Flow Chemistry Publications - Vapourtec
Flow Chemistry PublicationsThe following (non-exhaustive) list of papers shows peer reviewed work that has been published using the Vapourtec RSeries and E-Series flow chemistry systems. As new work is continually published, please check on our website for updates.C(sp3)–H functionalizations of light hydrocarbons using decatungstate photocatalysis in flowGabriele Laudadio1*, Yuchao Deng1,2,3,*, Klaas van der Wal1, Davide Ravelli4, Manuel Nuño5, Maurizio Fagnoni4, DuncanGuthrie5, Yuhan Sun2,3, Timothy Noël1,†1Micro Flow Chemistry and Synthetic Methodology, Department of Chemical Engineering and Chemistry, EindhovenUniversity of Technology, Eindhoven, Netherlands.2School of Physical Science and Technology, ShanghaiTech University, Shanghai 201210, P. R. China.3Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai 201210, P. R. China.4PhotoGreen Lab, Department of Chemistry, University of Pavia, Pavia 27100, Italy.5Vapourtec, Fornham St Genevieve, Bury St Edmunds, Suffolk IP28 6TS, /92Preparation of Diorganomagnesium Reagents by Halogen–Lithium Exchange of Functionalized Heteroaryl Halides andSubsequent in situ Trapping with MgCl2·LiCl in Continuous FlowRodolfo Hideki Vicente Nishimuraa, Niels Weidmannb, Paul Knochel baColegiado de Ciências Farmacêuticas, Universidade Federal do Vale do São Francisco, Avenue José de Sá Maniçoba,Petrolina, 56304-205 Petrolina, BrazilbLudwig-Maximilians-Universität München, Department Chemie, Butenandtstraße 5–13, 81377 München, urnals/abstract/10.1055/s-0040-1707167Process of Manufacturing Surfactants and LubricantsInventors: Raghuraman, Arjun (Pearland, TX, US), Heath, William H. (Lake Jackson, TX, US), Hook, Bruce D. (Lake Jackson, TX,US), Yu, Wanglin (Pearland, TX, US), Mukhopadhyay, Sukrit (Midland, MI, US), Spinney, Heather A. (Midland, MI, US), Wilson,David R. (Midland, MI, US), Notestein, Justin M. (Evanston, IL, US), Nguyen, Sonbinh T. (Evanston, IL, US)aEcoSynth,Industrielaan 12, 9800 Deinze, BelgiumAssingnees: Dow Global Technologies LLC (Midland, MI, US), Northwestern University (Evanston, IL, htmlDisposable cartridge concept for the on-demand synthesis of turbo Grignards, Knochel–Hauser amides, and magnesiumalkoxidesMateo Berton1, Kevin Sheehan2, Andrea Adamo2, D. Tyler McQuade11Department of Chemical and Life Sciences Engineering, Virginia Commonwealth University, Biotech Eight, 737 N. 5th St., Box980100, Richmond, VA 23219, USA2Zaiput Flow Technologies, 300 2nd Avenue, Waltham, MA 02451, s/16/115Flow Chemistry System for Carbohydrate Analysis by Rapid Labeling of Saccharides after Glycan HydrolysisWei-Ting Hung1, Yi-Ting Chen1, Chung-Hsuan Chen1, Yuan Chuan Lee2, Jim-Min Fang1, 3, Wen-Bin Yang11The Genomics Research Center, Academia Sinica, Taipei2Department of Biology, Johns Hopkins University, Baltimore, MD, USA3Department of Chemistry, National Taiwan University, 7/2472630320924620Continuous-Flow Approach for the Multi-Gram Scale Synthesis of C2-Alkyl- or β-Amino Functionalized 1,3-DicarbonylDerivatives and Ondansetron Drug Using 1,3-DicarbonylsNirmala Mohant, Krishna Nair, Dasharath Vishambar Sutar, Boopathy Gnanaprakasam*Flow Chemistry Publications-1-www.vapourtec.co.uk/publications
