Karl Fischer Titration Titration Excellence
Karl Fischer TitrationKarl Fischer TitratorsCompact VolumetricCompact CoulometricTitration ExcellenceOne Click Water DeterminationSimple & Secure
Karl Fischer TitrationKnow Your Water Contentin One Click How do you guarantee the quality and shelf life of your pharmaceutical products? What’sthe best way to check if a lubricant is still able to protect against wear? Water content cangive you important information about your product. Karl Fischer titration is the specificstandard method for the determination of water content and gives accurate and preciseresults within minutes. With the METTLER TOLEDO Karl Fischer titrators your operatorsneed only to press one button to run a water determination!One Click Burette RinsePress Shortcut to rinse the buretteSimple and fast operation thanksto One Click water determinationThe Touchscreen user interface is optimized fordirect access to routine tasks and provides clearinformation to the user. One unique Home Screenfor each user with their own Shortcut buttons offersOne Click access to all routine tasks. Users canchoose their own language for the Touchscreen andfor printouts. Everybody feels at home right from thestart, which reduces learning time and increasesdata security.The Home button always leads back to the HomeScreen.The Task button gives direct access to all ongoingand scheduled tasks.If a task needs to be stopped the Reset button canbe pressed for an immediate stop.The Online help explains all parameters shown onthe current screen.One Click Solvent ExchangePress Shortcut to exchange the solventor reagents2
Safe handling of chemicalsContact with Karl Fischer reagentsshould always be avoided. TheSolvent Manager takes care of filling, draining and exchange of thereagents. It is fully controlled bythe titrator which offers One Click access to all tasks; full securityagainst overflows is guaranteed bythe level sensor in the waste bottle.One Click Method StartPress Shortcut to run thecorresponding methodTotal security with PC softwareLabX titration PC software supportsthe user in every action performedwith the titrator. The Dual modeallows operation from the Touchscreen or from the PC (or fromboth). All results are stored in theLabX database, independent ofwhere it was started. Integratingthe titrator to a network is possiblewithout further cost thanks to theintegral Ethernet connection.METTLER TOLEDO takes into account the variability of requirements from different industriesand offers an optimal range of instruments andmethods to cope with any sample. Decades ofexperience in the determination of the moistureor water content enable METTLER TOLEDO tofind the answer to any question.One Click Series StartPress Shortcut to start apredefined sample series3
Compact Volumetric TitratorsThe Generalistsfor Water Determination up to 100%The Compact Volumetric Karl Fischer Titrators have been designed for a wide range of water content applications: determinations from 100 ppm to 100% water – fast and precisely.The titration vessel is optimized to retain a low drift value and offers the possibility to determine the water content of liquid, solid and gaseous samples.Security guaranteed byintelligent burettesIs the correct titrant installed? Is theconcentration right? Has the concentration determination expired?All this information is stored on theRFID burette chip and the titratorautomatically verifies all parameters when a titration is started.4Full information and direct accessImproving the ease of use of an instrument meanskeeping the user fully informed on what’s happening while offering all possible task choices asdirectly as possible. The online screen alwaysshows the condition of the titration vessel andoffers a direct One Click for every importanttask, e.g. start of sample or concentrationdetermination. When a method is startedthe user can easily type in the samplesize and can see immediately howmuch water has already been titrated.Clear information and direct operation are key factors for simple andsecure operation.
