The Chemistry Of Life: Treating Cancer With Nanoparticles .
10/6/2016We will begin momentarily at 2pm ETSlides available now! Recordings available as an exclusive ACS member benefit.www.acs.org/acswebinarsContact ACS Webinars at acswebinars@acs.org1Have Questions?Type them into questions box!“Why am I muted?”Don’t worry. Everyone is mutedexcept the presenter and host.Thank you and enjoy the show.Contact ACS Webinars at acswebinars@acs.org21
10/6/2016Have you discovered the missing element?http://bit.ly/benefitsACSFind the many benefits of ACS membership!3Benefits of ACS MembershipChemical & Engineering News (C&EN)The preeminent weekly news source.NEW! Free Access to ACS Presentations on Demand ACS Member only access to over 1,000 presentationrecordings from recent ACS meetings and select events.NEW! ACS Career NavigatorYour source for leadership development, professionaleducation, career services, and much more.http://bit.ly/benefitsACS42
10/6/2016Let’s get Social post, tweet, and link to ACSWebinars during today’s ch for “acswebinars”and connect!5How has ACS Webinars benefited you?“I know quite a lot about shear thickening in paints andpigment pastes and spent many years trying to preventits occurrence in commercial products. I thought theexplanations of shear thickening were excellent and Iwas fascinated by the practical applications for good ofthe phenomenon.”Quote in reference to: http://bit.ly/STFTechnologyDaniel A. Green,Clifford SchoffConsultant, Schoff AssociatesACS member for 48 years strong!Be a featured fan on an upcoming webinar! Write to us @ acswebinars@acs.org63
10/6/20167Learn from the best and brightest minds in chemistry! Hundredsof webinars presented by subject matter experts in the chemicalenterprise.Recordings are available to current ACS members one week afterthe Live broadcast date. www.acs.org/acswebinarsBroadcasts of ACS Webinars continue to be available to the generalpublic LIVE every Thursday at 2pm ET!www.acs.org/acswebinars84
10/6/2016ChemIDP.orgPOLYMER Division of theAmerican Chemical SocietyWe invite you to participate in the many activities and benefits ofThe Division of Polymer Chemistry - one of the largest andmost active non-profit, international groups devoted to theadvancement of Polymer Science.Become a Member of POLY to enjoy these benefits! Technical programming at the National ACS meetings Discounted workshops on contemporary topics in Polymer Science Industrial scientist support and networking through the IAB(Industrial Advisory Board) Support for Student Chapters, student symposia, and student awardswww.polyacs.org105
10/6/20162016 Material Science ver the material science innovationsthat make a healthy life possible!The 2016 Material Science Series is co-produced withACS Industry Member Programs, C&EN, and the ACS POLY Division11National Nanotechnology Day:October 9, 2016A joint project of the National Nanotechnology Coordinating Office andscientific societies, National Nanotechnology Day features a series ofcommunity-led events and activities on or around Oct. 9 to help to raiseawareness of nanotechnology, how it is currently used in products thatenrich our daily lives and the challenges and opportunities it holds for thefuture. The date pays homage to the nanometer scale, 10-9 meters!www.acs.org/nano126
10/6/2016Upcoming ACS Webinarswww.acs.org/acswebinarsSPECIAL BROADCAST: Tuesday, October 11, 2016 @ 7pm ETThe Chemists' Code for Success: 3 Essential Skill Setsfor Your CareerPatricia Simpson, Owner/Consultant, Game Changing Etiquette and Director ofAcademic Advising and Career Services, University of IllinoisAmanda Yarnell, Managing editor, editorial, Chemical & Engineering NewsThursday, October 13, 2016Failure: Why Science Is So SuccessfulStuart Firestein, Professor of Neurobiology, Columbia UniversityDarren Griffin, Professor of Genetics, University of KentContact ACS Webinars at acswebinars@acs.org132016 Material Science Series“Treating Cancer with Nanoparticles Powered by the Sound of Light”Justin HarrisLead Research Scientist,NanoHybridsMark JonesExecutive External Strategy andCommunications Fellow,Dow ChemicalSlides available now! Recordings will be available to ACS memberswww.acs.org/acswebinarsThe 2016 Material Science Series is co-produced withACS Industry Member Programs, C&EN, and the ACS POLY Division147