Department of Chemistry, Indian Institute of Science Education and Research (IISER) Pune, Dr. Homi Bhabha Road, Pune411008, Maharashtra, tion of Mono- and Diisocyanates in Flow from Renewable Carboxylic AcidsMichael D. Burkar1, Thien An Phung Hai1, Laurent J. S. De Backer2, Nicholas D. P. Cosford21Department of Chemistry and Biochemistry and The California Center for Algae Biotechnology, University of California, SanDiego, La Jolla, California 92093-0358, United States2Cancer Metabolism & Signaling Networks Program, NCI-Designated Cancer Center, Sanford Burnham Prebys MedicalDiscovery Institute, La Jolla, California 92037, United rd.0c00167Accelerating Electrochemical Synthesis through Automated Flow: Efficient Synthesis of ChalcogenophosphitesNasser Amri, Thomas Wirth*School of Chemistry, Cardiff University, Park Place, Cardiff, CF10 3AT, /abstract/10.1055/s-0040-1707141Rearrangement of 3-Hydroxyazetidines into 2-OxazolinesIan R. Baxendale1, Michele Ruggeri1, Amanda W. Dombrowski2, Stevan W. Djuric31Department of Chemistry, University of Durham, Durham DH1 3LE, United Kingdom2Discovery Chemistry and Technology AbbVie Inc., North Chicago, Illinois 60064, United States3Discovery Chemistry and Technology Consulting LLC, New Bern, North Carolina 28562, United .0c00656Selective DIBAL‑H Monoreduction of a Diester Using Continuous Flow Chemistry: From Benchtop to Kilo LabNick Uhlig1, Andrew Martins1, Detian Gao21Process Development, Gilead Alberta ULC, Edmonton, Alberta T6S 1A1, Canada2Commercial API Process Optimization, Gilead Alberta ULC, Edmonton, Alberta T6S 1A1, d.0c00158Flow Reactor Synthesis of Bio-Based Polyol from Soybean Oil for the Production of Rigid Polyurethane FoamKai Guo1, Zheng Fang2, Wei He2, Peng Kang3, Jingying Hao4, Hao Wu2, Yuchen Zhu51College of Biotechnology and Pharmaceutical Engineering and State Key Laboratory of Materials-Oriented ChemicalEngineering, Nanjing Tech University, Nanjing 211816, China2College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing 211816, China3SINOPEC Beijing Research Institute of Chemical Industry, Beijing 100013, China4The Research Institute of SINOPEC Co., Ltd, Tianjin Branch, Tianjin 10000, China5School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing 211816, r.0c01175Ir/Ni Photoredox Dual Catalysis with Heterogeneous Base Enabled by an Oscillatory Plug Flow PhotoreactorWouter Debrouwer,a*, Wim Kimpea, Ruben Dangreau,a, Kevin Huvaere,a, Hannes P.L. Gemoets,b, Milad Mottaghi,c, SimonKuhn,c, Koen Van AkenabaEcoSynth, Industrielaan 12, 9800 Deinze, BelgiumbCreaflow, Industrielaan 12, 9800 Deinze, BelgiumcDepartment of Chemical Engineering, KU Leuven, Celestijnenlaan 200F, 3001, Leuven, rd.0c00150Visible Light Mediated N-Desulfonylation of N-Heterocycles using a Heteroleptic Copper (I) Complex as a PhotocatalystCameron J. Hunter, Michael J. Boyd, Gregory D. May, Robert Fimognari*Vertex Pharmaceuticals Incorporated, 50 Northern Avenue, Boston, Massachusetts 02210, United .0c00983Flow Chemistry Publications-2-www.vapourtec.co.uk/publications
A Flow Process Built upon a Batch Foundation—Preparation of a Key Amino Alcohol Intermediate via MultistageContinuous SynthesisJohn Jin Lim,*,†, Kenneth Arrington,*,†, Anna L. Dunn,†, David C. Leitch,‡,†, Ian Andrews,†, Neil R. Curtis,§, Mark J. Hughes,§,Daniel R. Tray,§, Charles E. Wade,§, Matthew P. Whiting,§, Charles Goss, , Yangmu Chloe Liu,§, Brian M. Roesch§†Chemical Development, API Chemistry, GlaxoSmithKline, Upper Providence, Pennsylvania 19426, United States‡Department of Chemistry, University of Victoria, Victoria, BC V8P 5C2, Canada§Chemical Development, API Chemistry, GlaxoSmithKline, Stevenage SG1 2NY, U.K. Chemical Development, Product and Process Engineering, GlaxoSmithKline, Upper Providence, Pennsylvania 19426, acs.oprd.9b00478Streamlined Synthesis of FluoroquinolonesGupton, Frank B. (Midlothian, VA, US) Tosso, Perrer N. (Glen Allen, VA, US)VIRGINIA COMMONWEALTH UNIVERSITY (Richmond, VA, htmlContinuous-Flow Accelerated Sulfation of Heparan Sulfate IntermediatesSaurabh Anand, Sandhya