Solvent BottleSolventManagerFillWaste BottleDrainSolventManagerSimple and secure solvent monitoringThe solvent needs to be replaced regularly in orderto guarantee consistently correct results. The SolventControl supports the user by monitoring three different parameters. For example, if only ten samples aresoluble in 100 mL of the solvent the Solvent Control reminds the user after 10 samples to exchange the solvent and offers this with a One Click task button. Evenwhen an instrument is running on Standby the SolventControl is active and automatically starts conditioningof the fresh solvent after exchange. With minor user interaction the system is always kept in optimum condition ready to ensure a quick, accurate result wheneverrequired.Water regulates the product characteristicsPolyols are raw materials for the production of a bigvariety of polyurethane-based products obtained bypolymerization reaction with Di-Isocyanates. An example are foams, which can be used for sound insulation. It is important to know the exact water content ofthe polyol, since the water reacts with the isocyanategroups to form CO2. The CO2 regulates the degree ofexpansion of the foam, i.e. it determines the productcharacteristics. Therefore the water content is an important indicator, which can be easily and preciselydetermined by volumetric Karl Fischer tion5
Compact CoulometersThe Fast and Most Precise Solutionfor Very Low Water ContentAccuracy and precision is improved further if the titrant is not added with a burette, butproduced directly in the solution with a current applied by a generator cell. This also makes a titrant concentration determination obsolete. The Compact coulometric Karl FischerTitrators offer particularly fast and precise titration of samples with a low water contentfrom 1 ppm to 5%. The titration vessel is made completely from glass which ensures auniquely low drift and hence makes the most accurate and precise results possible.Fast results and direct operationwith large TouchscreenThe Coulometer keeps the user informed on thecell condition and makes all tasks (e.g. sampleand drift determination) available to be started withOne Click . If the expected water content is knownthe optimum sample weight can be calculated. TheOnline Screen offers all ongoing information for thetitration and direct access to all data and tasks thatfurther accelerates the complete workflow.Most convenient without diaphragmHandling of different reagents for catholyte and anolytecan be complicated and expensive. For most samplesthe cell without diaphragm offers more conveniencein use. No catholyte is needed and the anolyte can beexchanged with the Solvent Manager on One Click .Only a few samples still require a cell with diaphragm,which is clearly explained in the METTLER TOLEDOapplications brochure.6
Reagent BottleSolventManagerFillWaste BottleDrainSolventManagerAlways in good shape thanks to Reagent ControlThe reagents play an important role in the coulometric Karl Fischer titration. The Reagent Control keeps aneye on three parameters so that once the maximumcapacity is reached the user is prompted to replace thereagents. The Control offers the possibility to start theexchange with One Click even when a method is running on Standby and the fresh reagent will immediately start being conditioned. Contact with any of the reagents is avoided and the user always has an optimalsystem, ready to use and prepared to generate correct,repeatable results.Low water content of oils– easy with the METTLER TOLEDO CoulometersIn the Service department of an engine producer alloils, lubricants and fuels used in the engine are tested for water content. If the result exceeds 500 ppm(0.05%) the parts in contact with the liquid are checked for corrosion. The simple water content determination saves significant time and money, as only therisky parts need further investigation. The preventionof corrosion protects the engine from failure, which iscrucial, for example, in ion7
Titration ExcellenceThe Universal Solution for Karl Fischerand other Titration ApplicationsTitrations vary much between different users, applications or industries. The TitrationExcellence line has been designed with the utmost modularity in mind so that it caneven match unique requirements perfectly. Each piece of the titration system can bechosen and combined into an easy to use, powerful and compact instrument. With theMETTLER TOLEDO Excellence titrators modularity is not just a slogan, but a clear conceptthat includes simple and secure water determination as well as any of titration."Simple operationthanks to One Click user interface.""Efficient titration byprofessional automation.""Secure handlingthrough intelligence."8Flexible and modulartitration solutionThe modular hardware conceptenables the Excellence Titrator tosuit every user's needs perfectly.Whenever more than one personworks on the same instrument usersecurity plays an important role;the Titration Excellence user management system offers maximumsecurity. Different rights can beassigned to different user groupsand a login password can be enforced to guarantee that only userswho log in have the ability to workwith the instrument. This high levelof security also makes workingeasier, as every user only sees thebuttons he needs.
