Name: Sharon-Lise Teresa Normand - Harvard University

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Normand, S-LHarvard Medical SchoolLast Updated: June 2019Name:Sharon-Lise Teresa NormandOffice Address:Harvard Medical SchoolDepartment of Health Care Policy180 Longwood Avenue, Suite 302Boston, MA 02115-5899Home Address:122 Winchester StBrookline, MA arvard.edu617-432-0173Place of Birth:Capreol, Ontario, CanadaU.S. D.StatisticsStatisticsBiostatisticsUniversity of Western OntarioUniversity of Western OntarioUniversity of TorontoPostdoctoral Training1990–1992Department of Health Care Policy, Harvard Medical SchoolAcademic 20032003–20182003–2003 2018 Assistant Professor of Biostatistics, Department of Health Care Policy, Harvard MedicalSchoolAssistant Professor, Department of Biostatistics, Harvard School of Public HealthAssociate Professor of Biostatistics, Department of Health Care Policy, Harvard MedicalSchoolAssociate Professor, Department of Biostatistics, Harvard School of Public HealthProfessor of Health Care Policy (Biostatistics), Harvard Medical SchoolProfessor, Department of Biostatistics, Harvard School of Public HealthAffiliate, Center for Basic Research in the Social Sciences, Faculty of Arts and Sciences,Harvard UniversityS. James Adelstein Professor of Health Care Policy, Harvard Medical SchoolMajor Harvard Committee AssignmentsHarvard University1997–Evaluation & Statistics Committee, Ph.D. in Health Policy Program, Member1999–2001Admissions Committee, Member, Health Policy Ph.D. Program2000–Standing Committee on the Degree of Doctor of Philosophy in Health Policy, Member2005Ad Hoc Tenure Committee, Faculty of Arts and Science, Member2017Harvard Data Science Initiative Planning Committee, memberHarvard Medical School & Harvard School of Dental Medicine2004–2005Faculty Diversity Committee, Member2004–2010Standing Committee on Human Studies in the Faculty of Medicine, Member1

Normand, S-L2006–200820072008–2009-201220122015-Harvard Medical SchoolFaculty Council, Senior Faculty Representative of the Department of Health Care PolicyScreening Committee, MemberHarvard Catalyst Pilot Grants, ReviewerPromotions, Reappointments, and Appointments Committee, MemberFinancial Interest Review Committee, MemberSocial Science Advisory GroupDepartment of Biostatistics, Harvard School of Public Health1995–1998Curriculum Committee, Department of Biostatistics1996–1997Computing Committee, Department of Biostatistics1997–1999Seminar Committee, Department of Biostatistics1999–2000Practical Training Committee, Department of Biostatistics2000–2001Postdoctoral Committee, Department of Biostatistics2001–2002Student Interview Committee, Department of Biostatistics2002–2003Chair, Seminar Committee, Department of Biostatistics2003–2004Degree Program Committee, Department of Biostatistics2004–2005Chair, Seminar Committee, Department of Biostatistics2006–2007Admissions and Recruiting Committee, Department of Biostatistics2007–2008Faculty Development Committee, Department of BiostatisticsDepartment of Health Care Policy, Harvard Medical School1995,1998Statistics Postdoctoral Search Committee, Department of Health Care Policy1996–1997MD Faculty Search Committee, Department of Health Care Policy1996–2001Statistics Faculty Search Committee, Department of Health Care PolicyMajor Regional and National Committee 122007–20082008–2009Board of Directors, New England Quality Council, Inc.Massachusetts Cardiac Care Quality Advisory Commission, MassachusettsDepartment of Public HealthDirector, Massachusetts Data Analysis Center, Commonwealth of MassachusettsMember, Expert Panel on Prevention and Control of Healthcare AssociatedInfections in Massachusetts, Massachusetts Department of Public Health and theBetsy Lehman Center for Public Safety and Medical Error ReductionMember, Technical Advisory Group, Healthcare Associated Infections,Massachusetts Department of Public Health and the Betsy Lehman Center for PublicSafety and Medical Error 8–19991998–20001998–2001Reviewer, Statistics and Probability Section, National Science Foundation ProgramReview Member, Behavioral Science Track Award for Rapid Transition Program,National Institute of Mental HealthSmall Project Grant Program Review Member, Agency for Health Care Policy andResearchReserve Review Member, Health Services Research Initial Review Group Committee,Agency for Health Care Policy and ResearchCardiovascular Outcomes Research Conference – Working Group Member, AmericanHeart AssociationRegional Advisory Board Member, ENARPatient Care and Outcomes Review Group Committee Member, American HeartAssociation

