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Abstract ID: 11016Title: Higher surgical volume is associated with better outcomes for frail patients undergoing surgery forovarian cancerPresenting Author: Morcos Nakhla, MSObjectives: Frailty is a syndrome of decreased physiologic reserve and decreased resilience to stressthat has been associated with adverse outcomes following many operative procedures. We aimed toevaluate these findings among patients undergoing surgery for ovarian cancer (OC) using a nationwidedatabase.Methods: Inpatient hospitalizations were identified for patients undergoing surgery for OC using the2005-2017 National Inpatient Sample database. International Classification of Diseases-9th and -10thRevision (ICD-9 and ICD-10) codes were used in conjunction with the Johns Hopkins Adjusted ClinicalGroups (ACG) frailty-defining diagnosis indicator to designate frailty. Multivariate regression modelswere used to assess the association of frailty with postoperative outcomes and resource utilization.Results: Of an estimated 198,820 patients, 6.1% (12,085) were considered frail. Frail patients were older(66 vs. 60 years; p 0.001) and had a greater burden of comorbidities as measured by the Elixhausercomorbidity index (4.3 vs 2.9; p 0.001). The proportion of frail patients undergoing surgery increasedsignificantly throughout the study period (p 0.001) while the overall rate of in-hospital mortalitydecreased over time (p 0.001). Adjusting for patient and hospital characteristics, frailty was associatedwith an increased likelihood of mortality (Adjusted Odds Ratio (AOR): 2.5 (CI 1.8 to 3.6)), non-homedischarge (AOR:3.4 (CI 2.9 to 4.0)) and complications (AOR:1.6 (CI 1.4 to 1.8)), including respiratory(AOR:1.8 (CI 1.6 to 2.0)) and infectious (AOR:1.9 (CI 1.6 to 2.3)) complications. When evaluating surgicalvolume in tertiles, frail patients were less likely to be treated at the highest volume institutions (31% vs36%; p 0.012). Increased surgical volume was associated with decreased mortality among frail patientscompared to non-frail counterparts (Figure). Frailty was also associated with a 4-day longer length ofstay per hospitalization (β 4.3 days; p 0.001) as well as a 12,139 increase in hospitalization costs (β 12,139; p 0.001).Conclusions: While frailty is associated with worse outcomes in surgical patients with OC, theseoutcomes have improved significantly over the study period despite a simultaneous increase in frailpatients. Although frail patients are less likely to be treated at institutions with higher surgical volumecompared to their non-frail counterparts, those frail patients who do undergo surgery at these centershave decreased inpatient mortality rate. Efforts to mitigate the impact of frailty among OC patientsshould be further explored.

Abstract ID: 10463Title: Frailty repels the knife: The impact of frailty index on surgical intervention and outcomesPresenting Author: Katelyn Handley, MDObjectives: We aimed to assess the impact of frailty in ovarian cancer patients on surgical proceduresand outcomes.Methods: A retrospective review of a prospectively collected database from April 2013 to September2017 was performed. Patients with advanced disease were triaged by laparoscopy to determine primaryresectability. The modified frailty index score (mFI) was calculated based on the sum of 10 items: chronicobstructive pulmonary disease or recent pneumonia, congestive heart failure, myocardial infarction,coronary artery disease, diabetes, hypertension, peripheral vascular disease, cerebrovascular disease(CVA), CVA with neurologic deficit, and Eastern Cooperative Oncology Group (ECOG) status 3 or 4, witheach item receiving a score of 1 if present. Patients with an mFI 2 were classified as high frailty. Clinicaloutcomes were assessed and compared by mFI using t-test or Fisher’s exact test. Progression-freesurvival (PFS) and overall survival (OS) were estimated using the Kaplan-Meier method.Results: A total of 591 patients met inclusion criteria. A total of 57% of patients had an mFI of 0, 29%mFI of 1, and 14% mFI 2. There was no difference in stage by mFI (p 0.984). Patients with high frailtywere less likely to be offered a laparoscopic surgery to determine primary resectability than those withan mFI of 1 or 0 (27.63% vs 42.77% vs 48.58%, respectively, p 0.004). If laparoscopy was performed,the modified Fagotti score was more likely to be 8 in patients with a higher frailty score (58%, 48%,and 34% for a score of 2, 1, and 0, respectively, p 0.038), leading to only 17% of the high frailtycohort proceeding with primary debulking surgery, compared to 26% and 34% in patients with mFI 1and mFI 0 (p 0.015). Furthermore, patients with a higher frailty score were less likely to undergo anytumor reductive surgery (TRS), whether primary or interval (59% vs 74% vs 85% for a score of 2, 1, and0, respectively, p 0.001). Death was a more frequent reason for lack of TRS in patients with a higherfrailty score (52% vs 24% vs 22% in patients with a frailty score 2, 1, and 0, respectively, p 0.011).Patients with high frailty were more likely to undergo splenectomy (20% vs 3% vs 6% for a frailty scoreof 2, 1, and 0, respectively, p 0.001) and small bowel resection (SBR) (14% vs 8% vs 3% for a frailtyscore 2, 1, and 0, respectively, p 0.006). Intraoperative complications were more frequent in patientswith higher mFI (43% vs 37% vs 26% for a score of 2, 1, and 0, respectively). Postoperativecomplications were similarly correlated with higher mFI, more specifically, increased intraoperativehematologic complications and increased postoperative respiratory, gastrointestinal, and woundcomplications. The median postoperative length of stay was 4 days regardless of frailty score. Onmultivariate analysis, high frailty was associated with a worse PFS (p 0.009) and tended towards worseOS (p 0.079).Conclusions: Frailty is associated with bulkier disease, decreased surgical intervention, and worseclinical outcomes.

