NMDF211 Nutritional Biochemistry

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SUBJECT OUTLINESubject Name:Subject Code:Nutritional BiochemistryNMDF211SECTION 1 – GENERAL INFORMATIONAward/s:Total Course Credit Points:Level:Bachelor of Health Science (Naturopathy)1282nd YearBachelor of Health Science (Nutritional and Dietetic Medicine)962nd YearDuration:1 SemesterSubject is:CoreSubject Credit Points:2Student Workload:No. timetabled hours per week:3No. personal study hours per week:2Total hours per week:5Delivery Mode*: On campus Online / Digital Blended IntensiveWeekly Session Format/s - 1 session per week: Livestream lectures: 2 hours 3 hours1 x 3 hour lecture/tutorial per week*All modes are supported by the online learning management system which will include subject documents suchas handouts, readings, assessment guides and elearning support modules. A ‘session’ is made up of 3 hours of timetabled / online study time per week unless otherwise specified. Eachsubject has a set number of sessions as outlined above.Note: As they are aware, international students on a Student Visa (500) must attend livestream classes on theirlocal campus, using the Virtual Classrooms provided.Study Pattern: Full Time Part TimePre-requisites:BIOH122, NMDF121Co-requisites:NilSECTION 2 – ACADEMIC DETAILSSubject RationaleThis subject draws on students’ understanding of biochemistry and explores the biochemical activity of nutrientsand food constituents in the human body. Students gain an appreciation of the clinical relevance of nutritionalbiochemistry and the influence of dietary modification and nutritional intervention on physiology and physiologicaldysfunction. Essential biochemical pathways are explored in relation to the nutritional influences that modulatethose pathways. Students further develop their understanding of the role that biological oxidation and the metabolicrelease of energy plays in disease processes. Students learn about the influence of nutritional biochemistry in liverdetoxification, neurotransmitter synthesis, antioxidant pathways, immune and mitochondrial function. This subjectAustralian College of Natural Medicine Pty Ltd trading as Endeavour College of Natural Health, FIAFitnation (National CRICOS #00231G, RTO #31489)NMDF211 Nutritional BiochemistryLast modified: 11-Aug-2021Version: 21.0Page 1 of 6

deepens students’ understanding of nutrition and diet therapy while developing their investigative skills in a waythat will augment later nutritional medicine and clinical practicum subjects.Learning Outcomes1.Identify nutrient cofactors and enzymes and sequential stages in the biochemical absorption, transport,storage, and function of macro- and micro- nutrients in facilitating homeostatic status within the body.2.Explain components and relevance of microbiome and liver detoxification along with evidence-basedinvestigation into the inter-relationship between the nutrients, pathways and metabolites involved.3.Recall processes of inflammation and oxidation; function of antioxidants and the impact these can have ondeveloping physiological dysfunctions that translate into diseases.4.Discuss the importance of mitochondria and gene expression and their modulation through dietary / nutrientsupport with the strategic aim to prevent metabolic dysfunction.5.Recognise the implications of deficiency of nutrients necessary in the synthesis of eicosanoids andneurotransmitters.Assessment TasksTypeLearning OutcomesAssessedSession ContentDeliveredDueWeighting11-5Week 620%1-21-7Week 830%2-56 - 13FinalExaminationPeriod50%Case Study – Part AOnline quiz(30 minutes)Case Study – Part BReport(500 words)Final Written Exammultiple choice, shortanswer, and case studyquestions(1.5 hours)All written assessments and online quizzes are due at 11:55 p.m. Sunday and submitted through the LMSPrescribed Readings:1. Gropper, S. S., & Smith, J. L. (2018). Advanced nutrition and human metabolism (7th ed.). Wadsworth;Cengage Learning. [eBook available]Australian College of Natural Medicine Pty Ltd trading as Endeavour College of Natural Health, FIAFitnation (National CRICOS #00231G, RTO #31489)NMDF211 Nutritional BiochemistryLast modified: 11-Aug-2021Version: 21.0Page 2 of 6