Normand, –200520032003–20052003–200720042004Harvard Medical SchoolReview Member, Health Care Technology & Decision Sciences Review Committee,Agency for Healthcare Policy and ResearchScientific Program Committee Member, ENARQuality of Care and Outcomes Research Expert Panel Member, American HeartAssociationHealth Policy Statistics Section, Program Chair (2001); Program Chair-Elect (2000),American Statistical AssociationJoint Task Force on Performance Measures Member, American College of Cardiology &the American Heart AssociationHeart Failure Performance Measures Writing Group Member, American College ofCardiology & the American Heart Association3rd , 4th , 5th, 6th Scientific Forums on Quality of Care and Outcomes Research inCardiovascular Disease and Stroke Program Committee Member, American HeartAssociationHeart Failure GAP Project Advisory Panel Member, American College of Cardiology &American Heart AssociationTechnical Expert Panel Member, Centers for Medicaid and Medicare Services Doctor’sOffice Quality ProjectSpecial Emphasis Panel (Statistics) Chairperson, Review Panel, National Institute forMental HealthTemporary Review Member, Small Business Innovation Research, National Institute forMental HealthMember, Subcommittee on Standards for NCDR Scientific and Clinical Support,American College of CardiologyReview Member, National Institute for Mental Health, InterventionsSecretary, Eastern North American Region (ENAR) of the International BiometricsSocietyMember, Circulatory Systems Devices Advisory Panel, Food and Drug Administration,US Department of Health and Human ServicesMember, Institute of Medicine of the National Academies, Subcommittee onPerformance Measures for Redesigning Health Insurance Benefits, Payment andPerformance Improvement ProgramsMember, ENAR Distinguished Student Paper Awards Committee2005–2007Statistical Society of Canada Representative to the Florence Nightingale David AwardCommittee, Committee of Presidents of Statistical Societies2006–2007Member, Institute of Medicine Committee to Review NASA’s Space Flight HealthStandardsMember, IOM Committee to Review NASA’s Space Flight Health StandardsMember, Measures Implementation and Evaluation Advisory Committee, AmericanMedical AssociationHealth Policy Statistics Section Chair (2004) and Chair Elect (2003), AmericanStatistical AssociationMember, Quality Strategic Directions Committee, Appropriateness Criteria WorkingGroups, American College of CardiologyMember, AcademyHealth Methods CouncilMember, Agency for Healthcare Research and Quality (AHRQ) Quality IndicatorsWorkgroup on Risk Adjustment Approaches to Administrative DataMember, IOM Committee to Review NASA’s Space Flight Health StandardsMember, IOM Committee to Aerospace Medicine and the Medicine of ExtremeEnvironmentsMember, Institute of Medicine of the National Academies, Committee of AerospaceMedicine and the Medicine of Extreme EnvironmentsReview Member, Special Emphasis Panel ITMA, National Institute of Mental 007