Excellence in Karl Fischer titration combinedwith general titrationMore than 500 general titration applications canbe combined with volumetric Karl Fischer titrationand have the possibility to be run in parallel on thesame instrument. Titration Excellence means a twoin-one instrument and offers the utmost application power with simplest operation using minimumbench space.Controlled HomogenizationSolid samples which do not dissolve in the Karl Fischer solventcan be added to the titration vesseland ground with a Homogenizer.The Homogenizer speed is controlled by the Excellence titrator viathe RS-interface and documented;this guarantees a maximum ofsecurity and full GLP-compliance.Special chemicals for extraction areavoided using the Homogenizer forgrinding.Powerful parallel titration of active ingredientand water contentThe content determination of many pharmaceuticalsubstances is analyzed using titration and often corrected with the water content. The Titration ExcellenceT90 system takes care of the complete analysis, e.g.Titration for Aspartame content is performed with perchloric acid and at the same time water content canbe determined with a Karl Fischer titration running inparallel on the same instrument. The water content value is saved in the Result Buffer and automatically usedfor the calculation of the Aspartame content. Much timeis saved as the water determination is fast and the calculations are automatically done by the ion9
Gas Phase Extraction OvensElegant Automationfor Many Kinds of SamplesGas phase extraction is the perfect solution for samples that are unable to be directly added into the titration vessel. In this process samples are placed into a sample boat or vialand moved to the oven or sample rack. When heated to the sample specific temperature(up to 300 C) the water evaporates and is transported into the titration vessel by a constant flow of dry air or nitrogen.Automation gains time and improves repeatabilityThe Stromboli Karl Fischer sample changer enables14 samples to be titrated in an unattended operationmode. The unit is fully controlled by the titrator andautomatically recognized whenever connected to thetitrator. A predefined method can easily be started fora simple series measurement. For a combination ofmultiple blank vials, different sample series at differenttemperatures, and check samples, the titrator’s method editor allows full flexibility and easy programming.Stromboli is the compact and flexible friend to everyuser who wants to use his time for other work ratherthan just changing samples.Gas phase extraction allows easy andaccurate water determination of solid orviscous samples, for example: Substances releasing water only at elevated temperatures: plastics in powderor granular form Substances causing side reactions withKarl Fischer reagents: oxidizing inorganic salts Substances causing problems in thetitration vessel due to their consistency:fibrous or pasty substances Substances poorly soluble or insoluble:lubricants, wool, dough, tar or coal10
Simple, clever mechanismThe robust design of Stromboli‘s samplehandling mechanism ensures trouble-freeprocessing of samples and correct results.The sample vial is lifted from the turntablewith a heating plate and moved up into theoven. Inside the oven the vial is constantlyheated from all sides to assure an eventemperature distribution. The foil betweenthe rubber seal and the vial is pierced bythe glass capillary. The water released bythe sample is transferred to the titration vessel via the applied gas flow. The speciallydesigned rubber seal ensures that novapors can escape.The simple solutionThe manual oven DO308 allowssafe oven applications with singlesamples using manual sampleaddition.Safe surgical operations require reliable analysisFor closing wounds after surgery, fibers made of PGA(Polyglycolic acid) are used; the so called suturescompletely degrade into water soluble monomers after 17 to 21 days and thus avoid further surgery tobe removed since they simply disappear. If the watercontent of the PGA exceeds 400 ppm the suture candegrade too fast leading to severe complications. Thewater content of PGA fibres is determined with theStromboli oven sample changer and the C30 Coulometer. Several samples are heated to 180 C and theevaporated water is transferred into the coulometercell. If the water content exceeds 400 ppm the fibrescannot be used for on11