Recommended Readings:1. Lord, R. S., & Bralley, J. A. (Eds.). (2008). Laboratory evaluations for integrative and functional medicine (2nded.). Metametrix Institute.2. Nelson, D. L., & Cox, M. M. (2016). Lehninger principles of biochemistry (7th ed., international ed.). W.H.Freeman.3. Pagana, K. D., & Pagana, T. J. (2018). Mosby’s manual of diagnostic and laboratory tests (6th ed.). Elsevier.[eBook available 5th ed.]4. Stipanuk, M. H., & Caudill, M. A. (2019). Biochemical, physiological, and molecular aspects of human nutrition(4th ed.). Elsevier.Subject ContentWeek1.LecturesPersonal Study ActivitiesIntroduction (Subject Outline / Subject Aims /Assessment / Teaching Resources)Pre LectureStimulation and Hormonal Regulation of theDigestive SystemMacronutrient PharmacokineticsBiochemicalmechanismsabsorption, and metabolismofdigestion,Watch a video on Transport mechanisms andSodium potassium pumpRevise the previous knowledge on Stimulationand Hormonal Regulation of the DigestiveSystemPost LectureTransport and storage physiologyRevision of lipid absorption and transportQuizGroup discussion on the impact of gastricsurgery on nutrient absorption2.Water Soluble Vitamin PharmacokineticsBiochemicalmechanismsabsorption, and metabolismofdigestion,Transport and storage physiologyPre LectureRevision activity through a reading on LMS onthe food sources, deficiency symptoms andexcess of vitamin BsPost LectureAgonists and antagonistsRevision of Vitamin B12 absorption andtransportQuiz3.Fat Soluble Vitamin PharmacokineticsBiochemicalmechanismsabsorption, and metabolismofPre Lecturedigestion,Transport and storage physiologyRevision activity through a reading on LMS onthe food sources, deficiency symptoms andexcess of fat-soluble vitaminsPost LectureAgonists and antagonistsWatch animated video on absorption andtransport of Vitamin D.Revise: Vitamin D activationQuizAustralian College of Natural Medicine Pty Ltd trading as Endeavour College of Natural Health, FIAFitnation (National CRICOS #00231G, RTO #31489)NMDF211 Nutritional BiochemistryLast modified: 11-Aug-2021Version: 21.0Page 3 of 6

4.Macromineral PharmacokineticsBiochemicalmechanismsabsorption, and metabolismPre Lectureofdigestion,Transport and storage physiologyRevision activity through a reading on LMS onthe food sources, deficiency symptoms andexcess of macro-mineralsPost LectureAgonists and antagonistsQuiz5.Micromineral PharmacokineticsBiochemicalmechanismsabsorption, and metabolismPre Lectureofdigestion,Role of electrolytes in Acid-base balanceTransport and storage physiologyPost LectureAgonists and antagonistsAbsorption, storage, and transport of IronIn Class ActivityReading on ‘Clinical importance of Zinc’Critical discussion on ‘for’ and ‘against’ onAlkaline diet (based on research reading)6.Revision of importance of micromineralsMicrobiome Prebiotics and ProbioticsQuizPre LectureFunctions and importance of microbiome inhuman healthSIBO / Gut dysbiosis and association withdiseasesGut-liver axisRevision of types of fibre and their food sourcesReading on ‘Influence of diet on the gutmicrobiome’Watch TED talk on how food affects our gutPost LectureProbiotics and prebiotics:definition,importance, sources, and their role inmoderating food intolerance, immunity, andmalabsorption syndromesIntroduction to microbiome testingWatch Catalyst videoQuizWatch a video by ‘Microba’ on Introduction tomicrobiome testingIn Class Blended ActivityDiscussion on ‘Dietary sources and recipes ofprebiotic and probiotic foods’7.Liver DetoxificationPre LectureKupffer cellsRevise the functions and importance of Liverthrough animated videosLiver Phase One PathwayPost LectureImportance of GlutathioneQuizLiver Phase Two PathwaysCase study-based questionsAlcohol DetoxificationReading on Liver function testRead an article on ‘Glutathione’8.Integration of Mind and BodyPre LectureHPA axis and stress systems overviewRevisepre-learnedsystems and StressCofactors and nutrients requiredHormonal regulation of biochemical pathwaysconcepts-EndocrinePost LectureGroup discussion based on Research basedreading on understanding effect of lifestyleAustralian College of Natural Medicine Pty Ltd trading as Endeavour College of Natural Health, FIAFitnation (National CRICOS #00231G, RTO #31489)NMDF211 Nutritional BiochemistryLast modified: 11-Aug-2021Version: 21.0Page 4 of 6