Normand, -20192018–2018–Harvard Medical SchoolStatistical Leader, FDA-DCRI Cardiac Safety Critical Path Initiative: Drug Eluting StentThrombosis and Dual Anti-Platelet Therapy Group.Member, AHA Evaluation of Novel Markers of Cardiovascular Risk and SubclinicalAtherosclerosis Writing GroupSteering Committee Member, Registry of Angioplasty Registries (ROAR), NationalHeart, Lung, and Blood InstituteConsultant, Circulatory Systems Devices Advisory Panel, Food and Drug Administration,US Department of Health and Human ServicesMember, Board of Advisors for the NCHS/AcademyHealth Policy FellowshipReview Member, Special Emphasis Panel ITMA, National Institute of Mental HealthMember, ACC/AHA Quality in Technology Working GroupMember, ACC/AHA Performance Measurement Methodology Update CommitteeMember, ACC/AHA Guidelines Methodology Review WorkgroupReview Member, Special Emphasis Panel, ZMH1 ERB-N, National Institute of MentalHealthAdvisory Committee Member, Dual Antiplatelet Therapy (DAPT) StudyExecutive Operations Committee Member, Dual Antiplatelet Therapy (DAPT) StudyMember, IOM Committee on Future Directions for the National Healthcare Quality andDisparities ReportsMember, IOM Committee on a National Surveillance System for Cardiovascular andSelect Chronic DiseasesMember, Medicare Evidence Development and Coverage Advisory CommitteeVice Chair, Methodology Committee, Patient-Centered Outcomes Research InstituteBoard Member, Frontier Science and Technology Research Foundation, Inc.Scientific Advisory Board Member, Institute of Clinical Evaluative Sciences, Toronto,CanadaMember, Committee on Applied and Theoretical Statistics, National Academy ofSciencesCo-Chair, Panel on the Review of the Compliance, Safety, Accountability Program of theFederal Motor Carrier Safety Administration, Committee on National StatisticsMember, National Academies of Sciences, Engineering, and Medicine, The IntelligenceScience and Technology Experts Group (ISTEG)Member, Fisher Lecture Selection Committee, Committee of Presidents of StatisticalSocieties (COPSS)Chair, Fisher Award Committee, Committee of Presidents of Statistical SocietiesCo-Chair, Standing Committee on the Federal Motor Carrier Safety Administration’sCorrelation Study, Committee on National Statistics, National AcademiesChair, Methods Subcommittee, National Evaluation System for health TechnologyCoordinating Center (NESTcc)International2013-2016Member, Executive Board, International Biometrics SocietyProfessional 99–2000–2002–2007–Statistical Society of CanadaRoyal Statistical SocietyInternational Biometric SocietyInstitute of Mathematical StatisticsAmerican Statistical AssociationAssociation for Health Services Research (Now AcademyHealth)Society for Clinical TrialsAmerican Public Health AssociationAmerican College of CardiologySociety of Thoracic Surgeons

Normand, S-L2007–Harvard Medical SchoolAmerican Heart AssociationCommunity Service Related to Professional Work1985–19901993–20011995–20031996, 20002001Junior Statistical Consultant, Clinical Research Support Unit, Department of PreventiveMedicine & Biostatistics, University of TorontoJSM Session Organizer, American Statistical Association (IRT Modeling: Applications toHealth Policy (2001); Statistical Methods for Profiling Medical Providers (1999); ModernMethods for Incorporating Uncertainty in Health Policy Analyses (1997); StatisticalMethods in Mental Health Services Research (1995); Bayesian Methods in HealthServices Research (1993)Scientific Program Committee Member, International Conference on Health PolicyResearch (Bi-annual Meeting), Health Policy Statistics Section, American StatisticalAssociationENAR Session Organizer (Design & Analysis of Medical Device Trials: Regulatory,Industry, Statistical, and Clinical Perspectives (2000); Statistical Methods for Measuring,Assessing, and Modeling Compliance (1996)External Examiner, University of Toronto, School of Graduate Studies, MultipleImputation of Missing Data in Clinical Trials (Biostatistics).

Normand, S-LHarvard Medical SchoolEditorial BoardsAd-Hoc ReviewerAmerican Journal of Public HealthAnnals of Internal MedicineArchives of General PsychiatryBayesian Statistics 4 & 5BiometricsCanadian Medical Association JournalCardiac FailureCirculationCommunication in Statistics: Theory & MethodsHealth Risk AnalysisHealth Services ResearchInternational Journal for Quality in Health CareJoint Commission Journal of QualityImprovementJournal of Clinical Outcomes ManagementJournal d’Economie Medicale (France)Journal of Health EconomicsJournal of Multivariate AnalysisJournal of the American Academy of Child &Adolescent PsychiatryJournal of the American Medical AssociationJournal of the American Statistical AssociationJournal of the Royal Statistical SocietyLife Time Data AnalysisMedical CareMilbank QuarterlyNew England Journal of MedicineScienceSociological Methods and ResearchStatistical ScienceStatistics in MedicineBoard l BoardMemberGuest EditorMemberAssociate EditorAssociate EditorMethods EditorAssociate EditorAssociate EditorStatisticalConsultantHealth Services and Outcomes Research MethodologySpecial Issue of Health Services and Outcomes ResearchMethodologyMedical Decision MakingHealth Services and Outcomes Research MethodologyBiometricsPsychiatric ServicesStatistics in MedicineCirculation: Cardiovascular Quality and OutcomesNew England Journal of Medicine