Abstract ID: 10453Title: Long-term follow-up of anal cytology and HPV genotyping among women with lower genital tractneoplasiaPresenting Author: Ashley Valenzuela, DOObjectives: Determine the risk of abnormal anal cytology among women with a history of cervical,vulvar or vaginal high-grade dysplasia or cancer (high-risk cohort) 5 years following initial anal dysplasiascreening. Determine the persistence, progression, or regression of anal dysplasia or cancer in this highrisk group over a 5 year period.Methods: This is a 5-year follow up of an IRB approved prospective cohort study that compared the rateof abnormal anal cytology between a high-risk cohort and control group. The high-risk cohort wasidentified as women with a history of cervical, vulvar or vaginal high-grade dysplasia or cancer. Thecharts of the patients in the high-risk cohort were reviewed to determine the prevalence of analdysplasia or cancer as well as the rate of persistence, progression, or regression based on screeningresults in the primary study.Results: The 190 patients in the high-risk cohort were reviewed 5 years after initial data collection. Inour prior study, 22% of the control cohort (women without a history of cervical, vulvar, or vaginaldysplasia or cancer) had abnormal anal cytology compared to 41% of the high-risk cohort. High-risk HPVwas detected in the anal canal of 1.2% of the control group compared to 20.8% of the high-risk group.No anal dysplasia was detected in the control group while 13.4% in the high-risk group had analintraepithelial neoplasia (AIN), including eight women (4.3%) with AIN 2 or anal cancer.A total of 5years after initial anal Pap smear, only 17 women (9%) of the high-risk cohort had repeat anal Pap smearperformed. Of these, all 17 patients had abnormal anal cytology at initial anal Pap smear. A total of 3patients had multiple repeat anal Pap smears in the follow up period. A total of 9 of these women (53%)had persistence of anal dysplasia after 5 years. One patient (6%) had progression from AIN 1 to AIN 3over the 5 year period. Seven patients (41%) had regression of AIN to normal cytology.Conclusions: While women with a history of HPV-related genital neoplasias are at risk for anal dysplasiaand cancers, the role of screening in this population remains unclear. Anal cytology screening amongHIV-positive individuals has become more common, but the appropriate frequency of screening remainsunknown. While follow up was rare in this cohort, the data from this long-term follow up reveals thatwomen with lower genital tract dysplasia or carcinoma are at increased risk for anal dysplasia orcarcinoma. Routine anal Pap screening should be considered in this high-risk population. Future studiesaim to contact these women to collect repeat anal cytology for a better understanding on the long-termrisk of anal dysplasia with lower gynecologic tract dysplasia or malignancies.

Abstract ID: 10663Title: COVID‐19 outcomes of patients with gynecologic cancer in New York City: An updated analysisPresenting Author: Olivia Lara, MD, MSObjectives: Despite a growing body of literature, characterization of COVID-19 infection in patients withgynecologic cancer remains limited. Here we present an update of COVID-19 outcomes in New York City(NYC) from the initial surge of severe acute respiratory syndrome coronavirus 2 (coronavirus disease2019 [COVID‐19]). We sought to determine the hospitalization and mortality rates and their associatedfactors, specifically recent chemotherapy and immunotherapy use.Methods: Data were abstracted from gynecologic oncology patients with COVID-19 infection among 8New York City (NYC) area hospital systems. Multivariable logistic regression was utilized to analyzeCOVID-19 related hospitalization and mortality.Results: Of 193 patients with gynecologic cancer and COVID-19, the median age at diagnosis was 65.0years (interquartile range, 53.0-73.0 years). A total of 106 of the 193 patients (54.9%) requiredhospitalization; among the hospitalized patients 13 (12.3%) required invasive mechanical ventilation and39 (36.8%) required ICU admission. No patients requiring mechanical ventilation survived. A total of 34of 193 (17.6%) patients died of COVID-19 complications. On multivariable analysis, hospitalization wasassociated with an age greater than or equal to 65 years (odds ratio [OR] 2.12, 95% confidence interval[CI] 1.11, 4.07), Black race (OR 2.53, CI 1.24, 5.32), performance status greater than or equal to 2 (OR3.67, CI 1.25, 13.55) and greater than or equal to 3 comorbidities (OR 2.00, CI 1.05, 3.84). Only former orcurrent history of smoking (OR 2.75, CI 1.21, 6.22) was associated with death due to COVID-19 onmultivariable analysis. A total of 13 of 34 (38.23%) patients who died of COVID-19 complicationsreceived cytotoxic chemotherapy, while 4 of 34 (11.76%) patients received immunotherapy. However,recent cytotoxic chemotherapy use was not predictive of COVID-19 hospitalization or mortality onmultivariable analysis.Conclusions: The case fatality rate among gynecologic oncology patients with COVID-19 infection is17.6%. Cancer-directed therapy, including immunotherapy use, is not associated with an increased riskof mortality related to COVID-19 infection in this larger cohort.