Mardhekar, Rakesh Raigawali, Nirmala Mohanta, Prashant Jain, Chethan D. Shanthamurthy &Boopathy Gnanaprakasam* & Raghavendra Kikkeri*Indian Institute of Science Education and Research, Dr. Homi Bhabha Road, Pune-411 008, ett.0c00878Development of a Large-Scale Cyanation Process Using Continuous Flow Chemistry en Route to the Synthesis ofRemdesivirTiago Vieira1*, Andrew C. Stevens1*, Andrei Chtchemelinine2, Detian Gao1, Pavel Badalov1, Lars Heumann21Gilead Alberta ULC, 1021 Hayter Road, Edmonton, Alberta T6S 1A1, Canada2Gilead Sciences, Inc. 333 Lakeside Drive, Foster City, California 94404, United d.0c00172Tropylium-promoted prenylation reactions of phenols in continuous flowKlaus Omoregbee1,2, Kevin N. H. Luc1, An H. Dinh1, Thanh Vinh Nguyen11School of Chemistry, University of New South Wales, Sydney, Australia2Department of Biology, Chemistry and Pharmacy, Freie Universität Berlin, Berlin, 41981-020-00082-wMaking electrochemistry easily accessible to the synthetic chemistChristiane Schotten*a, Thomas P. Nichollsa, Richard A. Bourneb, Nikil Kapurc, Bao N. Nguyena, Charlotte E. Willans*aaSchool of Chemistry, University of Leeds, Leeds LS2 9JT, UK.bSchool of Chemical and Process Engineering, University of Leeds, Leeds LS2 9JT, UKcSchool of Mechanical Engineering, University of Leeds, Leeds LS2 9JT, /gc/d0gc01247eScale-up and Optimization of a Continuous Flow Synthesis of an α-Thio-β-chloroacrylamideOlga C. Dennehy1, Denis Lynch1, Stuart G. Collins1*, Anita R. Maguire2*, Humphrey A. Moynihan1*1School of Chemistry, Analytical and Biological Chemistry Research Facility, Synthesis and Solid State Pharmaceutical Centre,University College Cork, Cork T12 K8AF, Ireland.2School of Chemistry and School of Pharmacy, Analytical and Biological Chemistry Research Facility, Synthesis and Solid StatePharmaceutical Centre, University College Cork, Cork T12 K8AF, rd.0c00079Automated Glycan Assembly in a Variable-Bed Flow Reactor Provides Insights into Oligosaccharide–Resin InteractionsEric T. Sletten1, José Danglad-Flores1, Manuel Nuño2, Duncan Guthrie2 & Peter H. Seeberger11Department of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, Am Mühlenberg 1, 14476 Potsdam,Flow Chemistry Publications-3-www.vapourtec.co.uk/publications
Germany2Vapourtec, Ltd., Park Farm Business Centre, Fornham St. Genevieve, Bury St. Edmunds, Suffolk IP28 6TS, United rglett.0c01264Photocatalytic α‐Tertiary Amine Synthesis via C–H Alkylation of Unmasked Primary AminesAlison S. H. Rydera, William B. Cunninghamb, George Ballantyneb, Tom Mulesb, Anna G. Kinsellab, Jacob Turner-Doreb,Catherine M. Alderc, Lee J. Edwardsc, Blandine S. J. McKayc, Matthew N. Graysonb & Alexander J. Cresswellb*aCentre for Sustainable Chemical Technologies, 1 South, University of Bath, Claverton Down, Bath, BA2 7AY (UK)bDepartment of Chemistry, 1 South, University of Bath, Claverton Down, Bath, BA2 7AY (UK)cMedicines Design, GSK Medicines Research Centre, Gunnels Wood Rd, Stevenage, SG1 2NY 2/anie.202005294Electrochemistry in continuous systemsThomas P. Nicholls, Christiane Schotten & Charlotte E. WillansSchool of Chemistry, University of Leeds, Leeds, LS2 9JT, i/S2452223620300444Dynamic Crystallization Pathways of Polymorphic Pharmaceuticals Revealed in Segmented Flow with Inline Powder XRDMark Alan Levenstein1, 2, Lois E Wayment3, 4, 5, C. Daniel Scott3, 6, Ruth A Lunt3, 4, Pierre-Baptiste Flandrin3, Sarah Day5, ChiuTang5, Chick C. Wilson3, Fiona C. Meldrum2 & Nikil Kapur11School of Mechanical Engineering, University of Leeds, Woodhouse Lane, Leeds LS2 9JT, UK2School of Chemistry, University of Leeds, Woodhouse Lane, Leeds LS2 9JT, UK3Department of