Normand, S-LHarvard Medical SchoolAwards and 82019University Gold Medal in Mathematical Statistics, University of Western Ontario,London, Ontario CANADAEntrance Scholarship, Faculty of Graduate Studies, University of Western Ontario,London, Ontario CANADASpecial University Scholarship, Faculty of Graduate Studies, University of WesternOntario, London, Ontario CANADAOntario Graduate Scholarship, University of Toronto, CANADALife Sciences Committee Scholarship in Cancer Research, University of Toronto,Toronto, Ontario CANADALife Sciences Graduate Degree Completion Scholarship, University of Toronto,Toronto, Ontario CANADAthNational Science Foundation: Young Researcher Award, Support for the 4Valencia International Meeting on Bayesian Statistics USAElected Fellow, American College of CardiologyElected Fellow, American Statistical Association for “influential application ofBayesian methodology to health policy problems, for leadership in the new area ofhealth policy statistics, and for promoting and communicating statistical methodsand assessments of the quality of cardiovascular disease and mental illness.”Excellence in Mental Health Policy and Economics Research Award, Best Paper,Journal of Mental Health Policy and EconomicsCanadian Institute of Health Research Institute of Aging Age Plus Award,Excellence in Research on Aging for British Medical Journal article “Atypicalantipsychotic drugs and risk of ischemic stroke: population based retrospectivecohort study”, BMJ 2005, 330(7489):445-450.Finalist, 2007 NIH Director’s Pioneer Award “Rethinking evidence for medicaltherapies.”Elected Associate, Society of Thoracic SurgeonsFellow, American Heart AssociationOutstanding Publication Award, American Association of Cardiovascular andPulmonary Rehabilitation. Suaya JA, Stason WB, Ades PA, Normand S-LT,Shepard DS. “Cardiac rehabilitation and survival in older coronary patients.Journal of the American College of Cardiology, 2009;54:25-33.”IBM Faculty Award, nominated by IBM Healthcare Transformation GroupLong Term Excellence Award, American Statistical Association, Health PolicyStatistics SectionDistinguished Scientist Award, American Heart AssociationDistinguished Service Award, International Society for Pharmacoeconomics andOutcomes ResearchElected, Society for Research Synthesis MethodologyL. Adrienne Cupples Award for Excellence in Teaching, Research, and Service inBiostatistics, Boston UniversityOutstanding Lifetime Achievement Award, Council on Quality of Care andOutcomes Research, American Heart AssociationMosteller Statistician of the Year, American Statistical Association, BostonChapterElected Fellow, American Association for the Advancement of ScienceRESEARCH, TEACHING, AND CLINICAL CONTRIBUTIONSReport of Past Funding Information

