Infant Flow Driver Advance Set Up Guideline - Networks

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JAUNDICE 2PHYSIOLOGICAL &PATHALOGICAL JAUNDICELYNSEY WARDNETWORK NURSE EDUCATOR31ST MARCH 2006

JAUNDICE

OUTCOMES To understand what Jaundice is. To understand what Biliruben is. To identify the difference betweenpathological and physiological jaundice. Management and treatment of Jaundice

What is Jaundice Neonatal jaundice Definition Neonatal jaundice is the term used when anewborn has an excessive amount of bilirubin inthe blood. Bilirubin is a yellowish-red pigmentthat is formed and released into the bloodstreamwhen red blood cells are broken down. Jaundicecomes from the French word jaune, which meansyellow; thus a jaundiced baby is one whose skincolour appears yellow due to bilirubin.

Predisposing causes ofJaundice A newborn baby has a haemoglobin (Hb) level of18-19g/dl. This is necessary during fetal life tofacilitate oxygen carrying capacity. As soon as the baby is born and able to breatheoxygen the high Hb level is not needed and startsto drop. In the first week of life the baby’s Hb will drop toabout 11g/dl and this breakdown of the foetalRBC’s may cause bilirubin to exceed the plasmacarrying capacity of the blood. Therefore causing Physiological JAUNDICE

What is BILIRUBEN? Bilirubin is a product of haemoglobinbreak-down. Haemoglobin is contained inthe red blood cells and it’s most importantfunction is to carry oxygen to the tissues. When a red blood cell reaches the end ofit’s life, the reticuloendothial system takes itout of circulation. This consists of the liver and spleen.

What is BILIRUBEN? The haemoglobin is broken down into it’s twoconstituents: Haem and Globin. The globin is a protein which is re-used by the body. The Haem is an iron compound and so can’t be re-used. Itis broken down to be excreted. Biliruben is a product of this last process and theaccumulation in the blood causes yellow staining on theskin: JAUNDICE. Biliruben can cross the blood/brain barrier and stain thebasal ganglia. The staining is permanent, Damageirreversible, which is why high SBR is so dangerous

Types of Jaundice Physiological Jaundice Pathological Jaundice

Types of JaundicePhysiological This occurs in the first few days after birthand will have cleared by day 10 It occurs because of physiological changestaking place during the transition fromintrauterine to neonatal life It is the consequence of:immature liver enzymes, high red cell mass

Other Factors which mayincrease Physiological Jaundice PrematurityBruisingPolycythemiaBreast feeding

Types of JaundicePathological This refers to jaundice that arises from factors thatalter the usual process involved in bilirubenmetabolism in the liver It is significant in the first 24hrs of life especiallyif there is Rhesus incompatibility It may persist more than 2 weeks in someconditions when the baby will be jaundice all overand may appear a muddy yellow colour

Pathological Jaundice This includes : Group incompatibility(Haemolytic Diseaseof the Newborn)Rhesus factor, ABOincompatibility Hypoxemia Sepsis Endocrine ormetabolic disordersand bile ductobstruction hypoglycaemia

Management of Jaundice The aim of the management of Jaundice isto prevent biliruben encephalopathy(kinicterus) developing as a result of highlevels of serum biliruben.

Management of JaundiceStart investigations if: Jaundice is significant inthe first 24hrs Jaundice persists after 10days If the SBR is above250umol/l or less inpreterm babies If Jaundice is present in ababy who is already ill

Management of Jaundice Ascertain mothers blood group forcompatibility and rhesus antibody status.Coombes antibody status should beobtained from mothers notes. Check baby’s blood group for Rhesusstatus, and Hb in case the jaundice is causedby haemolysis causing anaemia Check baby for Infection

Management of Jaundice If the baby’s SBR is above thetreatment line (depending onwhich charts your unit uses)Photo therapy can commence. You may need to increase thebaby’s fluid depending on youunits policy. (you need to befamiliar with unit policy) Indomethacin dislodgesBiliruben from it’s plasmabinding site so increases SBR

JAUNDICE You may require I.V.access. You may need to passan Ng/Og tube. Once Phototherapyhas commenced youneed to take an SBR atregular intervals thefrequency dependingon how high it is.

Management of Jaundice If the therapy that is being given isn’t reducing theSBR you may need to consider an ExchangeTransfusion. The decision to exchange transfuse isnot just determined by the level but by the rate ofwhich the increase, which is why it is so importantto plot SBR result on a time/SBR level graph Generally Jaundice reduces by following theprocedures already mentioned Therefore after a few days of treatment, thejaundice will subside and the treatment can bediscontinued.

JAUNDICE

What is Jaundice Neonatal jaundice Definition Neonatal jaundice is the term used when a newborn has an excessive amount of bilirubin in the blood. Bilirubin is a yellowish-red pigment that is formed and released into the bloodstream when red blood cells are broken down. Jaundice comes from the French word jaune, which means

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