10/6/2016Chemistry of Life:Treating Cancer with Nanoparticles Powered by theSound of LightDr. Justin Harris – NanoHybrids Inc.Photoacoustic d PhotoacousticsMonitoringCombinedUltrasound omicalmm 10-3 mFunctionalMolecularnm 10-9 m168
10/6/2016Agenda Photoacoustic imaging: an overviewGenerating contrast: endogenous vs exogenousNanoparticle contrast agentsEPR effect and imagingMolecular targeting and imagingTheranostics– Photothermal therapy– Drug delivery and sensing– Laser-triggered drug release Path to the Clinic17Photoacoustic ImagingPhotoacoustic signal is generatedfrom agents with high opticalabsorption cross sectionsOptical FibersTransducerPhotoacoustic Effect Nanosecond pulses of laser light irradiate tissue Nanoparticles absorb light and thermoelastically expand Ultrasonic acoustic waves are producedImage Source: Homan et al, "Combined Photoacoustic and Ultrasound Imaging of Metal Nanoparticles In Vivo," inNanoimaging, Pan Stanford Publishing, Singapore (2010).189
10/6/2016Photoacoustic Imaging19Photoacoustic Imaging No harmful ionizing radiationSub-millimeter structure image resolution with high penetration depthNear real-time imaging capabilityExcellent contrast agents and molecular targeting at imaging depthRequires only modest floor-space and offers ultra-mobile units for point ofcare useGreater convenience at lower cost2010
10/6/2016What is the best light for maximum penetration andphotoacoustic imaging resolution? Ultraviolet Visible Near-Infrared Infrared21Endogenous vs ExogenousNanoparticle Contrast Agents “Tissue Optical Window”– Minimum absorptionand scattering by tissue– Enables deeperpenetration of light– Perfect zone to tunenanoparticle contrastagents!22Homan et al., "Prospects of molecular photoacoustic imaging at 1064 nm wavelength," Opt Lett 35(15), 2663-2665(2010)11
10/6/2016Absorption ModesMolecular AbsorptionImage Source: Dr. Van Duyne (Northwestern University)Surface Plasmon Resonance23Plasmonic NanoparticlesGold NanoSpheres– Diameter from 5 – 150 nm– Tunable peak absorption– 510 – 650 nm400500600700800900Wavelength (nm)2412
10/6/2016Tuning in the NIRGold NanoRods– Aspect ratio adjusts λ– 2 SPR modes– Silica-coating stabilizes– 600 – 1400 nm450550650750850950Wavelength (nm)25USPA ImagingCombined Ultrasound and Photoacoustic (USPA) ImagingABCDY. S. Chen, W. Frey, S. Kim, P. Kruizinga, K. Homan and S. Emelianov, "Silica-coatedgold nanorods as photoacoustic signal nanoamplifiers," Nano Lett 11(2), 348-354 (2011)2613
10/6/2016Exogenous Contrast via EPRAfter NP injectionBefore NP injection(63 bC[HbO2]HbO2PAamplitudePAamplitudeUSNanoparticles accumulate via enhanced permeabilityand retention (EPR) effect in tumors27Molecular Imaging with USPAMolecularly specificnanoparticle probesMultimodal imagingtechnique28Image: tages.html14
10/6/2016What is necessary to achieve molecular specificityfor virtual histology with USPA imaging? Conjugate PEG to particle surface Utilize EPR effect Conjugate biospecific molecules to particle surface Nanobots29Virtual Histology Future of photoacoustics:– Molecular profiling in vivo using contrast agents– Longitudinal animal studies Monitoring molecular responses to therapy Decreasing animal sacrifice Limiting the need for histologyUltrasoundTumorPhotoacoustic (PA)Molecular PA-l3015
10/6/2016Molecular TargetingDarkfield Microscopy of J774A.1 cells after 24 hour incubation with Agnanoplates. Imaging is 10 hour time lapse, 6 images/hour, video at 2 fps31Molecular TargetingNo Contrast AgentNon-TargetedContrast AgentTargetedContrast Agent3216
10/6/2016In Vivo StudiesDelivered anti-FRβ functionalized ICG-loaded liposomes systemically in vivo to apoE-deficient mouse models of atherosclerosisFRβ Targeted Liposomes33Theranostic NanoparticlesTheranostics Therapy Diagnostics3417