Normand, 999–20032000 20032000 20032000 2005Harvard Medical SchoolAHCPR (PI: McNeil), Co-Investigator/Statistician. The consequences of variation intreatment for acute MI.AHCPR (PI: McNeil), Co-Investigator/Statistician. The consequences of variation intreatment for acute MI.AHCPR (PI: Epstein), Co-Investigator/Senior Statistician. Do re-admissions matter?VHA – Institutional Participation Agreement (PI: McNeil), Co-Investigator/SeniorStatistician. The consequences of variation in treatment after AMI in VHA.AHCPR (PI: Morris), Co-Investigator. Hierarchical statistical modeling in health policyresearch.HCFA (PI: McNeil): subcontract to Duke Medical School, Co-Investigator/SeniorStatistician. Analysis of the pilot Cooperative Cardiovascular Project data.NCI (PI: Normand), Principal Investigator. Hierarchical modeling for assessing breastcancer care.AHCPR (PI: McNeil), Co-Investigator/Senior Statistician. Validating guidelines for thecare of AMI patients.VHA – Institutional Participation Agreement (PI: McNeil), Co-Investigator/SeniorStatistician. Social factors & cardiac outcomes: A prospective study.VHA – Institutional Participation Agreement (PI: McNeil), Co-Investigator/SeniorStatistician. Appropriateness and necessity of cardiac procedure use after AMI in VHA.NIMH (PI: Dickey), Co-Investigator/Senior Statistician. Regional variation in mentalhealth treatment and cost.AHCPR (PI: Guadagnoli): subcontract to Boston University, Co-Investigator/SeniorStatistician. Adjuvant tamoxifen in old age.SAMHSA (PI: Frank): subcontract to Brandeis University, Co-Investigator/Senior Statistician.State substance abuse treatment managed care evaluation program.U18 HS09487 (PI: McNeil) AHCPR, Co-Investigator/Senior Statistician. Quality of caremeasures for cardiovascular patients.USQA (PI: McNeil), Co-Investigator/Senior Statistician. Use of cholesterol loweringagents as secondary prevention after acute myocardial infarction.MacArthur Foundation (PI: Frank), Co-Investigator/Senior Statistician. Determining thevalue of mental health.R01 MH54076 (PI: Dickey) NIMH, Co-Investigator/Senior Statistician. Outcomes ofMedicaid managed care.NIMH (PI: Normand), NIMH, subcontract to University of Massachusetts Medical Center:Principal Investigator. Managed care effects on arrest and forensic commitment.AHCPR (PI: McNeil), Co-Investigator/Senior Statistician. Financial incentives and care ofchronic cardiac patients.AAHP (PI: McNeil), Co-Investigator/Senior Statistician. Financial incentives and care ofchronic cardiac patients.MERCK (PI: McNeil), Co-Investigator/Senior Statistician. Understanding the use ofcholesterol lowering agents after myocardial infarction.NCI (PI: Guadagnoli), Co-Investigator/Senior Statistician. Data sources and patterns ofcare for breast cancer.R01 MH58288 (PI: Normand) NIMH: subcontract to McLean Hospital, Belmont, MA,Research: Principal Investigator. Mental illness, co-morbidity, and mortality.R01 MH58240 (PI: Normand) NIMH, subcontract to McLean Hospital, PrincipalInvestigator. BASIS 32: A Consumer Mental Health Outcome Measure.HHS 100-00-0025 (PI: Frank) DHHS, Co-Investigator/Senior Statistician. Evaluation ofParity in the Federal Employees Health Benefits (FEHB) Program.R01 MH620282 (PI: Frank) NIMH, Co-Investigator/Senior Statistician. Price Indexes ofMental Health Treatment.P01 HS10803 (PI: Newhouse) AHRQ, Co-Investigator/Senior Statistician. StructuringMarkets and Competition in Health Care.