Chemistry, University of Bath, Claverton Down, Bath BA2 7AY, UK4CMAC Future Manufacturing Hub, University of Bath, Claverton Down, Bath BA2 7AY, UK5Diamond Light Source, Harwell Campus, Didcot, Oxfordshire OX11 0DE, UK6Centre for Sustainable Chemical Technologies, University of Bath, Claverton Down, Bath BA2 7AY, m.0c00860A Metallaphotoredox Method for the Expansion of Benzyl SAR on Electron-Deficient AminesMeghan D. Shea, Umar Faruk Mansoor & Brett A. Hopkins*Discovery Chemistry, Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United d.0c00109Management of the Heat of Reaction under Continuous Flow Conditions Using In-Line Monitoring TechnologiesMasahiro Hosoya, Shogo Nishijima & Noriyuki KuroseAPI R&D Laboratory, CMC R&D Division, Shionogi and Co., Ltd., 1-3, Kuise Terajima 2-chome, Amagasaki, Hyogo /acs.oprd.0c00109Use of Photon Equivalents as a Parameter for Scaling Photoredox Reactions in Flow: the translation of a photocatalytic C‐Ncross‐coupling from lab scale to multikilogram scaleEmily B. Corcoran*a, Jonathan P. McMullen*b, François Lévesqueb, Michael K. Wismerc, John R. NaberbaProcess Research & Development, Merck & Co., Inc., Boston, MA 02115 (USA)bProcess Research & Development, Merck & Co., Inc., Rahway, NJ 07065 (USA)cScientific Engineering & Design, Merck & Co., Inc., Kenilworth, NJ 07033 02/ange.201915412Disposable Cartridge Concept for On-Demand Synthesis of Turbo Grignards, Knochel-Hauser Amides and MagnesiumAlkoxidesMateo Berton1*, Kevin Sheehan2, Andrea Adamo2, Tyler McQuade1*1Department of Chemical and Life Sciences Engineering, Virginia Commonwealth University, Biotech Eight, 737 N. 5th St, Box980100, Richmond, VA 23219, USAFlow Chemistry Publications-4-www.vapourtec.co.uk/publications
Zaiput Flow Technologies, 300 2nd Avenue, Waltham, MA 02451, nts/202040A Flow Process Built upon a Batch Foundation—Preparation of a Key Amino Alcohol Intermediate via MultistageContinuous SynthesisJohn Jin Lim,*,†, Kenneth Arrington,*,†, Anna L. Dunn,†, David C. Leitch,‡,†, Ian Andrews,†, Neil R. Curtis,§, Mark J. Hughes,§,Daniel R. Tray,§, Charles E. Wade,§, Matthew P. Whiting,§, Charles Goss, , Yangmu Chloe Liu,§, Brian M. Roesch§†Chemical Development, API Chemistry, GlaxoSmithKline, Upper Providence, Pennsylvania 19426, United States‡Department of Chemistry, University of Victoria, Victoria, BC V8P 5C2, Canada§Chemical Development, API Chemistry, GlaxoSmithKline, Stevenage SG1 2NY, U.K. Chemical Development, Product and Process Engineering, GlaxoSmithKline, Upper Providence, Pennsylvania 19426, /acs.oprd.9b00478A Continuous Flow Sulfuryl Chloride Based Reaction – Synthesis of a Key Intermediate in a New Route TowardEmtricitabine and LamivudineJuliana M. de Souza, Mateo Berton, David R. Snead*, D. Tyler McQuadeDepartment of Chemical and Life Science Engineering, Virginia Commonwealth University, Richmond, VA, 23284-3068, 146Automated radial synthesis of organic moleculesSourav Chatterjee 1, Mara Guidi 1,2, Peter H. Seeberger 1,2 & Kerry Gilmore 11Department of Biomolecular Systems, Max-Planck-Institute of Colloids and Interfaces, Potsdam, Germany2Freie Universität Berlin, Institute of Chemistry and Biochemistry, Berlin, 2083-5An Enzymatic Flow-Based Preparative Route to VidarabineLucia Tamborini1, Clelia Previtali 1, Francesca Annunziata 1, Teodora Bavaro 2, Marco Terreni 2 , Enrica Calleri 2, FrancescaRinaldi 2, Andrea Pinto 3, Giovanna Speranza 4, Daniela Ubiali 2* & Paola Conti 11Department of Pharmaceutical Sciences, University of Milan, via Mangiagalli 25, 20133 Milano, Italy2Department of Drug Sciences, University of Pavia, viale Taramelli 12, 27100 Pavia, Italy3Department of