10/6/2016Photothermal Therapy (PTT)PTT is non-invasive, focal, and precise PTT provides selective destruction of cancer cells via hyperthermiaHow it works: Cancer targeted nanorods are injected systemically and accumulate in the tumor The nanorods bind preferentially to cancer cells Irradiation with near-infrared light causes selective heating of the nanorods,inducing cancer cell deathImage Credit: Yun-Sheng Chen35What temperature is required to achieve cell deathvia hyperthermia? 35oC 40oC 50oC 60oC3618
10/6/2016Photothermal Therapy (PTT)180 sec0 ΔT 15 201612840012Time (min)3 4 5C[NP] 50%0 ΔT0ºC0 ΔT15 ThermalMaximum ΔT ( )60 secUS / PA0 sec15 USPA Guided Drug DeliveryLipo-ICGLiposomal encapsulation of ICG J-aggregates for useas a biological sensor and imaging agent.PhospholipidCholesterolTargeting MoietyPEGJ-Aggregated ICG3819
10/6/2016Sensor Capabilities Spectral shifts present upon uptake– Shift due to breakdown of J-aggregates– Observed in vitro via UV-Vis and PAimaging– USPA guided drug delivery!39Triggered Drug ReleaseLaser-Initiated NanoSyringe(LINS)TargetingMoiety4020
10/6/2016Summary Photoacoustic imaging improves characterization of diseaseContrast agents greatly aid in visualizationBiofunctionalization enables molecular imaging and virtual histologyTheranostic therapies combine therapy with diagnosticsNovel particle design can enable targeted therapyPhospholipidUltrasoundPhotoacoustic (PA)CholesterolMolecular PA-lTargeting MoietyPEGTumorJ-Aggregated ICG41Bringing Benchtop Science to the ClinicSBIR and AIP Programs4221
10/6/2016Patents and References Emelianov, S., Sokolov, K., Luke, G., Bayer, C., Harris, J., and Lee, A. Methods OfDetecting Biological Activity, Cellular Behavior And Drug Delivery UsingEncapsulated Polymethine Aggregates. Provisional US patent 62113477 (2015).Sethuraman, S., Amirian, J. H., Litovsky, S. H., Smalling, R. W. & Emelianov, S. Y.Spectroscopic intravascular photoacoustic imaging to differentiate atheroscleroticplaques. Optics express 16, 3362-3367 (2008).Wang, B., Emelianov, S., et al. Plasmonic Intravascular Photoacoustic Imaging forDetection of Macrophages in Atherosclerotic Plaques. Nano Letters 9, 2212-2217,doi:10.1021/nl801852e (2009).Yeager, D., Emelianov, S., et al. Intravascular photoacoustic imaging of exogenouslylabeled atherosclerotic plaque through luminal blood. Journal of biomedical optics17, 106016-106016 (2012).Luke, G. P., Yeager, D. & Emelianov, S. Y. Biomedical applications of photoacousticimaging with exogenous contrast agents. Annals of biomedical engineering 40,422-437 (2012).Luke, G. P., Nam, S. Y. & Emelianov, S. Y. Optical wavelength selection for improvedspectroscopic photoacoustic imaging. Photoacoustics 1, 36-42 (2013).NanoHybrids Confidential4322
10/6/20162016 Material Science Series“Treating Cancer with Nanoparticles Powered by the Sound of Light”Justin HarrisLead Research Scientist,NanoHybridsMark JonesExecutive External Strategy andCommunications Fellow,Dow ChemicalSlides available now! Recordings will be available to ACS memberswww.acs.org/acswebinarsThe 2016 Material Science Series is co-produced withACS Industry Member Programs, C&EN, and the ACS POLY Division452016 Material Science ver the material science innovationsthat make a healthy life possible!The 2016 Material Science Series is co-produced withACS Industry Member Programs, C&EN, and the ACS POLY Division4623
10/6/2016National Nanotechnology Day:October 9, 2016A joint project of the National Nanotechnology Coordinating Office andscientific societies, National Nanotechnology Day features a series ofcommunity-led events and activities on or around Oct. 9 to help to raiseawareness of nanotechnology, how it is currently used in products thatenrich our daily lives and the challenges and opportunities it holds for thefuture. The date pays homage to the nanometer scale, 10-9 meters!www.acs.org/nano47Upcoming ACS Webinarswww.acs.org/acswebinarsSPECIAL BROADCAST: Tuesday, October 11, 2016 @ 7pm ETThe Chemists' Code for Success: 3 Essential Skill Setsfor Your CareerPatricia Simpson, Owner/Consultant, Game Changing Etiquette and Director ofAcademic Advising and Career Services, University of IllinoisAmanda Yarnell, Managing editor, editorial, Chemical & Engineering NewsThursday, October 13, 2016Failure: Why Science Is So SuccessfulStuart Firestein, Professor of Neurobiology, Columbia UniversityDarren Griffin, Professor of Genetics, University of KentContact ACS Webinars at acswebinars@acs.org4824