Abstract ID: 10947Title: Widening cancer care disparities in the adoption of telemedicine during COVID 19: Who is leftbehind?Presenting Author: Michael Richardson, MDObjectives: To determine the racial disparities in oncology visits of racial minorities before and afterCOVID-19.Methods: Data were obtained from the electronic health records, a multi-specialty healthcare systemserving a racially/ethnically diverse patient population in northern California. The study cohort includedpatients who had at least one oncology visit from January 2019 to August 2020. We examined the trendsin the volume of oncology office visits and adoption of video visits during the ongoing COVID-19pandemic period. Chi-square test and multivariate logistic regression were performed to examinevariability in use of video visits by specific patient characteristics (sex, age, race/ethnicity and languagebarrier).Results: Of 63,903 cancer patients (median age: 66; 68% female), Whites, Blacks, Hispanics, Asians andothers composed of 64.8%, 3.5%, 9.2%, 11.7% and 10.8% of our study cohort. Over the 20 month studyperiod, the drop in in-person visits began in March and peaked in April 2020. Compared to the year2019, the office visits decreased by -16.6%, -55.9%, and -50.9% in March, April, and May of 2020.Although there was a trend towards increased office visits in June (-21.9% compared to 2019), this againdecreased to -35% in July 2020. The proportion of visits conducted by video began at 16.6% in the firstweek after California’s shelter-in-place order in March, peaked at a high rate of 43.4% in April, andremained at a rate of 33.8% in August. We focused on variability by specific patient subgroups whentelemedicine was offered and used prevalently during early pandemic in April. Based on age, theyounger cohorts, 18-50 and 51-64 year olds, were more likely to utilize video visit at 50.6%, and 50.6%compared to only 38.0% and 36.7% of the older groups (65-75 and 76 years old, p 0.001). In fact, thelargest discrepancy, 21% difference between the younger vs older groups, was observed towards theend of April. With respect to race, Asians had the highest use of video visits (51.4%) compared toHispanic (34.5%) and Black patients (40.3%) in April (p 0.001). Although the gap narrowed over thenext 4 months with only a 4% difference by August, these cancelled visits were not recovered in theminority groups. Finally, 44.6% of those who did not require an interpreter utilized video visits ascompared to only 19.8% who did require an interpreter (p 0.001). Age and race/ethnicity remainstrong predictors of video visit use after adjusting the main and interaction effects of patientcharacteristics, with Asians 51-64 year old having the highest rate (58%) and Hispanics 76 year old thelowest rate (30%).Conclusions: Overall office visits have decreased significantly during the COVID-19 pandemic. Olderpatients, Black patients, Hispanic patients, and patients who required interpreting services were lesslikely to be treated through video visits. Future studies are needed to better understand the barriers totelemedicine care.