Food, Environmental and Nutritional Sciences, University of Milan, via Celoria 2, 20133 Milano, Italy4Department of Chemistry, University of Milan, via Golgi 19, 20133 Milano, nuous-flow synthesis and application of polymer-supported BODIPY Photosensitisers for the generation of singletoxygen; process optimised by in-line NMR spectroscopyChristopher G. Thomson 1, Callum M. S. Jones 2, Georgina Rosair 1, David Ellis, Jose Marques-Hueso 2, Ai-Lan Lee 1 & FilipeVilela 11Institute of Chemical Sciences, School of Engineering and Physical Sciences, Heriot-Watt University, Edinburgh, Scotland,EH14 4AS, UK2Institute of Sensors, Signals and Systems, School of Engineering & Physical Sciences, Heriot-Watt University, Edinburgh,EH14 4AS, -019-00067-4Preparation of 5-Hydroxymethylfurfural from High Fructose Corn Syrup Using Organic Weak Acid in Situ as CatalystChangqu Lin, Hongli Wu, Junyi Wang, Jinsha Huang, Fei Cao*, Wei Zhuang*, Yanyu Lu, Jiao Chen, Honghua Jia, Pingkai OuyangCollege of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, 30 South Puzhu Road, Nanjing 211816, P.R. .9b06602Amino Alcohol Acrylonitriles as Activators of the Aryl hydrocarbon Receptor Pathway, An Unexpected MTT PhenotypicFlow Chemistry Publications-5-www.vapourtec.co.uk/publications
Screening OutcomeJennifer Baker1, Cecilia C Russel1, Jayne Gilbert2, Jennette Sakoff2, Adam McCluskey11The University of Newcastle, Department of Chemistry, University Drive, Callaghan, 2308 Newcastle, AUSTRALIA2Calvary Mater Hospital, Medical Oncology, Eidith Street, Waratah, 2308 Newcastle, 0.1002/cmdc.201900643Continuous flow aminolysis under high temperature and pressureBryan Li, Scott Bader, Steve M. Guinness, Sally Gut Ruggeri, Cheryl M. Hayward, Steve Hoagland, John Lucas, Ruizhi Li, DavidLimburg, J. Christopher McWilliams, Jeffrey Raggon & John Van AlstenWorldwide Research and Development, Pfizer Inc., Eastern Point Road, Groton, CT, 06340, USACelgene Corporation, 556 Morris Ave, Summit, NJ, USAWorldwide Research and Development, Pfizer Inc., Eastern Point Road, Groton, CT, 06340, USARhodes Technologies, 498 Washington Street, Coventry, RI, 1-019-00049-6Continuous Flow Photochemistry for the Preparation of Bioactive MoleculesMara Di Filippo, Cormac Bracken and Marcus Baumann *School of Chemistry, University College Dublin, Science Centre South, Belfield, Dublin 4, lopment of a Continuous Flow Photoisomerization Reaction Converting Isoxazoles into Diverse Oxazole ProductsCormac Bracken, Marcus Baumann*School of Chemistry, University College Dublin, Science Centre South, Belfield, Dublin 4, c.9b03399Continuous-Flow Biocatalytic Process for the Synthesis of the Best Stereoisomers of the Commercial Fragrances LeatherCyclohexanol (4-Isopropylcyclohexanol) and Woody Acetate (4-(Tert-Butyl)Cyclohexyl Acetate)Francesca Tentori 1,† , Elisabetta Brenna 1,2,* , Michele Crotti 1 , Giuseppe Pedrocchi-Fantoni 2 , Maria Chiara Ghezzi 1 andDavide Tessaro 11Dipartimento di Chimica, Materiali ed Ingegneria Chimica “Giulio Natta”, Politecnico di Milano, Via Mancinelli 7, 20131Milano, Italy2Istituto di Scienze e Tecnologie Chimiche – CNR, Via Mancinelli 7, 20131 Milano, e Light-Mediated (Hetero)aryl Amination Using Ni(II) Salts and Photoredox Catalysis in Flow: A Synthesis ofTetracaineBoyoung Y. Par
2School of Chemistry, University of Leeds, Woodhouse Lane, Leeds LS2 9JT, UK 3Department of Chemistry, University of Bath, Claverton Down, Bath BA2 7AY, UK 4CMAC Future Manufacturing Hub, University of Bath, Claverton Down, Bath BA2 7AY, UK 5Diamond Light Source, Harwell Campus, Didcot, Oxfordshire OX11 0DE, UK
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