Good Titration Practice Reliable ResultsThrough the Complete Life CycleThe basis of reliable results is set long before the daily routine: evaluation and selection ofa suitable titration system as well as proper installation and training on correct operation.Appropriate maintenance and regular calibration guarantee accuracy and repeatability ona long term as well as fulfilling the increasing demands of regulatory requirements. Ateach phase METTLER TOLEDO accompanies you and offers competent support and the righttools to ensure that your investment is lasting and risks are minimized.Good Evaluation Which is the parameter of interest: moisture or watercontent or dynamic vapor sorption analysis? Is volumetric or coulometric titration appropriate? Is combination with general titration needed? Which application, which method? How many samples are to be determined:is automation necessary? What reagents are ideal for this sample? Which accessories make sense?METTLER TOLEDO has an excellent knowledge in anykind of moisture and water content determination,therefore offers the appropriate products to fulfill everyanalysis task.Moisture determination byHalogene Moisture Analyzers12Moisture determination byloss on drying methodWater determination byKarl Fischer TitrationDynamic vapor sorption byTGA Sorption Analyzer System
Good RoutineProper installation, professionalimplementation into operation anduser training are key factors forgood titrations right from the start.Equipment qualification and/orvalidation accompanied by thesuitable documentation are reasonable complements in many cases.METTLER TOLEDO supports youwith a variety of service productsand services for these purposes:Achievement of good titrationresults relies on three key parameters: the instrument, its correctoperation and service:IPacTitration ExcellenceManufacturer: METTLER TOLEDOInstrument type:Instrument internal number:Instrument serial number:Initial Qualification PackageEQPacTitration CompactEquipment Qualification PackageDL31/DL38 IPac: Initial Qualification Package comprising: InstallationQualification (IQ), OperationalQualification (OQ), recommendation for Performance Qualification (PQ) and the definition of theMaintenance Qualification (MQ).Good Titration Practice Good InstallationReduced CostSecure AuditsReliable ResultsThrough Good Titration Practice The instrument's intelligencechecks its own parameters asconcentration limits, solvent andreagent lifetime or service intervals and reminds the user if anyaction is necessary. User interference is reduced to the minimum. Users are trained in samplepreparation, operation and maintenance, what is recorded e.g. inthe qualification documentation.The monograph "Good TitrationPractice in Karl Fischer Titration"gives valuable tips and hints. TheKarl Fischer Applications brochure and the user informationmagazine UserCom give additional information about samplesand applications.Guaranteed QualityMinimized Risk12Analytical ChemistryTitration, pH Systems, Density- & RefractometersAutomated titration of coating bathsUserComContents 1/2007Customer ReportsL. CandreiaIn Vienna, the capital of Austria, a fully automated Titration Excellence system is installed that can independently determine the nickel,hypophosphite and orthophosphate concentration of nickel baths. Ittakes care of the entire sample preparation, analysis and calculation andcloses the beakers after the analysis. To do all this, it uses several veryinteresting tricks.DAA C P 6HP EGD9J8:9P 6G9P 8 GDB JBP8D6I C HP ;DGP I :P B68 C:P C9JHIGNP H C8:P P CP0 :CC6 P#CPI :PE6HIPIL:CINPN:6GH PI :P 8DBE6CNP 6HP 7:8DB:P 6P HE:8 6A HIP;DGP RIG 7DAD 86AP 8D6I C HVP ;DGP I :P 6JID BD7 A:P C9JHIGN P . :P G6C :P D;P EGD9J8IHP C8AJ9:HP 8D6I C HP HJ8 P 6HP 6G9P 8 GD B JB P .G ;ADC] P !A6IDM]P 6C9P -@ CI:8 ]P6HP EJG:P B:I6AP 8D6I C H P B:I6AP DM 9:P8D6I C H P DGP 9 HE:GH DCP 8DBEDH I:P 8D6I C H P . :NP ;JA; AAP 6P A6G :P CJB7:GP D;P I :PG:FJ G:B:CIHPD;PHJEEA :GHPD;P8DBEDC:CIHPIDP I :P 6JIDBD7 A:P C9JHIGNP ;DGP L:6GPG:H HI6C8: P8DCIGDAA:9P;G 8I DCPI6G :IPK6A J:H P 8DGGDH DCP G:H HI6C8:P 6C9P 9:8DG6I K:P6EE:6G6C8:P;DGPH6;:INPHNHI:BH P9G K:PHNH I:BH P ;J:AP HNHI:BH P DGP AD8@ C P