals compared tocounties with 2 hospitals (P .036).Conclusions: Rural Michigan counties showed significantly higher rates of mortality due to CLRD, cancer,and suicide compared to urban counties.Significance: With the majority of Michigan residents residing in rural counties, it’s important to investigatevariables affecting their healthcare. Findings may suggest avenues for public health efforts in Michigan andbeyond.

Abstract #1Vivian Wang, Submitting AuthorAbstract Title:An Assessment of COVID-19 Misinformation Among Patients in Rural MichiganAuthor(s):Vivian Wang, Samantha Liu, Renee Fuller MD, Chin-I Cheng PhD, Neli Ragina PhDAffiliation:Central Michigan University;MidMichigan Health;Abstract Category: Population Health/Quality Improvement/Clinical Mentor(s): Dr. Neli Ragina; Dr.Cheng.Purpose – Reducing the spread of misinformation is an important component of an effective public healthstrategy to combat COVID-19. Understanding where individuals learn of COVID-19 news, both substantiatedand unsubstantiated, can help identify potential drivers of misinformation and polarization of COVID-19 in acommunity. The prevalence and effect of misinformation in rural communities are not well studied. Thisstudy investigates current COVID-19 knowledge and practices, prevalence of misinformation regarding thevirus, and its potential sources in a rural community in Michigan, a state that has been a prime example ofthe threat and polarization of misinformation during the COVID-19 pandemic.Methods – Data was collected using a survey that gauges participant COVID-19 knowledge, perceptions andpublic health practices as well as their primary news sources. 258 patients were recruited as participants at aclinic in Gladwin, MI. Logistic regression was used to examine associations between variables.Findings – The most commonly reported news source was mainstream broadcast television channels likeCBS and FOX, but the most trusted news source was friends and family. 44.6% of participants reported thatthey would be somewhat or extremely unlikely to get a COVID-19 vaccine. Overall, older participants arebetter informed and are more likely to practice safe public health practices than younger participants. Thedata support that public health interventions in rural communities should be targeted toward youngerpeople and interventions beyond education should be considered.Conclusions – Although misinformation is prevalent in rural Michigan, the majority of the population wesurvey was well informed about safe public health practices and COVID-19 characteristics.

Poster OnlyPresentationsSorted alphabetically by Submitting Author. Use email links to reach out with questions.

CMED Medical Student Research Forum 2021Poster Only Presentations(Sorted alphabetically by Submitting Author. Use email links to reach out with questions.)Author(s)Abstract TitleMentor(s)AbstractPageNumber Number923Fadi AboonaCovid effects on AthletesDr. MansuriBartosek, Nathanial; Buttinger, Jessica;Christophel, Taylor; Hiltzik, David; Ilkka,Paul; Smith, Zach; Weingartz, Lucas;Cascio, ArielAssessing the Effect of Interventional Education onMedical Student and Physician Comfort andKnowledge Regarding LGBT Patients: ASystematic ReviewDr. Ariel Cascio, Ph.D.;Central MichiganUniversity College ofMedicineRebecca Renirie; MedicalLibrarian, CentralMichigan University1024Bartosek, N.C.; Gallo, K.; Srinageshwar, B;Gallien, J; Dunbar, G; Sharma, N; Bakke, J;Rossignol, JOptimizing PAMAM Dendrimer as a Vector forNovel Treatment of Glioblastoma in Vitro.Dr. Jesse BakkeDr. Julien Rossignol1125J. Buttinger., MBS, N. Ragina., PhD, B.Herold, MS, CRC., S. Jahanfar., PhD.Maternal Autoimmune Diseases and InflammatoryProcesses and Subsequent Risk of Autism SpectrumDisorder: A Systematic Review of the LiteratureDr. Ragina1226

CMED Medical Student Research Forum 2021Poster Only Presentations(Sorted alphabetically by Submitting Author. Use email links to reach out with questions.)Author(s)Abstract TitleMentor(s)Ryan C. Crane1, Steven Ojemann2,3, AvivaAbosch4, Drew S. Kern2,3, John A.Thompson2,3Interhemispheric Differences inElectrophysiological Profile of Basal GangliaStructures Between Staged Deep Brain StimulationSurgeries in Parkinson’s Disease PatientsJohn A. ThompsonZain El-amir, Dr. Asim KichlooVentilator-Associated Pneumonia—InpatientMortality and OutcomesHighlights from the National Inpatient Database2016-2017Dr. Asim Kichloo1428Cody Hall, M.S.The Role of miR-9/9* in Oxidative Metabolism ofOvarian Cancer Cells Grown as 3-DimensionalSpheroidsD. Stave Kohtz, PhD1529Samuel Borer; Jacob Horsley; NickolasKinachtchouk; Haley MaserAssociation Between Sleep Duration andBeth Bailey, PhDCardiovascular Health Among US Adults -- NHANES16301: College of Medicine, Central Michigan University, MountPleasant, MI, USA2: Department of Neurosurgery, University of ColoradoAnschutz Medical Campus, Aurora, CO, USA3: Department of Neurology, University of Colorado AnschutzMedical Campus, Aurora, CO, USA4: Department of Neurosurgery, University of Nebraska MedicalCenter, Omaha, NE 68198AbstractPageNumber Number1327

CMED Medical Student Research Forum 2021Poster Only Presentations(Sorted alphabetically by Submitting Author. Use email links to reach out with questions.)Author(s)Abstract TitleMentor(s)AbstractPageNumber Number1731Rasha Jawad and Richard D. McCabe, Ph.D.Teaching Cardiovascular Response of ExerciseUsing an Integrated Model of The CardiovascularSystemRichard D. McCabe, Ph.D.Erin

Abstract Category: Basic & Translational Science Mentor(s): Patrice E. Fort Background: Diabetic Retinopathy (DR) is characterized clinically by microvascular damage to retinal vessels leading to vision loss and ultimately blindness. Much research on disease progression of DR

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