Normand, S-L2001 20042001 20042002 20032002 20052002 20172003 20062003 20082004 Harvard Medical SchoolR01 MH61434 (PI: Normand) NIMH, Principal Investigator. Modeling Treatment Use &Effectiveness in Mental Illness.R01 HS11651 (PI: Landon) AHRQ, Co-Investigator/Senior Statistician. MD GroupCharacteristics and Quality of Care for CHD.(PI: McNeil) MERCK, Co-Principal Investigator. Sample Sizes in PerformanceMeasurement.NO1 AA21011 (PI: Colditz) NIAA, Co-Investigator. Estimating Alcohol AttributableFractions of US Morbidity and Mortality Based on Meta-Analyses of EpidemiologicalStudies.620022A4PRE (PI: Normand) Commonwealth of Massachusetts, Department of PublicHealth, Principal Investigator. Cardiac Surgery Study.R01 HS13335-01A1 (PI: Epstein) AHRQ, Co-Investigator. The Patterns and Impact ofValue-Based Purchasing.P20 MD000537 (PI: McGuire) NCMHD, Co-Investigator. Exploratory EXPORT Center:Bridging Communities.R01 MH54693 (PI: Laird) NIMH, Co-Investigator. Analysis of Multiple Informant Data inPsychiatry.R01 MH06972-01 (Frank RG: PI) NIMH, Co-Investigator/Statistician. Economic Impactsof New Drugs.P50 DA10233-06A2 (PI: Frank) NIDA, Co-Investigator. The Brandeis/Harvard CenterStudy of Managed Care and Drug Abuse Treatment.(PI: McNeil), Harvard University, Co-Investigator. Programs for Health SystemsImprovement.R01 HS014774 (PI: Landon) AHRQ, Co-Investigator. Incentive Formularies and theCosts and Quality of Care.2-R01 MH061434 (PI: Normand) NIMH. Modeling Treatment Use & Effectiveness inMental IllnessP50 MH073469 (PI: McGuire), NIMH/CHA, Co-Investigator, Advanced Center for Latinoand MH Systems Research.R01-LM008142 (PI: Resnic), NLM/BWH, Co-Investigator, A System to Monitor MedicalDevice Safety in Interventional Cardiology.(PI: Normand/Mauri), Harvard Clinical Research Institute, Principal Investigator. TheMass COMM Trial.R01-LM008142 (PI: Resnic), NLM/BWH, Co-Investigator, A System to Monitor MedicalDevice Safety in Interventional Cardiology.2-R01-MH54693 (PI: Normand), NIMH. Analysis of Multiple Informant Data inPsychiatry.R01-MH081819 (PI: Frank), NIMH, Co-Investigator, Mental Health Spending and Qualityof Care.R01-MH080797 (PI: Huskamp), NIMH, Co-Investigator, Effects of Mental Health Parityon High-Cost and Severely Ill Individuals.(PI: Normand), Division of Health Care Finance and Policy, Massachusetts Departmentof Public Health, Hospital-Wide Mortality Measurement Evaluation.IPA (PI: Normand), Center for Devices and Radiographic Devices, Food and DrugAdministration, Development of Statistical Surveillance Techniques for Hip Arthroplasty.R01-HL101996 (PI: Reede, Joan), NHLBI, Co-Investigator, Factors that Promote andSupport Careers of Women of Color in Academic Medicine.5R01-NR010727 (PI:Termkin-Greener), NNR, Co-Investigator, End-of-Life Quality ofCare in Nursing Homes.1074629 (PI: Normand), DHHS/FDA, Innovative Methods for Evidence Synthesis forMedical Devices.R01-MH087488 (PI: Horvitz-Lennon/Normand), NIMH, An In-Depth Investigation ofRacial & Ethnic Disparities in Schizophrenia Care.1RC4 MH092717-01 (PI: O'Malley), NIMH, Accounting for Confounding Bias and