HNHI:BH P. :P 8D6I C HP 6K:P 6P I 8@C:HHP D;P P IDP- Automated titration of coating baths1- Titrate precious metals to strictstandards4Applications- Automated determination ofconductivity in high purity water- Density, refractive index, pH andcolor simultaneously69- Determination of the complex stabilityconstant by potentiometric titration13- Automated measurement ofconductivity, pH and turbidityin potable water16Expert Tips- Titrimetric analysis of acid or basicpolyol samples- Accurate determination of theconcentration of etching acids2023- Tailor-made laboratory electrodes forpH measurement in difficult products 26New Products- Titration Excellence Version 2.028- pH- and conductivity metersFiveEasy and FiveGo 30- A new generation of InLab sensors 30- Brix meter Quick-Brix 31 METTLER TOLEDO offers tailoredservice contracts to maintain thesystem, to make sure the resultsremain reliable for years and tosupport you in fulfillment of regulatory requirements. EQPac: Equipment QualificationPackage containing: comprehensive IQ, OQ, definition of PQ,establishing of MQ as well as theexpandable logbook for monitoring the equipment and keepingthe instrument records throughthe entire lifetime. Software Validation: The LabXvalidation manuals I&II makesystem validation straightforwardand complete. The two manuals contain all the information,instructions and forms you needin order to satisfy any regulatorybody.13
Models & AccessoriesFor Every Purpose the Perfect MatchModel OverviewV20 – Routine VolumetricEverything you need for Routine Volumetric Karl FischerTitration from 100 ppm up to100% water is included.Measure sample after samplewith the standard method orone of five user methods.V30 – All-round VolumetricAdditional security with Solvent Control, user management Expert–Routine, automation with Stromboli andmore. Ready-to-use andcomplete.Feature comparison tableOne ClickTitration C20 – Routine CoulometerEverything you need for Routine Coulometric Karl FischerTitration from 1 ppm up to 5%water is included. Measuresample after sample with thestandard method or one of fiveuser methods. Includes cellwith or without diaphragm.V20V30C20User specific Home Screen with Shortcuts C30 Shortcuts per user412412Solvent or Reagent Control- - Solvent Manager Burette recognition with titrant and titer --External Dosing Unit- --USB printer Memory stick USB barcode reader AutomationStromboli oven sample changer- - UserManagement"Expert – Routine" user groups- - Fully flexible----General titrations----External Extraction / Dissolution- - Bromine Index determination--- "if then" conditions in methods----120120120120HotPlug & PlayMethodsand seriesNumber of samples per seriesPreprogrammed METTLER TOLEDO methods-11-11Max. number of user methods51205120User defined calculations- - Number of tasks-10-10Number of tasks running in parallel----Online Help Parallel titration----Task listLanguagesPC software14C30 – All-round CoulometerAdditional security withReagent Control, user management Expert–Routine,automation with Stromboliand more. Ready-to-use andcomplete, includes cell withor without diaphragm.HomogenizerEnglish / German / French / Spanish / Italian /LabX titration connectivity light and pro LabX pro FDA 21 CFR part 11 support- - -TTL--
Accessories OverviewPC softwareLabX titration proLabX titration lightSoftwareUSB-P25compact paperroll printerPrinterUSB printerXP or XS seriesanalytical balancesAnalytical balancesT70 – Universal titratorFor volumetric KarlFischer and general titration. Modularity, securityand application possibilities with the One Click user interface. Fullymodular and flexible.T90 – Unlimited powerRuns volumetric KarlFischer and general titration in parallel. Maximumapplications power andautomation capability ina modular and tailoredsystem.T70T90 1212 -- --- 120120 50 50120120 103078 - BurettesDV1000 serieswith volumes of1, 5, 10 or 20 mLGas phaseextractionovensExternalDosing Unitto add auxiliaryreagentsStrombolioven samplechangerDO308manual ovenHomogenizerSampling deviceThermostatable vesselAdapter Setfor Kinematicaor IKA HomogenizersTBox DR42for use of ahomogenizercontrolled byTTLVisco Spoon for viscoussamplesFor KF titration atelevated or reducedtemperatureChinese / Russian / Polish / Korean RS / TTLRS / TTLTitration ExcellenceKarl Fischer kitIncluding Solvent Manager,titration stand, vessel, sensor,tubes and all accessories(only for T70/T90)15