evision of ‘Management of stress’Mindfulness activity with musicNON-TEACHING WEEK (note that make-up classes may be scheduled in this week)Semester 1 – This aligns with the week after Easter so it may fall between Weeks 6 to 8Semester 2 & Online students – The non-teaching week falls between Weeks 7 and 89.Nutrient Control of Gene ExpressionPre LectureOverview of DNA structureWatch animated videos to revise the concept ofDNA structure, functions, and gene expressionOne carbon metabolismPost LectureTelomeresGroup discussion after Reading on ions for patients applying forhealth/life cs relating to testing and challenges/considerations for patients applying forhealth/life insurance10.Managing OxidationQuizRevision of epigenetics and geneticsPre LectureFree radical generationFood based AntioxidantsWatch video on the effect of antioxidants onquenching free radicals in human bodyEndogenous antioxidantsReading to revise understanding of free radicalsPost LectureRegeneration / redox pathwaysRevision of free radical damageResearch reading on ‘the role of exercise andantioxidants in moderating oxidative stress’Quiz11.Inflammation: UnderlyingOrigins of DiseasesMechanismsofOverview of Essential fatty acids and foodsourcesThe role of prostaglandins, thromboxane,leukotrienes, and cytokinesAssociation of eicosanoid related inflammationwith chronic metabolic diseasesNutrients to address inflammationPre LectureReading on ‘Disease prevention by modulatinginflammation through an Anti-inflammatorydiet’Post LectureQuizRevision of inflammatory responseGroup discussion on dietary interventions andinflammatory modulationsIn Class Blended Activity24 hr self-dietary recall for list of antiinflammatory foods/nutrients consumed12.NeurotransmittersPre LectureFunctions and synthesis of ssificationofAustralian College of Natural Medicine Pty Ltd trading as Endeavour College of Natural Health, FIAFitnation (National CRICOS #00231G, RTO #31489)NMDF211 Nutritional BiochemistryLast modified: 11-Aug-2021Version: 21.0Page 5 of 6

Nutrient and cofactors required for optimalfunctionPost LectureCase study questionsRelevance for mental healthQuizIn Class Blended ActivityDevelop a strategic dietary plan to balanceneurotransmitters for a University studentbased on discussion of a research article13.Mitochondrial DysfunctionPre LectureMitochondrial dynamicsRevision of cellular respiration and energypathwaysNutrients as cofactors to support mitochondrialpathwaysRole in chronic diseasesIntroduction to mitochondriaPost LectureQuizTED talk on mitochondrial dysfunction14.Non-Teaching Week/Practical Examination Week 1Note that make-up classes may be scheduled in this week15.Non-Teaching Week/Practical Examination Week 2Note that make-up classes may be scheduled in this week16.Final Examination Week 1Students are required to sit examinations using the Respondus Lockdown Browser software per theExamination Policy – Higher Education. Refer to the LMS for exam opening and closing times.17.Final Examination Week 2Students are required to sit examinations using the Respondus Lockdown Browser software per theExamination Policy – Higher Education. Refer to the LMS for exam opening and closing times.Australian College of Natural Medicine Pty Ltd trading as Endeavour College of Natural Health, FIAFitnation (National CRICOS #00231G, RTO #31489)NMDF211 Nutritional BiochemistryLast modified: 11-Aug-2021Version: 21.0Page 6 of 6

Aug 11, 2021 · Aug 11, 2021 · NMDF211 Nutritional Biochemistry Last modified: 11-Aug-2021 Version: 21.0 Page 2 of 6 deepens students’ understanding of nutrition and diet therapy while developing their investigative skills in a way that will augment later nutritional medic

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