Normand, 13-20152013-20182014-2018Harvard Medical SchoolHeterogeneity in Comparative Effectiveness.HHSF223201110172C (PI: Normand), Chickasaw Nation Industries (CNI)/Food & DrugAdministration, The Medical Device Epidemiology Network (MDEpiNET) MethodologyCenter.R01MH094290 (PI: McGuire), NIMH, Mental Health Coverage in Health Care Reform.R01MH093359 (PI: Huskamp/Donohue), NIMH, Influences on Psychiatric Prescribing ofAntipsychotics.U01FD004493 (PI: Normand), FDA, The MDEPINET Medical Counter Measure Study.Harvard Medical School/Portugal (PI: Normand), Comparative analysis and diagnostictreatment procedures provided to coronary artery disease patients: a critical evaluationstudy between the US and Portuguese health care systems.R21HD076442 (PI: Chien/Newhouse), NICHD, Improving Pediatric Risk AdjustmentAlgorithms.R01HL118314 (PI: Charytan/Normand), B&W/NIDDK, Optimizing Revascularization ofCoronary Artery Disease in Chronic Kidney Disease.R01CA181360 (PI: Haneuse), NIH/NCI, Clustered semi-competing risks analysis inquality of end-of-life care studies.Report of Current Research H103018 (PI: Normand/Huskamp). Technology Diffusion Pathways. Using a richcollection of data for the period 2005-2015, we examine the relationship between physicianorganization traits and diffusion of technology. We (a) study the diffusion of selected newtechnologies, including technologies we designate to be of higher and lower value, in 4 diseasecategories - cancer, depression, cardiac, and hip degeneration - as a function of organizationcharacteristics, providing new approaches to characterize the path of technology adoption;using quality measures promulgated by professional societies, technology characteristics, andFDA alerts, we distinguish higher from lower value services, identify organizational factorspredictive of their use, and determine if decisions to adopt higher vs. lower value services arecorrelated; and identify organizational characteristics, adjusting for physician and patientfactors, associated with spending for new technologies and for lower vs. higher value services.R01GM111339 (PI: Normand). Bayesian Methods for Comparative Effectiveness ResearchUsing Observational Data. We develop new Bayesian methods (1) for causal inference in largeobservational data to a) estimate average causal effects accounting for model uncertainty in theselection of measured confounders and b) estimate average causal effects in sub-populationsaccounting for uncertainty in the selection of the subgroups; and (2) for assessing treatmenteffects in the presence of unmeasured confounders that moderate treatment effects in largeobservational data. We apply the new methods to observational studies to provide new and fullyreproducible knowledge in the areas of medical devices, surgical procedures, andpharmaceutical treatments; and develop flexible, efficient, robust, well documented, userfriendly R libraries and SAS macros, facilitating dissemination of our newly developed methods.U01FD005478 (PI: Normand/Sedrakyan). Creating National Surveillance Infrastructure forPriority Medical Devices. We capitalize on a novel partnership within the FDA’s MDEpiNet tobuild national infrastructure: the Science & Infrastructure Center at Cornell University, theMethodology Center at Harvard Medical School, and major registry partners. We (1) linkregistries with Medicare, commercial, and state discharge billing claims, and Clinical DataResearch Network data to enable post-market surveillance for orthopedic and vascular devices;(2) illustrate pilots for automation in registry creation using electronic health records; and (3)develop, implement, and distribute new methodological approaches that address key dataissues emerging from the large linked databases.P30DA035772 (PI: Horgan/Busch). Center to Improve System Performance of Drug AbuseTreatment. The Center uses research on payment methods and service delivery approaches toexpand the evidence base on improving substance use disorder (SUD) care quality and reduce

Normand, S-L2016-20202017-20212018-2020Harvard Medical Schoolthe cost of health care services, and to inform policy decisions that will profoundly affect thecost, quality and availability of SUD treatment services.1R01 MH106682 (PI: Normand/Horvitz-Lennon). Improving Value of Publicly Funded MentalHealth Care. We propose a program of research to investigate antipsychotic utilization and itsimpacts among Medicaid, Medicare, and dually eligible beneficiaries, and using these findings,to simulate the impacts of strategies to improve value of care. We will quantify antipsychoticoveruse among all adult beneficiaries. Among those with serious mental illness, we will assessthe short- and long-term health, and economic impacts of cumulative antipsychotic exposureand model the effects of value-enhancing strategies. Health impacts include cardiometabolicdisorders; economic impacts include drug purchasing costs, diabetes and cardiovascularprevention or treatment costs, and total health care spending. We use longitudinal Medicaidand Medicare data for adults enrolled in one or both programs in six diverse states andcomplement these with other data sources.1R01MD012428-01 (PI: Normand/Horvitz-Lennon). Improving Minority Health by MonitoringMedicaid Quality, Disparities and Value. We propose a program of research that seeks toreduce health disparities and improve the health of minority populations served in publiclyfunded settings through measurement of quality disparities and other critical domains ofMedicaid-financed care delivered to adults with schizophrenia. Our ultimate goal is to enableevidence-based policymaking by developing a user-friendly interactive tool to monitor quality,quality disparities, costs, and value, and determine cost of eliminating quality disparities.The Society of Thoracic Surgeons (PI: Normand). STS Congenital Heart Surgery Database.This project proposes the development of machine learning and sparse data approaches toenable a better understanding of the quality of surgical care delivered to pediatric andcongenital heart disease populations. We will develop diagnosis-based approaches that makeuse of procedure-specific risk factors utilizing high-dimensional cluster analyses to createhomogeneous patient strata; we will then apply non-parametric approaches to assess hospitalsurgical quality. Methods will be illustrated using data contained in t

2003– Professor, Department of Biostatistics, Harvard School of Public Health . 2003 Affiliate, Center for Basic Research in the Social Sciences, Faculty of Arts and Sciences, Harvard University . 2018 S. James Adelstein Professor of Health Care Policy, Harvard Medical School . Major Harvard C

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