Titration ExcellenceOne Click Titration for any application – simple, efficient, secure and modular. Choose a tailored systemwhich matches your requirements perfectly and thatoffers perfect results for all kinds of titrations in justOne Click .Titration SensorsThe sensor is the key to every titration analysis.METTLER TOLEDO offers a comprehensive range ofpowerful and reliable sensors for every application.Plug & Play means all sensor and calibration data issent to the Excellence titrator when plugged in.Titration AutomationTitration puts a high demand on automation dueto the large range of sample types and numbers.METTLER TOLEDO automation solutions can run theentire analysis process automatically - from sample preparation to the titration itself and then finallythrough cleaning/conditioning of the sensor and accessories.LabX PC softwareThis market approved titration software offers fullcontrol over your titration systems, secure databasearchiving, efficient result management with controlcharts and individual search filters, rapid and clearmethod development for new applications, and complete traceability by providing user management, audittrail, method history and electronic signature.www.mt.comFor more informationQuality certificate. Development, productionand testing according to ISO 9001.Environmental management systemaccording to ISO 14001.“European conformity”. The CE conformitymark provides you with the assurance that ourproducts comply with the EU directives.
give you important information about your product. Karl Fischer titration is the specifi c standard method for the determination of water content and gives accurate and precise results within minutes. With the METTLER TOLEDO Karl Fischer titrators your operators need only to press one button to run a water determination! One Click Burette RinseFile Size: 1MBPage Count: 16
Test. 5. One Is Known As Volumetric Karl Fischer Titration. The Other Method Is Known As Coulometric Karl Fischer Titration. KF METHODS Volumetric Titration Coulometric . PRINCIPLE OF WORKING 1. The Principle Of Karl Fischer . Amount Of Karl Fischer Reagent To Reach The Characteristic Endpoint. 2. Weight Accurately 150 - 350 Mg Of Sodium .
Karl Fischer titration is the method of choice for water content determination. With the . with test certificate according to DIN 50049-2.3 First titrator (METTLER TOLEDO DL55) with online curves E f(t) and V f(t) for Karl Fischer titration. 1997 New DV705 KF Titration Stand with very low drift value ( 2μg/min) for the METTLER
fischer service engineers GERMANY fischerwerke GmbH & Co. KG Klaus-Fischer-Straße 1 72178 Waldachtal Germany Phone 49 (0)74 43 12 - 45 53 act@fischer.de · www.fischer.de Further information and approvals can be downloaded from the homepage of fischer: www.fischer.de ACT Service Argentina fischer Argentina S.A. Armenia 3044 1605 Munro .
Karl Fischer titration method Diméthylether (DME) pour carburants et combustibles — Détermination de la teneur en eau — Méthode par titrage Karl Fischer INTERNATIONAL STANDARD ISO 17197 First edition 2014-11-15 Reference number ISO 17197:2014(E) This is a preview of "BS ISO 17197:2014". Click here to purchase the full version from the .
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10.7.3 Solubility of sample 34 10.8 Execution of a volumetric Karl Fischer titration 35 10.9 Interferences of Karl Fischer titration 35 10.9.1 Influence of pH 35 10.9.2 Side reactions 36 11 Glossary 37
As an in-service oil test, moisture content is a critical parameter. Again, the critical values are the percent saturation and the percent moisture by dry weight calculated from the oil temperature and the moisture content in ppm reported by the Karl Fischer Titration. KARL FISCHER Karl Fischer Moisture (KF) MOISTURE (KF) ASTM D1533
The American Revolution This French snuffbox pictures (left to right) Voltaire, Rousseau, and colonial states-man Benjamin Franklin. Enlightenment and Revolution641 Americans Win Independence In 1754, war erupted on the North American continent between the English and the French. As you recall, the French had also colonized parts of North America through-out the 1600s and 1700s. The conflict .