10/6/20162016 Material Science Series“Treating Cancer with Nanoparticles Powered by the Sound of Light”Justin HarrisLead Research Scientist,NanoHybridsMark JonesExecutive External Strategy andCommunications Fellow,Dow ChemicalSlides available now! Recordings will be available to ACS memberswww.acs.org/acswebinarsThe 2016 Material Science Series is co-produced withACS Industry Member Programs, C&EN, and the ACS POLY Division49How has ACS Webinars benefited you?“I know quite a lot about shear thickening in paints andpigment pastes and spent many years trying to preventits occurrence in commercial products. I thought theexplanations of shear thickening were excellent and Iwas fascinated by the practical applications for good ofthe phenomenon.”Quote in reference to: http://bit.ly/STFTechnologyDaniel A. Green,Clifford SchoffConsultant, Schoff AssociatesACS member for 48 years strong!Be a featured fan on an upcoming webinar! Write to us @ acswebinars@acs.org5025
10/6/201651Benefits of ACS MembershipChemical & Engineering News (C&EN)The preeminent weekly news source.NEW! Free Access to ACS Presentations on Demand ACS Member only access to over 1,000 presentationrecordings from recent ACS meetings and select events.NEW! ACS Career NavigatorYour source for leadership development, professionaleducation, career services, and much more.http://bit.ly/benefitsACS5226
10/6/2016 ACS Webinars does not endorse any products orservices. The views expressed in this presentation arethose of the presenter and do not necessarily reflectthe views or policies of the American ChemicalSociety.Contact ACS Webinars at acswebinars@acs.org53Upcoming ACS Webinarswww.acs.org/acswebinarsSPECIAL BROADCAST: Tuesday, October 11, 2016 @ 7pm ETThe Chemists' Code for Success: 3 Essential Skill Setsfor Your CareerPatricia Simpson, Owner/Consultant, Game Changing Etiquette and Director ofAcademic Advising and Career Services, University of IllinoisAmanda Yarnell, Managing editor, editorial, Chemical & Engineering NewsThursday, October 13, 2016Failure: Why Science Is So SuccessfulStuart Firestein, Professor of Neurobiology, Columbia UniversityDarren Griffin, Professor of Genetics, University of KentContact ACS Webinars at acswebinars@acs.org5427
Nanoparticles absorb light and thermoelastically expand Ultrasonic acoustic waves are produced Photoacoustic Effect Photoacoustic signal is generated from agents with high optical absorption cross sections Image Source: Homan et al, "Combined Photoacoustic and Ultrasound Imaging of Metal Nanoparticles In Vivo," in
May 02, 2018 · D. Program Evaluation ͟The organization has provided a description of the framework for how each program will be evaluated. The framework should include all the elements below: ͟The evaluation methods are cost-effective for the organization ͟Quantitative and qualitative data is being collected (at Basics tier, data collection must have begun)
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Chính Văn.- Còn đức Thế tôn thì tuệ giác cực kỳ trong sạch 8: hiện hành bất nhị 9, đạt đến vô tướng 10, đứng vào chỗ đứng của các đức Thế tôn 11, thể hiện tính bình đẳng của các Ngài, đến chỗ không còn chướng ngại 12, giáo pháp không thể khuynh đảo, tâm thức không bị cản trở, cái được
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Le genou de Lucy. Odile Jacob. 1999. Coppens Y. Pré-textes. L’homme préhistorique en morceaux. Eds Odile Jacob. 2011. Costentin J., Delaveau P. Café, thé, chocolat, les bons effets sur le cerveau et pour le corps. Editions Odile Jacob. 2010. Crawford M., Marsh D. The driving force : food in human evolution and the future.