Abstract ID: 11002Title: Cancer never stops: SARS-CoV-2 pandemic and the effect on research within GOG partnersPresenting Author: Brian Slomovitz, MDObjectives: The SARS-CoV-2 pandemic forced a shift in conducting clinical research. Ensuring the safetyof all stakeholders (patients, research personnel, family members), maintaining financial viability, andovercoming operational restrictions (limited access to sites, workforce restrictions, reduced datacollection) are barriers to continuing clnical research. GOG Partners, the GOG Foundation industrysponsored clinical trials group, has been proactive to implement the following: - Immediatecompliance with CDC, FDA, and NIH guidelines with regard to clinical trial management. - Systems thatallowed for remote monitoring and other remote activities (telemedicine patient visits, remote datacollection, shipping of drug to patients, virtual study start-up). - Enhance enrollment opportunitesaway from university-based sites towards community-based practices. - Increased frequency of ouroperations meetings with industry. The objective of this report is to describe how the pandemicaffected accrual to GOG Partners’ trials.Methods: Accrual data for GOG Partners trials over the past 4 years (2017- July 2020) were collected.'Pandemic' months were considered March thru July 2020. Information collected included accrualnumbers, institution type (university versus non-university), and region of country. Descriptive statisticswere analyzed.Results: Over the past 4 years, the median monthly accrual to GOG Partners trials was 43 patients(range: 14-95). Between March and July 2020, the median accrual was 59 patients (range: 43-72). Forthe same 5-month period over the past 3 years (March to July 2017, 2018, 2019) the median accrual was36 (14-95). Accrual in March 2020 was 69 patients. Accrual decreased to 43 patients in April 2020 and 47patients in May 2020 with respective z-scores of -0.25 and -0.01. June and July 2020 showed increasedaccrual with 59 and 72 patients respectively. The median number of participating sites per month overthe past 4 years was 32 (9-66). There was an immediate decline in the number of sites participating fromApril to May 2020 of 36%. The number of sites participating in June and July were 38 and 52,respectively. During the pandemic, the accrual in the New England, Mid-Atlantic, Pacific and SouthAtlantic regions varied from their baselines. These variations followed the trends in COVID-19 spread.Non-university institutions accrued at a near-average rate throughout the months of April and May.During that same period, universities observed a decline in accrual of 48%.Conclusions: Accrual to GOG Partners' trials increased 37% over the median monthly accrual since thepandemic began. During the pandemic, total monthly accrual fell below or reached the median duringonly 1 month. Regional diversity of sites participating in GOG Partners' studies helped in preventing amore dramatic drop in participation. While overall accrual has historically shown to be relativelybalanced between institution types, non-university institutions were less negatively impacted.

Abstract ID: 11163Title: Preoperative wait times in high-grade endometrial cancer: Do surgical delays impact patientsurvival?Presenting Author: Andra Nica, MD, MSc, FRCSCObjectives: Practice guidelines advocating for the regionalization of endometrial cancer surgery togynecologic oncologists practicing in designated gynecologic oncology centres were released by CancerCare Ontario in June 2013. We sought to determine the impact this policy had on contemporary surgicalwait times. Moreover, a discussion about the impact of delays in treatment has never been more timelythan in the context of the current COVID19 pandemic, which has burdened health care systems aroundthe world. Our primary objective was to establish whether longer wait time to surgery is a predictor ofsurvival in patients with high grade endometrial cancer.Methods: This was a retrospective cohort study, which included patients diagnosed with nonendometrioid high-grade endometrial cancer (serous, carcinosarcoma, clear cell, and undifferentiated)between 2003 and 2017. A total of 2 regionalization periods were defined, before and after January2014 to allow 6 months for knowledge translation after guideline publication. Patients were identified inpopulation-based administrative provincial data sources. Multivariable Cox proportional hazardsregression with a spline function was used to model the relationship between wait time and overallsurvival, as measured from time of surgery.Results: We identified 3518 patients with high grade endometrial cancer. Median wait time betweendiagnosis and surgery for the entire cohort did not significantly change with regionalization of care (50vs 52 days, p 0.14). Patients who had surgery with a gynecologic oncologist had a median surgical waittime from diagnosis to hysterectomy of 55 days compared to 59 days pre-regionalization (p 0.0002),and from first gynecologic oncology consultation to hysterectomy of 29 days compared to 32 days preregionalization (p 0.0006). Survival was worst for patients who had surgery within 14 days of diagnosis(HR death 2.7, 95%CI 1.61-4.51 for 1-7 days and HR death 1.96, 95%CI 1.5-2.57 for 8-14 days), indicatingdisease severity. Decreased survival occurred with surgical wait times of more than 45 days from thepatient’s first gynecologic-oncology appointment (HR death 1.19, 95%CI 1.04-1.36 for 46-60 days and HRdeath 1.42, 95%CI 1.11-1.82).Conclusions: Regionalization of surgery for high grade endometrial cancer has not had a negative impacton surgical wait times. Impact on survival is seen with patients who have surgery more than 45 daysafter surgical consultation.

Abstract ID: 11139Title: Long-term safety and secondary efficacy endpoints in the ENGOT-OV16/NOVA phase III trial ofniraparib in recurrent ovarian cancerPresenting Author: Ursula Matulonis, MDObjectives: In the ENGOT-OV16/NOVA study, maintenance therapy with niraparib significantlyp

ovarian cancer Presenting Author: Morcos Nakhla, MS Objectives: Frailty is a syndrome of decreased physiologic reserve and decreased resilience to stress that has been associated with adverse outcomes following many operative procedures. We aimed to evaluate these findings among patients undergoing surgery f